[3H]WAY-100635 for 5-HT(1A) receptor autoradiography in human brain: A comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia

Neurochemistry International

Volumn 30, Issue 6, 1997, Pages 565-574

  Burnet, P W J ^a,b   Eastwood, S L ^a   Harrison, P J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BRAIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; TRITIUM; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN; BRAIN CORTEX; CINGULATE GYRUS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYOPRESERVATION; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RADIOASSAY; RAPHE NUCLEUS; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; SCHIZOPHRENIA; FRONTAL LOBE; METABOLISM; MIDDLE AGED;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADULT; AGED; AUTORADIOGRAPHY; FEMALE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; PYRIDINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SCHIZOPHRENIA; SEROTONIN ANTAGONISTS; TRITIUM;

EID: 0030610492     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00124-6     Document Type: Article

References (46)

1. 1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology 14, 35-46.
2. Beck, S. G., Choi, K. C. and List, T. J. (1992) Comparison of 5-hydroxytryptaminelA-mediated hyper-polarization in CA1 and CA3 hippocampal pyramidal cells. J. Pharmacol. Exp. Ther. 263, 350-359.
3. Bowen, D. M., Francis, P. T., Pangalos, M. N., Stephens, P. H., Procter, A. W. and Chessell, I. P. (1993) "Traditional" pharmacotherapy may succeed in Alzheimer's disease. Trends Neurosci. 15, 84-85.
4. 2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age. Neurosci. Lett. 178, 85-89.
5. 2A receptor mRNA in human brain. Brain Res. 676, 157-168.
6. 2A receptor mRNAs and binding site densties are differentially altered in schizophrenia. Neuropsychopharmacology 15, 442-455.
7. Burnet, P. W. J., Chen, C. P. L.-H., McGowan, S., Franklin, M. and Harrison, P. J. (1996b) The effects of clozapine and haloperidol on serotonin-1A, -2A, and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience 73, 531-540.
8. 1 binding sites in depressed suicides. Psychopharmacology 102, 544-548.
9. 1A receptor binding in the human brain post-mortem: effects of age and alcohol. Brain Res. 554, 56-64.
10. 1A binding sites with G regulatory proteins. Biochem. Pharmacol. 39, 7-18.
11. 1A receptor antagonist. Behav. Brain Res. 73, 337-353.
12. 1A receptor antagonist WAY-100635. Eur. J. Pharmacol. 281, 81-88.
13. 3H]PAT. Nature 305, 140-142.
14. 1A receptors in rat brain membranes. Eur. J. Pharmacol. Mol. Pharmacol. 288, 173-186.
15. 3H]8-Hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44, 1685-1696.
16. Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B. and Pearson, R. C. A. (1995) The importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective vulnerability amongst mRNAs and comparison with their encoded proteins. Neurosci. Lett. 200, 151-154.
17. 1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci. 48, 355-363.
18. Hjorth, S., Carlsson, A., Lindberg, P., Sanchez, D., Wikstrom, H., Arvidsson, L. E., Hacksell, U. and Nilsson, J. L. G. (1982) 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT receptor stimulating activities. J. Neural Transm. 55, 169-188.
19. 1A receptors in rat brain. Eur. J. Pharmacol. 271, 515-523.
20. 2 receptors in striatum and cortex of schizophrenics, non-schizophrenic suicides and controls. Neuropsychopharmacology 8, 315-336.
21. Kazmi, S. M. I., Ramwani, J., Srivastava, L. K., Rajakumar, G., Ross, G. M., Cullen, M. and Mishra, R. K. (1986) Characterisation of high affinity dopamine D2 receptors and modulation of affinity states by guanidine nucleotides in cholate-solubilised bovine striatal preparations. J. Neurochem. 47, 1493-1502.
22. 1A receptor antagonist. Brain Res. 673, 217-225.
23. 1A receptor antagonist, to rat brain. J. Neurochem. 64, 2716-2726.
24. 1A receptors in the rat central nervous system. J. Comp. Neurol. 365, 289-305.
25. Kobilka, B. (1992) Adrenergic receptors as models for G-protein-coupled receptors. Annu. Rev. Neurosci. 15, 87-114.
26. 3H]WAY 100635 in the mouse. Eur. J. Pharmacol. 271, 505-514.
27. 1A receptor agonist 8-OH-DPAT. Neuropharmacology 29, 85-91.
28. Lesch, K. P. and Lerer, B. (1991) The 5-HT receptor-G-protein-effector system complex in depression. I. Effect of glucocorticoids. J. Neural Transm. 84, 3-18.
29. Lohse, M., Klotz, K.-N., Lindenborn-Fotinos, J., Reddington, M., Schwabe, U. and Olssen, R. A. (1987) 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX): a selective high affinity antagonist radioligand for α1 adenosine receptors. Naunyn-Schmiedebergs Arch. Pharmacol. 336, 204-210.
30. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11, 449-458.
31. 1A binding sites in the frontal cortex of suicide victims. J. Neural Transm. [Gen. Sect.] 85, 181-194.
32. 1A agonists. Mol. Pharmacol. 37, 231-237.
33. 1A receptor in rat hippocampus. Brain Res. 590, 229-238.
34. 3H]-(hydroxydipropylamino) tetralin. J.Neurochem. 62, 1822-1834.
35. 3H]8-OH-DPAT binding sites in rat cerebral cortex and hippocampus. Neurochem. Res. 21, 167-176.
36. 1B receptor subtypes in rat brain. Eur. J. Pharmacol. 281, 229-239.
37. 1A receptor-G-protein interactions in the cerebral cortex of patients with Alzheimer's disease. Neurosci. Lett. 133, 15-19.
38. Pazos, A., Probst, A. and Palacios, J. M. (1987) Serotonin receptors in the human brain. III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 21, 97-122.
39. Peroutka, S. (1994) Molecular biology of serotonin (5-HT) receptors. Synapse 18, 241-260.
40. 11C]WAY-100635. Eur. J. Pharmacol. 301, R5-R7.
41. 1A receptor binding sites in the rat brain: a quantitative autoradiographic study. J. Neurochem. 58, 1338-1346.
42. 3H]-8-OH-DPAT reveals localised increases in ventral prefrontal cortex in schizophrenia. Biol. Psychiatry 39, 919-928.
43. 1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology 27, 707-715.
44. 1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res. 708, 209-214.
45. Vogt, B. A., Pandya, D. N. and Rosene, D. L. (1987) Cingulate cortex of the rhesus monkey: Cytoarchitecture and thalamic afferents. J. Comp. Neurol. 262, 256-270.
46. 3H]8-hydroxy-N,N-dipropyl-2-aminotetralin serotonergic binding site in Alzheimer's disease. Behav. Brain Res. 73, 325-329.