-
1
-
-
0031001720
-
Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study
-
Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997; 349:1 498-504.
-
(1997)
Lancet
, vol.349
, Issue.1
, pp. 498-504
-
-
Murray, C.J.1
Lopez, A.D.2
-
2
-
-
0034721232
-
Chronic obstructive pulmonary disease
-
Barnes PJ. Chronic obstructive pulmonary disease. N Engl J Med 2000; 343: 269-80.
-
(2000)
N Engl J Med
, vol.343
, pp. 269-280
-
-
Barnes, P.J.1
-
3
-
-
0028827084
-
Standard for the diagnosis and care of patients with chronic obstructive pulmonary disease
-
American Thoracic Society
-
American Thoracic Society: Standard for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152: S77-S120.
-
(1995)
Am J Respir Crit Care Med
, vol.152
-
-
-
4
-
-
0003736032
-
-
National institute of healthy, National Heart, Lung and Blood Institute, Global Initiative for Chronic Obstructive Lung Disease, 2701, Publication Number
-
National institute of healthy, National Heart, Lung and Blood Institute, Global Initiative for Chronic Obstructive Lung Disease: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary diseases. Publication Number 2701, 2001.
-
(2001)
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary diseases
-
-
-
6
-
-
33644821154
-
Guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease
-
Japnese Respiratory Society
-
Japnese Respiratory Society: Guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease. Nihon Kokyuki Gakkai Zasshi 2009; (Suppl):1-137.
-
(2009)
Nihon Kokyuki Gakkai Zasshi
, Issue.SUPPL.
, pp. 1-137
-
-
-
7
-
-
0344088442
-
Neutrophil chemotactic activity of sputum from patients with COPD: Role of interleukin 8 and leukotriene B4
-
Beeh KM, Kornmann O, Buhl R, Culpitt SV Giembycz MA, Barnes PJ. Neutrophil chemotactic activity of sputum from patients with COPD: Role of interleukin 8 and leukotriene B4. Chest 2003; 123: 1240-7.
-
(2003)
Chest
, vol.123
, pp. 1240-1247
-
-
Beeh, K.M.1
Kornmann, O.2
Buhl, R.3
Culpitt, S.V.4
Giembycz, M.A.5
Barnes, P.J.6
-
9
-
-
0033034660
-
Bacterial endotoxin is an active component of cigarette smoke
-
Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W. Bacterial endotoxin is an active component of cigarette smoke. Chest 1999; 115: 829-35.
-
(1999)
Chest
, vol.115
, pp. 829-835
-
-
Hasday, J.D.1
Bascom, R.2
Costa, J.J.3
Fitzgerald, T.4
Dubin, W.5
-
10
-
-
0030296896
-
Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke
-
Gebremichael A, Tullis K, Denison MS, Cheek JM, Pinkerton KE. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol 1996; 141: 76-83.
-
(1996)
Toxicol Appl Pharmacol
, vol.141
, pp. 76-83
-
-
Gebremichael, A.1
Tullis, K.2
Denison, M.S.3
Cheek, J.M.4
Pinkerton, K.E.5
-
11
-
-
34249339752
-
Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway
-
Kitamura M, Kasai A. Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway. Cancer Lett 2007; 252: 184-94.
-
(2007)
Cancer Lett
, vol.252
, pp. 184-194
-
-
Kitamura, M.1
Kasai, A.2
-
12
-
-
77957315403
-
Redox compartmentalization and cellular stress
-
Jones DP, Go Y-M. Redox compartmentalization and cellular stress. Diabetes Obes Metab 2010;12 (Suppl 2):116-25.
-
(2010)
Diabetes Obes Metab
, vol.12
, Issue.SUPPL. 2
, pp. 116-125
-
-
Jones, D.P.1
Go, Y.-M.2
-
13
-
-
79952670311
-
Cellular responses to cigarette smoke and oxidants
-
Cantin AM. Cellular responses to cigarette smoke and oxidants. Proc Am Thrac Soc 2010; 7: 368-75.
-
(2010)
Proc Am Thrac Soc
, vol.7
, pp. 368-375
-
-
Cantin, A.M.1
-
14
-
-
33751242330
-
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema
-
Tudor RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I. Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc 2006; 3: 673-9.
-
(2006)
Proc Am Thorac Soc
, vol.3
, pp. 673-679
-
-
Tudor, R.M.1
Yoshida, T.2
Fijalkowka, I.3
Biswal, S.4
Petrache, I.5
-
15
-
-
0002549698
-
-
In: Sies H ed. Oxidative Stress. London: Academic Press
-
Sies H. Oxidative stress. In: Sies H ed. Oxidative Stress. London: Academic Press, 1985;1-8.
-
(1985)
Oxidative stress
, pp. 1-8
-
-
Sies, H.1
-
16
-
-
80054997454
-
Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation
-
Stanojkovic I, Kotur-Stevuljevic J, Milenkovic B, Spasic S, Vujic T, Stefanovic A, et al. Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. Respir Med 2011; (Suppl105): S31-7.
-
(2011)
Respir Med
, Issue.SUPPL. 105
-
-
Stanojkovic, I.1
Kotur-Stevuljevic, J.2
Milenkovic, B.3
Spasic, S.4
Vujic, T.5
Stefanovic, A.6
-
17
-
-
77955506279
-
Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking
-
Montaño M, Cisneros J, Ramírez-Venegas A, Pedraza-Chaverri J, Mercado D, Ramos C, et al. Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking. Inhal Toxicol 2010; 22: 868-74.
-
(2010)
Inhal Toxicol
, vol.22
, pp. 868-874
-
-
Montaño, M.1
Cisneros, J.2
Ramírez-Venegas, A.3
Pedraza-Chaverri, J.4
Mercado, D.5
Ramos, C.6
-
18
-
-
43049150693
-
Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease
-
Kirkil G, Mahdi MM, Seckin D, Sahin K, Kucuk O. Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease. Respir Med 2008; 102: 840-4.
-
(2008)
Respir Med
, vol.102
, pp. 840-844
-
-
Kirkil, G.1
Mahdi, M.M.2
Seckin, D.3
Sahin, K.4
Kucuk, O.5
-
19
-
-
33645977165
-
Oxidant-antioxidant balance in patients with COPD
-
Hant I, Kocabase A, Canacankatan N, Kuleci S, Seydaoglu G. Oxidant-antioxidant balance in patients with COPD. Lung 2006; 184: 51-5.
