메뉴 건너뛰기




Volumn 4, Issue 3, 2013, Pages 186-196

Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells

Author keywords

chronic myeloid leukemia; leukemia stem cell; molecular mechanisms

Indexed keywords

ACYL COENZYME A DESATURASE; BCR ABL PROTEIN; IMATINIB; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN BCL 6; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL ANTIGEN 1; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR FOXO;

EID: 84874849505     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-013-2115-0     Document Type: Review
Times cited : (27)

References (97)
  • 3
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia, R., Holtz, M., Niu, N., Gray, R., Snyder, D. S., Sawyers, C. L., Arber, D. A., Slovak, M. L., and Forman, S. J. (2003). Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101, 4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3    Gray, R.4    Snyder, D.S.5    Sawyers, C.L.6    Arber, D.A.7    Slovak, M.L.8    Forman, S.J.9
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D., and Dick, J. E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3, 730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 5
    • 79953765304 scopus 로고    scopus 로고
    • Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036
    • Chan, W. W., Wise, S. C., Kaufman, M. D., Ahn, Y. M., Ensinger, C. L., Haack, T., Hood, M. M., Jones, J., Lord, J. W., Lu, W. P., et al. (2011). Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell 19, 556-568.
    • (2011) Cancer Cell , vol.19 , pp. 556-568
    • Chan, W.W.1    Wise, S.C.2    Kaufman, M.D.3    Ahn, Y.M.4    Ensinger, C.L.5    Haack, T.6    Hood, M.M.7    Jones, J.8    Lord, J.W.9    Lu, W.P.10
  • 6
    • 67649861052 scopus 로고    scopus 로고
    • Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    • Chen, Y., Hu, Y., Zhang, H., Peng, C., and Li, S. (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 41, 783-792.
    • (2009) Nat Genet , vol.41 , pp. 783-792
    • Chen, Y.1    Hu, Y.2    Zhang, H.3    Peng, C.4    Li, S.5
  • 7
    • 79953151232 scopus 로고    scopus 로고
    • Molecular and cellular bases of chronic myeloid leukemia
    • Chen, Y., Peng, C., Li, D., and Li, S. (2010a). Molecular and cellular bases of chronic myeloid leukemia. Protein Cell 1, 124-132.
    • (2010) Protein Cell , vol.1 , pp. 124-132
    • Chen, Y.1    Peng, C.2    Li, D.3    Li, S.4
  • 8
    • 77956440189 scopus 로고    scopus 로고
    • Critical molecular pathways in cancer stem cells of chronic myeloid leukemia
    • Chen, Y., Peng, C., Sullivan, C., Li, D., and Li, S. (2010b). Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia 24, 1545-1554.
    • (2010) Leukemia , vol.24 , pp. 1545-1554
    • Chen, Y.1    Peng, C.2    Sullivan, C.3    Li, D.4    Li, S.5
  • 9
    • 78650949272 scopus 로고    scopus 로고
    • Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
    • Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W., and Druker, B. J. (2011). Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest 121, 396-409.
    • (2011) J Clin Invest , vol.121 , pp. 396-409
    • Corbin, A.S.1    Agarwal, A.2    Loriaux, M.3    Cortes, J.4    Deininger, M.W.5    Druker, B.J.6
  • 10
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • Cortes, J., O'Brien, S., and Kantarjian, H. (2004). Discontinuation of imatinib therapy after achieving a molecular response. Blood 104, 2204-2205.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 11
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes, J., Rousselot, P., Kim, D. W., Ritchie, E., Hamerschlak, N., Coutre, S., Hochhaus, A., Guilhot, F., Saglio, G., Apperley, J., et al. (2007). Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 109, 3207-3213.
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3    Ritchie, E.4    Hamerschlak, N.5    Coutre, S.6    Hochhaus, A.7    Guilhot, F.8    Saglio, G.9    Apperley, J.10
  • 14
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • Donato, N. J., Wu, J. Y., Stapley, J., Gallick, G., Lin, H., Arlinghaus, R., and Talpaz, M. (2003). BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101, 690-698.
