5-HT(1A) 5-HT(2A) receptor mRNAs and binding site densities are differentially altered in schizophrenia

Neuropsychopharmacology

Volumn 15, Issue 5, 1996, Pages 442-455

  Burnet, Philip W J ^a,b   Eastwood, Sharon L ^a   Harrison, Paul J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

5 HT(1A) receptor; 5 HT(2A) receptor; Cortex; In situ hybridization; Receptor autoradiography; Schizophrenia; Serotonin receptor

Indexed keywords

HALOPERIDOL; RNA; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXY 2 N,N DIPROPYLAMINOTETRALIN; 5-HYDROXY-2-N,N-DIPROPYLAMINOTETRALIN; DRUG DERIVATIVE; KETANSERIN; MESSENGER RNA; NEUROLEPTIC AGENT; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ADULT; AGED; ARTICLE; BINDING SITE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; ANIMAL; AUTORADIOGRAPHY; BRAIN; COMPARATIVE STUDY; DRUG EFFECT; METABOLISM; MIDDLE AGED; RAT; SPRAGUE DAWLEY RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADULT; AGED; ANIMALS; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; FEMALE; HALOPERIDOL; HUMANS; KETANSERIN; MALE; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 0030273870     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(96)00053-X     Document Type: Article

References (71)