-
(2006)
Lung
, vol.184
, pp. 51-55
-
-
Hant, I.1
Kocabase, A.2
Canacankatan, N.3
Kuleci, S.4
Seydaoglu, G.5
-
20
-
-
33947532332
-
The association between oxidative stress and obstructive lung impairment in patients with COPD
-
Kluchova Z Petraxova D, Jppa P, Dorkova and Tkacov R. The association between oxidative stress and obstructive lung impairment in patients with COPD. Physiol Res 2007; 56: 51-6.
-
(2007)
Physiol Res
, vol.56
, pp. 51-56
-
-
Kluchova, Z.1
Petraxova, D.2
Jppa, P.D.3
Tkacov, R.4
-
21
-
-
33645872899
-
Increase DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass
-
Ceylan E, Kocyigit A, Gencer M, Aksoy N, Selek S. Increase DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass. Respir Med 2006; 100: 1270-6.
-
(2006)
Respir Med
, vol.100
, pp. 1270-1276
-
-
Ceylan, E.1
Kocyigit, A.2
Gencer, M.3
Aksoy, N.4
Selek, S.5
-
22
-
-
4544384233
-
Antioxidant vitamins and malonyldialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease
-
Tug T, Karatas F, Terzi SM. Antioxidant vitamins and malonyldialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease. Clin Invest Med 2005; 27: 123-8.
-
(2005)
Clin Invest Med
, vol.27
, pp. 123-128
-
-
Tug, T.1
Karatas, F.2
Terzi, S.M.3
-
23
-
-
31344443712
-
Increased oxidative stress in patients with chronic obstructive pulmonary disease (COPD) as measured by redox status of plasma coenzyme Q10
-
Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, et al. Increased oxidative stress in patients with chronic obstructive pulmonary disease (COPD) as measured by redox status of plasma coenzyme Q10. Pathophysiology 2006; 13: 29-33.
-
(2006)
Pathophysiology
, vol.13
, pp. 29-33
-
-
Wada, H.1
Hagiwara, S.2
Saitoh, E.3
Ieki, R.4
Okamura, T.5
Ota, T.6
-
24
-
-
0036430983
-
The levels of serum vitamin C, malonyldialdehyde and erythrocyte reduced glutathione in chronic obstructive pulmonary disease and in healthy smokers
-
Calikoglu M, Unlu A, Tamer L, Ercan B, Bugadayci R, Atik U. The levels of serum vitamin C, malonyldialdehyde and erythrocyte reduced glutathione in chronic obstructive pulmonary disease and in healthy smokers. Clin Chem Lab Med 2002; 40: 1028-31.
-
(2002)
Clin Chem Lab Med
, vol.40
, pp. 1028-1031
-
-
Calikoglu, M.1
Unlu, A.2
Tamer, L.3
Ercan, B.4
Bugadayci, R.5
Atik, U.6
-
25
-
-
80052665199
-
Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases
-
Bartoli ML, Novelli F, Costa F, Malagrinò L, Melosini L, Bacci E, et al. Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases. Mediators Inflamm 2011; 2011: 891752.
-
(2011)
Mediators Inflamm
, vol.2011
, pp. 891752
-
-
Bartoli, M.L.1
Novelli, F.2
Costa, F.3
Malagrinò, L.4
Melosini, L.5
Bacci, E.6
-
26
-
-
10444285353
-
Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation
-
Corradi M, Pignatti P, Manini P, Andreoli R, Goldoni M, Poppa M et al. Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation. Eur Repir J 2004; 24: 1011-7.
-
(2004)
Eur Repir J
, vol.24
, pp. 1011-1017
-
-
Corradi, M.1
Pignatti, P.2
Manini, P.3
Andreoli, R.4
Goldoni, M.5
Poppa, M.6
-
27
-
-
74849106935
-
Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009; 6: 693-6.
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 693-696
-
-
Barnes, P.J.1
-
28
-
-
21044458874
-
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
-
Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005; 352: 1967-76.
-
(2005)
N Engl J Med
, vol.352
, pp. 1967-1976
-
-
Ito, K.1
Ito, M.2
Elliott, W.M.3
Cosio, B.4
Caramori, G.5
Kon, O.M.6
-
29
-
-
57349120676
-
Future treatments for chronic obstructive pulmonary disease and its co-morbidities
-
Barnes PJ. Future treatments for chronic obstructive pulmonary disease and its co-morbidities. Proc Am Thorac Soc 2008; 5: 857-64.
-
(2008)
Proc Am Thorac Soc
, vol.5
, pp. 857-864
-
-
Barnes, P.J.1
-
31
-
-
0036683630
-
Expression and activity of histone deacetylases in human asthmatic airways
-
Ito K, Caramori G, Lim S, Oates T, Chung KF, Barnes PJ, et al. Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 2002; 166: 392-6.
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 392-396
-
-
Ito, K.1
Caramori, G.2
Lim, S.3
Oates, T.4
Chung, K.F.5
Barnes, P.J.6
-
32
-
-
3142676314
-
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma
-
Cosío BG, Mann B, Ito K, Jazrawi E, Barnes PJ, Chung KF, et al. Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med 2004; 170: 141-7.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 141-147
-
-
Cosío, B.G.1
Mann, B.2
Ito, K.3
Jazrawi, E.4
Barnes, P.J.5
Chung, K.F.6
-
33
-
-
33745728358
-
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
-
Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, et al. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol 2006; 291: L46-57.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Yang, S.R.1
Chida, A.S.2
Bauter, M.R.3
Shafiq, N.4
Seweryniak, K.5
Maggirwar, S.B.6
-
34
-
-
84865784413
-
Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD)
-
[Epub ahead of print]
-
Wada H, Hagiwara S, Saitoh E, Ieki R, Yamamoto Y, Adcock IM, et al. Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD). Biomarkers 2012; [Epub ahead of print].
-
(2012)
Biomarkers
-
-
Wada, H.1
Hagiwara, S.2
Saitoh, E.3
Ieki, R.4
Yamamoto, Y.5
Adcock, I.M.6
-
35
-
-
19844383336
-
Leukotriene B4 in exhaled breath condensate and sputum supernatant in patients with COPD and asthma
-
Kostikas K, Gaga M, Papatheodorou G, Karamanis T, Orphanidou D, Loukides S. Leukotriene B4 in exhaled breath condensate and sputum supernatant in patients with COPD and asthma. Chest 2005; 127: 1553-9.
