Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis

Cell Death and Differentiation

Volumn 20, Issue 4, 2013, Pages 639-648

  Song, H ^a   Hyun Boo, J ^b   Ho Kim, K ^a   Kim, C ^a   Kim, Y E ^c   Ahn, J H ^c   Sun Jeon, G ^a   Ryu, H ^a,d   Kang, D E ^a,b   Mook Jung, I ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Cell death; DNA damage; Presenilin; Promyelocytic leukemia

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CAMPTOTHECIN; CYCLIN D1; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MESSENGER RNA; PRESENILIN 1; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P53;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN TISSUE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG EXPOSURE; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN TISSUE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; BRAIN; CAMPTOTHECIN; CARBAMATES; CELL LINE; DIPEPTIDES; DNA DAMAGE; GENE EXPRESSION; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; NUCLEAR PROTEINS; PRESENILINS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84874950266     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.162     Document Type: Article

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