Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia

Schizophrenia Research

Volumn 44, Issue 1, 2000, Pages 35-45

  Pralong, Danièle ^a   Tomaskovic Crook, Eva ^b   Opeskin, Ken ^a   Copolov, David ^a   Dean, Brian ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

5HT2A; Antipsychotic; Autoradiography; Planum temporale; Schizophrenia; 3H ketanserin

Indexed keywords

BENZATROPINE; CARBAMAZEPINE; CHLORPROMAZINE; CLONAZEPAM; CLOZAPINE; DIAZEPAM; DOXEPIN; FLUOXETINE; FLUPENTIXOL; FLUPHENAZINE; HALOPERIDOL; KETANSERIN; NITRAZEPAM; PHENOTHIAZINE DERIVATIVE; PIMOZIDE; PROCYCLIDINE; SEROTONIN 2A RECEPTOR; SPIPERONE; TEMAZEPAM; TRIFLUOPERAZINE; TRIHEXYPHENIDYL;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RECEPTOR DENSITY; SCHIZOPHRENIA; SENSORY CORTEX;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; DOMINANCE, CEREBRAL; FEMALE; HALOPERIDOL; HUMANS; MALE; MIDDLE AGED; PHENOTHIAZINES; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SCHIZOPHRENIA; SYNAPTIC MEMBRANES; TEMPORAL LOBE;

EID: 0034617336     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(99)00150-4     Document Type: Article

References (36)