-
(2005)
Chest
, vol.127
, pp. 1553-1559
-
-
Kostikas, K.1
Gaga, M.2
Papatheodorou, G.3
Karamanis, T.4
Orphanidou, D.5
Loukides, S.6
-
36
-
-
0032446729
-
Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress
-
Praticò D, Basili S, Vieri M, Cordova C, Violi F, Fitzgerald GA. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. Am J Respir Crit Care Med 1998; 158: 1709-14.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1709-1714
-
-
Praticò, D.1
Basili, S.2
Vieri, M.3
Cordova, C.4
Violi, F.5
Fitzgerald, G.A.6
-
37
-
-
0036890753
-
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway
-
Pawliczak R, Huang XL, Nanavaty UB, Lawrence M, Madara P, Shelhamer JH. Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway. Am J Respir Cell Mol Biol 2002; 27: 722-31.
-
(2002)
Am J Respir Cell Mol Biol
, vol.27
, pp. 722-731
-
-
Pawliczak, R.1
Huang, X.L.2
Nanavaty, U.B.3
Lawrence, M.4
Madara, P.5
Shelhamer, J.H.6
-
38
-
-
0037424233
-
Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress
-
Asai K, Hirabayashi T, Houjou T, Uozumi N, Taguchi R, Shimizu T. Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress. J Biol Chem 2003; 278: 8809-14.
-
(2003)
J Biol Chem
, vol.278
, pp. 8809-8814
-
-
Asai, K.1
Hirabayashi, T.2
Houjou, T.3
Uozumi, N.4
Taguchi, R.5
Shimizu, T.6
-
39
-
-
33749626549
-
Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smoking in public places
-
Menzies D, Nair A, Williamson PA, Schembri S, Al-Khairalla MZ, Barnes M, et al. Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smoking in public places. JAMA 2006; 296: 1742-8.
-
(2006)
JAMA
, vol.296
, pp. 1742-1748
-
-
Menzies, D.1
Nair, A.2
Williamson, P.A.3
Schembri, S.4
Al-Khairalla, M.Z.5
Barnes, M.6
-
40
-
-
73149095385
-
The aging lung and chronic obstructive pulmonary disease: Similarity and difference
-
Fukuchi Y. The aging lung and chronic obstructive pulmonary disease: Similarity and difference. Proc Am Thorac Soc 2009; 6: 570-2.
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 570-572
-
-
Fukuchi, Y.1
-
41
-
-
58249099942
-
COPD as a disease of accelerated lung aging
-
Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 2009; 135: 173-80.
-
(2009)
Chest
, vol.135
, pp. 173-180
-
-
Ito, K.1
Barnes, P.J.2
-
42
-
-
34247854749
-
TORCH Clinical Endpoint Committee. Ascertainment of causespecific mortality in COPD: Operations of the TORCH Clinical Endpoint Committee
-
McGarvey LP, John M, Anderson JA, Zvarich M, Wise RA. TORCH Clinical Endpoint Committee. Ascertainment of causespecific mortality in COPD: Operations of the TORCH Clinical Endpoint Committee. Thorax 2007; 62: 411-5.
-
(2007)
Thorax
, vol.62
, pp. 411-415
-
-
McGarvey, L.P.1
John, M.2
Anderson, J.A.3
Zvarich, M.4
Wise, R.A.5
-
44
-
-
34347372635
-
The redox status of coenzyme Q10 associated to the chronological age
-
Wada H, Hagiwara S, Goto H, Yamamoto Y. The redox status of coenzyme Q10 associated to the chronological age. J Am Geriatrics Soc 2007; 55: 1141-2.
-
(2007)
J Am Geriatrics Soc
, vol.55
, pp. 1141-1142
-
-
Wada, H.1
Hagiwara, S.2
Goto, H.3
Yamamoto, Y.4
-
45
-
-
70349324812
-
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
-
Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 2009; 23: 2810-9.
-
(2009)
FASEB J
, vol.23
, pp. 2810-2819
-
-
Nakamaru, Y.1
Vuppusetty, C.2
Wada, H.3
Milne, J.C.4
Ito, M.5
Rossios, C.6
-
46
-
-
42649146208
-
SIRT1, an anti-inflammatory and anti-aging protein, is decrease in lungs of patients with chronic obstructive pulmonary disease
-
Rajendrasozhan S, Yang WR, Kinnula VL, Rhaman I. SIRT1, an anti-inflammatory and anti-aging protein, is decrease in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177: 861-70.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 861-870
-
-
Rajendrasozhan, S.1
Yang, W.R.2
Kinnula, V.L.3
Rhaman, I.4
-
47
-
-
79958206937
-
Sirtuins, aging, and medicine
-
Guarente L. Sirtuins, aging, and medicine. N Engl J Med 2011; 364: 2235-44.
-
(2011)
N Engl J Med
, vol.364
, pp. 2235-2244
-
-
Guarente, L.1
-
48
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000; 908: 244-54.
-
(2000)
Ann N Y Acad Sci
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafè, M.2
Valensin, S.3
Olivieri, F.4
De Luca, M.5
Ottaviani, E.6
-
49
-
-
77449152992
-
Oxidative stress and its role in the pathogenesis of ischaemic stroke
-
Allen CL, and Bayraktutan U. Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 2009; 4: 461-70.
-
(2009)
Int J Stroke
, vol.4
, pp. 461-470
-
-
Allen, C.L.1
Bayraktutan, U.2
-
50
-
-
71049180369
-
Inflammatory mechanisms in ischemic stroke: Therapeutic approaches
-
Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: Therapeutic approaches. J Transl Med 2009; 7: 97.
-
(2009)
J Transl Med
, vol.7
, pp. 97
-
-
Lakhan, S.E.1
Kirchgessner, A.2
Hofer, M.3
-
51
-
-
80053337585
-
Clinical review oxygen as a signaling molecule
-
Bartz RR, Piantadosi CA. Clinical review oxygen as a signaling molecule. Crit Care 2010; 14: 234.
-
(2010)
Crit Care
, vol.14
, pp. 234
-
-
Bartz, R.R.1
Piantadosi, C.A.2
-
52
-
-
57149105188
-
Infection in the pathogenesis and ourse of chronic obstructive pulmonary disease
-
Sethi S, Murphy TF. Infection in the pathogenesis and ourse of chronic obstructive pulmonary disease. N Engl J Med 2008; 359: 2355-65.
-
(2008)
N Engl J Med
, vol.359
, pp. 2355-2365
-
-
Sethi, S.1
Murphy, T.F.2
-
53
-
-
70349547108
-
Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): A prespecified subgroup analysis of a randomized controlled trial
-
UPLIFT investigators
-
Decramer M, Celli B, Kesten S, Lystig T, Mehra S, Tashkin DP; UPLIFT investigators. Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): A prespecified subgroup analysis of a randomized controlled trial. Lancet 2009; 374: 1171-8.
