메뉴 건너뛰기




Volumn 12, Issue 21, 2012, Pages 2375-2392

Neurochemistry of schizophrenia: The contribution of neuroimaging postmortem pathology and neurochemistry in schizophrenia

Author keywords

Cannabinoid; Dopamine; Glutamate; Muscarinic; Neuroimaging; Schizophrenia; Serotonin

Indexed keywords

6 FLUORODOPAMINE F 18; AMPHETAMINE; BENZODIAZEPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; DOXEPIN; METHAMPHETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; SEROTONIN;

EID: 84874913750     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802612805289935     Document Type: Review
Times cited : (29)

References (199)
  • 1
    • 0345276638 scopus 로고    scopus 로고
    • Molecular imaging of the brain: A historical perspective
    • Frost, J. J. Molecular imaging of the brain: a historical perspective Neuroimaging Clin.N.Am., 2003, 13, 653-658.
    • (2003) Neuroimaging Clin.N.Am , vol.13 , pp. 653-658
    • Frost, J.J.1
  • 2
    • 0032910319 scopus 로고    scopus 로고
    • Environment and vulnerability to major psychiatric illness: A case control study of early parental loss in major depression, bipolar disorder and schizophrenia
    • Agid, O.; Shapira, B.; Zislin, J.; Ritsner, M.; Hanin, B.; Murad, H.; Troudart, T.; Bloch, M.; Heresco-Levy, U.; Lerer, B. Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Mol Psychiatry, 1999, 4, 163-172.
    • (1999) Mol Psychiatry , vol.4 , pp. 163-172
    • Agid, O.1    Shapira, B.2    Zislin, J.3    Ritsner, M.4    Hanin, B.5    Murad, H.6    Troudart, T.7    Bloch, M.8    Heresco-Levy, U.9    Lerer, B.10
  • 3
    • 0033956237 scopus 로고    scopus 로고
    • Schizophrenia: Genes and environment
    • Tsuang, M. Schizophrenia: genes and environment. Biological Psychiatry, 2000, 47, 210-220.
    • (2000) Biological Psychiatry , vol.47 , pp. 210-220
    • Tsuang, M.1
  • 4
    • 0034010367 scopus 로고    scopus 로고
    • Schizophrenia as the price that homo sapiens pays for language: A resolution of the central paradox in the origin of the species
    • Crow, T. J. Schizophrenia as the price that homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Res.Brain Res.Rev., 2000, 31, 118-129.
    • (2000) Brain Res.Brain Res.Rev , vol.31 , pp. 118-129
    • Crow, T.J.1
  • 5
    • 58049116046 scopus 로고    scopus 로고
    • Is schizophrenia the price of human central nervous system complexity?
    • Dean, B. Is schizophrenia the price of human central nervous system complexity? Aust.N.Z.J.Psychiatry, 2009, 43, 13-24.
    • (2009) Aust.N.Z.J.Psychiatry , vol.43 , pp. 13-24
    • Dean, B.1
  • 6
    • 0030951230 scopus 로고    scopus 로고
    • Schizophrenia: A disorder of neurodevelopment?
    • Harrison, P. J. Schizophrenia: a disorder of neurodevelopment? Curr.Opin.Neurobiol., 1997, 7, 285-289.
    • (1997) Curr.Opin.Neurobiol , vol.7 , pp. 285-289
    • Harrison, P.J.1
  • 7
    • 0023576255 scopus 로고
    • Biological studies in schizophrenia
    • Meltzer, H. Y. Biological studies in schizophrenia. Schizophr.Bull., 1987, 13, 77-111.
    • (1987) Schizophr.Bull , vol.13 , pp. 77-111
    • Meltzer, H.Y.1
  • 8
    • 0033931250 scopus 로고    scopus 로고
    • Signal transmission, rather than reception, is the underlying neurochemical abnormality in schizophrenia
    • Dean, B. Signal transmission, rather than reception, is the underlying neurochemical abnormality in schizophrenia. Aust.N.Z.J.Psychiatry, 2000, 34, 560-569.
    • (2000) Aust.N.Z.J.Psychiatry , vol.34 , pp. 560-569
    • Dean, B.1
  • 9
    • 1842861930 scopus 로고    scopus 로고
    • The neurobiology of bipolar disorder: Findings using human postmortem central nervous system tissue
    • Dean, B. The neurobiology of bipolar disorder: findings using human postmortem central nervous system tissue. Aust.N.Z.J.Psychiatry, 2004, 38, 135-140.
    • (2004) Aust.N.Z.J.Psychiatry , vol.38 , pp. 135-140
    • Dean, B.1
  • 10
    • 0017651563 scopus 로고
    • Does dopamine play a role in schizophrenia?
    • Carlsson, A. Does dopamine play a role in schizophrenia? Psychol.Med., 1977, 7, 583-597.
    • (1977) Psychol.Med , vol.7 , pp. 583-597
    • Carlsson, A.1
  • 11
  • 12
    • 0016592484 scopus 로고
    • Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons
    • Seeman, P.; Lee, T. Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science, 1975, 188, 1217-1219.
    • (1975) Science , vol.188 , pp. 1217-1219
    • Seeman, P.1    Lee, T.2
  • 15
    • 0024471511 scopus 로고
    • Striatal D2 dopaminergic receptor status ascertained in vivo by positron emission tomography and 76Br-bromospiperone in untreated schizophrenics
    • Martinot, J. L.; Huret, J. D.; Peron-Magnan, P.; Mazoyer, B. M.; Baron, J. C.; Caillard, V.; Syrota, A.; Loo, H. Striatal D2 dopaminergic receptor status ascertained in vivo by positron emission tomography and 76Br-bromospiperone in untreated schizophrenics. Psychiatry Research, 1989, 29, 357-358.
    • (1989) Psychiatry Research , vol.29 , pp. 357-358
    • Martinot, J.L.1    Huret, J.D.2    Peron-Magnan, P.3    Mazoyer, B.M.4    Baron, J.C.5    Caillard, V.6    Syrota, A.7    Loo, H.8
  • 17
    • 0030607991 scopus 로고    scopus 로고
    • Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects
    • Tune, L.; Barta, P.; Wong, D.; Powers, R. E.; Pearlson, G.; Tien, A. Y.; Wagner, H. N. Striatal dopamine D2 receptor quantification and superior temporal gyrus: volume determination in 14 chronic schizophrenic subjects. Psychiatry Research, 1996, 67, 155-158.
    • (1996) Psychiatry Research , vol.67 , pp. 155-158
    • Tune, L.1    Barta, P.2    Wong, D.3    Powers, R.E.4    Pearlson, G.5    Tien, A.Y.6    Wagner, H.N.7
  • 22
    • 0028983794 scopus 로고
    • No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N- methylspiperone
    • Nordstrom, A. L.; Farde, L.; Eriksson, L.; Halldin, C. No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N- methylspiperone. Psychiatry Research, 1995, 61, 67-83.
    • (1995) Psychiatry Research , vol.61 , pp. 67-83
    • Nordstrom, A.L.1    Farde, L.2    Eriksson, L.3    Halldin, C.4
  • 23
    • 0025194556 scopus 로고
    • D2 dopamine receptors in neuroleptic- naive schizophrenic patients. A positron emission tomography study with [11C]raclopride
    • Farde, L.; Wiesel, F. A.; Stone-Elander, S.; Halldin, C.; Nordstrom, A. L.; Hall, H.; Sedvall, G. D2 dopamine receptors in neuroleptic- naive schizophrenic patients. A positron emission tomography study with [11C]raclopride. Arch.Gen.Psychiatry, 1990, 47, 213-219.
