High altitude-induced pulmonary oedema

Cardiovascular Research

Volumn 72, Issue 1, 2006, Pages 41-50

  Maggiorini, Marco ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Capillary pressure; Dexamethasone; High altitude pulmonary oedema; Hypoxic pulmonary vasoconstriction; Nifedipine; Tadalafil; Trans epithelial Na transport

Indexed keywords

ACETAZOLAMIDE; DEXAMETHASONE; NIFEDIPINE; SALMETEROL; TADALAFIL;

ALTITUDE; ALTITUDE DISEASE; CHEST TIGHTNESS; CLINICAL EXAMINATION; CONGENITAL MALFORMATION; COUGHING; DISEASE PREDISPOSITION; DYSPNEA; EXERCISE; FATIGUE; HEART CATHETERIZATION; HEMOPTYSIS; HIGH ALTITUDE INDUCED LUNG EDEMA; HIGH RISK POPULATION; HUMAN; HYPOXEMIA; LUNG ARTERY PRESSURE; LUNG CAPILLARY PRESSURE; LUNG DIFFUSION; LUNG EDEMA; LUNG VASOCONSTRICTION; ORTHOPNEA; OXYGEN THERAPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; SPUTUM; THORAX RADIOGRAPHY;

ACCLIMATIZATION; ALTITUDE SICKNESS; DISEASE SUSCEPTIBILITY; HUMANS; HYPERTENSION, PULMONARY; NIFEDIPINE; PULMONARY ARTERY; PULMONARY EDEMA; VASODILATOR AGENTS;

EID: 33748203675     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.07.004     Document Type: Review

References (128)

1. Montgomery A.B., Millis J., and Luce J.M. Incidence of acute mountain sickness at intermediate altitude. JAMA 261 (1989) 732-734
2. Hackett P.H., Rennie D., and Levine H.D. The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 2 7996 (1976) 1149-1154
3. Maggiorini M., Bühler B., Walter M., and Oelz O. Prevalence of acute mountain sickness in the Swiss Alps. BMJ 301 (1990) 853-855
4. Ziaee V., Yunesian M., Ahmadinejad Z., Halabchi F., Kordi R., Alizadeh R., et al. Acute mountain sickness in Iranian trekkers around Mount Damavand (5671 m) in Iran. Wilderness Environ Med 14 (2003 (Winter)) 214-219
5. Basnyat B., Lemaster J., and Litch J.A. Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas. Aviat Space Environ Med 70 (1999) 867-873
6. Schneider M., Bernasch D., Weymann J., Holle R., and Bartsch P. Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate. Med Sci Sports Exerc 34 (2002) 1886-1891
7. Gaillard S., Dellasanta P., Loutan L., and Kayser B. Awareness, prevalence, medication use, and risk factors of acute mountain sickness in tourists trekking around the Annapurnas in Nepal: a 12-year follow-up. High Alt Med Biol 5 (2004) 410-419
8. Pesce C., Leal C., Pinto H., Gonzalez G., Maggiorini M., Schneider M., et al. Determinants of acute mountain sickness and success on Mount Aconcagua (6962 m). High Alt Med Biol 6 (2005) 158-166
9. Sophocles Jr. A.M. High-altitude pulmonary edema in Vail, Colorado, 1975-1982. High Alt Med Biol 144 (1986) 569-573
10. Hochstrasser J., Nanzer A., and Oelz O. Altitude edema in the Swiss Alps. Observations on the incidence and clinical course in 50 patients 1980-1984. Schweiz Med Wochenschr 116 (1986) 866-873
11. Hackett P.H., and Rennie D. Rales, peripheral edema, retinal hemorrhage and acute mountain sickness. Am J Med 67 (1979) 214-218
12. Bärtsch P, Vock P, Maggiorini M, Franciolli M, Fretz C, Schobersberger W, et al. Respiratory symptoms, radiographic and physiologic correlations at high altitude. In: Decker, editor. Phyladelphia. Hypoxia: The Adaptation: JR Sutton, G Coates, JE Remmers; 1990.
13. Singh I., and Roy S.B. High altitude pulmonary edema: clinical, hemodynamic, and pathologic studies. In: Command UARaD (Ed). Biomedicine of high terrestrial elevation problems (1969) 108-120 Washington D.C.