-
(2009)
Lancet
, vol.374
, pp. 1171-1178
-
-
Decramer, M.1
Celli, B.2
Kesten, S.3
Lystig, T.4
Mehra, S.5
Tashkin, D.P.6
-
54
-
-
84855280191
-
Annual changes in pulmonary function and clinical phenotype in chronic obstructive pulmonary diseases
-
Nishimura M, Makita H, Nagai K, Konno S, Nasuhara Y, Hasegawa M, et al. Annual changes in pulmonary function and clinical phenotype in chronic obstructive pulmonary diseases. Am J Respir Crit Care Med 2012; 185: 44-52.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 44-52
-
-
Nishimura, M.1
Makita, H.2
Nagai, K.3
Konno, S.4
Nasuhara, Y.5
Hasegawa, M.6
-
55
-
-
0035446990
-
Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
-
O'Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: 770-7.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 770-777
-
-
O'Donnell, D.E.1
Revill, S.M.2
Webb, K.A.3
-
56
-
-
2942720573
-
The nature of small-airway obstruction in chronic obstructive pulmonary disease
-
Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645-53.
-
(2004)
N Engl J Med
, vol.350
, pp. 2645-2653
-
-
Hogg, J.C.1
Chu, F.2
Utokaparch, S.3
Woods, R.4
Elliott, W.M.5
Buzatu, L.6
-
57
-
-
0018885920
-
Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial
-
Nocturnal Oxygen Therapy Trial Group
-
Nocturnal Oxygen Therapy Trial Group: Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Ann Intern Med 1980; 93: 391-8.
-
(1980)
Ann Intern Med
, vol.93
, pp. 391-398
-
-
-
58
-
-
0019460452
-
Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema
-
Report of the Medical Research Council Working Party
-
Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981; 1: 681-6.
-
(1981)
Lancet
, vol.1
, pp. 681-686
-
-
-
59
-
-
33845715562
-
Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD
-
Fujimoto K, Yoshiike F, Yasuo M, Kitaguchi Y, Urushihata K, Kubo K, et al. Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD. Respirology 2007; 12: 93-9.
-
(2007)
Respirology
, vol.12
, pp. 93-99
-
-
Fujimoto, K.1
Yoshiike, F.2
Yasuo, M.3
Kitaguchi, Y.4
Urushihata, K.5
Kubo, K.6
-
60
-
-
77954800883
-
Once-daily bronchodilators for chronic obstructive pulmonary disease: Indacaterol versus tiotropium
-
Donohue JF, Fogarty C, Lötvall J, Mahler DA, Worth H, Yorgancioglu A. et al. Once-daily bronchodilators for chronic obstructive pulmonary disease: Indacaterol versus tiotropium. Am J Respir Crit Care Med 2010; 182: 155-62.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 155-162
-
-
Donohue, J.F.1
Fogarty, C.2
Lötvall, J.3
Mahler, D.A.4
Worth, H.5
Yorgancioglu, A.6
-
61
-
-
77953707790
-
Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD
-
Dahl R, Chung KF, Buhl R, Magnussen H, Nonikov V, Jack D, et al. Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD. Thorax 2010; 65: 473-9.
-
(2010)
Thorax
, vol.65
, pp. 473-479
-
-
Dahl, R.1
Chung, K.F.2
Buhl, R.3
Magnussen, H.4
Nonikov, V.5
Jack, D.6
-
62
-
-
77955658621
-
Effects of tiotropium and formoterol on dynamic hyper inflation and exercise endurance in COPD
-
Berton DC, Reis M, Siqueira AC, Barroco AC, Takara LS, Bravo DM, et al. Effects of tiotropium and formoterol on dynamic hyper inflation and exercise endurance in COPD. Respir Med 2010; 104: 1288-96.
-
(2010)
Respir Med
, vol.104
, pp. 1288-1296
-
-
Berton, D.C.1
Reis, M.2
Siqueira, A.C.3
Barroco, A.C.4
Takara, L.S.5
Bravo, D.M.6
-
63
-
-
82955195821
-
Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD
-
Hanania NA, Crater GD, Morris AN, Emmett AH, O'Dell DM, Niewoehner DE. Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. Respir Med 2012; 106: 91-101.
-
(2012)
Respir Med
, vol.106
, pp. 91-101
-
-
Hanania, N.A.1
Crater, G.D.2
Morris, A.N.3
Emmett, A.H.4
O'Dell, D.M.5
Niewoehner, D.E.6
-
64
-
-
60949104107
-
Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD
-
Tashkin DP, Donohue JF, Mahler DA, Huang H, Goodwin E, Schaefer K, et al. Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD. Respir Med 2009; 103: 516-24.
-
(2009)
Respir Med
, vol.103
, pp. 516-524
-
-
Tashkin, D.P.1
Donohue, J.F.2
Mahler, D.A.3
Huang, H.4
Goodwin, E.5
Schaefer, K.6
-
65
-
-
33847172367
-
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
-
Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007; 356: 775-89.
-
(2007)
N Engl J Med
, vol.356
, pp. 775-789
-
-
Calverley, P.M.1
Anderson, J.A.2
Celli, B.3
Ferguson, G.T.4
Jenkins, C.5
Jones, P.W.6
-
66
-
-
72849144086
-
Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease
-
Celli B, Decramer M, Kesten S, Liu D, Mehra S, Tashkin DP, et al. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 180: 948-55.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 948-955
-
-
Celli, B.1
Decramer, M.2
Kesten, S.3
Liu, D.4
Mehra, S.5
Tashkin, D.P.6
-
67
-
-
71049148969
-
Efficacy of moxifloxacin in the treatment of bronchial colonisation in COPD
-
Miravitlles M, Marín A, Monsó E, Vilà S, de la Roza C, Hervás R, et al. Efficacy of moxifloxacin in the treatment of bronchial colonisation in COPD. Eur Respir J 2009; 34: 1066-71.
-
(2009)
Eur Respir J
, vol.34
, pp. 1066-1071
-
-
Miravitlles, M.1
Marín, A.2
Monsó, E.3
Vilà, S.4
de la Roza, C.5
Hervás, R.6
-
68
-
-
0035894617
-
Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: A randomised placebo-controlled trial
-
Nouira S, Marghli S, Belghith M, Besbes L, Elatrous S, Abroug F. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: A randomised placebo-controlled trial. Lancet 2001; 358: 2020-5.
