No change in the density of the serotonin(1A) receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia

Neurochemistry International

Volumn 34, Issue 2, 1999, Pages 109-115

  Dean, B ^a   Tomaskovic Crook, E ^a   Opeskin, K ^b   Keks, N ^a   Copolov, D ^a  

^a Div Molec Schizophrenia Mental H   (Australia)

^b Vic Institute of Forensic Medicine   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 1A RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN TRANSPORTER; CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; SLC6A4 PROTEIN, HUMAN;

ADULT; AGE; AGED; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROPATHOLOGY; PATHOGENESIS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; SCHIZOPHRENIA; METABOLISM; RADIOASSAY;

CARRIER PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PREFRONTAL CORTEX; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT4; SCHIZOPHRENIA; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0032588747     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(98)00074-6     Document Type: Article

References (27)

1. Altar, C.A., Wasley, A.M., Neale, R.F., Stone, G.A., 1986. Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain. Brain Res. Bull.16, 517-525.
2. American Psychiatric Association, 1987. Diagnostic and statistical manual of mental disorders, 3rd ed. revised. American Psychiatric Association, Washington, D.C.
3. Arora, R.C., Meltzer, H.Y., 1991. Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J. Neural. Transm. Gen. Sect. 85, 19-29.
4. Bennett, J.P., Enna, S.J., Bylund, D.B., Gillin, J.C., Wyatt, R.J., Snyder, S.H., 1979.Neurotransmitter receptors in frontal cortex of schizophrenics. Arch. Gen. Psychiatry 36, 927-934.
5. Bonhomme, N., De Deurwaèrdere, P., Le Moal, M., Spampinato, U., 1995. Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: A microdialysis study in the halothane-anesthetized rat. Neuropharmacol. 34, 269-279.
6. Burnet, P.W.J., Eastwood, S.L., Harrison, P.J., 1996. 5-HT1A and 5-HT2A receptor mRNA and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacol. 15, 442-455.
7. 3H]citalopram. Neurosci. 54, 691-699.
8. De Deurwaèrdere, P., Lhirondel, M., Bonhomme, N., Lucas, G., Cheramy, A., Spampinato, U., 1997. Serotonin stimulation of 5-HT4 receptors indirectly enhances in vivo dopamine release in rat striatum. J. Neurochem. 68, 195-203.
9. 2A receptors in subjects with schizophrenia. Schizophr. Res. 21, 133-139.
10. 3H]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. J. Neurochem. 64, 1197-1202.
11. 2A receptors in Brodmanns area 9 from schizophrenic subjects: A pathological or pharmacological phenomenon? Mol. Cell. Path. (In press).
12. Doménech, T., Beleta, J., Fernández, A.G., Gristwood, R.W., Cruz-Sánchez, F.F., Tolosa, E., Palacios, J.M., 1994. Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: Comparison with other mammalian species. Mol. Brain Res. 21, 176-180.
13. Foster, P., 1989. Neuroleptic equivalence. Pharmcol. J. 243, 431-432.
14. Hashimoto, T., Nishino, N., Nakai, H., Tanaka, C., 1991. Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci. 48, 355-363.
15. Hayakawa, H., Shimizu, M., Nishida, A., Motohashi, N., Yamawaki, S., 1994. Increase in serotonin 1A receptors in the dentate gyrus as revealed by autoradiographic analysis following repeated electroconvulsive shock but not imipramine treatment. Neuropsychobiol. 30, 53-56.
16. Hill, C., Keks, N.A., Roberts, S., Opeskin, K., Dean, B., Copolov, D.L., 1996. Postmortem brain studies in schizophrenia: The problems of diagnosis. Am. J. Psychiatr. 153, 533-537.
17. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R., Humphrey, P.P.A., 1994. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacolog. Rev. 46, 157-204.
18. 3H]BIMU-1. Neuropharmacol. 33, 1027-1038.
19. Joyce, J.N., Shane, A., Lexow, N., Winokur, A., Casanova, M.F., Kleinman, J.E., 1993. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacol. 8, 315-336.
20. Laruelle, M., Abi-Dargham, A., Casanova, M.F., Toti, R., Weinberger, D.R., Kleinman, J.E., 1993. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: A postmortem study. Arch. Gen. Psychiatry. 50, 810-818.
21. 3H-ligand for serotonin S2 receptor binding sites. Mol. Pharmacol. 21, 301-314.
22. Meltzer, H.Y., 1987. Biological studies in schizophrenia. Schizophr. Bull. 13, 77-107.
23. Mita, T., Hanada, S., Nishino, N., Kuno, T., Nakai, H., Yamadori, Y., Tanaka, C., 1986. Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics. Biol. Psychiatr. 21, 1407-1414.
24. Pazos, A., Palacios, J.M., 1985. Quantitative autoradiography: Mapping of serotonin receptors in the rat brain. J. Serotonin-1 receptors. Brain Res. 346, 205-230.
25. Rutter, J.J., Gundlah, C., Auerbach, S.B., 1994. Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci. Letts 171, 183-186.
26. 3H]8-OH-DPAT reveals increases in 5-HT1A receptors in ventral prefrontal cortex in schizophrenia. Biol. Psychiatr. 39, 919-928.
27. Whitaker, P.M., Crow, T.J., Ferrier, I.N., 1981. Tritiated LSD binding in frontal cortex in schizophrenia. Arch. Gen. Psychiatry. 38, 278-280.