    • (1990) Arch.Gen.Psychiatry , vol.47 , pp. 213-219
    • Farde, L.1    Wiesel, F.A.2    Stone-Elander, S.3    Halldin, C.4    Nordstrom, A.L.5    Hall, H.6    Sedvall, G.7
  • 24
    • 0742288285 scopus 로고    scopus 로고
    • Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: A PET study with [11C]FLB 457
    • Talvik, M.; Nordstrom, A. L.; Olsson, H.; Halldin, C.; Farde, L. Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: a PET study with [11C]FLB 457. Int.J.Neuropsychopharmacol., 2003, 6, 361-370.
    • (2003) Int.J.Neuropsychopharmacol , vol.6 , pp. 361-370
    • Talvik, M.1    Nordstrom, A.L.2    Olsson, H.3    Halldin, C.4    Farde, L.5
  • 26
    • 0028176855 scopus 로고
    • D2 dopamine receptor binding in the basal ganglia of antipsychotic-free schizophrenic patients. An 123I- IBZM single photon emission computerised tomography study
    • Pilowsky, L. S.; Costa, D. C.; Ell, P. J.; Verhoeff, N. P.; Murray, R. M.; Kerwin, R. W. D2 dopamine receptor binding in the basal ganglia of antipsychotic-free schizophrenic patients. An 123I- IBZM single photon emission computerised tomography study. Br.J.Psychiatry, 1994, 164, 16-26.
    • (1994) Br.J.Psychiatry , vol.164 , pp. 16-26
    • Pilowsky, L.S.1    Costa, D.C.2    Ell, P.J.3    Verhoeff, N.P.4    Murray, R.M.5    Kerwin, R.W.6
  • 27
    • 0030721766 scopus 로고    scopus 로고
    • Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia. [123I]-iodobenzamide SPECT study
    • Knable, M. B.; Egan, M. F.; Heinz, A.; Gorey, J.; Lee, K. S.; Coppola, R.; Weinberger, D. R. Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia. [123I]-iodobenzamide SPECT study. Br.J.Psychiatry, 1997, 171, 574-577.
    • (1997) Br.J.Psychiatry , vol.171 , pp. 574-577
    • Knable, M.B.1    Egan, M.F.2    Heinz, A.3    Gorey, J.4    Lee, K.S.5    Coppola, R.6    Weinberger, D.R.7
  • 28
    • 0031590183 scopus 로고    scopus 로고
    • Gender differences in D2 dopamine receptor binding in drug-naive patients with schizophrenia: An [123I]iodobenzamide single photon emission computed tomography study
    • Schroder, J.; Bubeck, B.; Silvestri, S.; Demisch, S.; Sauer, H. Gender differences in D2 dopamine receptor binding in drug-naive patients with schizophrenia: an [123I]iodobenzamide single photon emission computed tomography study. Psychiatry Research, 1997, 75, 115-123.
    • (1997) Psychiatry Research , vol.75 , pp. 115-123
    • Schroder, J.1    Bubeck, B.2    Silvestri, S.3    Demisch, S.4    Sauer, H.5
  • 29
    • 1642350062 scopus 로고    scopus 로고
    • Striatal dopamine D2 receptor density in neuroleptic-naive and in neuroleptic-free schizophrenic patients: An 123I-IBZM-SPECT study
    • Lomena, F.; Catafau, A. M.; Parellada, E.; Bernardo, M.; Font, M.; Gutierrez, F.; Pavia, J. Striatal dopamine D2 receptor density in neuroleptic-naive and in neuroleptic-free schizophrenic patients: an 123I-IBZM-SPECT study. Psychophamacology (Berlin), 2004, 172, 165-169.
    • (2004) Psychophamacology (Berlin) , vol.172 , pp. 165-169
    • Lomena, F.1    Catafau, A.M.2    Parellada, E.3    Bernardo, M.4    Font, M.5    Gutierrez, F.6    Pavia, J.7
  • 32
    • 0025284551 scopus 로고
    • Dopamine receptors and transporters in Parkinson's disease and schizophrenia
    • Seeman, P.; Niznik, H. B. Dopamine receptors and transporters in Parkinson's disease and schizophrenia. FASEB J., 1990, 4, 2737-2744.
    • (1990) FASEB J , vol.4 , pp. 2737-2744
    • Seeman, P.1    Niznik, H.B.2
  • 33
    • 0023105869 scopus 로고
    • Dopamine receptor subtype imbalance in schizophrenia
    • Hess, E. J.; Bracha, H. S.; Kleinman, J. E.; Creese, I. Dopamine receptor subtype imbalance in schizophrenia. Life Sci., 1987, 40, 1487-1497.
    • (1987) Life Sci , vol.40 , pp. 1487-1497
    • Hess, E.J.1    Bracha, H.S.2    Kleinman, J.E.3    Creese, I.4
  • 34
    • 0030610876 scopus 로고    scopus 로고
    • [3H]raclopride binding to brain tissue from subjects with schizophrenia: Methodological aspects
    • Dean, B.; Pavey, G.; Opeskin, K. [3H]raclopride binding to brain tissue from subjects with schizophrenia: methodological aspects. Neuropharmacology, 1997, 36, 779-786.
    • (1997) Neuropharmacology , vol.36 , pp. 779-786
    • Dean, B.1    Pavey, G.2    Opeskin, K.3
  • 35
    • 0028670706 scopus 로고
    • Quantitative autoradiography of dopamine-D1 receptors, D2 receptors, and dopamine uptake sites in postmortem striatal specimens from schizophrenic patients
    • Knable, M. B.; Hyde, T. M.; Herman, M. M.; Carter, J. M.; Bigelow, L.; Kleinman, J. E. Quantitative autoradiography of dopamine-D1 receptors, D2 receptors, and dopamine uptake sites in postmortem striatal specimens from schizophrenic patients. Biological Psychiatry, 1994, 36, 827-835.
    • (1994) Biological Psychiatry , vol.36 , pp. 827-835
    • Knable, M.B.1    Hyde, T.M.2    Herman, M.M.3    Carter, J.M.4    Bigelow, L.5    Kleinman, J.E.6
  • 38
    • 0030786677 scopus 로고    scopus 로고
    • Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    • Meador-Woodruff, J. H.; Haroutunian, V.; Powchik, P.; Davidson, M.; Davis, K. L.; Watson, S. J. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. Arch.Gen.Psychiatry, 1997, 54, 1089-1095.
    • (1997) Arch.Gen.Psychiatry , vol.54 , pp. 1089-1095
    • Meador-Woodruff, J.H.1    Haroutunian, V.2    Powchik, P.3    Davidson, M.4    Davis, K.L.5    Watson, S.J.6
  • 39
    • 0037154979 scopus 로고    scopus 로고
    • Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: An autoradiographic study
    • Zavitsanou, K.; Huang, X. F. Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study. Neuroscience, 2002, 109, 709-716.
    • (2002) Neuroscience , vol.109 , pp. 709-716
    • Zavitsanou, K.1    Huang, X.F.2
  • 40
    • 0032586747 scopus 로고    scopus 로고
    • Changes in serotonin2A and GABA(A) receptors in schizophrenia: Studies on the human dorsolateral prefrontal cortex
    • Dean, B.; Hussain, T.; Hayes, W.; Scarr, E.; Kitsoulis, S.; Hill, C.; Opeskin, K.; Copolov, D. L. Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex. J.Neurochem., 1999, 72, 1593-1599.