14. Hultgren N.H., Lopez C.E., Lundberg E., and Miller H. Physiologic studies of pulmonary edema at high altitude. Circulation 29 (1964) 393-408
15. Kobayashi T., Koyama S., Kubo K.M.F., and Kusama S. Clinical features of patients with high altitude pulmonary edema in Japan. Chest 92 (1987) 814-821
16. Maggiorini M., Bärtsch P., and Oelz O. Association between raised body temperature and acute mountain sickness: a cross sectional study. BMJ 315 (1997) 403-404
17. Vock P., Fretz C., Franciolli M., and Bärtsch P. High altitude pulmonary edema: findings at high altitude chest radiography and physical examination. Radiology 170 (1989) 661-666
18. Houston C.S., and Dickinson J. Cerebral form of high-altitude illness. Lancet 2 (1975) 758-761
19. Koyama S., Kobayashi T., Kubo K., Fukushima M., Yoshimura K., Shibamoto T., et al. The increased sympathoadrenal activity in patients with high altitude pulmonary edema is centrally mediated. Jpn J Med 27 (1988) 10-16
20. Vock P., Brutsche M.H., Nanzer A., and Bärtsch P. Variable radiomorphologic data of high altitude pulmonary edema. Chest 100 (1991) 1306-1311
21. Kleger G.-R., Bärtsch P., Vock P., Heilig B., Roberts L.J., and Ballmer P.E. Evidence against an increase in capillary permeability in subjects exposed to high altitude. J Appl Physiol 81 (1996) 1917-1923
22. Swenson S., Maggiorini M., Mongovin S., Gibbs S., Greve I., Maierbaurl H., et al. High altitude pulmonary edema is a non-inflammatory high permeability leak of the alveolar-capillary barrier. JAMA 287 (2002) 2226-2235
23. Schoene R., Hackett P.H., Hederson W.R., Sage E.H., Chow M., Roach R.C., et al. High altitude pulmonary edema. Characteristics of lung lavage fluid. J Am Med Assoc 256 (1986) 63-69
24. Mosso A. Fisiologia dell'uomo sulle alpi. Milano: Fratelli Treves, Editori 1889.
25. Nayak N.C., Roy S., and Narayanan T.K. Pathologic features of altitude sickness. Am J Pathol 45 (1964) 381-391
26. Roy B.S., Guleria J.S., Khanna P.K., Manchanda S.C., Pande J.N., and Subba P.S. Haemodynamic studies in high altitude pulmonary edema. Br Heart J 31 (1969) 52-58
27. Penaloza D., and Sime F. Circulatory dynamics during high altitude pulmonary edema. Am J Cardiol 23 (1969) 368-378
28. Kronenberg R.G., Safar P., Wright F., Noble W., Wahrenbrock E., Hickey R., et al. Pulmonary artery pressure and alveolar gas exchange in men during acclimatization to 12,470 ft. J Clin Invest 50 (1971) 827-837
29. Hultgren H.N., Grover R.F., and Hartley L.H. Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation 44 (1971) 759-770
30. Maggiorini M., Mélot C., Pierre S., Pfeiffer F., Greve I., Sartori C., et al. High altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 103 (2001) 2078-2083
31. Oelz O., Maggiorini M., Ritter M., Waber U., Jenni R., Vock P., et al. Nifedipine for high altitude pulmonary oedema. Lancet 2 (1989) 1241-1244
32. Bärtsch P., Maggiorini M., Ritter M., Noti C., Vock P., and Oelz O. Prevention of high altitude pulmonary edema by nifedipine. N Engl J Med 325 (1991) 1284-1289
33. Maggiorini M., Brunner-La Rocca H.-P., Bärtsch P., Fischler M., Böhm T., Bloch K.E., et al. Dexamethasone and tadalafil prophylaxis prevents both excessive pulmonary constriction and high altitude pulmonary edema in susceptible subjects. Eur Respir J 24 Suppl 28 (2004) S110
34. Weir E.K., Lopez-Barneo J., Buckler K.J., and Archer S.L. Acute oxygen-sensing mechanisms. N Engl J Med 353 (2005) 2042-2055
35. Murray F., Insel P.A., and Yuan J.X. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol 151 (2006) 192-208
36. Gao Y., and Raj J.U. Role of veins in regulation of pulmonary circulation. Am J Phys 288 (2005 (Feb)) L213-L226
37. 2+ channels. High Alt Med Biol 6 (2005) 133-146
38. Johnson T.S., Rock P.B., Young J.B., Fulco C.S., and Trad L.A. Hemodynamic and sympathoadrenal responses to altitude in humans: effect of dexamethasone. Aviat Space Environ Med 59 (1988) 208-212