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 16
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker, B. J., Sawyers, C. L., Kantarjian, H., Resta, D. J., Reese, S. F., Ford, J. M., Capdeville, R., and Talpaz, M. (2001a). Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344, 1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 18
  • 21
    • 0036849558 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats
    • Falvella, F. S., Pascale, R. M., Gariboldi, M., Manenti, G., De Miglio, M. R., Simile, M. M., Dragani, T. A., and Feo, F. (2002). Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis 23, 1933-1936.
    • (2002) Carcinogenesis , vol.23 , pp. 1933-1936
    • Falvella, F.S.1    Pascale, R.M.2    Gariboldi, M.3    Manenti, G.4    De Miglio, M.R.5    Simile, M.M.6    Dragani, T.A.7    Feo, F.8
  • 22
    • 34248198871 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    • Flowers, J. B., Rabaglia, M. E., Schueler, K. L., Flowers, M. T., Lan, H., Keller, M. P., Ntambi, J. M., and Attie, A. D. (2007). Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56, 1228-1239.
    • (2007) Diabetes , vol.56 , pp. 1228-1239
    • Flowers, J.B.1    Rabaglia, M.E.2    Schueler, K.L.3    Flowers, M.T.4    Lan, H.5    Keller, M.P.6    Ntambi, J.M.7    Attie, A.D.8
  • 23
    • 0029796725 scopus 로고    scopus 로고
    • BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats
    • Frank, D. A., and Varticovski, L. (1996). BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 10, 1724-1730.
    • (1996) Leukemia , vol.10 , pp. 1724-1730
    • Frank, D.A.1    Varticovski, L.2
  • 24
    • 77955121375 scopus 로고    scopus 로고
    • Identification of a cell of origin for human prostate cancer
    • Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., and Witte, O. N. (2010). Identification of a cell of origin for human prostate cancer. Science 329, 568-571.
    • (2010) Science , vol.329 , pp. 568-571
    • Goldstein, A.S.1    Huang, J.2    Guo, C.3    Garraway, I.P.4    Witte, O.N.5
  • 25
    • 0037108448 scopus 로고    scopus 로고
    • BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
    • Gorre, M. E., Ellwood-Yen, K., Chiosis, G., Rosen, N., and Sawyers, C. L. (2002). BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 100, 3041-3044.
    • (2002) Blood , vol.100 , pp. 3041-3044
    • Gorre, M.E.1    Ellwood-Yen, K.2    Chiosis, G.3    Rosen, N.4    Sawyers, C.L.5
  • 26
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre, M. E., Mohammed, M., Ellwood, K., Hsu, N., Paquette, R., Rao, P. N., and Sawyers, C. L. (2001). Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 27
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham, S. M., Jorgensen, H. G., Allan, E., Pearson, C., Alcorn, M. J., Richmond, L., and Holyoake, T. L. (2002). Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99, 319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6    Holyoake, T.L.7
  • 28
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
    • Guilhot, F., Apperley, J., Kim, D. W., Bullorsky, E. O., Baccarani, M., Roboz, G. J., Amadori, S., de Souza, C. A., Lipton, J. H., Hochhaus, A., et al. (2007). Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 109, 4143-4150.
    • (2007) Blood , vol.109 , pp. 4143-4150
    • Guilhot, F.1    Apperley, J.2    Kim, D.W.3    Bullorsky, E.O.4    Baccarani, M.5    Roboz, G.J.6    Amadori, S.7    de Souza, C.A.8    Lipton, J.H.9    Hochhaus, A.10
  • 31
    • 77956210076 scopus 로고    scopus 로고
    • Inhibition of stearoyl-CoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells
    • Hess, D., Chisholm, J. W., and Igal, R. A. (2010). Inhibition of stearoyl-CoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 5, e11394.
    • (2010) PLoS One , vol.5
    • Hess, D.1    Chisholm, J.W.2    Igal, R.A.3
  • 33
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu, Y., Liu, Y., Pelletier, S., Buchdunger, E., Warmuth, M., Fabbro, D., Hallek, M., van Etten, R. A., and Li, S. (2004). Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 36, 453-461.
