메뉴 건너뛰기




Volumn 19, Issue 4, 2010, Pages 342-351

The use of roflumilast in COPD: A primary care perspective

Author keywords

Chronic bronchitis; COPD; Exacerbations; Maintenance treatment; PDE4 inhibitors; Phenotypes; Primary care; RCT evidence; Roflumilast; Severe

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CORTICOSTEROID; LONG ACTING DRUG; MUSCARINIC RECEPTOR BLOCKING AGENT; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; ROFLUMILAST; SALBUTAMOL; SALMETEROL; SHORT ACTING DRUG; THEOPHYLLINE; TIOTROPIUM BROMIDE;

EID: 79551617104     PISSN: 14714418     EISSN: 14751534     Source Type: Journal    
DOI: 10.4104/pcrj.2010.00066     Document Type: Review
Times cited : (19)

References (30)
  • 1
    • 0003661910 scopus 로고    scopus 로고
    • World Health Organization, Available online at, Last accessed: 6/11/09
    • World Health Organization. World Health Statistics 2008. Available online at http://www.who.int/whosis/whostat/2008/en/index.html [Last accessed: 6/11/09].
    • (2008) World Health Statistics
  • 2
    • 79551650545 scopus 로고    scopus 로고
    • Clearing the air: A national study of chronic obstructive pulmonary disease
    • Healthcare Commission
    • Healthcare Commission. Clearing the air: A national study of chronic obstructive pulmonary disease. Healthcare Commission, 2006
    • (2006) Healthcare Commission
  • 3
    • 33745239737 scopus 로고    scopus 로고
    • Misdiagnosis of COPD and Asthma in Primary Care Patients 40 Years of Age and Over
    • Tinkelman DG, Price DB, Nordyke RJ, Halbert RJ. Misdiagnosis of COPD and Asthma in Primary Care Patients 40 Years of Age and Over. J Asthma 2006;43(1):75-80. http://dx.doi.org/10.1080/02770900500448738
    • (2006) J Asthma , vol.43 , Issue.1 , pp. 75-80
    • Tinkelman, D.G.1    Price, D.B.2    Nordyke, R.J.3    Halbert, R.J.4
  • 6
    • 1542405163 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Management of chronic obstructive pulmonary disease in adults in primary and secondary care. Clinical guideline 12
    • National Institute for Clinical Excellence
    • National Institute for Clinical Excellence. Chronic obstructive pulmonary disease: management of chronic obstructive pulmonary disease in adults in primary and secondary care. Clinical guideline 12. Thorax 2004;59(Suppl I):i1-i232.
    • (2004) Thorax , vol.59 , Issue.SUPPL. 1
  • 7
    • 31544480666 scopus 로고    scopus 로고
    • International Primary care respiratory group (IPCRG) guidelines: Diagnosis of respiratory diseases in primary care
    • Levy ML, Fletcher M, Price DB, Hausen T, Halbert RJ, Yawn BP. International Primary Care Respiratory Group (IPCRG) Guidelines: diagnosis of respiratory diseases in primary care. Prim Care Resp J 2006;15:20-34. http://dx.doi.org/ 10.1016/j.pcrj.2005.10.004
    • (2006) Prim Care Resp J , vol.15 , pp. 20-34
    • Levy, M.L.1    Fletcher, M.2    Price, D.B.3    Hausen, T.4    Halbert, R.J.5    Yawn, B.P.6
  • 8
    • 36049036539 scopus 로고    scopus 로고
    • Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease-2007 update
    • O'Donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J 2007;14 Suppl B:5B-32B.
    • (2007) Can Respir J , vol.14 , Issue.SUPPL. B
    • O'Donnell, D.E.1    Aaron, S.2    Bourbeau, J.3
  • 9
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • and committee members
    • Celli BR, MacNee W, and committee members. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004;23:932-46. http://dx.doi.org/10.1183/09031936.04.00014304
    • (2004) Eur Respir J , vol.23 , pp. 932-946
    • Celli, B.R.1    Macnee, W.2
  • 10
    • 79551639044 scopus 로고    scopus 로고
    • Efficacy and safety of varenicline for smoking cessation in patients with mild to moderate COPD