39. Bärtsch P., Shaw S., Franciolli M., Gnädinger M.P., and Weidmann P. Atrial natriuretic peptide in acute mountain sickness. J Appl Physiol 65 (1988) 1929-1937
40. Duplain H., Vollenweider L., Delabays A., Nicod P., Bartsch P., and Scherrer U. Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 99 (1999) 1713-1718
41. Goerre S., Wenk M., Bärtsch P., Lüscher T.F., Niroomand F., Hohenhaus E., et al. Endothelin-1 in pulmonary hypertension associated with high altitude exposure. Circulation 90 (1995) 359-364
42. Sartori C., Vollenweider L., Loffler B.M., Delabays A., Nicod P., Bartsch P., et al. Exaggerated endothelin release in high-altitude pulmonary edema. Circulation 99 (1999) 2665-2668
43. Berger M.M., Hesse C., Dehnert C., Siedler H., Kleinbongard P., Bardenheuer H.J., et al. Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema. Am J Respir Crit Care Med 172 (2005) 763-767
44. Duplain H., Sartori C., Lepori M., Egli M., Allemann Y., Nicod P., et al. Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am J Respir Crit Care Med 162 (2000) 221-224
45. Busch T., Bartsch P., Pappert D., Grunig E., Hildebrandt W., Elser H., et al. Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am J Respir Crit Care Med 163 (2001) 368-373
46. Weiss J., Haefeli W.E., Gasse C., Hoffmann M.M., Weyman J., Gibbs S., et al. Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the no pathway. High Alt Med Biol 4 (2003) 355-366
47. Droma Y., Hanaoka M., Ota M., Katsuyama Y., Koizumi T., Fujimoto K., et al. Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema. Circulation 106 (2002) 826-830
48. Hakim T.S., and Kelly S. Occlusion pressures vs. micropipette pressures in the pulmonary circulation. J Appl Physiol 67 (1989) 1277-1285
49. Homik L.A., Bshouty Z., Light R.B., and Younes M. Effect of alveolar hypoxia on pulmonary fluid filtration in in situ dog lungs. J Appl Physiol 65 (1988) 46-52
50. Drake R.E., Smith J.H., and Gabel J.C. Estimation of the filtration coefficient in intact dog lungs. Am J Physiol 238 (1980) H430-H438
51. Hultgren N.H. High altitude pulmonary edema. In: Staub N. (Ed). Lung water and solute exchange (1978), Marcel Dekker, New York 437-464
52. Hopkins S.R., Garg J., Bolar D.S., Balouch J., and Levin D.L. Pulmonary blood flow heterogeneity during hypoxia and high altitude pulmonary edema. Am J Respir Crit Care Med 14 (2004) 14
53. Hillier S.C., Graham J.A., Hanger C.C., Godbey P.S., Glenny R.W., and Wagner Jr. W.W. Hypoxic vasoconstriction in pulmonary arterioles and venules. J Appl Physiol 82 (1997) 1084-1090
54. Hlastala M.P., Lamm W.J., Karp A., Polissar N.L., Starr I.R., and Glenny R.W. Spatial distribution of hypoxic pulmonary vasoconstriction in the supine pig. J Appl Physiol 96 (2004) 1589-1599
55. Lamm W.J., Starr I.R., Neradilek B., Polissar N.L., Glenny R.W., and Hlastala M.P. Hypoxic pulmonary vasoconstriction is heterogeneously distributed in the prone dog. Respir Physiol Neurobiol 144 (2004) 281-294
56. Podolsky A., Eldridge M.W., Richardson R.S., Knight D.R., Johnson E.C., Hopkins S.R., et al. Exercise-induced Va/Q inequality in subjects with prior high-altitude pulmonary edema. J Appl Physiol 81 (1996) 922-932
57. Walker B.R. Evidence for uneven distribution of l-type calcium channels in rat pulmonary circulation. Am J Physiol 269 (1995) H2051-H2056
58. Weir E.K., Reeve H.L., Cornfield D.N., Tristani-Firouzi M., Peterson D.A., and Archer S.L. Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Kidney Int 51 (1997) 462-466
59. 2+ stores in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 289 (2005) L338-L348
60. Raj J.U., and Chen P. Micropuncture measurement of microvascular pressures in isolated lamb lungs during hypoxia. Circ Res 59 (1986) 398-404