-
(2001)
Lancet
, vol.358
, pp. 2020-2025
-
-
Nouira, S.1
Marghli, S.2
Belghith, M.3
Besbes, L.4
Elatrous, S.5
Abroug, F.6
-
69
-
-
10444284244
-
Levofloxacin versus clarithromycin in COPD exacerbation: Focus on exacerbation-free interval
-
Evaluation of Therapy-Free Interval in COPD Patients Study Group
-
Lode H, Eller J, Linnhoff A, Ioanas M, Evaluation of Therapy-Free Interval in COPD Patients Study Group. Levofloxacin versus clarithromycin in COPD exacerbation: Focus on exacerbation-free interval. Eur Respir J 2004; 24: 947-53.
-
(2004)
Eur Respir J
, vol.24
, pp. 947-953
-
-
Lode, H.1
Eller, J.2
Linnhoff, A.3
Ioanas, M.4
-
70
-
-
80052157895
-
Azithromycin for prevention of exacerbations of COPD
-
Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA Jr, Criner GJ, et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med 2001; 365: 689-98.
-
(2001)
N Engl J Med
, vol.365
, pp. 689-698
-
-
Albert, R.K.1
Connett, J.2
Bailey, W.C.3
Casaburi, R.4
Cooper Jr., J.A.5
Criner, G.J.6
-
71
-
-
79959747756
-
Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke
-
Mikura S, Wada H, Higaki M, Yasutake T, Ishii H, Kamiya S, et al. Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke. Transl Res 2011; 158: 30-7.
-
(2011)
Transl Res
, vol.158
, pp. 30-37
-
-
Mikura, S.1
Wada, H.2
Higaki, M.3
Yasutake, T.4
Ishii, H.5
Kamiya, S.6
-
73
-
-
84855280797
-
Late intervention with a myeloperoxidase inhibitor stops progression of experimental COPD
-
Churg A, Marshall CV, Sin DD, Bolton S, Zhou S, Thain K, et al. Late intervention with a myeloperoxidase inhibitor stops progression of experimental COPD. Am J Respir Crit Care Med 2012; 185: 34-43.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 34-43
-
-
Churg, A.1
Marshall, C.V.2
Sin, D.D.3
Bolton, S.4
Zhou, S.5
Thain, K.6
-
74
-
-
0030770030
-
Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress
-
Yamamoto Y, Yamashita S. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Mol Aspects Med 1997; (Suppl18): S79-84.
-
(1997)
Mol Aspects Med
, Issue.SUPPL. 18
-
-
Yamamoto, Y.1
Yamashita, S.2
-
75
-
-
0033062387
-
Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion
-
Yamamoto Y, Yamashita S. Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. Biofactors 1999; 9: 241-6.
-
(1999)
Biofactors
, vol.9
, pp. 241-246
-
-
Yamamoto, Y.1
Yamashita, S.2
-
76
-
-
0032499595
-
Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants
-
Yamamoto Y, Yamashita S, Fujisawa A, Kokura S, Yoshikawa T. Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants. Biochem Biophys Res Commun 1998; 247: 166-70.
-
(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 166-170
-
-
Yamamoto, Y.1
Yamashita, S.2
Fujisawa, A.3
Kokura, S.4
Yoshikawa, T.5
-
77
-
-
4444278377
-
Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
-
Sohmiya M, Tanaka M, Tak NW, Yanagisawa M, Tanino Y, Suzuki Y, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. J Neurol Sci 2004; 223: 161-6.
-
(2004)
J Neurol Sci
, vol.223
, pp. 161-166
-
-
Sohmiya, M.1
Tanaka, M.2
Tak, N.W.3
Yanagisawa, M.4
Tanino, Y.5
Suzuki, Y.6
-
78
-
-
10644241578
-
An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
-
Sohmiya M, Tanaka M, Suzuki Y, Tanino Y, Okamoto K, Yamamoto Y. An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients. J Neurol Sci 2005; 228: 49-53.
-
(2005)
J Neurol Sci
, vol.228
, pp. 49-53
-
-
Sohmiya, M.1
Tanaka, M.2
Suzuki, Y.3
Tanino, Y.4
Okamoto, K.5
Yamamoto, Y.6
-
79
-
-
0033515773
-
Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids
-
Hara K, Yamashita S, Fujisawa A, Ishiwa S, Ogawa T, Yamamoto Y. Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids. Biochem Biophys Res Commun 1999; 257: 244-8.
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 244-248
-
-
Hara, K.1
Yamashita, S.2
Fujisawa, A.3
Ishiwa, S.4
Ogawa, T.5
Yamamoto, Y.6
-
80
-
-
77957554800
-
CORONA Study Group. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: A pre-specified sub study of CORONA (controlled rosuvastatin multinational study in heart failure)
-
McMurray JJ, Dunselman P, Wedel H, Cleland JG, Lindberg M, Hjalmarson A, et al. CORONA Study Group. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: A pre-specified sub study of CORONA (controlled rosuvastatin multinational study in heart failure). J Am Coll Cardiol 2010; 56: 1196-204.
-
(2010)
J Am Coll Cardiol
, vol.56
, pp. 1196-1204
-
-
McMurray, J.J.1
Dunselman, P.2
Wedel, H.3
Cleland, J.G.4
Lindberg, M.5
Hjalmarson, A.6
-
81
-
-
84961886540
-
Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension
-
Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev 2009; (4): CD007435.
-
(2009)
Cochrane Database Syst Rev
, Issue.4
-
-
Ho, M.J.1
Bellusci, A.2
Wright, J.M.3
-
83
-
-
0026355154
-
Effects of ubidecarenone in an exercise training program for patients with chronic obstructive pulmonary diseases
-
Satta A, Grandi M, Landoni CV, Migliori GB, Spanevello A, Vocaturo G, et al. Effects of ubidecarenone in an exercise training program for patients with chronic obstructive pulmonary diseases. Clin Ther 1991; 13: 754-7.
-
(1991)
Clin Ther
, vol.13
, pp. 754-757
-
-
Satta, A.1
Grandi, M.2
Landoni, C.V.3
Migliori, G.B.4
Spanevello, A.5
Vocaturo, G.6
-
84
-
-
0034761884
-
Comparison of the bronchodilating effect of salmeterol and zafirlukast in combination with that of their use as single treatments in asthma and chronic obstructive pulmonary disease
-
Cazzola M, Centanni S, Boveri B, Di Marco F, Santus P, Matera MG, et al. Comparison of the bronchodilating effect of salmeterol and zafirlukast in combination with that of their use as single treatments in asthma and chronic obstructive pulmonary disease. Respiration 2001; 68: 452-9.