1. 2 receptor stimulation. Mol Pharmacol 43:349-355
2. 2 receptors in rat cerebral cortex. J Neurochem 46:191-197
3. 2) receptor binding in the frontal cortex of schizophrenic patients. Am J Psychiatry 146:730-736
4. 2A receptor gene. Lancet 346:281-282.
5. Barton AJL, Pearson RCA, Najlerahim A, Harrison PJ (1993): Pre and post mortem influences on brain RNA. J Neurochem 61:1-11
6. Benes FM, McSparren J, Bird ED, SanGiovanni LP, Vincent SL (1991): Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 48:996-1001
7. A receptor binding in superficial layers of cingulate cortex in schizophrenics. J Neurosci 12:924-929
8. Bennett JP, Enna SJ, Bylund DB, Gillin JC, Wyatt RJ, Snyder SH (1979): Neurotransmitter receptors in frontal cortex of schizophrenics. Arch Gen Psychiatry 36:927-934
9. 2 binding site after chronic administration of agonists and antagonists. Neuropharmacology 25:1267-1271
10. Bleich A, Brown SL, Kahn R, van Praag HM (1988): The role of serotonin in schizophrenia. Schizophr Bull 114:297-315
11. 2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography on [18F]-setoperone. Brain 116:497-510
12. Breier A (1995): Serotonin, schizophrenia and antipsychotic drug action. Schizophr Res 14:187-202
13. 2A receptor and response to clozapine. Lancet 346: 909
14. 2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age. Neurosci Lett 178:85-89
15. 2A and the abundance of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res 638:311-324
16. 2A receptor mRNA in human brain. Brain Res 676:157-168
17. 2A receptor gene expression. Neuroreport 6:901-904
18. Burnet PWJ, Chen CPL-H, McGowan S, Franklin M, Harrison PJ (1996): The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience (in press)
19. Chen CPL-H, Eastwood SL, Cooper S, Esiri MM (1995): Selective loss of serotonergic neurons in the rostral raphe nuclei of schizophrenics [abst]. British Neuropathological Society, Oxford meeting, July 1995, Neuropathol Appl Neurobiol (suppl), pp 13-14
20. Dillon KA, Gross-Isseroff C, Israeli M, Biegon A (1991): Autoradiographic analysis of 5-HT1A receptor binding in the human brain post-mortem: Effects of age and alcohol. Brain Res 554:56-64
21. Doty RW (1989): Schizophrenia: A disease of interhemispheric processes at forebrain and brainstem levels? Behav Brain Res 34:1-33
22. Eastwood SL, Harrison PJ (1995): Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated by immunoautoradiography. Neuroscience 69:339-343
23. Eastwood SL, Burnet PWJ, Harrison PJ (1995): Altered synaptophysin gene expression as a marker of synaptic pathology in schizophrenia. Neuroscience 66:309-319
24. 2 receptors in P11 cells. Mol Pharmacol 43:726-733
25. Francis PT, Sims NR, Procter AW, Bowen DM (1993): Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives. J Neurochem 60:1589-1604
26. Frohna PA, Neal-Beliveau BS, Joyce JN (1995): Neonatal 6-hydroxydopamine lesions lead to opposing changes in the levels of dopamine receptors and their messenger RNAs. Neuroscience 68:505-518
27. 1A receptor. Neuroscience 62: 721-739
28. 1A receptor density by nonhydrolysable GTP analogues. J Neurochem 54:294-299
29. Harrison PJ (1986): The pathogenesis of Alzhemer's disease: Beyond the cholinergic hypothesis. J R Soc Med 79:347-351
30. Harrison PJ (1995a): On the neuropathology of schizophrenia and its dementia: Neurodevelopmental, neurodegenerative, or both? Neurodegeneration 4:1-12
31. Harrison PJ (1995b): In vitro imaging: Techniques for studying and localizing the pathogenesis of psychiatric diseases. In Kerwin RW (ed), Neurobiology and Psychiatry, vol 3, Neuroimaging. Cambridge, Cambridge University Press, pp 157-174
32. Harrison PJ, Heath PR, Eastwood SL, Burnet PWJ, McDonald B, Pearson RCA (1995): The importance of premortem brain acidosis and postmortem interval for human brain gene expression studies: Selective vulnerability amongst mRNAs and comparison with their encoded proteins. Neurosci Lett 200:151-154
33. 1A receptors in prefrontal and temporal cortices of brains of patients with chronic schizophrenia. Life Sci 48:355-363
34. Hoffman RE, McGlashan TH (1994): Corticocortical connectivity, autonomous networks, and schizophrenia. Schizophr Bull 20:257-261
35. 2 and α1-adrenergic receptor in human brain cortex. J Cardiovasc Pharmacol 10[Suppl 3]:S48-S50
36. Jones EG (1984): Laminar distribution of cortical efferent cells. In Peters A, Jones EG (eds), Cerebral Cortex, vol 1, Cellular Components of the Cerebral Cortex. New York, Plenum Press, pp 521-553
37. Joyce JN, Shane A, Lexow N, Winokur A, Casanova M, Kleinman JE (1993): Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315-336
38. Kahn RS, Davidson M (1993): Serotonin, dopamine and their interactions in schizophrenia. Psychopharmacology 112(Suppl):S1-S4
39. Khawaga X (1995): Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist. Brain Res 673:217-225
40. Kingsbury AE, Foster OJ, Nisbet AP, Cairns N, Bray L, Eve DJ, Lees AJ, Marsden CD (1995): Tissue pH as an indicator of mRNA preservation in human postmortem brain. Mol Brain Res 28:311-318
41. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE (1993): Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. Arch Gen Psychiatry 50:810-818
42. 2) receptor numbers in the rat brain. Psychiatry Res 12:277-285
43. Lewis DA, Hayes TL, Lund JS, Oeth KM (1992): Dopamine and the neural circuitry of primate prefrontal cortex: Implications for schizophrenia research. Neuropsychopharmacology 6:127-134
44. 2-serotinergic sites in the primate cerebral cortex [abst] Schizophr Res 15:158
45. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11:449-458
46. 2 receptor density in rat cerebral cortex. Life Sci 45:1397-1406
47. Meltzer HY (1992): The importance of serotonin-dopamine interactions in the action of clozapine. Br J Psychiatry 17(Suppl):46-53
48. 2A receptors in relation to suicide. Arch Gen Psychiatry 51:1003
49. Mita T, Handa S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka C (1986): Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics. Biol Psychiatry 21:1407-1414
50. Mrini A, Soucy JP, Lafaille F, Lemoine P, Descarries L (1995): Quantification of the serotonin hyperinnervation in adult rat neostriatum after neonatal 6-hydroxydopamine lesion of nigral dopamine neurons. Brain Res 669:303-308
51. Nieuwenhuys R (1994): The neocortex. An overview of its evolutionary development, structural organization and synaptology. Anat Embryol 190:307-337
52. Nordstrom A-L, Farde L, Nyberg S, Karlsson P, Halldin C, Sedvall G (1995): D1, D2 and 5-HT2 receptor occupancy in relation to clozapine serum concentration: A PET study of schizophrenic patients. Am J Psychiatry 152:1444-1449
53. Park D, Stone DM, Baker H, Wessel TC, Kim KS, Towle AC, Joh TH (1993): Changes in activity and mRNA for rat tryptophan hydroxylase and aromatic L-amino acid decarboxylase of brain serotonergic cell bodies and terminals following neonatal 5,7-dihydroxytryptamine. Brain Res 609:59-66
54. Pazos A, Probst A, Palacios JM (1987a): Serotonin receptors in the human brain. III. Autoradiographic mapping of sertonin-1 receptors. Neuroscience 21:97-122
55. Pazos A, Probst A, Palacios JM (1987b): Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience 21:123-139
56. Peroutka S (1994): Molecular biology of serotonin (5-HT) receptors. Synapse 18:241-260
57. 1A binding sites in rats with chronic neonatal 5.7-dihydroxytryptamine lesions. Dev Brain Res 80:1-6
58. 2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: A quantitative autoradiographic study. Brain Res 606: 273-285
59. 2A signal transduction in senescent rats: Reversal following inhibition of protein kinase C. Neuroscience 66:891-901
60. Reynolds GP, Rossor MN, Iversen LL (1983): Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action. J Neural Transm 18:273-277
61. Roth BL, Meltzer HY (1995): The role of serotonin in schizophrenia. In Bloom FE, Kupfer DJ (eds), Psychopharmacology: The Fourth Generation of Progress. New York Raven Press, pp 1215-1228
62. 2 receptor mRNA levels. Eur J Pharmacol 207:169-172
63. Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD (1994): Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 151:842-848
64. Schmidt CJ, Sorensen SM, Kehne JH, Carr AA, Palfreyman MG (1995): The role of 5-HT2A receptors in antipsychotic activity. Life Sci 56:2209-2222
65. Shapiro RM (1993): Regional neuropathology in schizophrenia: Where are we? Where are we going? Schizophr Res 10:187-239
66. Simpson MDC, Lubman DI, Slater P, Deakin JFW (1996): Autoradiography with [3H]-8-OH-DPAT reveals localized increases in ventral prefrontal cortex in schizophrenia. Biol Psychiatry (in press)
67. Toth M, Shenk T (1994): Antagonist mediated down regulation of 5-Hydroxtryptamine type 2 receptor gene expression: Modulation of gene expression. Mol Pharmacol 45:1095-1100
68. Weinberger DR, Lipska BK (1995): Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: A search for common ground. Schizophr Res 16:87-110
69. Whitaker PM, Crow TJ, Ferrier IN (1981): Tritiated LSD binding in frontal cortex in schizophrenia. Arch Gen Psychiatry 38:278-280
70. 2) receptor in the rat brain. Brain Res 487:288-298
71. Zhu Q-S, Chen K, Shih JC (1995): Characterization of the human 5-HT2A receptor gene promoter. J Neurosci 15:4885-4895