61. Zhao Y., Packer C.S., and Rhoades R.A. Pulmonary vein contracts in response to hypoxia. Am J Physiol 265 (1993) L87-L92
62. Mitzner W., and Sylvester J.T. Hypoxic vasoconstriction and fluid filtration in pig lungs. J Appl Physiol 51 (1981) 1065-1071
63. Whayne Jr. T.F., and Severinghaus J.W. Experimental hypoxic pulmonary edema in the rat. J Appl Physiol 25 (1968) 729-732
64. West J.B., Tsukimoto K., Mathieu-Costello O., and Prediletto R. Stress failure in pulmonary capillaries. J Appl Physiol 70 (1991) 1731-1742
65. Bachofen H., Schurch S., and Weibel E.R. Experimental hydrostatic pulmonary edema in rabbit lungs. Barrier lesions. Am Rev Respir Dis 147 (1993) 997-1004
66. Bachofen H., Schurch S., Michel R.P., and Weibel E.R. Experimental hydrostatic pulmonary edema in rabbit lungs. Morphology. Am Rev Respir Dis 147 (1993) 989-996
67. Kubo K., Hanaoka M., Yamaguchi S., Hayano T., Hayasaka M., Koizumi T., et al. Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary edema at moderate altitude in Japan. Thorax 51 (1996) 739-742
68. Schutte H., Lohmeyer J., Rosseau S., Ziegler S., Siebert C., Kielisch H., et al. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur Respir J 9 (1996) 1858-1867
69. De Pasquale C.G., Arnolda L.F., Doyle I.R., Grant R.L., Aylward P.E., and Bersten A.D. Prolonged alveolocapillary barrier damage after acute cardiogenic pulmonary edema. Crit Care Med 31 (2003) 1060-1067
70. Zimmerman G.A., and Crapo R.O. Adult respiratory distress syndrome secondary to high altitude pulmonary edema. High Alt Med Biol 133 (1980) 335-337
71. Mairbaurl H., Schwobel F., Hoschele S., Maggiorini M., Gibbs S., Swenson E.R., et al. Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edema. J Appl Physiol 95 (2003) 1843-1850
72. Wodopia R., Ko H.S., Billian J., Wiesner R., Bartsch P., and Mairbaurl H. Hypoxia decreases proteins involved in epithelial electrolyte transport in a549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol 279 (2000) L1110-L1119
73. Planes C., Escoubet B., Blot-Chabaud M., Friedlander G., Farman N., and Clerici C. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 17 (1997) 508-518
74. Vivona M.L., Matthay M., Chabaud M.B., Friedlander G., and Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol 25 (2001) 554-561
75. Knowles M.R., Carson J.L., Collier A.M., Gatzy J.T., and Boucher R.C. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am Rev Respir Dis 124 (1981) 484-490
76. Mairbaurl H., Weymann J., Mohrlein A., Swenson E.R., Maggiorini M., Gibbs J.S., et al. Nasal potential difference at high altitude (4559 m): evidence for secretion. Am J Respir Crit Care Med 9 (2003) 9
77. Sartori C., Duplain H., Lepori M., Egli M., Maggiorini M., Nicod P., et al. High altitude impairs nasal transepithelial sodium transport in HAPE-prone subjects. Eur Respir J 23 (2004) 916-920
78. Sartori C., Allemann Y., Duplain H., Lepori M., Egli M., Lipp E., et al. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 346 (2002) 1631-1636
79. Perkins G.D., McAuley D.F., Thickett D.R., and Gao F. The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 173 (2006) 281-287
80. Groshaus H.E., Manocha S., Walley K.R., and Russell J.A. Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema. Crit Care 8 (2004) 234-242
81. Matthay M.A., and Abraham E. Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med 173 (2006) 254-255
82. Adding L.C., Agvald P., Artlich A., Persson M.G., and Gustafsson L.E. Beta-adrenoceptor agonist stimulation of pulmonary nitric oxide production in the rabbit. Br J Pharmacol 126 (1999) 833-839
83. Khimenko P.L., Barnard J.W., Moore T.M., Wilson P.S., Ballard S.T., and Taylor A.E. Vascular permeability and epithelial transport effects on lung edema formation in ischemia and reperfusion. J Appl Physiol 77 (1994) 1116-1121
84. Parker J.C., and Ivey C.L. Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 83 (1997) 1962-1967