-
(2001)
Respiration
, vol.68
, pp. 452-459
-
-
Cazzola, M.1
Centanni, S.2
Boveri, B.3
Di Marco, F.4
Santus, P.5
Matera, M.G.6
-
85
-
-
14844304651
-
Short-term effects of montelukast in stable patients with moderate to severe COPD
-
Celik P, Sakar A, Havlucu Y, Yuksel H, Turkdogan P, Yorgancioglu A. Short-term effects of montelukast in stable patients with moderate to severe COPD. Respir Med 2005; 99: 444-50.
-
(2005)
Respir Med
, vol.99
, pp. 444-450
-
-
Celik, P.1
Sakar, A.2
Havlucu, Y.3
Yuksel, H.4
Turkdogan, P.5
Yorgancioglu, A.6
-
86
-
-
0842323816
-
Long-term motelukast therapy in moderate to severe COPD-a preliminary observation
-
Rubinstein I, Kumar B, and Schriever C. Long-term motelukast therapy in moderate to severe COPD-a preliminary observation. Respir Med 2004; 98: 134-8.
-
(2004)
Respir Med
, vol.98
, pp. 134-138
-
-
Rubinstein, I.1
Kumar, B.2
Schriever, C.3
-
87
-
-
39749178346
-
Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease
-
Grönke L, Beeh KM, Cameron R, Kornmann O, Beier J, Shaw M, et al. Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2008; 21: 409-17.
-
(2008)
Pulm Pharmacol Ther
, vol.21
, pp. 409-417
-
-
Grönke, L.1
Beeh, K.M.2
Cameron, R.3
Kornmann, O.4
Beier, J.5
Shaw, M.6
-
88
-
-
77952104701
-
Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates
-
Hicks A, Goodnow R Jr, Cavallo G, Tannu SA, Ventre JD, Lavelle D, et al. Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins Other Lipid Mediat 2010; 92: 33-43.
-
(2010)
Prostaglandins Other Lipid Mediat
, vol.92
, pp. 33-43
-
-
Hicks, A.1
Goodnow Jr., R.2
Cavallo, G.3
Tannu, S.A.4
Ventre, J.D.5
Lavelle, D.6
-
89
-
-
84874842832
-
-
US7939527
-
Bacani, G.M., Diego, B.D., Eugene, Y., Cheung, E.Y., Christa, C., Chrovian, C.C., Deng, X., Laurent, G., Grice, C. A., Kearney, A.M., Landry-Bayle, A. M., Lee-Dutra, A., Liang, J. T., Lochner, S., Mani, N. S., Santillán, A. Jr., Sappey, K., Sepassi, K., Tanis, V. M., Wickboldt, A. T., Wiener, J.J.M. Zinser, H. Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine as modulators of leukotriene A4 hydrolase. US7939527 (2011).
-
(2011)
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine as modulators of leukotriene A4 hydrolase
-
-
Bacani, G.M.1
Diego, B.D.2
Eugene, Y.3
Cheung, E.Y.4
Christa, C.5
Chrovian, C.C.6
Deng, X.7
Laurent, G.8
Grice, C.A.9
Kearney, A.M.10
Landry-Bayle, A.M.11
Lee-Dutra, A.12
Liang, J.T.13
Lochner, S.14
Mani, N.S.15
Santillán Jr., A.16
Sappey, K.17
Sepassi, K.18
Tanis, V.M.19
Wickboldt, A.T.20
Wiener, J.J.M.21
Zinser, H.22
more..
-
90
-
-
84874866479
-
-
WO2010108856
-
Dominique, R., Goodnow, R. A. Jr., Kowalczyk, A., Qiao, Q., Sidduri, A., Tilley, J.W. Leukotriene B4 inhibitors. WO2010108856 (2010).
-
(2010)
Leukotriene B4 inhibitors
-
-
Dominique, R.1
Goodnow Jr., R.A.2
Kowalczyk, A.3
Qiao, Q.4
Sidduri, A.5
Tilley, J.W.6
-
91
-
-
84874925868
-
-
EP1834953
-
Kumar, V.A., Sanjay, M., Abhijit, R., Raj, K.S. Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors. EP1834953 (2007).
-
(2007)
Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors
-
-
Kumar, V.A.1
Sanjay, M.2
Abhijit, R.3
Raj, K.S.4
-
92
-
-
79851476200
-
Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
-
Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA Jr et al. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD 2011; 8: 21-9.
-
(2011)
COPD
, vol.8
, pp. 21-29
-
-
Woodruff, P.G.1
Albert, R.K.2
Bailey, W.C.3
Casaburi, R.4
Connett, J.E.5
Cooper Jr., J.A.6
-
93
-
-
65249119361
-
Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
-
Shimizu T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu Rev Pharmacol Toxicol 2009; 49: 123-50.
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 123-150
-
-
Shimizu, T.1
-
94
-
-
77954790495
-
New therapies for chronic obstructive pulmonary disease
-
Barnes PJ. New therapies for chronic obstructive pulmonary disease. Med Princ Pract 2010; 19: 330-8.
-
(2010)
Med Princ Pract
, vol.19
, pp. 330-338
-
-
Barnes, P.J.1
-
95
-
-
79952587807
-
Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
-
Milara J, Navarro A, Almudever P, Lluch J, Morcillo EJ, Cortijo J. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin Exp Allergy 2011; 41: 535-46.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 535-546
-
-
Milara, J.1
Navarro, A.2
Almudever, P.3
Lluch, J.4
Morcillo, E.J.5
Cortijo, J.6
-
96
-
-
33845485874
-
The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4
-
Brown DM, Hutchson L, Donaldson K, MacKenzie SJ, Dick CA, Stone V. The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4. Toxicol Lett 2007; 168: 1-6.