    • Tashkin D, Rennard S, Taylor Hays J, et al. Efficacy and safety of varenicline for smoking cessation in patients with mild to moderate COPD. Chest Meeting Abstracts. 2009;136:151S-b-152S-b.
    • (2009) Chest Meeting Abstracts , vol.136
    • Tashkin, D.1    Rennard, S.2    Taylor, H.J.3
  • 11
    • 33750138265 scopus 로고    scopus 로고
    • Mucolytic agents for chronic bronchitis and chronic obstructive pulmonary disease
    • Poole PJ, Black PN. Mucolytic agents for chronic bronchitis and chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006;3:CD001287.
    • (2006) Cochrane Database Syst Rev , vol.3
    • Poole, P.J.1    Black, P.N.2
  • 12
    • 70449299442 scopus 로고
    • The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population
    • Fletcher CM, Elmes PC, Fairbairn MB, et al. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. BMJ 1959;2:257-66.
    • (1959) BMJ , vol.2 , pp. 257-266
    • Fletcher, C.M.1    Elmes, P.C.2    Fairbairn, M.B.3
  • 13
    • 42149166529 scopus 로고    scopus 로고
    • Superiority of triple therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD
    • Singh D, Brooks J, Hagan G, et al. Superiority of triple therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax 2008;63(7):592-8. http://dx.doi.org/10.1136/thx.2007.087213
    • (2008) Thorax , vol.63 , Issue.7 , pp. 592-598
    • Singh, D.1    Brooks, J.2    Hagan, G.3
  • 14
    • 69149103642 scopus 로고    scopus 로고
    • Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
    • Calverley PM, Rabe KF, Goehring UM, et al. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet 2009;374(4691):685-94. http://dx.doi.org/10.1016/S0140-6736(09)61255-1
    • (2009) Lancet , vol.374 , Issue.4691 , pp. 685-694
    • Calverley, P.M.1    Rabe, K.F.2    Goehring, U.M.3
  • 15
    • 69149098943 scopus 로고    scopus 로고
    • Roflumilast in moderate-tosevere chronic obstructive pulmonary disease treated with long-acting bronchodilators: Two randomised clinical trials
    • Fabbri LM, Calverley PM, Izquierdo-Alonso JL, et al. Roflumilast in moderate-tosevere chronic obstructive pulmonary disease treated with long-acting bronchodilators: two randomised clinical trials. Lancet 2009; 374(4691):695-703. http://dx.doi.org/10.1016/S0140-6736(09)61252-6
    • (2009) Lancet , vol.374 , Issue.4691 , pp. 695-703
    • Fabbri, L.M.1    Calverley, P.M.2    Izquierdo-Alonso, J.L.3
  • 16
    • 79251473278 scopus 로고    scopus 로고
    • European Medicines Agency Science Medicines Health, Available online at
    • European Medicines Agency Science Medicines Health. Summary of opinion (initial authorisation) Daxas: roflumilast. 22 April 2010. Available online at: http://www.ema.europa.eu/pdfs/human/opinion/Daxas_15986110en.pdf
    • (2010) Summary of opinion (initial authorisation) Daxas: Roflumilast
  • 17
    • 17144464849 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Emerging medical therapies
    • MacIntyre NR. Chronic obstructive pulmonary disease: emerging medical therapies. Respir Care 2004;49(1):6-9.
    • (2004) Respir Care , vol.49 , Issue.1 , pp. 6-9
    • MacIntyre, N.R.1
  • 18
    • 0036260880 scopus 로고    scopus 로고
    • Airways Inflammation and COPD
    • Pettersen CA, Adler KB. Airways Inflammation and COPD. Chest 2002;121(5 Suppl):142S-150S. http://dx.doi.org/10.1378/chest.121.5_suppl.142S
    • (2002) Chest , vol.121 , Issue.5
    • Pettersen, C.A.1    Adler, K.B.2
  • 19
    • 15244355257 scopus 로고    scopus 로고
    • Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease
    • Molet S, Belleguic C, Lena H, et al. Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflammation Res. 2005;54(1):31-6. http://dx.doi.org/10.1007/s00011-004-1319-4
    • (2005) Inflammation Res , vol.54 , Issue.1 , pp. 31-36
    • Molet, S.1    Belleguic, C.2    Lena, H.3
  • 20
    • 0033994635 scopus 로고    scopus 로고
    • Mechanisms in COPD: Differences from asthma
