Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD

Respiratory Medicine

Volumn 104, Issue 9, 2010, Pages 1288-1296

  Berton, Danilo C ^a,b   Reis, Michel ^a   Siqueira, Ana Cristina B ^a   Barroco, Adriano C ^a   Takara, Luciana S ^a   Bravo, Daniela M ^a   Andreoni, Solange ^a   Neder, J Alberto ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE FEEVALE   (Brazil)

Author keywords

Bronchodilators; COPD; Dyspnoea; Exercise testing; Formoterol; Tiotropium

Indexed keywords

FLUIR; FORMOTEROL FUMARATE; PLACEBO; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ENDURANCE TRAINING; FEMALE; HUMAN; HYPERINFLATION; LUNG VOLUME; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREADMILL;

BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DYSPNEA; ETHANOLAMINES; EXERCISE TOLERANCE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SCOPOLAMINE DERIVATIVES; TOTAL LUNG CAPACITY; TREATMENT OUTCOME;

EID: 77955658621     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2010.05.017     Document Type: Article

References (38)

1. B.R. Celli Update on the management of COPD Chest 133 2008 1451 1462
2. Global Strategy for the Diagnosis Management and prevention of COPD, global initiative for chronic obstructive lung disease (GOLD) Available from: http://www.goldcopd.org 2007
3. J. Lötvall Pharmacological similarities and differences between β2-agonists Respir Med 95S 2001 S7 S11
4. D.E. O'Donnell, T. Fluge, F. Gerken, A. Hamilton, K. Webb, and B. Aguilaniu et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD Eur Respir J 23 2004 832 840
5. F. Maltais, A. Hamilton, D. Marciniuk, P. Hernandez, F.C. Sciurba, and K. Richter et al. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD Chest 128 2005 1168 1178
6. J.A. Neder, J.P. Fuld, T. Overend, J. Thirlwell, R. Carter, and R. Stevenson et al. Effects of formoterol on exercise tolerance in severely disabled patients with COPD Respir Med 101 2007 2056 2064
7. M. Cazzola, F. Di Marco, P. Santus, B. Boveri, M. Verga, and M.G. Matera et al. The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD Pulm Pharmacol Ther 17 2004 35 39
8. 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified? Curr Opin Pharmacol 3 2003 270 276
9. J.A. van Noord, J.L. Aumann, E. Janssens, J.J. Smeets, J. Verhaert, and B. Disse et al. Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD Eur Respir J 26 2005 214 222
10. J.A. van Noord, J.L. Aumann, E. Janssens, J. Verhaert, J.J. Smeets, and A. Mueller et al. Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD Chest 129 2006 509 517
11. D.P. Tashkin, M. Littner, C.P. Andrews, L. Tomlinson, M. Rinehart, and K. Denis-Mize Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial Respir Med 102 2008 479 487
12. C. Vogelmeier, P. Kardos, S. Harari, S.J. Gans, S. Stenglein, and J. Thirlwell Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study Respir Med 102 2008 1511 1520
13. D.P. Tashkin, J.F. Donohue, D.A. Mahler, H. Huang, E. Goodwin, and K. Schaefer et al. Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD Respir Med 103 2009 516 524
14. D.P. Tashkin, N.A. Hanania, J. McGinty, K. Denis-Mize, and I. Chaudry Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary disease Adv Ther 26 2009 1024 1034
15. N.A. Hanania, A. Boota, E. Kerwin, L. Tomlinson, and K. Denis-Mize Efficacy and safety of nebulized formoterol as add-on therapy in COPD patients receiving maintenance tiotropium bromide Drugs 69 2009 1205 1216
16. D.E. O'Donnell Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2006 180 184
17. C.B. Cooper Airflow obstruction and exercise Respir Med 103 2009 325 334
18. R.M. Kaplan, A.L. Ries, J. Reilly, and Z. Mohsenifar Measurement of health-related quality of life in the National Emphysema Treatment Trial Chest 126 2004 781 789
19. C.D. Brown, J.O. Benditt, F.C. Sciurba, S.M. Lee, G.J. Criner, and Z. Mosenifar et al. Exercise testing in severe emphysema: association with quality of life and lung function COPD 5 2008 117 124
20. D.A. Mahler, D.H. Weinberg, C.K. Wells, and A.R. Feinstein The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes Chest 85 1984 751 758
21. J.A. Neder, S. Andreoni, A. Castelo-Filho, and L.E. Nery Reference values for lung function tests. I. Static volumes Braz J Med Biol Res 32 1999 703 717
22. J.A. Neder, S. Andreoni, C. Peres, and L.E. Nery Reference values for lung function tests. III. Carbon monoxide diffusing capacity (transfer factor) Braz J Med Biol Res 32 1999 729 737
23. G.A. Borg Psychophysical bases of perceived exertion Med Sci Sports Exerc 14 1982 377 381
24. R. Casaburi, D. Kukafka, C.B. Cooper, T.J. Witek Jr., and S. Kesten Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD Chest 127 2005 809 817
25. R. Casaburi Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions COPD 2 2005 131 136
26. L. Puente-Maestu, F. Villar, J. de Miguel, W.W. Stringer, P. Sanz, and M.L. Sanz et al. Clinical relevance of constant power exercise duration changes in COPD Eur Respir J 34 2009 340 345
27. R. Pellegrino, G. Viegi, V. Brusasco, R.O. Crapo, F. Burgos, and R. Casaburi et al. Interpretative strategies for lung function tests Eur Respir J 26 2005 948 968
28. D.A. Mahler Mechanisms and measurement of dyspnea in chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2006 234 238
29. D.E. O'Donnell, and P. Laveneziana The clinical importance of dynamic lung hyperinflation in COPD COPD 3 2006 219 232 (Pubitemid 44949062)
30. D.E. O'Donnell, A.L. Hamilton, and K.A. Webb Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD J Appl Physiol 101 2006 1025 1035
31. D.A. Mahler, G. Fierro-Carrion, R. Mejia-Alfaro, J. Ward, and J.C. Baird Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD Med Sci Sports Exerc 37 2005 529 535
32. D.A. Mahler, R. Mejia-Alfaro, J. Ward, and J.C. Baird Continuous measurement of breathlessness during exercise: validity, reliability, and responsiveness J Appl Physiol 90 2001 2188 2196
33. G. Fierro-Carrion, D.A. Mahler, J. Ward, and J.C. Baird Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjects Chest 125 2004 77 84
34. N.J. Gross, E. Co, and M.S. Skorodin Cholinergic bronchomotor tone in COPD. Estimates of its amount in comparison with that in normal subjects Chest 96 1989 984 987
35. N. Umeda, T. Yoshikawa, H. Kanazawa, K. Hirata, and S. Fujimoto Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD Respirology 13 2008 346 352
36. V. Pepin, D. Saey, F. Whittom, P. LeBlanc, and F. Maltais Walking versus cycling: sensitivity to bronchodilation in chronic obstructive pulmonary disease Am J Respir Crit Care Med 172 2005 1517 1522
37. J.A. Neder, P.W. Jones, L.E. Nery, and B.J. Whipp Determinants of the exercise endurance capacity in patients with chronic obstructive pulmonary disease. The power-duration relationship Am J Respir Crit Care Med 162 2000 497 504
38. D.P. Tashkin, J. Pearle, D. Iezzoni, and S.T. Varghese Formoterol and tiotropium compared with tiotropium alone for treatment of COPD COPD 6 2009 17 25