-
(2007)
Toxicol Lett
, vol.168
, pp. 1-6
-
-
Brown, D.M.1
Hutchson, L.2
Donaldson, K.3
McKenzie, S.J.4
Dick, C.A.5
Stone, V.6
-
97
-
-
34548587662
-
Phosphodiesterase 4 inhibitors and inflammatory bowel disease: Emerging therapies in inflammatory bowel disease
-
Keshavarzian A, Mutlu E, Guzman JP, Forsyth C, Banan A. Phosphodiesterase 4 inhibitors and inflammatory bowel disease: Emerging therapies in inflammatory bowel disease. Expert Opin Investig Drugs 2007; 16: 1489-506.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 1489-1506
-
-
Keshavarzian, A.1
Mutlu, E.2
Guzman, J.P.3
Forsyth, C.4
Banan, A.5
-
98
-
-
77953105482
-
The preclinical pharmacology of roflumilast-selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
-
Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, et al. The preclinical pharmacology of roflumilast-selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010; 23: 235-56.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 235-256
-
-
Hatzelmann, A.1
Morcillo, E.J.2
Lungarella, G.3
Adnot, S.4
Sanjar, S.5
Beume, R.6
-
99
-
-
52949103280
-
Can the anti-inflammatory potential of PDE4 inhibitors be realized: Guarded optimism or wishful thinking?
-
Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: Guarded optimism or wishful thinking? Br J Pharmacol 2008; 155: 288-290.
-
(2008)
Br J Pharmacol
, vol.155
, pp. 288-290
-
-
Giembycz, M.A.1
-
100
-
-
44649112330
-
Frontrunners in novel pharmacotherapy of COPD
-
Barnes PJ. Frontrunners in novel pharmacotherapy of COPD. Curr Opin Pharmacol 2008; 8: 300-7.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 300-307
-
-
Barnes, P.J.1
-
101
-
-
79551617104
-
The use of roflumilast in COPD: A primary care perspective
-
Price D, Chisholm A, Ryan D, Crockett A, Jones R. The use of roflumilast in COPD: A primary care perspective. Prim Care Respir J 2010; 19: 342-51.
-
(2010)
Prim Care Respir J
, vol.19
, pp. 342-351
-
-
Price, D.1
Chisholm, A.2
Ryan, D.3
Crockett, A.4
Jones, R.5
-
102
-
-
79851471591
-
Roflumilast: First phosphodiesterase 4 inhibitor approved for treatment of COPD
-
Giembycz MA, Field SK. Roflumilast: First phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des Devel Ther 2010; 4: 147-58.
-
(2010)
Drug Des Devel Ther
, vol.4
, pp. 147-158
-
-
Giembycz, M.A.1
Field, S.K.2
-
103
-
-
69149098943
-
M2-127 and M2-128 study groups. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials
-
Fabbri LM, Calverley PM, Izquierdo-Alonso JL, Bundschuh DS, Brose M, Martinez FJ, et al. M2-127 and M2-128 study groups. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials. Lancet 2009; 374: 695-703.
-
(2009)
Lancet
, vol.374
, pp. 695-703
-
-
Fabbri, L.M.1
Calverley, P.M.2
Izquierdo-Alonso, J.L.3
Bundschuh, D.S.4
Brose, M.5
Martinez, F.J.6
-
104
-
-
79953700575
-
Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
-
Rabe KF. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol 2011; 163: 53-67.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 53-67
-
-
Rabe, K.F.1
-
105
-
-
69149103642
-
Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
-
Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ, et al. Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials. Lancet 2009; 374: 685-94.
-
(2009)
Lancet
, vol.374
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
Kristiansen, S.4
Fabbri, L.M.5
Martinez, F.J.6
-
106
-
-
79957513424
-
Roflumilast with long-acting β2-agonists for COPD: Influence of exacerbation history
-
Bateman ED, Rabe KF, Calverley PM, Goehring UM, Brose M, Bredenbröker D, et al. Roflumilast with long-acting β2-agonists for COPD: Influence of exacerbation history. Eur Respir J 2011; 38: 553-60.
-
(2011)
Eur Respir J
, vol.38
, pp. 553-560
-
-
Bateman, E.D.1
Rabe, K.F.2
Calverley, P.M.3
Goehring, U.M.4
Brose, M.5
Bredenbröker, D.6
-
107
-
-
79251588730
-
Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD
-
Rennard SI, Calverley PM, Goehring UM, Bredenbröker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD. Respir Res 2011; 12: 18.
-
(2011)
Respir Res
, vol.12
, pp. 18
-
-
Rennard, S.I.1
Calverley, P.M.2
Goehring, U.M.3
Bredenbröker, D.4
Martinez, F.J.5
-
108
-
-
33947358942
-
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
-
Ito K, Caramori G, Adcock IM. Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 2007; 321: 1-8.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 1-8
-
-
Ito, K.1
Caramori, G.2
Adcock, I.M.3
-
109
-
-
65249151877
-
Inhibition of PI3K delta restores glucocorticoid function in smoking induced airway inflammation in mice
-
Marwick JA, Caramori G, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, et al. Inhibition of PI3K delta restores glucocorticoid function in smoking induced airway inflammation in mice. Am J Respir Cirt Care Med 2009; 179: 542-8
-
(2009)
Am J Respir Cirt Care Med
, vol.179
, pp. 542-548
-
-
Marwick, J.A.1
Caramori, G.2
Stevenson, C.S.3
Casolari, P.4
Jazrawi, E.5
Barnes, P.J.6
-
110
-
-
48449097032
-
Inhibitory effects of macrolide antibiotics on exacerbations and hospitalization in chronic obstructive pulmonary disease in Japan: A retrospective multicenter analysis
-
Yamaya M, Azuma A, Tanaka H, Takizawa H, Chida K, Taguchi Y, et al. Inhibitory effects of macrolide antibiotics on exacerbations and hospitalization in chronic obstructive pulmonary disease in Japan: A retrospective multicenter analysis. J Am Geriatr Soc 2008; 56: 1358-60.
-
(2008)
J Am Geriatr Soc
, vol.56
, pp. 1358-1360
-
-
Yamaya, M.1
Azuma, A.2
Tanaka, H.3
Takizawa, H.4
Chida, K.5
Taguchi, Y.6
-
112
-
-
2142700049
-
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: Possible role in the signaling pathway that regulates nuclear factor-kappaB activation
-
Desaki M, Okazaki H, Sunazuka T, Omura S, Yamamoto K, Takizawa H. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: Possible role in the signaling pathway that regulates nuclear factor-kappaB activation. Antimicrob Agents Chemother 2004; 48: 1581-5.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1581-1585
-
-
Desaki, M.1
Okazaki, H.2
Sunazuka, T.3
Omura, S.4
Yamamoto, K.5
Takizawa, H.6
-
113
-
-
14844308020
-
Clinical implications of the immunomodulatory effects of macrolides
-
Tamaoki J, Kadota J, Takizawa H. Clinical implications of the immunomodulatory effects of macrolides. Am J Med 2004; 117 (Suppl 9A): 5S-11S.
