Hypoxia and Hypoxia Mimetics Decrease Aquaporin 5 (AQP5) Expression through Both Hypoxia Inducible Factor-1α and Proteasome-Mediated Pathways

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Kawedia, Jitesh D ^a,f   Yang, Fan ^a,e   Sartor, Maureen A ^b   Gozal, David ^c   Czyzyk Krzeska, Maria ^a,d   Menon, Anil G ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AQUAPORIN 5; COBALT; CYCLOHEXIMIDE; DIMETHYLOXALOYLGLYCINE; ENZYME INHIBITOR; FG 0041; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTACYSTIN; MESSENGER RNA; PROTEASOME; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; HYPOXIA; LUNG; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLCYSTEINE; ANIMALS; ANOXIA; AQUAPORIN 5; CELL HYPOXIA; CELL LINE; COBALT; EPITHELIAL CELLS; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG; MICE; OXYGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN STABILITY; RESPIRATORY MUCOSA; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; WATER;

EID: 84874580236     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057541     Document Type: Article

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