    • Barnes PJ. Mechanisms in COPD: Differences from asthma. Chest 2000;117(2 Suppl):10S-14S. http://dx.doi.org/10.1378/chest.117.2_suppl.10S
    • (2000) Chest , vol.117 , Issue.SUPPL. 2
    • Barnes, P.J.1
  • 21
    • 2342464897 scopus 로고    scopus 로고
    • COPD: Is there light at the end of the tunnel?
    • Barnes PJ. COPD: is there light at the end of the tunnel? Curr Opin Pharmacol 2004;4(3):263-72. http://dx.doi.org/10.1016/j.coph.2004.03.001
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.3 , pp. 263-272
    • Barnes, P.J.1
  • 22
    • 4444280869 scopus 로고    scopus 로고
    • Prospects for new drugs for chronic obstructive pulmonary disease
    • Barnes PJ, Hansel TT. Prospects for new drugs for chronic obstructive pulmonary disease. Lancet 2004;364(9438):985-96. http://dx.doi.org/10.1016/S0140- 6736(04)17025-6
    • (2004) Lancet , vol.364 , Issue.9438 , pp. 985-996
    • Barnes, P.J.1    Hansel, T.T.2
  • 23
    • 62849097837 scopus 로고    scopus 로고
    • Pharmacology of a novel, orally active PDE4 inhibitor
    • Dastidar SG, Ray A, Shirumalla R, et al. Pharmacology of a novel, orally active PDE4 inhibitor. Pharmacology 2009;83(5):275-86. http://dx.doi.org/10.1159/000209608
    • (2009) Pharmacology , vol.83 , Issue.5 , pp. 275-286
    • Dastidar, S.G.1    Ray, A.2    Shirumalla, R.3
  • 25
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • Humbert M, Beasley R, Ayres J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 2005;60(3):309-16. http://dx.doi.org/10.1111/j.1398-9995.2004.00772.x
    • (2005) Allergy , vol.60 , Issue.3 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3
  • 26
    • 51249109930 scopus 로고    scopus 로고
    • Proportional classifications of COPD phenotypes
    • Marsh SE, Travers J, Weatherall M, et al. Proportional classifications of COPD phenotypes. Thorax 2008;63(9):761-7. http://dx.doi.org/10.1136/thx.2007.089193
    • (2008) Thorax , vol.63 , Issue.9 , pp. 761-767
    • Marsh, S.E.1    Travers, J.2    Weatherall, M.3
  • 27
    • 79551649554 scopus 로고    scopus 로고
    • Optimum Patient Care, May, Available online at
    • Optimum Patient Care. Audit Review Services. May 2010. Available online at: http://www.optimumpatientcare.org/audit/audit.html
    • (2010) Audit Review Services
  • 28
    • 72549113283 scopus 로고    scopus 로고
    • Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: The DOSE Index
    • Jones RC, Donaldson GC, Chavannes NH, et al. Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: the DOSE Index. Am J Respir Crit Care Med 2009;180:1189-95. http://dx.doi.org/10.1164/rccm.200902-0271OC
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 1189-1195
    • Jones, R.C.1    Donaldson, G.C.2    Chavannes, N.H.3
  • 29
    • 0018169569 scopus 로고
    • Inhibition of human pulmonary phosphodiesterase activity by therapeutic levels of theophylline
    • Poolson JB, Kazanowski JJ, Goldman AL, Szentivanyi A. Inhibition of human pulmonary phosphodiesterase activity by therapeutic levels of theophylline. Clin Exp Pharmacol Physiol 1978;5:535-39. http://dx.doi.org/10.1111/j.1440-1681.1978.tb00707.x
    • (1978) Clin Exp Pharmacol Physiol , vol.5 , pp. 535-539
    • Poolson, J.B.1    Kazanowski, J.J.2    Goldman, A.L.3    Szentivanyi, A.4
  • 30
    • 54049140448 scopus 로고    scopus 로고
    • Effect of Single and Repeated Doses of Ketoconazole on the Pharmacokinetics of Roflumilast and Roflumilast N-Oxide
    • Lahu G, Huennemeyer A, von Richter O, et al. Effect of Single and Repeated Doses of Ketoconazole on the Pharmacokinetics of Roflumilast and Roflumilast N-Oxide. J Clin Pharmacol 2008;11:1339-49. http://dx.doi.org/10.1177/0091270008321941
    • (2008) J Clin Pharmacol , vol.11 , pp. 1339-1349
    • Lahu, G.1    Huennemeyer, A.2    von Richter, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.