-
(2004)
Am J Med
, vol.117
, Issue.SUPPL. 9A
-
-
Tamaoki, J.1
Kadota, J.2
Takizawa, H.3
-
114
-
-
60749133504
-
Clarithromycin prevents smoke-induced emphysema in mice
-
Nakanishi Y, Kobayashi D, Asano Y, Sakurai T, Kashimura M, Okuyama S, et al. Clarithromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med 2009; 179: 271-8.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 271-278
-
-
Nakanishi, Y.1
Kobayashi, D.2
Asano, Y.3
Sakurai, T.4
Kashimura, M.5
Okuyama, S.6
-
116
-
-
84874844367
-
-
US20090054357
-
Napoletano, M., Moriggi, E., Mereu, A., Ornaghi, F., Morazzoni, G., Longoni, R., Riva, C., Pacchetti, L., Pellacini, F. Macrolide compounds endowed with anti-inflammatory activity. US20090054357 (2009).
-
(2009)
Macrolide compounds endowed with anti-inflammatory activity
-
-
Napoletano, M.1
Moriggi, E.2
Mereu, A.3
Ornaghi, F.4
Morazzoni, G.5
Longoni, R.6
Riva, C.7
Pacchetti, L.8
Pellacini, F.9
-
117
-
-
79958273737
-
Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway
-
Cheng C, Ho WE, Goh FY, Guan SP, Kong LR, Lai WQ, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One 2011; 6: e20932.
-
(2011)
PLoS One
, vol.6
-
-
Cheng, C.1
Ho, W.E.2
Goh, F.Y.3
Guan, S.P.4
Kong, L.R.5
Lai, W.Q.6
-
118
-
-
79955002992
-
Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinasesigma
-
Mercado N, To Y, Ito K, Barnes PJ. Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinasesigma. J Pharmacol Exp Ther 2011; 337: 465-70.
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 465-470
-
-
Mercado, N.1
To, Y.2
Ito, K.3
Barnes, P.J.4
-
119
-
-
77958173826
-
Targeting phosphoinositide 3 kinase delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
-
To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, et al. Targeting phosphoinositide 3 kinase delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 182: 897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
Failla, M.4
Ito, M.5
Kusama, T.6
-
120
-
-
84864260190
-
Corticosteroid insensitivity is reversed by formoterol via phosphorinositol 3 kinase inhibitor
-
doi: 10.1111/j.1476-5381.2012.01864.x
-
Rossios C, To Y, Osoata G, Ito M, Barnes PJ, Ito K. Corticosteroid insensitivity is reversed by formoterol via phosphorinositol 3 kinase inhibitor. Br J Pharmacol 2012; doi: 10.1111/j.1476-5381.2012.01864.x.
-
(2012)
Br J Pharmacol
-
-
Rossios, C.1
To, Y.2
Osoata, G.3
Ito, M.4
Barnes, P.J.5
Ito, K.6
-
121
-
-
79954542852
-
Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model
-
Harvey CJ, Thimmulappa RK, Sethi S, Kong X, Yarmus L, Brown RH, et al. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci Transl Med 2011; 3: 78ra32.
-
(2011)
Sci Transl Med
, vol.3
-
-
Harvey, C.J.1
Thimmulappa, R.K.2
Sethi, S.3
Kong, X.4
Yarmus, L.5
Brown, R.H.6
-
122
-
-
70849095823
-
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice
-
Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, et al. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009; 30: 1949-56.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1949-1956
-
-
Moghaddam, S.J.1
Barta, P.2
Mirabolfathinejad, S.G.3
Ammar-Aouchiche, Z.4
Garza, N.T.5
Vo, T.T.6
-
123
-
-
51249121642
-
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC-2
-
Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC-2. Am J Respir Crit Care Med 2008; 39: 312-23.
-
(2008)
Am J Respir Crit Care Med
, vol.39
, pp. 312-323
-
-
Meja, K.K.1
Rajendrasozhan, S.2
Adenuga, D.3
Biswas, S.K.4
Sundar, I.K.5
Spooner, G.6
-
124
-
-
70350437290
-
The treterpenoid CDDO-Imidazolide confers potent protection against hyperoxic acute lung injury in mice
-
Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, et al. The treterpenoid CDDO-Imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med 2009; 180: 867-74.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 867-874
-
-
Reddy, N.M.1
Suryanaraya, V.2
Yates, M.S.3
Kleeberger, S.R.4
Hassoun, P.M.5
Yamamoto, M.6
-
125
-
-
77954067261
-
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes
-
Ichikawa T, Li Jinqin, Meyer CJ, Janicki JS, Hannink M, Cui T. Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLos One 2009; 4: e8391.
-
(2009)
PLos One
, vol.4
-
-
Ichikawa, T.1
Li Jinqin Meyer, C.J.2
Janicki, J.S.3
Hannink, M.4
Cui, T.5
-
126
-
-
80555124930
-
Denitrosylation of HDAC2 by targeting Nrf restores glucocorticosteroid sensitivity in macrophages form COPD patients
-
Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, et al. Denitrosylation of HDAC2 by targeting Nrf restores glucocorticosteroid sensitivity in macrophages form COPD patients. J Clin Invest 2011; 121:4289-302.
-
(2011)
J Clin Invest
, vol.121
, pp. 4289-4302
-
-
Malhotra, D.1
Thimmulappa, R.K.2
Mercado, N.3
Ito, K.4
Kombairaju, P.5
Kumar, S.6
-
127
-
-
79959429766
-
Novel chalcone derivatives as potent Nrf-2 activators in mice and human lung epithelial cells
-
Kumar V, Kumar S, Hassan M, Wu H, Thimmulappa RK, Kumar A, et al. Novel chalcone derivatives as potent Nrf-2 activators in mice and human lung epithelial cells. J Med Chem 2011; 54: 4147-59.
-
(2011)
J Med Chem
, vol.54
, pp. 4147-4159
-
-
Kumar, V.1
Kumar, S.2
Hassan, M.3
Wu, H.4
Thimmulappa, R.K.5
Kumar, A.6
-
128
-
-
78649861860
-
Sirtuin activators: Designing molecules to extend life span
-
Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Pelegri C, et al. Sirtuin activators: Designing molecules to extend life span. Biochim Biophys Acta 2010; 1799: 740-9.
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 740-749
-
-
Camins, A.1
Sureda, F.X.2
Junyent, F.3
Verdaguer, E.4
Folch, J.5
Pelegri, C.6
|