-
1
-
-
0030000980
-
Cadherin-catenin complex: Protein interactions and their implications for cadherin function
-
Aberle H, Schwartz H, Kemler R (1996) Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 61: 514-523.
-
(1996)
J Cell Biochem
, vol.61
, pp. 514-523
-
-
Aberle, H.1
Schwartz, H.2
Kemler, R.3
-
2
-
-
0031856533
-
Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin
-
Hsu SC, Galceran J, Grosschedl R (1998) Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol 18: 4807-4818.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4807-4818
-
-
Hsu, S.C.1
Galceran, J.2
Grosschedl, R.3
-
3
-
-
0028987249
-
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
-
Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P (1995) Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 92: 3046-3050.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 3046-3050
-
-
Munemitsu, S.1
Albert, I.2
Souza, B.3
Rubinfeld, B.4
Polakis, P.5
-
4
-
-
0032473355
-
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
-
Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, et al. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J 17: 1371-1384.
-
(1998)
EMBO J
, vol.17
, pp. 1371-1384
-
-
Ikeda, S.1
Kishida, S.2
Yamamoto, H.3
Murai, H.4
Koyama, S.5
-
5
-
-
0037155691
-
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
-
Liu C, Li Y, Semenov M, Han C, Baeg GH, et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
Li, Y.2
Semenov, M.3
Han, C.4
Baeg, G.H.5
-
6
-
-
0033034120
-
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
-
Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, et al. (1999) beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 96: 6273-6278.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6273-6278
-
-
Liu, C.1
Kato, Y.2
Zhang, Z.3
Do, V.M.4
Yankner, B.A.5
-
7
-
-
0030978351
-
beta-catenin is a target for the ubiquitin-proteasome pathway
-
Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16: 3797-3804.
-
(1997)
EMBO J
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
8
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375: 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
-
9
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy J (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20: 154-159.
-
(1997)
Trends Neurosci
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
10
-
-
0035911156
-
Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing
-
Soriano S, Kang DE, Fu M, Pestell R, Chevallier N, et al. (2001) Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol 152: 785-794.
-
(2001)
J Cell Biol
, vol.152
, pp. 785-794
-
-
Soriano, S.1
Kang, D.E.2
Fu, M.3
Pestell, R.4
Chevallier, N.5
-
11
-
-
0034640292
-
Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor
-
Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, et al. (2000) Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem 275: 14440-14445.
-
(2000)
J Biol Chem
, vol.275
, pp. 14440-14445
-
-
Pack-Chung, E.1
Meyers, M.B.2
Pettingell, W.P.3
Moir, R.D.4
Brownawell, A.M.5
-
12
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395: 698-702.
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
Abramowski, D.4
Sturchler-Pierrat, C.5
-
13
-
-
24744459453
-
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling
-
Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, et al. (2005) Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem 280: 31537-31547.
-
(2005)
J Biol Chem
, vol.280
, pp. 31537-31547
-
-
Kang, D.E.1
Yoon, I.S.2
Repetto, E.3
Busse, T.4
Yermian, N.5
-
14
-
-
33745632662
-
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease
-
Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sevalle J, Vincent B, et al. (2006) Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci 26: 6377-6385.
-
(2006)
J Neurosci
, vol.26
, pp. 6377-6385
-
-
Alves da Costa, C.1
Sunyach, C.2
Pardossi-Piquard, R.3
Sevalle, J.4
Vincent, B.5
-
15
-
-
0030779784
-
Skeletal and CNS defects in Presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, et al. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89: 629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
-
16
-
-
35748940970
-
Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway
-
Repetto E, Yoon IS, Zheng H, Kang DE (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem 282: 31504-31516.
-
(2007)
J Biol Chem
, vol.282
, pp. 31504-31516
-
-
Repetto, E.1
Yoon, I.S.2
Zheng, H.3
Kang, D.E.4
-
17
-
-
0037145062
-
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis
-
Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, et al. (2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 110: 751-762.
-
(2002)
Cell
, vol.110
, pp. 751-762
-
-
Kang, D.E.1
Soriano, S.2
Xia, X.3
Eberhart, C.G.4
De Strooper, B.5
-
18
-
-
33744981148
-
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
-
Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, et al. (2006) Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 12: 621-623.