    • (2004) Nat Genet , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3    Buchdunger, E.4    Warmuth, M.5    Fabbro, D.6    Hallek, M.7    van Etten, R.A.8    Li, S.9
  • 34
    • 33750937577 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    • Hu, Y., Swerdlow, S., Duffy, T. M., Weinmann, R., Lee, F. Y., and Li, S. (2006). Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A 103, 16870-16875.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16870-16875
    • Hu, Y.1    Swerdlow, S.2    Duffy, T.M.3    Weinmann, R.4    Lee, F.Y.5    Li, S.6
  • 35
    • 16844378799 scopus 로고    scopus 로고
    • Leukaemia stem cells and the evolution of cancer-stem-cell research
    • Huntly, B. J., and Gilliland, D. G. (2005). Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 5, 311-321.
    • (2005) Nat Rev Cancer , vol.5 , pp. 311-321
    • Huntly, B.J.1    Gilliland, D.G.2
  • 40
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith, B., and Simon, M. C. (2007). Hypoxia-inducible factors, stem cells, and cancer. Cell 129, 465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 42
    • 0033539886 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA de saturase genes: role in cellular metabolism and preadipocyte differentiation
    • Kim, Y. C., and Ntambi, J. M. (1999). Regulation of stearoyl-CoA de saturase genes: role in cellular metabolism and preadipocyte differentiation. Biochem Biophys Res Commun 266, 1-4.
    • (1999) Biochem Biophys Res Commun , vol.266 , pp. 1-4
    • Kim, Y.C.1    Ntambi, J.M.2
  • 43
    • 77954666269 scopus 로고    scopus 로고
    • Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism
    • Kinder, M., Wei, C., Shelat, S. G., Kundu, M., Zhao, L., Blair, I. A., and Pure, E. (2010). Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood 115, 5012-5022.
    • (2010) Blood , vol.115 , pp. 5012-5022
    • Kinder, M.1    Wei, C.2    Shelat, S.G.3    Kundu, M.4    Zhao, L.5    Blair, I.A.6    Pure, E.7
  • 44
    • 57149097077 scopus 로고    scopus 로고
    • Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells
    • Konig, H., Copland, M., Chu, S., Jove, R., Holyoake, T. L., and Bhatia, R. (2008). Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells. Cancer Res 68, 9624-9633.
    • (2008) Cancer Res , vol.68 , pp. 9624-9633
    • Konig, H.1    Copland, M.2    Chu, S.3    Jove, R.4    Holyoake, T.L.5    Bhatia, R.6
  • 45
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard, J., and Sauvageau, G. (2003). Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255-260.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 47
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo, L. J., Lee, F. Y., Chen, P., Norris, D., Barrish, J. C., Behnia, K., Castaneda, S., Cornelius, L. A., Das, J., Doweyko, A. M., et al. (2004). Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 47, 6658-6661.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3    Norris, D.4    Barrish, J.C.5    Behnia, K.6    Castaneda, S.7    Cornelius, L.A.8    Das, J.9    Doweyko, A.M.10
  • 48
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
    • Mayerhofer, M., Valent, P., Sperr, W. R., Griffin, J. D., and Sillaber, C. (2002). BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 100, 3767-3775.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3    Griffin, J.D.4    Sillaber, C.5
  • 49
    • 34249676964 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia as a model of disease evolution in human cancer
    • Melo, J. V., and Barnes, D. J. (2007). Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 7, 441-453.
    • (2007) Nat Rev Cancer , vol.7 , pp. 441-453
    • Melo, J.V.1    Barnes, D.J.2
  • 50
    • 77952863838 scopus 로고    scopus 로고
    • Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
    • Mendez, O., Zavadil, J., Esencay, M., Lukyanov, Y., Santovasi, D., Wang, S. C., Newcomb, E. W., and Zagzag, D. (2010). Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer 9, 133.
    • (2010) Mol Cancer , vol.9 , pp. 133
    • Mendez, O.1    Zavadil, J.2    Esencay, M.3    Lukyanov, Y.4    Santovasi, D.5    Wang, S.C.6    Newcomb, E.W.7    Zagzag, D.8
  • 51
    • 0030912071 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    • Meng, F., and Lowell, C. A. (1997). Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 185, 1661-1670.
    • (1997) J Exp Med , vol.185 , pp. 1661-1670
    • Meng, F.1    Lowell, C.A.2
  • 53
    • 0033959620 scopus 로고    scopus 로고
    • The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf
    • Neshat, M. S., Raitano, A. B., Wang, H. G., Reed, J. C., and Sawyers, C. L. (2000). The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol 20, 1179-1186.
