Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: A positron emission tomography imaging study with [11C]WAY 100635

Psychopharmacology

Volumn 189, Issue 2, 2006, Pages 155-164

  Frankle, W Gordon ^b   Lombardo, Ilise ^a   Kegeles, Lawrence S ^a   Slifstein, Mark ^a   Martin, John H ^a   Huang, Yiyun ^a   Hwang, Dah Ren ^a   Reich, Elisa ^a   Cangiano, Claudine ^a   Gil, Roberto ^a   Laruelle, Marc ^a   Abi Dargham, Anissa ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

11C WAY 100635; PET; Schizophrenia; Serotonin 5 HT1A receptor

Indexed keywords

CARBON 11; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE;

ADULT; ARTICLE; AUTOPSY; BRAIN; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; EQUILIBRIUM CONSTANT; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RECEPTOR BINDING; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA;

ADULT; AMYGDALA; BRAIN; CARBON RADIOISOTOPES; FEMALE; GYRUS CINGULI; HUMANS; MALE; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; PYRIDINES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA; SEROTONIN ANTAGONISTS; TEMPORAL LOBE;

EID: 33750610322     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0543-8     Document Type: Article

References (37)

1. Abi-Dargham A, Laruelle M, Seibyl J, Rattner Z, Baldwin RM, Zoghbi SS et al (1994) SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. J Nucl Med 35:228-238
2. Abi-Dargham A, Martinez D, Mawlawi O, Simpson N, Hwang DR, Slifstein M et al (2000) Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility. J Cereb Blood Flow Metab 20:225-243
3. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 57:289-300
4. Burnet PW, Eastwood SL, Harrison PJ (1996) 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology 15:442-455
5. Burnet PWJ, Eastwood SL, Harrison PJ (1997) [H-3]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [H-3]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochem Int 30:565-574
6. Cruz DA, Eggan SM, Azmitia EC, Lewis DA (2004) Serotonin1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophrenia. Am J Psychiatry 161:739-742
7. Duvernoy H (1991) The human brain. Surface, three-dimensional sectional anatomy and MRI. Springer, Berlin Heidelberg New York
8. Farde L, Ginovart N, Ito H, Lundkvist C, Pike VW, McCarron JA, Halldin C (1997) PET-characterization of [carbonyl-C-11]WAY-100635 binding to 5-HT1A receptors in the primate brain. Psychopharmacology (Berl) 133:196-202
9. Goldstein JM, Goodman JM, Seidman LJ, Kennedy DN, Makris N, Lee H et al (1999) Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry 56:537-547
10. Gurevich EV, Joyce JN (1997) Alterations in the cortical serotonergic system in schizophrenia: a postmortem study. Biol Psychiatry 42:529-545
11. Hall H, Lundkvist C, Halldin C, Farde L, Pike VW, McCarron JA et al (1997) Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C] WAY-100635. Brain Res 745:96-108
12. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
13. Hashimoto T, Nishino N, Nakai H, Tanaka C (1991) Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci 48:355-363
14. Hoyer D, Pazos A, Probst A, Palacios JM (1986) Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res 376:85-96
15. Hwang DR, Simpson N, Montoya J, Mann JJ, Laruelle M (1999) An improved one-pot procedure for the preparation of [11C-carbonyl] WAY 100635. Nucl Med Biol 26:815-819
16. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE (1993) Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315-336
17. Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL (1997) Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res 75:31-48
18. Kay SR, Fiszbein A, Opler LA (1987) The Positive and Negative Syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261-276
19. Killiany RJ, Moss MB, Nicholson T, Jolez F, Sandor T (1997) An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes. Hum Brain Mapp 5:355-363
20. Kopelman A, Andreasen NC, Nopoulos P (2005) Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposure. Am J Psychiatry 162:1872-1878
21. Martinez D, Hwang D, Mawlawi O, Slifstein M, Kent J, Simpson N et al (2001) Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol. A dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans. Neuropsychopharmacology 24:209-229
22. Mawlawi OM, Weiss R, Shinn A, Pidcock J, Slifstien M, Laruelle M (1999) Performance characteristics of a head immobilization device for PET imaging. J Nucl Med 40:281P
23. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15:217-227
24. Noga JT, Aylward E, Barta PE, Pearlson GD (1995) Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Res 61:201-208
25. Osman S, Lundkvist C, Pike VW, Halldin C, McCarron JA, Swahn CG et al (1996) Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behavior of an identified radioactive metabolite with parent radioligand in monkey using PET. Nucl Med Biol 23:627-634
26. Pani L, Gessa GL, Carboni S, Portas CM, Rossetti ZL (1990) Brain dialysis and dopamine: does the extracellular concentration of dopamine reflect synaptic release? Eur J Pharmacol 180:85-90
27. Parsey RV, Slifstein M, Hwang DR, Abi-Dargham A, Simpson N, Mawlawi O et al (2000) Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: comparison of arterial and reference tisssue input functions. J Cereb Blood Flow Metab 20:1111-1133
28. Simpson MD, Lubman DI, Slater P, Deakin JF (1996) Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT(1A) receptors in ventral prefrontal cortex in schizophrenia. Biol Psychiatry 39:919-928
29. Slater P, Doyle CA, Deakin JF (1998) Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates. J Neural Transm 105:305-315
30. Spitzer R, Williams J, Gibbon M, First M (1992) The structured clinical interview for DSM-III-R: 1. History, rationale and description. Arch Gen Psychiatry 49:624-629
31. Sumiyoshi T, Stockmeier CA, Overholser JC, Dilley GE, Meltzer HY (1996) Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res 708:209-214
32. Suzuki M, Nohara S, Hagino H, Kurokawa K, Yotsutsuji T, Kawasaki Y et al (2002) Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI. Schizophr Res 55:41-54
33. Szeszko PR, Bilder RM, Lencz T, Pollack S, Alvir JM, Ashtari M et al (1999) Investigation of frontal lobe subregions in first-episode schizophrenia. Psychiatry Res 90:1-15
34. Talairach J, Tournoux P (1988) Co-planar stereotactic atlas of the human brain. Three-dimensional proportional system: an approach of cerebral imaging. Theime Medical, New York
35. Tauscher J, Kapur S, Verhoeff NP, Hussey DF, Daskalakis ZJ, Tauscher-Wisniewski S et al (2002) Brain Serotonin 5-HT1A receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635. Arch Gen Psychiatry 59:514-520
36. Woods RP, Cherry SR, Mazziotta JC (1992) Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 16(4):620-633
37. Yasuno F, Suhara T, Ichimiya T, Takano A, Ando T, Okubo Y (2004) Decreased 5-HT1A receptor binding in amygdala of schizophrenia. Biol Psychiatry 55:439-444