[3H]raclopride binding to brain tissue from subjects with schizophrenia: Methodological aspects

Neuropharmacology

Volumn 36, Issue 6, 1997, Pages 779-786

  Dean, B ^a   Pavey, G ^c   Opeskin, K ^b  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b Vic Institute of Forensic Medicine   (Australia)

^c Mental Health Research Institute ^*

Author keywords

autoradiography; Caudate putamen; Dopamine D2 receptors; Human brain; Raclopride binding; Schizophrenia

Indexed keywords

RACLOPRIDE; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; SALICYLAMIDE DERIVATIVE;

ARTICLE; AUTORADIOGRAPHY; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG BINDING; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PUTAMEN; SCHIZOPHRENIA; ADULT; AGED; BRAIN; CELL MEMBRANE; FEMALE; IN VITRO STUDY; MALE; METABOLISM; MIDDLE AGED; PROTEIN BINDING;

ADULT; AGED; AUTORADIOGRAPHY; BRAIN; CAUDATE NUCLEUS; CELL MEMBRANE; DOPAMINE ANTAGONISTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN BINDING; PUTAMEN; RACLOPRIDE; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; SCHIZOPHRENIA;

EID: 0030610876     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00067-1     Document Type: Article

References (22)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised). Washington, D.C. American Psychiatric Association.
2. 3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics. European Journal of Pharmacology 237: 183-189.
3. 11C]raclopride. Archives of General Psychiatry 47: 213-219.
4. 11C]raclopride binding. Synapse 20: 200-208.
5. 3H]raclopride binding to homogenates from human putamen and accumbens. Neuroscience Letters 136: 79-82.
6. Hill C., Keks N. A., Roberts S., Opeskin K., Dean B. and Copolov D. L. (1996) Postmortem brain studies in schizophrenia: The problems of diagnosis. American Journal of Psychiatry 153: 533-537.
7. Knable M. B., Hyde T. M., Herman M. M., Carter J. M., Bigelow L. and Kleinman J. E. (1994) Quantitative autoradiography of dopamine-D1 receptors, D2 receptors, and dopamine uptake sites in postmortem striatal specimens from schizophrenic patients. Biology of Psychiatry 36: 827-835.
8. Kohler C., Hall H., Ogren S. O. and Gawell L. (1985) Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochemistry and Pharmacology 34: 2251-2259.
9. 4 receptor expressed in HEK293 cells. Methods of Finding Experimental and Clinical Pharmacology 16: 303-307.
10. Murray A. M., Hyde T. M., Knable M. B., Herman M. M., Bigelow L. B., Carter J. M., Weinberger D. R. and Kleinman J. E. (1995) Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia. Journal of Neuroscience 15: 2186-2191.
11. Pearce R. K. B., Seeman P., Jellinger K. and Tourtellotte W. W. (1990) Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia. European Neurology 30 (suppl. 1): 9-14.
12. 4 receptors increased in schizophrenia. Journal of Neurochemistry 63: 1576-1577.
13. 4 receptors in drug-treated schizophrenia. European Journal of Pharmacology 281: R5-R6.
14. 3H] raclopride binding sites in postmortem brains from schizophrenic violent suicide victims. Psychopharmacology (Berl) 109: 410-414.
15. Seeman P., Guan H.-C. and Van Tol H. H. M. (1993a) Dopamine D4 receptors elevated in schizophrenia. Nature 365: 441-445.
16. Seeman P., Guan H.-C., Van Tol H. H. M. and Niznik H. B. (1993b) Low density of dopamine D4 receptors in Parkinson's, schizophrenia and control brain striata. Synapse 14: 247-253.
17. 125I]epidepride. European Journal of Pharmacology 286: R3-R5.
18. 3H]nemonapride. Journal of Neurochemistry 64: 1413-1415.
19. 3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression. Brain Research 681: 109-116.
20. 3H]raclopride for dopamine D-2 receptor binding to rat striatum. European Journal of Pharmacology 173: 177-182.
21. Van Tol H. H. M., Bunzow J. R., Guan H.-C., Sunahara R. K., Seeman P., Niznik H. B. and Civelli O. (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614.
22. Wong D. F., Wagner H. N., Tune L. E., Dannals R. F., Pearlson G. D., Links J. M., Tamminga C. A., Broussolle E. P., Ravert H. T., Wilson A. A., Toung T., Malat J., Williams J. A., O'Tuama A., Snyder S. H., Kuhar M. J. and Gjedde A. (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234: 1558-1563.