    • (1999) J.Neurochem , vol.72 , pp. 1593-1599
    • Dean, B.1    Hussain, T.2    Hayes, W.3    Scarr, E.4    Kitsoulis, S.5    Hill, C.6    Opeskin, K.7    Copolov, D.L.8
  • 42
    • 33751016047 scopus 로고    scopus 로고
    • Dopamine D2 receptor binding in drug-naive patients with schizophrenia examined with raclopride-C11 and positron emission tomography
    • Talvik, M.; Nordstrom, A. L.; Okubo, Y.; Olsson, H.; Borg, J.; Halldin, C.; Farde, L. Dopamine D2 receptor binding in drug-naive patients with schizophrenia examined with raclopride-C11 and positron emission tomography. Psychiatry Research, 2006, 148, 165-173.
    • (2006) Psychiatry Research , vol.148 , pp. 165-173
    • Talvik, M.1    Nordstrom, A.L.2    Okubo, Y.3    Olsson, H.4    Borg, J.5    Halldin, C.6    Farde, L.7
  • 46
    • 34248145469 scopus 로고    scopus 로고
    • Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia
    • Dean, B.; Keriakous, D.; Scarr, E.; Thomas, E. A. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia. Aust.N.Z.J.Psychiatry, 2007, 41, 308-320.
    • (2007) Aust.N.Z.J.Psychiatry , vol.41 , pp. 308-320
    • Dean, B.1    Keriakous, D.2    Scarr, E.3    Thomas, E.A.4
  • 48
    • 66149180587 scopus 로고    scopus 로고
    • Normal human aging and early-stage schizophrenia share common molecular profiles
    • Tang, B.; Chang, W. L.; Lanigan, C. M.; Dean, B.; Sutcliffe, J. G.; Thomas, E. A. Normal human aging and early-stage schizophrenia share common molecular profiles. Aging Cell, 2009, 8, 339-342.
    • (2009) Aging Cell , vol.8 , pp. 339-342
    • Tang, B.1    Chang, W.L.2    Lanigan, C.M.3    Dean, B.4    Sutcliffe, J.G.5    Thomas, E.A.6
  • 49
    • 0018378511 scopus 로고
    • Multiple receptors for dopamine
    • Kebabian, J. W.; Calne, D. B. Multiple receptors for dopamine. Nature, 1979, 277, 93-96.
    • (1979) Nature , vol.277 , pp. 93-96
    • Kebabian, J.W.1    Calne, D.B.2
  • 50
    • 0028170808 scopus 로고
    • Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain
    • Hall, H.; Sedvall, G.; Magnusson, O.; Kopp, J.; Halldin, C.; Farde, L. Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacology, 1994, 11, 245-256.
    • (1994) Neuropsychopharmacology , vol.11 , pp. 245-256
    • Hall, H.1    Sedvall, G.2    Magnusson, O.3    Kopp, J.4    Halldin, C.5    Farde, L.6
  • 55
    • 0036242723 scopus 로고    scopus 로고
    • PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia
    • Karlsson, P.; Farde, L.; Halldin, C.; Sedvall, G. PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia. Am.J.Psychiatry, 2002, 159, 761-767.
    • (2002) Am.J.Psychiatry , vol.159 , pp. 761-767
    • Karlsson, P.1    Farde, L.2    Halldin, C.3    Sedvall, G.4
  • 56
    • 0022269254 scopus 로고
    • [3H]SCH 23390 labeled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease
    • Pimoule, C.; Schoemaker, H.; Reynolds, G. P.; Langer, S. Z. [3H]SCH 23390 labeled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease. Eur.J.Pharmacol., 1985, 114, 235-237.
    • (1985) Eur.J.Pharmacol , vol.114 , pp. 235-237
    • Pimoule, C.1    Schoemaker, H.2    Reynolds, G.P.3    Langer, S.Z.4
  • 58
    • 0030589459 scopus 로고    scopus 로고
    • A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls, and normal controls
    • Knable, M. B.; Hyde, T. M.; Murray, A. M.; Herman, M. M.; Kleinman, J. E. A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls, and normal controls. Biological Psychiatry, 1996, 40, 1191-1199.
    • (1996) Biological Psychiatry , vol.40 , pp. 1191-1199
    • Knable, M.B.1    Hyde, T.M.2    Murray, A.M.3    Herman, M.M.4    Kleinman, J.E.5
  • 59
    • 0035543729 scopus 로고    scopus 로고
    • An increase in [3H]SCH23390 binding in the cerebral cortex of postmortem brains of chronic schizophrenics
    • Domyo, T.; Kurumaji, A.; Toru, M. An increase in [3H]SCH23390 binding in the cerebral cortex of postmortem brains of chronic schizophrenics. J.Neural Transm., 2001, 108, 1475-1484.
    • (2001) J.Neural Transm , vol.108 , pp. 1475-1484
    • Domyo, T.1    Kurumaji, A.2    Toru, M.3
  • 60
    • 0026612908 scopus 로고
    • Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment
    • Buckland, P. R.; O'Donovan, M. C.; McGuffin, P. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychophamacology (Berlin), 1992, 106, 479-483.
    • (1992) Psychophamacology (Berlin) , vol.106 , pp. 479-483
    • Buckland, P.R.1    O'Donovan, M.C.2    McGuffin, P.3
  • 61
    • 0031415159 scopus 로고    scopus 로고
    • Antipsychotic regulation of dopamine D1, D2 and D3 receptor mRNA
    • D'Souza, U.; McGuffin, P.; Buckland, P. R. Antipsychotic regulation of dopamine D1, D2 and D3 receptor mRNA. Neuropharmacology, 1997, 36, 1689-1696.
    • (1997) Neuropharmacology , vol.36 , pp. 1689-1696
    • D'Souza, U.1    McGuffin, P.2    Buckland, P.R.3
  • 62
    • 0030924276 scopus 로고    scopus 로고
    • Down- regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs
    • Lidow, M. S.; Elsworth, J. D.; Goldman-Rakic, P. S. Down- regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. J.Pharmacol.Exp.Ther., 1997, 281, 597-603.
    • (1997) J.Pharmacol.Exp.Ther , vol.281 , pp. 597-603
    • Lidow, M.S.1    Elsworth, J.D.2    Goldman-Rakic, P.S.3
  • 63
    • 0035800423 scopus 로고    scopus 로고
    • Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum
    • Dean, B.; Hussain, T.; Scarr, E.; Pavey, G.; Copolov, D. L. Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum. Life Sci., 2001, 69, 1257-1268.
    • (2001) Life Sci , vol.69 , pp. 1257-1268
    • Dean, B.1    Hussain, T.2    Scarr, E.3    Pavey, G.4    Copolov, D.L.5
  • 64
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • Giros, B.; Jaber, M.; Jones, S. R.; Wightman, R. M.; Caron, M. G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 1996, 379, 606-612.
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 67
    • 0242415458 scopus 로고    scopus 로고
    • Dopamine transporter change in drug-naive schizophrenia: An imaging study with 99mTc-TRODAT-1
    • Hsiao, M. C.; Lin, K. J.; Liu, C. Y.; Tzen, K. Y.; Yen, T. C. Dopamine transporter change in drug-naive schizophrenia: an imaging study with 99mTc-TRODAT-1. Schizophr.Res., 2003, 65, 39-46.
    • (2003) Schizophr.Res , vol.65 , pp. 39-46
    • Hsiao, M.C.1    Lin, K.J.2    Liu, C.Y.3    Tzen, K.Y.4    Yen, T.C.5
  • 68
    • 3342977856 scopus 로고    scopus 로고
    • Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: A dual-isotope SPECT study
    • Yang, Y. K.; Yu, L.; Yeh, T. L.; Chiu, N. T.; Chen, P. S.; Lee, I. H. Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT study. Am.J.Psychiatry, 2004, 161, 1496-1498.