    • (2000) Mol Cell Biol , vol.20 , pp. 1179-1186
    • Neshat, M.S.1    Raitano, A.B.2    Wang, H.G.3    Reed, J.C.4    Sawyers, C.L.5
  • 54
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell P. C., and Hungerford, H. D. (1960). A minute chromosome in human chronic granulocytic leukemia. Science 132, 1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, H.D.2
  • 55
    • 0037832581 scopus 로고    scopus 로고
    • Recent insights into stearoyl-CoA desaturase-1
    • Ntambi, J. M., and Miyazaki, M. (2003). Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14, 255-261.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 255-261
    • Ntambi, J.M.1    Miyazaki, M.2
  • 56
    • 34548825795 scopus 로고    scopus 로고
    • Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
    • O'Hare, T., Eide, C. A., and Deininger, M. W. (2007). Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110, 2242-2249.
    • (2007) Blood , vol.110 , pp. 2242-2249
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.3
  • 57
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study
    • Ottmann, O., Dombret, H., Martinelli, G., Simonsson, B., Guilhot, F., Larson, R. A., Rege-Cambrin, G., Radich, J., Hochhaus, A., Apanovitch, A. M., et al. (2007). Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 110, 2309-2315.
    • (2007) Blood , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3    Simonsson, B.4    Guilhot, F.5    Larson, R.A.6    Rege-Cambrin, G.7    Radich, J.8    Hochhaus, A.9    Apanovitch, A.M.10
  • 59
    • 77449117864 scopus 로고    scopus 로고
    • PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
    • Peng, C., Chen, Y., Yang, Z., Zhang, H., Osterby, L., Rosmarin, A. G., and Li, S. (2010). PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood 115, 626-635.
    • (2010) Blood , vol.115 , pp. 626-635
    • Peng, C.1    Chen, Y.2    Yang, Z.3    Zhang, H.4    Osterby, L.5    Rosmarin, A.G.6    Li, S.7
  • 60
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • Phan, R. T., and Dalla-Favera, R. (2004). The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432, 635-639.
    • (2004) Nature , vol.432 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 63
    • 34848929062 scopus 로고    scopus 로고
    • Flying under the radar: the new wave of BCR-ABL inhibitors
    • Quintas-Cardama, A., Kantarjian, H., and Cortes, J. (2007). Flying under the radar: the new wave of BCR-ABL inhibitors. Nat Rev Drug Discov 6, 834-848.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 834-848
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3
  • 64
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates proteintyrosine phosphatase 1B in muscle
    • Rahman, S. M., Dobrzyn, A., Dobrzyn, P., Lee, S. H., Miyazaki, M., and Ntambi, J. M. (2003). Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates proteintyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A 100, 11110-11115.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.M.6
  • 65
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren, R. (2005). Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 5, 172-183.
    • (2005) Nat Rev Cancer , vol.5 , pp. 172-183
    • Ren, R.1
  • 66
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya, T., Morrison, S. J., Clarke, M. F., and Weissman, I. L. (2001). Stem cells, cancer, and cancer stem cells. Nature 414, 105-111.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 70
    • 84255163040 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation
    • Sampath, H., and Ntambi, J. M. (2011). The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann N Y Acad Sci 1243, 47-53.
    • (2011) Ann N Y Acad Sci , vol.1243 , pp. 47-53
    • Sampath, H.1    Ntambi, J.M.2
  • 71
    • 42549142280 scopus 로고    scopus 로고
    • Getting to the stem of chronic myeloid leukaemia
    • Savona, M., and Talpaz, M. (2008). Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer 8, 341-350.
    • (2008) Nat Rev Cancer , vol.8 , pp. 341-350
    • Savona, M.1    Talpaz, M.2
  • 72
    • 69449099939 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
    • Scaglia, N., Chisholm, J. W., and Igal, R. A. (2009). Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One 4, e 6812.
    • (2009) PLoS One , vol.4 , pp. 6812
    • Scaglia, N.1    Chisholm, J.W.2    Igal, R.A.3
  • 73
    • 21844432112 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
    • Scaglia, N., and Igal, R. A. (2005). Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J Biol Chem 280, 25339-25349.