1. Diagnostic and Statistical Manual of Mental Disorders. 1st ed. 1994;American Psychiatric Press, Washington, DC.
2. Andree T.H., Mikuni M., Tong C.Y., Koenig J.I., Meltzer H.Y. Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex. J. Neurochem. 46:1986;191-197.
3. Arora R.C., Meltzer H.Y. Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J. Neural Transm. Gen. Sect. 85:1991;19-29.
4. Burnet P.W., Eastwood S.L., Lacey K., Harrison P.J. The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain. Brain Res. 676:1995;157-168.
5. Burnet P.W., Eastwood S.L., Harrison P.J. 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology. 15:1996;442-455.
6. Burnet P.W., Chen C.P., McGowan S., Franklin M., Harrison P.J. The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience. 73:1996;531-540.
7. Cohen B.M., Tsuneizumi T., Baldessarini R.J., Campbell A., Babb S.M. Differences between antipsychotic drugs in persistence of brain levels and behavioral effects. Psychopharmacology (Berl.). 108:1992;338-344.
8. Dean B., Hayes W. Decreased frontal cortical serotonin2A receptors in subjects with schizophrenia. Schizophr. Res. 21:1996;133-139.
9. Dean B., Hayes W., Opeskin K., Naylor L., Pavey G., Hill C., et al. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behav. Brain Res. 73:1996;169-175.
10. Dean B., Hayes W., Hill C., Copolov D. Decreased serotonin2A receptor in Brodmann's area 9 from schizophrenic subjects: a pathological or pharmacological phenomenon? Mol. Neurochem. Neuropathol. 34:1998;133-145.
11. Falkai P., Bogerts B., Schneider T., Greve B., Pfeiffer U., Pilz K., et al. Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study. Schizophr. Res. 14:1995;161-176.
12. Galaburda A.M. The planum temporale. Arch. Neurol. 50:1993;457.
13. Gurevitch E.V., Joyce J.N. Alterations in the cortical serotoninergic system in schizophrenia: a postmortem study. Biol. Psychiatry. 42:1997;529-545.
14. Hashimoto T., Kitamura N., Kajimoto Y., Shirai Y., Shirakawa O., Mita T., et al. Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia. Psychopharmacology (Berl.). 112:1993;S35-S39.
15. Hill C., Keks N.A., Roberts S., Opeskin K., Dean B., Copolov D.L. Postmortem brain studies in schizophrenia: The problems of diagnosis. Am. J. Psychiatry. 153:1996;533-537.
16. Hill C., Roberts S., Keks N.A., Dean B., Mackinnon A., Copolov D. Diagnostic Instrument for Brain Studies. 1998;The Mental Health Research Institute, Victoria, Australia.
17. Hong M., Roots E.J., Jenner P., Marsden C.D. The effect of long-term treatment with amine-depleting drugs or chlorpromazine on alpha-adrenoreceptors and 5-HT2 receptors in the brain of the rat. Neuropharmacology. 27:1988;519-527.
18. Jones E.G. Laminar distribution of cortical efferent cells. Peter A., Jones E.G. Cerebral Cortex. 1984;521-553 Plenum Press, New York.
19. Joyce J.N., Shane A., Lexow N., Winokur A., Casanova M.P., Kleinman J.E. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropychopharmacology. 8:1993;315-336.
20. Laruelle M., Abi-Dargham A., Casanova M.F., Toti R., Weinberger D.R., Kleinman J.E. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: A postmortem study. Arch. Gen. Psychiatry. 50:1993;810-818.
21. Lewis R., Kapur S., Jones C., DaSilva J., Brown G.M., Wilson A.A., Houle S., Zipursky R.B. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naïve patients and normal subjects. Am. J. Psychiatry. 156:1999;72-78.
22. Leysen J.E., Janssen P.F.M., Schotte A., Luyten W.H.M.L., Megens A.A.H.P. Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors. Psychopharmacology. 112:1993;S40-S54.
23. Marek G.J., Aghajanian G.K. The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis. Biol. Psychiatry. 44:1998;1118-1127.
24. Matsubara S., Meltzer H.Y. Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex. Life Sci. 45:1989;1397-1406.
25. Mikuni M., Meltzer H.Y. Reduction of serotonin-2 receptors in rat cerebral cortex after subchronic administration of imipramine, chlorpromazine, and the combination thereof. Life Sci. 34:1984;87-92.
26. Mita T., Hanada S., Nishino N., Kuno T., Nakai H., Yamadori Y., et al. Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics. Biol. Psychiatry. 21:1986;1407-1414.
27. Owen F., Cross A.J., Poulter M., Waddington J.L. Change in the characteristics of 3H-spiperone binding to rat striatal membranes after acute chlorpromazine administration: effects of buffer washing of membranes. Life Sci. 25:1979;385-390.
28. Pazos A., Probst A., Palacios J.M. Serotonin receptors in the human brain - IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience. 21:1987;123-139.
29. Petty R.G., Barta P.E., Pearlson G.D., McGilchrist I.K., Lewis R.W., Tien A.Y., et al. Reversal asymmetry of the planum temporale in schizophrenia. Am. J. Psychiatry. 152:1995;715-721.
30. Ross C.A., Pearlson G.D. Schizophrenia, the heteromodal association neocortex and development: potential for a neurogenetic approach. Trends Neurosci. 19:1996;171-176.
31. Ross M.H., Reith E.J., Romrell L.J. Histology: a Text and Atlas. 2nd ed. 1989;Williams and Wilkins, Baltimore, MD.
32. Silbersweig D., Stern E. Functional neuroimaging of hallucinations in schizophrenia: toward an integration of bottom-up and top-down approaches. Mol. Psychiatry. 1:1996;367-375.
33. Suzuki M., Yuasa S., Minabe Y., Murata M., Kurachi M. Left superior temporal blood flow increases in schizophrenic and schizophreniform patients with auditory hallucinations: a longitudinal case study using 123I-IMP SPECT. Eur. Arch. Psychiatry Clin. Neurosci. 242:1993;257-261.
34. Trichard C., Paillere-Martinot M.L., Attar-Levy D., Blin J., Feline A., Martinot J.L. No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET. Schizophr. Res. 31:1998;13-17.
35. Woodruff P., Brammer M., Mellers J., Wright I., Bullmore E., Williams S. Auditory hallucinations and perception of external speech. Lancet. 346:1995;1035.
36. Woods F.B., Flowers D.L. Hypofrontal vs. hypo-Sylvian blood flow in schizophrenia. Schizophr. Bull. 16:1990;413-424.