-
(2006)
Nat Med
, vol.12
, pp. 621-623
-
-
Arumugam, T.V.1
Chan, S.L.2
Jo, D.G.3
Yilmaz, G.4
Tang, S.C.5
-
19
-
-
0037166349
-
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin
-
Leem JY, Vijayan S, Han P, Cai D, Machura M, et al. (2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem 277: 19236-19240.
-
(2002)
J Biol Chem
, vol.277
, pp. 19236-19240
-
-
Leem, J.Y.1
Vijayan, S.2
Han, P.3
Cai, D.4
Machura, M.5
-
20
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, et al. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 273: 16470-16475.
-
(1998)
J Biol Chem
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
-
21
-
-
0033151867
-
Excess beta-catenin promotes accumulation of transcriptionally active p53
-
Damalas A, Ben-Ze'ev A, Simcha I, Shtutman M, Leal JF, et al. (1999) Excess beta-catenin promotes accumulation of transcriptionally active p53. EMBO J 18: 3054-3063.
-
(1999)
EMBO J
, vol.18
, pp. 3054-3063
-
-
Damalas, A.1
Ben-Ze'ev, A.2
Simcha, I.3
Shtutman, M.4
Leal, J.F.5
-
22
-
-
0344255675
-
Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion
-
Usami N, Sekido Y, Maeda O, Yamamoto K, Minna JD, et al. (2003) Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion. Oncogene 22: 7923-7930.
-
(2003)
Oncogene
, vol.22
, pp. 7923-7930
-
-
Usami, N.1
Sekido, Y.2
Maeda, O.3
Yamamoto, K.4
Minna, J.D.5
-
23
-
-
0033790502
-
Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators
-
Kim K, Pang KM, Evans M, Hay ED (2000) Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11: 3509-3523.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 3509-3523
-
-
Kim, K.1
Pang, K.M.2
Evans, M.3
Hay, E.D.4
-
24
-
-
0141927326
-
Oxidative stress and activation of proteasome protease during serum deprivation-induced apoptosis in rat hepatoma cells; inhibition of cell death by melatonin
-
Pandey S, Lopez C, Jammu A (2003) Oxidative stress and activation of proteasome protease during serum deprivation-induced apoptosis in rat hepatoma cells; inhibition of cell death by melatonin. Apoptosis 8: 497-508.
-
(2003)
Apoptosis
, vol.8
, pp. 497-508
-
-
Pandey, S.1
Lopez, C.2
Jammu, A.3
-
25
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
-
Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273: 19929-19932.
-
(1998)
J Biol Chem
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
26
-
-
1942502180
-
The many faces of beta-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer
-
Fuchs SY, Spiegelman VS, Kumar KG (2004) The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23: 2028-2036.
-
(2004)
Oncogene
, vol.23
, pp. 2028-2036
-
-
Fuchs, S.Y.1
Spiegelman, V.S.2
Kumar, K.G.3
-
27
-
-
0031034160
-
Activation of the cell death program by inhibition of proteasome function
-
Drexler HC (1997) Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci U S A 94: 855-860.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 855-860
-
-
Drexler, H.C.1
-
28
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
-
29
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
-
Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, et al. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273: 30336-30343.
-
(1998)
J Biol Chem
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
McMurtrey, A.2
Kowalski, J.3
Yan, M.4
Keyt, B.A.5
-
30
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, et al. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A 96: 11872-11877.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
-
31
-
-
0037444574
-
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
-
Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, et al. (2003) gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. J Cell Sci 116: 1127-1136.
-
(2003)
J Cell Sci
, vol.116
, pp. 1127-1136
-
-
Herreman, A.1
Van Gassen, G.2
Bentahir, M.3
Nyabi, O.4
Craessaerts, K.5
-
32
-
-
30744453036
-
ERK1/2 is an endogenous negative regulator of the gamma-secretase activity
-
Kim SK, Park HJ, Hong HS, Baik EJ, Jung MW, et al. (2006) ERK1/2 is an endogenous negative regulator of the gamma-secretase activity. FASEB J 20: 157-159.
-
(2006)
FASEB J
, vol.20
, pp. 157-159
-
-
Kim, S.K.1
Park, H.J.2
Hong, H.S.3
Baik, E.J.4
Jung, M.W.5
-
33
-
-
0034774969
-
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, et al. (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2: 835-841.
-
(2001)
EMBO Rep
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
Capell, A.4
Multhaup, G.5
|