Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Cheng, Chang ^a,b   Ho, W Eugene ^a,b   Goh, Fera Y ^a,b   Guan, Shou Ping ^a,b   Kong, Li Ren ^a   Lai, Wen Qi ^a   Leung, Bernard P ^a   Wong, W S Fred ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EOTAXIN; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; MUCIN 5AC; OVALBUMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; TUBERIN; ANTIINFLAMMATORY AGENT; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; CYTOKINE;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG LAVAGE; MOUSE; MUCUS SECRETION; NONHUMAN; SIGNAL TRANSDUCTION; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; BRONCHUS; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; MUCUS; PATHOLOGY; PYROGLYPHIDAE; SECRETION; TH2 CELL;

ARTEMISIA ANNUA; ARTESUNATE; MUS; PYROGLYPHIDAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIMALARIALS; ARTEMISININS; ASTHMA; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPERSENSITIVITY; MICE; MICE, INBRED BALB C; MUCUS; OVALBUMIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYROGLYPHIDAE; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 79958273737     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020932     Document Type: Article

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