Development of a GMP Phase III purification process for VB4-845, an immunotoxin expressed in E. coli using high cell density fermentation

Protein Expression and Purification

Volumn 78, Issue 1, 2011, Pages 27-37

  Premsukh, Arjune ^a   Lavoie, Joelle M ^a   Cizeau, Jeannick ^a   Entwistle, Joycelyn ^a   MacDonald, Glen C ^a  

^a Viventia Biotech Inc   (Canada)

Author keywords

High cell density; Immunotoxin; Phase III production

Indexed keywords

HYBRID PROTEIN; IMMUNOTOXIN; OPORTUZUMAB MONATOX;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; BIOTECHNOLOGY; CELL COUNT; CHEMISTRY; ESCHERICHIA COLI; FERMENTATION; FOOD AND DRUG ADMINISTRATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PROTEIN BINDING; PROTEIN STABILITY; STANDARD; UNITED STATES; WESTERN BLOTTING;

BIOREACTORS; BIOTECHNOLOGY; BLOTTING, WESTERN; CELL COUNT; ESCHERICHIA COLI; FERMENTATION; IMMUNOTOXINS; PROTEIN BINDING; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS EXOTOXIN;

EID: 79955593880     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2011.03.009     Document Type: Article

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