Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia

Brain Research

Volumn 708, Issue 1-2, 1996, Pages 209-214

  Sumiyoshi, Tomiki ^a,b   Stockmeier, Craig A ^a   Overholser, James C ^a   Dilley, Ginny E ^a   Meltzer, Herbert Y ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Postmortem brain; Prefrontal cortex; Receptor; Schizophrenia; Serotonin 5 HT1A; Up regulation; 3H S OH DPAT

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; TRITIUM; SEROTONIN 1A RECEPTOR;

ADULT; ARTICLE; AUTOPSY; COMPARATIVE STUDY; FEMALE; HUMAN; KINETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PREFRONTAL CORTEX; RADIOASSAY; REFERENCE VALUE; SCHIZOPHRENIA; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR BINDING; SEROTONINERGIC SYSTEM;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADULT; AUTOPSY; FEMALE; HUMANS; KINETICS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; REFERENCE VALUES; SCHIZOPHRENIA; TRITIUM;

EID: 0029670799     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01361-X     Document Type: Article

References (29)

1. American Psychiatric Association, DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders, 3rd Ed., Rev., American Psychiatric Association, Washington, DC, 1987.
2. Andreasen, N., Endicott, J., Spitzer, R.L. and Winokur, G., The family history method using diagnostic criteria, reliability and validity, Arch. Gen. Psychiatry, 34 (1977) 1229-1235.
3. Arato, M., Demeter, E., Rihmer, Z. and Somogyi, E., Retrospective psychiatric assessment of 200 suicide in Budapest, Acta Psychiat. Scand., 77 (1988) 454-456.
4. 2) receptor binding in the frontal cortex of schizophrenic patients, J. Neural. Transm., 85 (1991) 19-29.
5. Corbett, R., Hartman, H., Kerman, L.L., Woods, A.T., Strupczewski, J.T., Helsley, G.C., Conway, P.C. and Dunn, R.W., Effects of atypical antipsychotic agents on social behaviour in rodents, Pharmacol. Biochem. Behav., 45 (1993) 9-17.
6. 1A receptor agonists and NMDA antagonists in the social interaction test and the elevated plus maze assay, Eur. J. Pharmacol., 169 (1989) 1-10.
7. Fuster, J.M., The Prefrontal Cortex, Anatomy, Physiology and Neurobiology of the Frontal Lobe, Raven Press, New York, 1980.
8. Goldman-Rakic, P.S., Working memory dysfunction in schizophre-nia, J. Neuropsychiat. Clin. Neurosci., 6 (1994) 348-357.
9. 3H]8-Hydroxy-2-(di-n-propylamino)tetraline binding to pre-and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain, J. Neurochem., 44 (1985) 1685-1696.
10. 1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia, Life Sci., 48 (1991) 355-363.
11. 2 receptor binding in patients with chronic schizophrenia, Psychopharmacology, 112 (1993) S35-S39.
12. Joyce, J.N., Shane, A., Lexow, N., Winokur, A., Casanova, M.F. and Kleinman, J.E., Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics, Neuropsychopharmacology, 8 (1993) 315-336.
13. Lenzenweger, M.F. and Korfine, L., Perceptual aberrations, schizotypy, and the Wisconsin Card Sorting Test, Schizophr. Bull., 20 (1994) 345-357.
14. Lesage, A.D., Boyer, R., Grunberg, F., Vanier, C., Morissette, R., Menard-Buteau, C. and Loyer, M., Suicide and mental disorders: a case-control study of young men, Am. J. Psychiatry, 151 (1994) 1063-1068.
15. Leysen, J.E., Gommeren, W., Eens, A., de Chaffoy de Courcelles, D., Stoof, J.C. and Janssen, P.A.J., Biochemical profile of risperidone, a new antipsychotic, J. Pharmacol. Exp. Ther., 247 (1988) 661-670.
16. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurements with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
17. 1A) receptors in human brain postmortem, Brain Res., 658 (1994) 55-59.
18. 1A binding sites in frontal cortex of suicide victims, J. Neural. Transm., 85 (1991) 181-194.
19. Meltzer, H.Y., The significance of serotonin for neuropsychiatrie disorders, J. Clin. Psychiatry, 52 (1991) 70-72.
20. Meltzer, H.Y. and Ranjan, R., Ipsapirone-induced Cortisol response and its relation to negative symptoms in schizophrenia, Soc. Neurosci. Abstr., 21 (1995) 260.
21. Munson, P.J. and Rodbard, D., LIGAND: a versatile computerized approach for the characterization of ligand binding systems, Anal. Biochem., 107 (1980) 220-239.
22. 3H]hydroxydipropylaminotetralin, J. Neurochem., 62 (1994) 1822-1834.
23. Park, S. and Holzman, P.S., Association of working memory deficit and eye tracking dysfunction in schizophrenia, Schizophr. Res., 11 (1993) 55-61.
24. Richelson, E., Neuroleptic binding to human brain receptors: relation to clinical effects, Ann. NY Acad. Sci., 537 (1988) 435-442.
25. Roth, B.L., Multiple serotonin receptors: clinical and experimental aspects, Ann. Clin. Psychiatry, 6 (1994) 1-13.
26. Selemon, L.D., Rajkowska, G. and Goldman-Rakic, P., Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17, Arch. Gen. Psychiatry., in press.
27. Sovner, R. and Parnell-Sovner, N., Use of buspirone in the treatment of schizophrenia, J. Clin. Psychopharmacol., 9 (1989) 61-62.
28. Spitzer, R.L. and Endicott, J., Schedule for Affective Disorders and Schizophrenia, Biometrics Research Division, New York State Psychiatric Institute, New York, 1979.
29. 3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression, Brain Res., 681 (1995) 109-116.