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1
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0018927306
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The receptosome: An intermediate organelle or receptor-mediated endocytosis in cultured fibroblasts
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Willingham MC, Pastan I (1980) The receptosome: an intermediate organelle or receptor-mediated endocytosis in cultured fibroblasts. Cell 21:67
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Cell
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Willingham, M.C.1
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2
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0020711710
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Adenovirus-induced release of epidermal growth factor and Pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis
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FitzGerald DJP, Padmanabhan R, Pastan IH, Willingham MC (1983) Adenovirus-induced release of epidermal growth factor and Pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell 32:607
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Cell
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FitzGerald, D.J.P.1
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3
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0021231875
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PE-anti-TAC: A cell-specific immunotoxin active against cells expressing the human T-cell growth factor receptor
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FitzGerald DJP, Waldmann TA, Willingham MC, Pastan I (1984) PE-anti-TAC: a cell-specific immunotoxin active against cells expressing the human T-cell growth factor receptor. J Clin Invest 74:966
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FitzGerald, D.J.P.1
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Willingham, M.C.3
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5
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0023657391
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Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
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Hwang J, FitzGerald DJP, Adhya S, Pastan I (1987) Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. Cell 48:129
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Cell
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Hwang, J.1
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Pastan, I.4
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6
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0025787660
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Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation
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Siegall CB, Ogata M, Pastan I, FitzGerald DJ (1991) Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation. Biochemistry 30:7154
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Biochemistry
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Siegall, C.B.1
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7
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0025826197
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Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas
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Pastan I, Lovelace ET, Gallo MG, Rutherford AV, Magnani JL, Willingham MC (1991) Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas. Cancer Res 51:3781
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Cancer Res
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Pastan, I.1
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Willingham, M.C.6
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8
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0029925934
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Treatment of advanced solid tumors with immunotoxin LMB-1: An antibody linked to Pseudomonas exotoxin
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Pai LH, Wittes R, Setser A, Willingham MC, Pastan I (1996) Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nature Med 2:350
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Pai, L.H.1
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Pastan, I.5
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9
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0024349836
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A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
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Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I (1989) A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 339:394
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Chaudhary, V.K.1
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Waldmann, T.A.4
FitzGerald, D.J.5
Pastan, I.6
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10
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0026510381
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Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: Influence of interdomain connections
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Brinkmann U, Buchner J, Pastan I (1992) Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections. Proc Natl Acad Sci USA 89:3075
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Proc Natl Acad Sci USA
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Brinkmann, U.1
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Pastan, I.3
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11
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0027183934
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A recombinant immunotoxin containing a disulfide-stabilized Fv fragment (dsFv)
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Brinkmann U, Reiter Y, Jung S-H, Lee B, Pastan I (1993) A recombinant immunotoxin containing a disulfide-stabilized Fv fragment (dsFv). Proc Natl Acad Sci USA 90:7538
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Brinkmann, U.1
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Lee, B.4
Pastan, I.5
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12
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0030954684
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Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors
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Mansfield E, Amlot P, Pastan I, FitzGerald D (1997) Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Blood 80:2020
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Blood
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Mansfield, E.1
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13
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0033047767
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Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-38 at doses tolerated by cynomolgus monkeys
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Kreitman RJ, Wang Q-C, FitzGerald DJP, Pastan I (1999) Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-38 at doses tolerated by cynomolgus monkeys. Int J Cancer 81:148
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Int J Cancer
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Kreitman, R.J.1
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Pastan, I.4
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14
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0035954624
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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
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Kreitman RJ, Wilson WH, Bergeron K, Raggio M, Stetler-Stevenson M, FitzGerald DJ, Pastan I (2001) Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med 345:241
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N Engl J Med
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Kreitman, R.J.1
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15
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0029165134
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Administration of disulfide-stabilized Fv-immunotoxins B1(dsFV)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice
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Benhar I, Reiter Y, Pai LH, Pastan I (1995) Administration of disulfide-stabilized Fv-immunotoxins B1(dsFV)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice. Int J Cancer 62:351
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Int J Cancer
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16
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0030069718
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Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas and ovarian cancers
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Chang K, Pastan I (1996) Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas and ovarian cancers. Proc Natl Acad Sci USA 93:136
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Chang, K.1
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0031931487
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Isolation of a high affinity stable single chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
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Chowdhury P, Viner JL, Beers R, Pastan I (1998) Isolation of a high affinity stable single chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proc Natl Acad Sci USA 95:669
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Chowdhury, P.1
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18
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0033056238
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Improving antibody affinity by mimicking somatic hypermutation in vitro
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Chowdhury PS, Pastan I (1999) Improving antibody affinity by mimicking somatic hypermutation in vitro. Nature Biotechnol 17:568
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Chowdhury, P.S.1
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19
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0032837077
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Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor
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Pai-Scherf L, Villa J, Pearson D, Watson T, Liu E, Willingham MC, Pastan I (1999) Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor. Clin Cancer Res 5:2311
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Clin Cancer Res
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Pai-Scherf, L.1
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0033302303
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Transport of molecules, particles, and cells in solid tumors
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Jain RK (1999) Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1:241
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Site-specific chemical modification of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
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Tsutsumi Y, Onda M, Nagata S, Lee B, Kreitman RJ, Pastan I (2000) Site-specific chemical modification of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proc Natl Acad Sci USA 97:8548
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22
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0027504119
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Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin
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Wang QC, Pai LH, Debinski W, FitzGerald DJ, Pastan I (1993) Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin. Cancer Res 53:4588
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Cancer Res
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Wang, Q.C.1
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