    • (2004) Am.J.Psychiatry , vol.161 , pp. 1496-1498
    • Yang, Y.K.1    Yu, L.2    Yeh, T.L.3    Chiu, N.T.4    Chen, P.S.5    Lee, I.H.6
  • 69
    • 25844448573 scopus 로고    scopus 로고
    • The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: Evaluation by the new SPECT-ligand[99mTc]TRODAT-1
    • Schmitt, G. J.; Meisenzahl, E. M.; Frodl, T.; La, F. C.; Hahn, K.; Moller, H. J.; Dresel, S. The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1. J.Psychopharmacol., 2005, 19, 488-493.
    • (2005) J.Psychopharmacol , vol.19 , pp. 488-493
    • Schmitt, G.J.1    Meisenzahl, E.M.2    Frodl, T.3    La, F.C.4    Hahn, K.5    Moller, H.J.6    Dresel, S.7
  • 71
    • 42749093700 scopus 로고    scopus 로고
    • Dual-isotope SPECT imaging of striatal dopamine: First episode, drug naive schizophrenic patients
    • Schmitt, G. J.; La, F. C.; Dresel, S.; Frodl, T.; Hahn, K.; Moller, H. J.; Meisenzahl, E. M. Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naive schizophrenic patients. Schizophr.Res., 2008, 101, 133-141.
    • (2008) Schizophr.Res , vol.101 , pp. 133-141
    • Schmitt, G.J.1    La, F.C.2    Dresel, S.3    Frodl, T.4    Hahn, K.5    Moller, H.J.6    Meisenzahl, E.M.7
  • 74
    • 27144486931 scopus 로고    scopus 로고
    • Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first- episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism
    • Mateos, J. J.; Lomena, F.; Parellada, E.; Font, M.; Fernandez, E.; Pavia, J.; Prats, A.; Pons, F.; Bernardo, M. Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first- episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism. Psychophamacology (Berlin), 2005, 181, 401-406.
    • (2005) Psychophamacology (Berlin) , vol.181 , pp. 401-406
    • Mateos, J.J.1    Lomena, F.2    Parellada, E.3    Font, M.4    Fernandez, E.5    Pavia, J.6    Prats, A.7    Pons, F.8    Bernardo, M.9
  • 75
    • 33847645454 scopus 로고    scopus 로고
    • Lower striatal dopamine transporter binding in neuroleptic-naive schizophrenic patients is not related to antipsychotic treatment but it suggests an illness trait
    • Mateos, J. J.; Lomena, F.; Parellada, E.; Mireia, F.; Fernandez- Egea, E.; Pavia, J.; Prats, A.; Pons, F.; Bernardo, M. Lower striatal dopamine transporter binding in neuroleptic-naive schizophrenic patients is not related to antipsychotic treatment but it suggests an illness trait. Psychophamacology (Berlin), 2007, 191, 805-811.
    • (2007) Psychophamacology (Berlin) , vol.191 , pp. 805-811
    • Mateos, J.J.1    Lomena, F.2    Parellada, E.3    Mireia, F.4    Fernandez-Egea, E.5    Pavia, J.6    Prats, A.7    Pons, F.8    Bernardo, M.9
  • 76
    • 3342935159 scopus 로고    scopus 로고
    • 123I-beta-CIT SPECT demonstrates increased presynaptic dopamine transporter binding sites in basal ganglia in vivo in schizophrenia
    • Sjoholm, H.; Bratlid, T.; Sundsfjord, J. 123I-beta-CIT SPECT demonstrates increased presynaptic dopamine transporter binding sites in basal ganglia in vivo in schizophrenia. Psychophamacology (Berlin), 2004, 173, 27-31.
    • (2004) Psychophamacology (Berlin) , vol.173 , pp. 27-31
    • Sjoholm, H.1    Bratlid, T.2    Sundsfjord, J.3
  • 78
    • 0028985154 scopus 로고
    • Age-related changes in [3H]GBR 12935 binding site density in the prefrontal cortex of controls and schizophrenics
    • Hitri, A.; Casanova, M. F.; Kleinman, J. E.; Weinberger, D. R.; Wyatt, R. J. Age-related changes in [3H]GBR 12935 binding site density in the prefrontal cortex of controls and schizophrenics. Biological Psychiatry, 1995, 37, 175-182.
    • (1995) Biological Psychiatry , vol.37 , pp. 175-182
    • Hitri, A.1    Casanova, M.F.2    Kleinman, J.E.3    Weinberger, D.R.4    Wyatt, R.J.5
  • 79
    • 0035476358 scopus 로고    scopus 로고
    • Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia
    • Dean, B.; Hussain, T. Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia. Schizophr.Res., 2001, 52, 107-114.
    • (2001) Schizophr.Res , vol.52 , pp. 107-114
    • Dean, B.1    Hussain, T.2
  • 80
    • 0034705659 scopus 로고    scopus 로고
    • Olanzapine, quetiapine, and risperidone: Long-term effects on monoamine transporters in rat forebrain
    • Tarazi, F. I.; Zhang, K.; Baldessarini, R. J. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neurosci.Lett., 2000, 287, 81-84.
    • (2000) Neurosci.Lett , vol.287 , pp. 81-84
    • Tarazi, F.I.1    Zhang, K.2    Baldessarini, R.J.3
  • 84
  • 85
    • 34547486316 scopus 로고    scopus 로고
    • Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: An [18F]fluorodopa/positron emission tomography study
    • Kumakura, Y.; Cumming, P.; Vernaleken, I.; Buchholz, H. G.; Siessmeier, T.; Heinz, A.; Kienast, T.; Bartenstein, P.; Grunder, G. Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study. J.Neurosci., 2007, 27, 8080-8087.
    • (2007) J.Neurosci , vol.27 , pp. 8080-8087
    • Kumakura, Y.1    Cumming, P.2    Vernaleken, I.3    Buchholz, H.G.4    Siessmeier, T.5    Heinz, A.6    Kienast, T.7    Bartenstein, P.8    Grunder, G.9
  • 87
    • 67349207461 scopus 로고    scopus 로고
    • Baseline and amphetamine-stimulated dopamine activity are related in drug-naive schizophrenic subjects
    • Abi-Dargham, A.; van de Giessen, E.; Slifstein, M.; Kegeles, L. S.; Laruelle, M. Baseline and amphetamine-stimulated dopamine activity are related in drug-naive schizophrenic subjects. Biological Psychiatry, 2009, 65, 1091-1093.
    • (2009) Biological Psychiatry , vol.65 , pp. 1091-1093
    • Abi-Dargham, A.1    van de Giessen, E.2    Slifstein, M.3    Kegeles, L.S.4    Laruelle, M.5
  • 94
    • 0025763177 scopus 로고
    • Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease
    • Gibb, W. R.; Lees, A. J. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J.Neurol.Neurosurg.Psychiatry, 1991, 54, 388-396.
    • (1991) J.Neurol.Neurosurg.Psychiatry , vol.54 , pp. 388-396
    • Gibb, W.R.1    Lees, A.J.2
  • 95
    • 0025274995 scopus 로고
    • Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease
    • Rinne, U. K.; Laihinen, A.; Rinne, J. O.; Nagren, K.; Bergman, J.; Ruotsalainen, U. Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease. Mov Disord., 1990, 5, 55-59.
    • (1990) Mov Disord , vol.5 , pp. 55-59
    • Rinne, U.K.1    Laihinen, A.2    Rinne, J.O.3    Nagren, K.4    Bergman, J.5    Ruotsalainen, U.6
  • 96
    • 0033957270 scopus 로고    scopus 로고
    • Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: A comparative PET study with [11C] raclopride and [11C]N-methylspiperone
    • Kaasinen, V.; Ruottinen, H. M.; Nagren, K.; Lehikoinen, P.; Oikonen, V.; Rinne, J. O. Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone. J.Nucl.Med., 2000, 41, 65-70.