85. McAuley D.F., Frank J.A., Fang X., and Matthay M.A. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med 32 (2004) 1470-1476
86. Maris N.A., de Vos A.F., Dessing M.C., Spek C.A., Lutter R., Jansen H.M., et al. Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers. Am J Respir Crit Care Med 172 (2005) 878-884
87. Bartsch P., and Roach R. Acute mountain sickness and high-altitude cerebral edema. In: Hornbein T.F., and Schoene R.B. (Eds). High altitude: an exploration of human adaptation (2001), Marcel Dekker, New York 731-776
88. Erba P., Anastasi S., Senn O., Maggiorirni M., and Bloch K.E. Acute mountain sickness is related to nocturnal hypoxemia but not to hypoventilation. Eur Respir J 24 (2004) 303-308
89. Hackett P.H., Roach R.C., Schoene R.B., Harrison G.L., and Mills Jr. W.J. Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol 64 (1988) 1268-1272
90. Matsuzawa Y., Fujimoto K., Kobayashi T., Namushi N.R., Harada K., Kohno H., et al. Blunted hypoxic ventilatory drive in subjects susceptible to high-altitude pulmonary edema. J Appl Physiol 66 (1989) 1152-1157
91. Hohenhaus E., Paul A., McCullough R.E., Kucherer H., and Bartsch P. Ventilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema. Eur Respir J 8 (1995) 1825-1833
92. Carpenter T.C., Reeves J.T., and Durmowicz A.G. Viral respiratory infection increases susceptibility of young rats to hypoxia-induced pulmonary edema. J Appl Physiol 84 (1998) 1048-1054
93. Durmowicz A.G., Noordeweir E., Nicholas R., and Reeves J.T. Inflammatory processes may predispose children to high-altitude pulmonary edema. J Pediatr 130 (1997) 838-840
94. Fiorenzano G., Rastelli V., Greco V., Di Stefano A., and Dottorini M. Unilateral high-altitude pulmonary edema in a subject with right pulmonary artery hypoplasia. Respiration 61 (1994) 51-54
95. Hackett P.H., Creagh C.E., Grover R.F., Honigman B., Houston C.S., Reeves J.T., et al. High altitude pulmonary edema in persons without the right pulmonary artery. N Engl J Med 302 (1980) 1070-1073
96. Hyers T.M., Fowler A.A., and Wicks A.B. Focal pulmonary edema after massive pulmonary embolism. Am Rev Respir Dis 123 (1981) 232-233
97. Nakagawa S., Kubo K., Koizumi T., Kobayashi T., and Sekiguchi M. High-altitude pulmonary edema with pulmonary thromboembolism. Chest 103 (1993) 948-950
98. Viswanathan R., Jain S.K., Subramanian S., Subramanian T.A.V., Dua G.L., and Giri J. Pulmonary edema of high altitude: II. Clinical, aerohemodynamic and biochemical studies in a group with history of pulmonary edema of high altitude. Am Rev Respir Dis 100 (1969) 334-349
99. Durmowicz A.G. Pulmonary edema in 6 children with Down syndrome during travel to moderate altitudes. Pediatrics 108 (2001) 443-447
100. Naeije R., De Backer D., Vachiery J.L., and De Vuyst P. High-altitude pulmonary edema with primary pulmonary hypertension. Chest 110 (1996) 286-289
101. Levine B.D., Grayburn P.A., Voyles W.F., Greene E.R., Roach R.C., and Hackett P.H. Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema. Ann Intern Med 114 (1991) 569-570
102. Eldridge M.W., Braun R.K., Yoneda K.Y., and Walby W.F. Effects of altitude and exercise on pulmonary capillary integrity: evidence for subclinical high-altitude pulmonary edema. J Appl Physiol 100 (2006) 972-980
103. Naeije R., Mélot C., Niset G., Delcroix M., and Wagner P.D. Improved arterial oxygenation by a pharmacological increase in chemosensitivity during hypoxic exercise in normal subjects. J Appl Physiol 78 (1993) 1666-1671
104. Reeves J.T., Dempsey J.A., and Grover R.F. Pulmonary circulation during exercise. In: Weir E.K., and Reeves J.T. (Eds). Pulmonary vascular physiology and pathophysiology (1989), Marcel Dekker, New York 107-133
105. Eldridge M.W., Podolsky A., Richardson R.S., Johnson D.H., Knight R.D., Johnson E.C., et al. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J Appl Physiol 81 (1996) 911-921