    • (2005) J Biol Chem , vol.280 , pp. 25339-25349
    • Scaglia, N.1    Igal, R.A.2
  • 75
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 76
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah, N. P., Tran, C., Lee, F. Y., Chen, P., Norris, D., and Sawyers, C. L. (2004). Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 77
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • Simon, M. C., and Keith, B. (2008). The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9, 285-296.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 82
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader, J. E., and Lindeman, G. J. (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8, 755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 83
    • 24344506258 scopus 로고    scopus 로고
    • Cancer stem cells: lessons from leukemia
    • Wang, J. C., and Dick, J. E. (2005). Cancer stem cells: lessons from leukemia. Trends Cell Biol 15, 494-501.
    • (2005) Trends Cell Biol , vol.15 , pp. 494-501
    • Wang, J.C.1    Dick, J.E.2
  • 84
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1a eliminates cancer stem cells in hematological malignancies
    • Wang, Y., Liu, Y., Malek, S. N., Zheng, P., and Liu, Y. (2011). Targeting HIF1a eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8, 399-411.
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4    Liu, Y.5
  • 85
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate
    • Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6    Cross, J.R.7    Fantin, V.R.8    Hedvat, C.V.9    Perl, A.E.10
  • 86
    • 0031455168 scopus 로고    scopus 로고
    • The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr
    • Warmuth, M., Bergmann, M., Priess, A., Hauslmann, K., Emmerich, B., and Hallek, M. (1997). The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem 272, 33260-33270.
    • (1997) J Biol Chem , vol.272 , pp. 33260-33270
    • Warmuth, M.1    Bergmann, M.2    Priess, A.3    Hauslmann, K.4    Emmerich, B.5    Hallek, M.6
  • 88
    • 2542441665 scopus 로고    scopus 로고
    • The BCR-ABL story: bench to bedside and back
    • Wong, S., and Witte, O. N. (2004). The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 22, 247-306.
    • (2004) Annu Rev Immunol , vol.22 , pp. 247-306
    • Wong, S.1    Witte, O.N.2
  • 89
    • 43549100498 scopus 로고    scopus 로고
    • Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells
    • Wu, J., Meng, F., Lu, H., Kong, L., Bornmann, W., Peng, Z., Talpaz, M., and Donato, N. J. (2008). Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood 111, 3821-3829.
    • (2008) Blood , vol.111 , pp. 3821-3829
    • Wu, J.1    Meng, F.2    Lu, H.3    Kong, L.4    Bornmann, W.5    Peng, Z.6    Talpaz, M.7    Donato, N.J.8
  • 90
    • 40549124306 scopus 로고    scopus 로고
    • Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
    • Xiao, W., Hong, H., Kawakami, Y., Lowell, C. A., and Kawakami, T. (2008). Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest 118, 924-934.
    • (2008) J Clin Invest , vol.118 , pp. 924-934
    • Xiao, W.1    Hong, H.2    Kawakami, Y.3    Lowell, C.A.4    Kawakami, T.5
  • 91
    • 84861385403 scopus 로고    scopus 로고
    • Scd1 plays a tumorsuppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia
    • Zhang, H., Li, H., Ho, N., Li, D., and Li, S. (2012a). Scd1 plays a tumorsuppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol Cell Biol 32, 1776-1787.
    • (2012) Mol Cell Biol , vol.32 , pp. 1776-1787
    • Zhang, H.1    Li, H.2    Ho, N.3    Li, D.4    Li, S.5
  • 92
    • 84863338358 scopus 로고    scopus 로고
    • HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells
    • Zhang, H., Li, H., Xi, H. S., and Li, S. (2012b). HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells. Blood 119, 2595-2607.
    • (2012) Blood , vol.119 , pp. 2595-2607
    • Zhang, H.1    Li, H.2    Xi, H.S.3    Li, S.4
  • 95
    • 36649002031 scopus 로고    scopus 로고
    • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    • Zhao, C., Blum, J., Chen, A., Kwon, H. Y., Jung, S. H., Cook, J. M., Lagoo, A., and Reya, T. (2007). Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12, 528-541.
    • (2007) Cancer Cell , vol.12 , pp. 528-541
    • Zhao, C.1    Blum, J.2    Chen, A.3    Kwon, H.Y.4    Jung, S.H.5    Cook, J.M.6    Lagoo, A.7    Reya, T.8
  • 97
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M. M., Simons, J. W., and Semenza, G. L. (2000). Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60, 1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.