    • (2000) J.Nucl.Med , vol.41 , pp. 65-70
    • Kaasinen, V.1    Ruottinen, H.M.2    Nagren, K.3    Lehikoinen, P.4    Oikonen, V.5    Rinne, J.O.6
  • 98
    • 0028855452 scopus 로고
    • Serotonin, schizophrenia and antipsychotic drug action
    • Breier, A. Serotonin, schizophrenia and antipsychotic drug action. Schizophr.Res., 1995, 14, 187-202.
    • (1995) Schizophr.Res , vol.14 , pp. 187-202
    • Breier, A.1
  • 99
    • 0018573963 scopus 로고
    • Multiple serotonin receptors: Differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol
    • Peroutka, S. J.; Snyder, S. H. Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol., 1979, 16, 687-699.
    • (1979) Mol Pharmacol , vol.16 , pp. 687-699
    • Peroutka, S.J.1    Snyder, S.H.2
  • 100
    • 8144229605 scopus 로고    scopus 로고
    • The serotonin hypothesis of schizophrenia: A historical case study on the heuristic value of theory in clinical neuroscience
    • Baumeister, A. A.; Hawkins, M. F. The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience. J.Hist Neurosci., 2004, 13, 277-291.
    • (2004) J.Hist Neurosci , vol.13 , pp. 277-291
    • Baumeister, A.A.1    Hawkins, M.F.2
  • 101
    • 0026602565 scopus 로고
    • The importance of serotonin-dopamine interactions in the action of clozapine
    • Meltzer, H. Y. The importance of serotonin-dopamine interactions in the action of clozapine. Br.J.Psychiatry Suppl, 1992, 22-29.
    • (1992) Br.J.Psychiatry Suppl , pp. 22-29
    • Meltzer, H.Y.1
  • 102
    • 0037374767 scopus 로고    scopus 로고
    • The cortical serotonin2A receptor and the pathology of schizophrenia: A likely accomplice
    • Dean, B. The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice. J.Neurochem., 2003, 85, 1-13.
    • (2003) J.Neurochem , vol.85 , pp. 1-13
    • Dean, B.1
  • 103
    • 0032481931 scopus 로고    scopus 로고
    • No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET
    • Trichard, C.; Paillere-Martinot, M. L.; Attar-Levy, D.; Blin, J.; Feline, A.; Martinot, J. L. No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET. Schizophr.Res., 1998, 31, 13-17.
    • (1998) Schizophr.Res , vol.31 , pp. 13-17
    • Trichard, C.1    Paillere-Martinot, M.L.2    Attar-Levy, D.3    Blin, J.4    Feline, A.5    Martinot, J.L.6
  • 104
    • 0032589898 scopus 로고    scopus 로고
    • Serotonin 5-HT2 receptors in schizophrenia: A PET study using [18F]setoperone in neuroleptic- naive patients and normal subjects
    • Lewis, R.; Kapur, S.; Jones, C.; DaSilva, J.; Brown, G. M.; Wilson, A. A.; Houle, S.; Zipursky, R. B. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic- naive patients and normal subjects. Am.J.Psychiatry, 1999, 156, 72-78.
    • (1999) Am.J.Psychiatry , vol.156 , pp. 72-78
    • Lewis, R.1    Kapur, S.2    Jones, C.3    Dasilva, J.4    Brown, G.M.5    Wilson, A.A.6    Houle, S.7    Zipursky, R.B.8
  • 106
    • 0034735673 scopus 로고    scopus 로고
    • A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia
    • Verhoeff, N. P.; Meyer, J. H.; Kecojevic, A.; Hussey, D.; Lewis, R.; Tauscher, J.; Zipursky, R. B.; Kapur, S. A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia. Psychiatry Research, 2000, 99, 123-135.
    • (2000) Psychiatry Research , vol.99 , pp. 123-135
    • Verhoeff, N.P.1    Meyer, J.H.2    Kecojevic, A.3    Hussey, D.4    Lewis, R.5    Tauscher, J.6    Zipursky, R.B.7    Kapur, S.8
  • 114
    • 0141567812 scopus 로고    scopus 로고
    • Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
    • Job, D. E.; Whalley, H. C.; McConnell, S.; Glabus, M.; Johnstone, E. C.; Lawrie, S. M. Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia. Schizophr.Res., 2003, 64, 1-13.
    • (2003) Schizophr.Res , vol.64 , pp. 1-13
    • Job, D.E.1    Whalley, H.C.2    McConnell, S.3    Glabus, M.4    Johnstone, E.C.5    Lawrie, S.M.6
  • 115
    • 78651312636 scopus 로고    scopus 로고
    • Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: An activation likelihood estimation meta- analysis of illness progression
    • Chan, R. C.; Di, X.; McAlonan, G. M.; Gong, Q. Y. Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: an activation likelihood estimation meta- analysis of illness progression. Schizophr.Bull., 2011, 37, 177-188.
    • (2011) Schizophr.Bull , vol.37 , pp. 177-188
    • Chan, R.C.1    Di, X.2    McAlonan, G.M.3    Gong, Q.Y.4
  • 117
    • 0025921604 scopus 로고
    • Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients
    • Arora, R. C.; Meltzer, H. Y. Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J.Neural Transm.Gen.Sect., 1991, 85, 19-29.
    • (1991) J.Neural Transm.Gen.Sect , vol.85 , pp. 19-29
    • Arora, R.C.1    Meltzer, H.Y.2
  • 118
    • 0030592323 scopus 로고    scopus 로고
    • Decreased frontal cortical serotonin2A receptors in schizophrenia
    • Dean, B.; Hayes, W. Decreased frontal cortical serotonin2A receptors in schizophrenia. Schizophr.Res., 1996, 21, 133-139.
    • (1996) Schizophr.Res , vol.21 , pp. 133-139
    • Dean, B.1    Hayes, W.2
  • 119
    • 0030273870 scopus 로고    scopus 로고
    • 5-HT1A and 5- HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia
    • Burnet, P. W.; Eastwood, S. L.; Harrison, P. J. 5-HT1A and 5- HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology, 1996, 15, 442-455.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 442-455
    • Burnet, P.W.1    Eastwood, S.L.2    Harrison, P.J.3
  • 120
    • 0031582414 scopus 로고    scopus 로고
    • 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia
    • Kouzmenko, A. P.; Hayes, W. L.; Pereira, A. M.; Dean, B.; Burnet, P. W.; Harrison, P. J. 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia. Lancet, 1997, 349, 1815
    • (1997) Lancet , vol.349 , pp. 1815
    • Kouzmenko, A.P.1    Hayes, W.L.2    Pereira, A.M.3    Dean, B.4    Burnet, P.W.5    Harrison, P.J.6
  • 121
    • 0032216770 scopus 로고    scopus 로고
    • Decreased serotonin2A receptors in Brodmann's area 9 from schizophrenic subjects. A pathologicalorpharmacological phenomenon
    • Dean, B.; Hayes, W.; Hill, C.; Copolov, D. Decreased serotonin2A receptors in Brodmann's area 9 from schizophrenic subjects. A pathologicalorpharmacological phenomenon? Mol.Chem.Neuropathol., 1998, 34, 133-145.
    • (1998) Mol.Chem.Neuropathol , vol.34 , pp. 133-145
    • Dean, B.1    Hayes, W.2    Hill, C.3    Copolov, D.4
  • 122
    • 0033031019 scopus 로고    scopus 로고
    • No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia
    • Kouzmenko, A. P.; Scaffidi, A.; Pereira, A. M.; Hayes, W. L.; Copolov, D. L.; Dean, B. No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia. Hum.Hered., 1999, 49, 103-105.