106. Ritter M., Jenni R., Maggiorini M., Grimm J., and Oelz O. Abnormal left ventricular diastolic filling patterns in acute hypoxic pulmonary hypertension at high altitude. Am J Noninvasive Cardiol 7 (1993) 33-38
107. Bartsch P., Mairbaurl H., Swenson E.R., and Maggiorini M. High altitude pulmonary oedema. Swiss Med Wkly 133 (2003) 377-384
108. Ghofrani H.A., Reichenberger F., Kohstall M.G., Mrosek E.H., Seeger T., Olschewski H., et al. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141 (2004) 169-177
109. Greene M.K., Kerr A.M., McIntosh I.B., and Prescott R.J. Acetazolamide in prevention of acute mountain sickness: a double-blind controlled cross-over study. Br Med J (Clin Res Ed) 283 (1981) 811-813
110. Basnyat B., Gertsch J.H., Johnson E.W., Castro-Marin F., Inoue Y., and Yeh C. Efficacy of low-dose acetazolamide (125 mg bid) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial. High Alt Med Biol 4 (2003) 45-52
111. Hohne C., Krebs M.O., Seiferheld M., Boemke W., Kaczmarczyk G., and Swenson E.R. Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs. J Appl Physiol 97 (2004) 515-521
112. Berg J.T., Ramanathan S., and Swenson E.R. Inhibitors of hypoxic pulmonary vasoconstriction prevent high-altitude pulmonary edema in rats. Wilderness Environ Med 15 (2004) 32-37
113. Rock P.B., Johnson T.S., Larsen R.F., Fulco C.S., Trad L.A., and Cymerman A. Dexamethasone as prophylaxis for acute mountain sickness. Effect of dose level. Chest 95 (1989) 568-573
114. Ellsworth A.J., Larson E.B., and Strickland D. A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis. Am J Med 83 (1987) 1024-1030
115. Murata T., Hori M., Sakamoto K., Karaki H., and Ozaki H. Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries. Am J Respir Crit Care Med 170 (2004) 647-655
116. 2+-dependent nitric oxide synthase activity in rat lung. Pediatr Res 48 (2000) 91-95
117. Scherrer U., Vollenweider P., Randin D., Jequier E., Nicod P., and Tappy L. Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans. Circulation 88 (1993) 388-394
118. Matthay M.A., Clerici C., and Saumon G. Invited review: active fluid clearance from the distal air spaces of the lung. J Appl Physiol 93 (2002) 1533-1541
119. Stelzner T.J., O'Brien R.F., Sato K., and Weil J.V. Hypoxia-induced increases in pulmonary transvascular protein escape in rats. Modulation by glucocorticoids. J Clin Invest 82 (1988) 1840-1847
120. Stenmark K.R., Davie N.J., Reeves J.T., and Frid M.G. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98 (2005) 715-721
121. Wang J.Y., Yeh T.F., Lin Y.C., Miyamura K., Holmskov U., and Reid K.B. Measurement of pulmonary status and surfactant protein levels during dexamethasone treatment of neonatal respiratory distress syndrome. Thorax 51 (1996) 907-913
122. Young S.L., and Silbajoris R. Dexamethasone increases adult rat lung surfactant lipids. J Appl Physiol 60 (1986) 1665-1672
123. King J.S., and Greenlee R.R. Successful use of the Gamow hyperbaric bag in the treatment of altitude illness at Mount Everest. J Wilderness Med 1 (1990) 193-202
124. Taber R.L. Protocols for the use of portable hyperbaric chamber for the treatment of high altitude disorders. J Wilderness Med 1 (1990) 181-192
125. Hultgren H.N., Honigman B., Theis K., and Nicholas D. High-altitude pulmonary edema at a ski resort. High Alt Med Biol 164 (1996) 222-227
126. Schoene R.B., Roach R.C., Hackett P.H., Harrison G., and Mills Jr. W.J. High altitude pulmonary edema and exercise at 4400 meters on Mount McKinley. Effect of expiratory positive airway pressure. Chest 87 (1985) 330-333
127. Larson E.B. Positive airway pressure for high-altitude pulmonary oedema. Lancet 1 (1985) 371-373
128. Oelz O. High altitude cerebral oedema after positive airway pressure breathing at high altitude. Lancet 2 (1983) 1148