    • (1999) Hum.Hered , vol.49 , pp. 103-105
    • Kouzmenko, A.P.1    Scaffidi, A.2    Pereira, A.M.3    Hayes, W.L.4    Copolov, D.L.5    Dean, B.6
  • 123
    • 0034617336 scopus 로고    scopus 로고
    • Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia
    • Pralong, D.; Tomaskovic-Crook, E.; Opeskin, K.; Copolov, D.; Dean, B. Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia. Schizophr.Res., 2000, 44, 35-45.
    • (2000) Schizophr.Res , vol.44 , pp. 35-45
    • Pralong, D.1    Tomaskovic-Crook, E.2    Opeskin, K.3    Copolov, D.4    Dean, B.5
  • 124
    • 17444423355 scopus 로고    scopus 로고
    • Dean, B. 5-HT2A and muscarinic receptors in schizophrenia: A postmortem study
    • Matsumoto, I.; Inoue, Y.; Iwazaki, T.; Pavey, G.; Dean, B. 5-HT2A and muscarinic receptors in schizophrenia: a postmortem study. Neurosci.Lett., 2005, 379, 164-168.
    • (2005) Neurosci.Lett , vol.379 , pp. 164-168
    • Matsumoto, I.1    Inoue, Y.2    Iwazaki, T.3    Pavey, G.4
  • 125
    • 67649236179 scopus 로고    scopus 로고
    • Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia--a postmortem study
    • Kang, K.; Huang, X. F.; Wang, Q.; Deng, C. Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia--a postmortem study. Progress in Neuro- psychopharmacology and Biological Psychiatry, 2009, 33, 867-871.
    • (2009) Progress In Neuro- Psychopharmacology and Biological Psychiatry , vol.33 , pp. 867-871
    • Kang, K.1    Huang, X.F.2    Wang, Q.3    Deng, C.4
  • 128
    • 50249163806 scopus 로고    scopus 로고
    • Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia
    • Dean, B.; Crossland, N.; Boer, S.; Scarr, E. Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia. Schizophr.Res., 2008, 104, 185-197.
    • (2008) Schizophr.Res , vol.104 , pp. 185-197
    • Dean, B.1    Crossland, N.2    Boer, S.3    Scarr, E.4
  • 129
    • 0027279038 scopus 로고
    • Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics
    • Joyce, J. N.; Shane, A.; Lexow, N.; Winokur, A.; Casanova, M. F.; Kleinman, J. E. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology, 1993, 8, 315-336.
    • (1993) Neuropsychopharmacology , vol.8 , pp. 315-336
    • Joyce, J.N.1    Shane, A.2    Lexow, N.3    Winokur, A.4    Casanova, M.F.5    Kleinman, J.E.6
  • 130
    • 0022632054 scopus 로고
    • Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex
    • Andree, T. H.; Mikuni, M.; Tong, C. Y.; Koenig, J. I.; Meltzer, H. Y. Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex. J.Neurochem., 1986, 46, 191-197.
    • (1986) J.Neurochem , vol.46 , pp. 191-197
    • Andree, T.H.1    Mikuni, M.2    Tong, C.Y.3    Koenig, J.I.4    Meltzer, H.Y.5
  • 131
    • 0024560135 scopus 로고
    • Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain
    • Wilmot, C. A.; Szczepanik, A. M. Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain. Brain Res., 1989, 487, 288-298.
    • (1989) Brain Res , vol.487 , pp. 288-298
    • Wilmot, C.A.1    Szczepanik, A.M.2
  • 132
    • 0025167982 scopus 로고
    • Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain
    • O'Dell, S. J.; La Hoste, G. J.; Widmark, C. B.; Shapiro, R. M.; Potkin, S. G.; Marshall, J. F. Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain. Synapse, 1990, 6, 146-153.
    • (1990) Synapse , vol.6 , pp. 146-153
    • O'Dell, S.J.1    la Hoste, G.J.2    Widmark, C.B.3    Shapiro, R.M.4    Potkin, S.G.5    Marshall, J.F.6
  • 133
    • 0021352730 scopus 로고
    • Reduction of serotonin-2 receptors in rat cerebral cortex after subchronic administration of imipramine, chlorpromazine, and the combination thereof
    • Mikuni, M.; Meltzer, H. Y. Reduction of serotonin-2 receptors in rat cerebral cortex after subchronic administration of imipramine, chlorpromazine, and the combination thereof. Life Sci., 1984, 34, 87-92.
    • (1984) Life Sci , vol.34 , pp. 87-92
    • Mikuni, M.1    Meltzer, H.Y.2
  • 134
    • 0029891621 scopus 로고    scopus 로고
    • The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain
    • Burnet, P. W.; Chen, C. P.; McGowan, S.; Franklin, M.; Harrison, P. J. The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience, 1996, 73, 531-540.
    • (1996) Neuroscience , vol.73 , pp. 531-540
    • Burnet, P.W.1    Chen, C.P.2    McGowan, S.3    Franklin, M.4    Harrison, P.J.5
  • 139
    • 0032588747 scopus 로고    scopus 로고
    • No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia
    • Dean, B.; Tomaskovic-Crook, E.; Opeskin, K.; Keks, N.; Copolov, D.No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia. Neurochem.Int., 1999, 34, 109-115.
    • (1999) Neurochem.Int , vol.34 , pp. 109-115
    • Dean, B.1    Tomaskovic-Crook, E.2    Opeskin, K.3    Keks, N.4    Copolov, D.5
  • 141
    • 0030610492 scopus 로고    scopus 로고
    • 3H WAY-100635 for 5-HT1A receptor autoradiography in human brain: A comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia
    • Burnet, P. W.; Eastwood, S. L.; Harrison, P. J. [3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochem.Int., 1997, 30, 565-574.
    • (1997) Neurochem.Int , vol.30 , pp. 565-574
    • Burnet, P.W.1    Eastwood, S.L.2    Harrison, P.J.3
  • 142
    • 0026098660 scopus 로고
    • Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia
    • Hashimoto, T.; Nishino, N.; Nakai, H.; Tanaka, C. Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci., 1991, 48, 355-363.
    • (1991) Life Sci , vol.48 , pp. 355-363
    • Hashimoto, T.1    Nishino, N.2    Nakai, H.3    Tanaka, C.4
  • 143
    • 0029658084 scopus 로고    scopus 로고
    • Autoradiography with [3H]8-OH-DPAT reveals increases in 5- HT(1A) receptors in ventral prefrontal cortex in schizophrenia
    • Simpson, M. D.; Lubman, D. I.; Slater, P.; Deakin, J. F. Autoradiography with [3H]8-OH-DPAT reveals increases in 5- HT(1A) receptors in ventral prefrontal cortex in schizophrenia. Biological Psychiatry, 1996, 39, 919-928.
    • (1996) Biological Psychiatry , vol.39 , pp. 919-928
    • Simpson, M.D.1    Lubman, D.I.2    Slater, P.3    Deakin, J.F.4
  • 144
    • 0029670799 scopus 로고    scopus 로고
    • Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia
    • Sumiyoshi, T.; Stockmeier, C. A.; Overholser, J. C.; Dilley, G. E.; Meltzer, H. Y. Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res., 1996, 708, 209-214.
    • (1996) Brain Res , vol.708 , pp. 209-214
    • Sumiyoshi, T.1    Stockmeier, C.A.2    Overholser, J.C.3    Dilley, G.E.4    Meltzer, H.Y.5
  • 146
    • 0028985065 scopus 로고
    • [3H]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia
    • Dean, B.; Opeskin, K.; Pavey, G.; Naylor, L.; Hill, C.; Keks, N.; Copolov, D. L. [3H]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. J.Neurochem., 1995, 64, 1197-1202.
    • (1995) J.Neurochem , vol.64 , pp. 1197-1202
    • Dean, B.1    Opeskin, K.2    Pavey, G.3    Naylor, L.4    Hill, C.5    Keks, N.6    Copolov, D.L.7
  • 147
    • 0031013988 scopus 로고    scopus 로고
    • Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia
    • Busatto, G. F.; Pilowsky, L. S.; Costa, D. C.; Ell, P. J.; David, A. S.; Lucey, J. V.; Kerwin, R. W. Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia. Am.J.Psychiatry, 1997, 154, 56-63.
    • (1997) Am.J.Psychiatry , vol.154 , pp. 56-63
    • Busatto, G.F.1    Pilowsky, L.S.2    Costa, D.C.3    Ell, P.J.4    David, A.S.5    Lucey, J.V.6    Kerwin, R.W.7
  • 150
    • 0027328850 scopus 로고
    • Hippocampal benzodiazepine receptors in schizophrenia
    • Reynolds, G. P.; Stroud, D. Hippocampal benzodiazepine receptors in schizophrenia. J.Neural Transm.Gen.Sect., 1993, 93, 151-155.
    • (1993) J.Neural Transm.Gen.Sect , vol.93 , pp. 151-155
    • Reynolds, G.P.1    Stroud, D.2
  • 153
    • 0030994817 scopus 로고    scopus 로고
    • Uncoupling of GABA(A) and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain
    • Benes, F. M.; Wickramasinghe, R.; Vincent, S. L.; Khan, Y.; Todtenkopf, M. Uncoupling of GABA(A) and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain. Brain Res., 1997, 755, 121-129.
    • (1997) Brain Res , vol.755 , pp. 121-129
    • Benes, F.M.1    Wickramasinghe, R.2    Vincent, S.L.3    Khan, Y.4    Todtenkopf, M.5
  • 154
    • 0034802824 scopus 로고    scopus 로고
    • A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder
    • Dean, B.; Pavey, G.; McLeod, M.; Opeskin, K.; Keks, N.; Copolov, D. A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder. Journal of Affective Disorders, 2001, 66, 147-158.
    • (2001) Journal of Affective Disorders , vol.66 , pp. 147-158
    • Dean, B.1    Pavey, G.2    McLeod, M.3    Opeskin, K.4    Keks, N.5    Copolov, D.6
  • 157
    • 0031463617 scopus 로고    scopus 로고
    • Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics
    • Kurumaji, A.; Wakai, T.; Toru, M. Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics. J.Neural Transm., 1997, 104, 1361-1370.
    • (1997) J.Neural Transm , vol.104 , pp. 1361-1370
    • Kurumaji, A.1    Wakai, T.2    Toru, M.3
  • 158
    • 0042213235 scopus 로고    scopus 로고
    • Traumatic brain injury leads to increased expression of peripheral- type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus
    • Raghavendra Rao, V. L.; Dogan, A.; Bowen, K. K.; Dempsey, R. J. Traumatic brain injury leads to increased expression of peripheral- type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp.Neurol., 2000, 161, 102-114.
    • (2000) Exp.Neurol , vol.161 , pp. 102-114
    • Raghavendra Rao, V.L.1    Dogan, A.2    Bowen, K.K.3    Dempsey, R.J.4
  • 162
    • 0025221418 scopus 로고
    • Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem
    • Kerwin, R.; Patel, S.; Meldrum, B. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience, 1990, 39, 25-32.
    • (1990) Neuroscience , vol.39 , pp. 25-32
    • Kerwin, R.1    Patel, S.2    Meldrum, B.3
  • 163
    • 0033914752 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: Effects of schizophrenia
    • Gao, X. M.; Sakai, K.; Roberts, R. C.; Conley, R. R.; Dean, B.; Tamminga, C. A. Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am.J.Psychiatry, 2000, 157, 1141-1149.
    • (2000) Am.J.Psychiatry , vol.157 , pp. 1141-1149
    • Gao, X.M.1    Sakai, K.2    Roberts, R.C.3    Conley, R.R.4    Dean, B.5    Tamminga, C.A.6
  • 164
    • 28244433460 scopus 로고    scopus 로고
    • NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder
    • Toro, C.; Deakin, J. F. NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr.Res., 2005, 80, 323-330.
    • (2005) Schizophr.Res , vol.80 , pp. 323-330
    • Toro, C.1    Deakin, J.F.2
  • 165
    • 0034094628 scopus 로고    scopus 로고
    • Glutamate receptor expression in schizophrenic brain
    • Meador-Woodruff, J. H.; Healy, D. J. Glutamate receptor expression in schizophrenic brain. Brain Res.Brain Res.Rev., 2000, 31, 288-294.
    • (2000) Brain Res.Brain Res.Rev , vol.31 , pp. 288-294
    • Meador-Woodruff, J.H.1    Healy, D.J.2
  • 167
    • 2942666210 scopus 로고    scopus 로고
    • Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder
    • Clinton, S. M.; Meador-Woodruff, J. H. Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder. Neuropsychopharmacology, 2004, 29, 1353-1362.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1353-1362
    • Clinton, S.M.1    Meador-Woodruff, J.H.2
  • 168
    • 44249097986 scopus 로고    scopus 로고
    • Ionotropic glutamate receptor mRNA expression in the human thalamus: Absence of change in schizophrenia
    • Dracheva, S.; Byne, W.; Chin, B.; Haroutunian, V. Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia. Brain Res., 2008, 1214, 23-34.
    • (2008) Brain Res , vol.1214 , pp. 23-34
    • Dracheva, S.1    Byne, W.2    Chin, B.3    Haroutunian, V.4
  • 171
    • 0030091175 scopus 로고    scopus 로고
    • The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia
    • Dean, B.; Crook, J. M.; Opeskin, K.; Hill, C.; Keks, N.; Copolov, D. L. The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia. Mol.Psychiatry, 1996, 1, 54-58.
    • (1996) Mol.Psychiatry , vol.1 , pp. 54-58
    • Dean, B.1    Crook, J.M.2    Opeskin, K.3    Hill, C.4    Keks, N.5    Copolov, D.L.6
  • 172
    • 0033515114 scopus 로고    scopus 로고
    • The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia
    • Crook, J. M.; Dean, B.; Pavey, G.; Copolov, D. The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia. Life Sci., 1999, 64, 1761-1771.
    • (1999) Life Sci , vol.64 , pp. 1761-1771
    • Crook, J.M.1    Dean, B.2    Pavey, G.3    Copolov, D.4
  • 173
    • 0034282537 scopus 로고    scopus 로고
    • Decreased muscarinic receptor binding in subjects with schizophrenia: A study of the human hippocampal formation
    • Crook, J. M.; Tomaskovic-Crook, E.; Copolov, D. L.; Dean, B. Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation. Biological Psychiatry, 2000, 48, 381-388.
    • (2000) Biological Psychiatry , vol.48 , pp. 381-388
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 174
    • 0034975130 scopus 로고    scopus 로고
    • Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: A study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment
    • Crook, J. M.; Tomaskovic-Crook, E.; Copolov, D. L.; Dean, B. Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment. Am.J.Psychiatry, 2001, 158, 918-925.
    • (2001) Am.J.Psychiatry , vol.158 , pp. 918-925
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 175
    • 0036932174 scopus 로고    scopus 로고
    • Decreased muscarinic(1) receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    • Dean, B.; McLeod, M.; Keriakous, D.; McKenzie, J.; Scarr, E. Decreased muscarinic(1) receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol.Psychiatry, 2002, 7, 1083-1091.
    • (2002) Mol.Psychiatry , vol.7 , pp. 1083-1091
    • Dean, B.1    McLeod, M.2    Keriakous, D.3    McKenzie, J.4    Scarr, E.5
  • 177
    • 1642415654 scopus 로고    scopus 로고
    • Investigation of M1/M4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder
    • Zavitsanou, K.; Katsifis, A.; Filomena, M.; Xu-Feng, H. Investigation of M1/M4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder. Neuropsychopharmacology, 2004, 29, 619-625.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 619-625
    • Zavitsanou, K.1    Katsifis, A.2    Filomena, M.3    Xu-Feng, H.4
  • 178
    • 27444444269 scopus 로고    scopus 로고
    • Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia
    • Deng, C.; Huang, X. F. Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia. J.Neurosci.Res., 2005, 81, 883-890.
    • (2005) J.Neurosci.Res , vol.81 , pp. 883-890
    • Deng, C.1    Huang, X.F.2
  • 179
    • 34247643222 scopus 로고    scopus 로고
    • Altered hippocampal muscarinic m4, but not m1, receptor expression from subjects with schizophrenia
    • Scarr, E.; Sundram, S.; Keriakous, D.; Dean, B. Altered hippocampal muscarinic m4, but not m1, receptor expression from subjects with schizophrenia. Biological Psychiatry, 2007, 61, 1161-1170.
    • (2007) Biological Psychiatry , vol.61 , pp. 1161-1170
    • Scarr, E.1    Sundram, S.2    Keriakous, D.3    Dean, B.4
  • 181
    • 70350446516 scopus 로고    scopus 로고
    • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    • Scarr, E.; Cowie, T. F.; Kanellakis, S.; Sundram, S.; Pantelis, C.; Dean, B. Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Mol Psychiatry, 2009, 14, 1017-1023.
    • (2009) Mol Psychiatry , vol.14 , pp. 1017-1023
    • Scarr, E.1    Cowie, T.F.2    Kanellakis, S.3    Sundram, S.4    Pantelis, C.5    Dean, B.6
  • 184
    • 31744438772 scopus 로고    scopus 로고
    • No change in cortical muscarinic M2, M3 receptors or [35S]GTPgammaS binding in schizophrenia
    • Scarr, E.; Keriakous, D.; Crossland, N.; Dean, B. No change in cortical muscarinic M2, M3 receptors or [35S]GTPgammaS binding in schizophrenia. Life Sci., 2006, 78, 1231-1237.
    • (2006) Life Sci , vol.78 , pp. 1231-1237
    • Scarr, E.1    Keriakous, D.2    Crossland, N.3    Dean, B.4
  • 185
    • 0033625466 scopus 로고    scopus 로고
    • Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: No change in m1 mRNA in schizophrenia
    • Dean, B.; Crook, J. M.; Pavey, G.; Opeskin, K.; Copolov, D. L. Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia. Mol.Psychiatry, 2000, 5, 203-207.
    • (2000) Mol.Psychiatry , vol.5 , pp. 203-207
    • Dean, B.1    Crook, J.M.2    Pavey, G.3    Opeskin, K.4    Copolov, D.L.5
  • 186
    • 2942665783 scopus 로고    scopus 로고
    • A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia
    • Dean, B.; Gray, L.; Keriakous, D.; Scarr, E. A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia. Thalamus and Related Systems, 2004, 2, 287-295.
    • (2004) Thalamus and Related Systems , vol.2 , pp. 287-295
    • Dean, B.1    Gray, L.2    Keriakous, D.3    Scarr, E.4
  • 188
    • 0035961131 scopus 로고    scopus 로고
    • Studies on [3H]CP-55940 binding in the human central nervous system: Regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
    • Dean, B.; Sundram, S.; Bradbury, R.; Scarr, E.; Copolov, D. Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use. Neuroscience, 2001, 103, 9-15.
    • (2001) Neuroscience , vol.103 , pp. 9-15
    • Dean, B.1    Sundram, S.2    Bradbury, R.3    Scarr, E.4    Copolov, D.5
  • 189
    • 1642523101 scopus 로고    scopus 로고
    • Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia
    • Zavitsanou, K.; Garrick, T.; Huang, X. F. Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia. Progress in Neuro-psychopharmacology and Biological Psychiatry, 2004, 28, 355-360.
    • (2004) Progress In Neuro-psychopharmacology and Biological Psychiatry , vol.28 , pp. 355-360
    • Zavitsanou, K.1    Garrick, T.2    Huang, X.F.3
  • 190
    • 38149115416 scopus 로고    scopus 로고
    • No changes in densities of cannabinoid receptors in the superior temporal gyrus in schizophrenia
    • Deng, C.; Han, M.; Huang, X. F. No changes in densities of cannabinoid receptors in the superior temporal gyrus in schizophrenia. Neurosci.Bull., 2007, 23, 341-347.
    • (2007) Neurosci.Bull , vol.23 , pp. 341-347
    • Deng, C.1    Han, M.2    Huang, X.F.3
  • 191
    • 46849111394 scopus 로고    scopus 로고
    • Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    • Eggan, S. M.; Hashimoto, T.; Lewis, D. A. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch.Gen.Psychiatry, 2008, 65, 772-784.
    • (2008) Arch.Gen.Psychiatry , vol.65 , pp. 772-784
    • Eggan, S.M.1    Hashimoto, T.2    Lewis, D.A.3
  • 192
    • 0035136656 scopus 로고    scopus 로고
    • Psychiatric effects of cannabis
    • Johns, A. Psychiatric effects of cannabis. Br.J.Psychiatry, 2001, 178, 116-122.
    • (2001) Br.J.Psychiatry , vol.178 , pp. 116-122
    • Johns, A.1
  • 194
    • 0025923082 scopus 로고
    • Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia
    • Nakai, T.; Kitamura, N.; Hashimoto, T.; Kajimoto, Y.; Nishino, N.; Mita, T.; Tanaka, C. Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia. Biological Psychiatry, 1991, 30, 349-356.
    • (1991) Biological Psychiatry , vol.30 , pp. 349-356
    • Nakai, T.1    Kitamura, N.2    Hashimoto, T.3    Kajimoto, Y.4    Nishino, N.5    Mita, T.6    Tanaka, C.7
  • 195
    • 48949099039 scopus 로고    scopus 로고
    • Accelerating new knowledge in schizophrenia
    • Tamminga, C. A. Accelerating new knowledge in schizophrenia. Am.J.Psychiatry, 2008, 165, 949-951.
    • (2008) Am.J.Psychiatry , vol.165 , pp. 949-951
    • Tamminga, C.A.1
  • 197
    • 68949201463 scopus 로고    scopus 로고
    • Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT
    • Schmitt, G. J.; Meisenzahl, E. M.; Frodl, T.; La, F. C.; Hahn, K.; Moller, H. J.; Dresel, S. Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT. Psychiatry Research, 2009, 173, 183-189.
    • (2009) Psychiatry Research , vol.173 , pp. 183-189
    • Schmitt, G.J.1    Meisenzahl, E.M.2    Frodl, T.3    La, F.C.4    Hahn, K.5    Moller, H.J.6    Dresel, S.7
  • 199
    • 39149127938 scopus 로고    scopus 로고
    • GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit
    • Asai, Y.; Takano, A.; Ito, H.; Okubo, Y.; Matsuura, M.; Otsuka, A.; Takahashi, H.; Ando, T.; Ito, S.; Arakawa, R.; Asai, K.; Suhara, T. GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit. Schizophr.Res., 2008, 99, 333-340.
    • (2008) Schizophr.Res , vol.99 , pp. 333-340
    • Asai, Y.1    Takano, A.2    Ito, H.3    Okubo, Y.4    Matsuura, M.5    Otsuka, A.6    Takahashi, H.7    Ando, T.8    Ito, S.9    Arakawa, R.10    Asai, K.11    Suhara, T.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.