Hypoxia reduces airway epithelial sodium transport in rats

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 277, Issue 5 21-5, 1999, Pages

  Tomlinson, L A ^a,b   Carpenter, T C ^a   Baker, E H ^b   Bridges, J B ^a   Weil, J V ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Ouabain; Transepithelial potential difference

Indexed keywords

AMILORIDE; OUABAIN;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; MALE; NONHUMAN; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; RAT; SODIUM ABSORPTION; SODIUM TRANSPORT;

EID: 0032785095     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.277.5.l881     Document Type: Article

References (22)

1. Alton, E. W., D. Currie, R. Logan-Sinclair, J. O. Warner, M. E. Hodson, and D. M. Geddes. Nasal potential difference: a clinical diagnostic test for cystic fibrosis. Eur. Respir. J. 3: 922-926, 1990.
2. Baker, E. H., X. Jeunemaitre, A. J. Portal, P. Grimbert, N. D. Markandu, A. Persu, P. Corvol, and G. A. MacGregor. Abnormalities of nasal potential difference measurement in Liddle's syndrome. J. Clin. Invest. 102: 10-14, 1998.
3. Baker, G. F., H. Llewellyn, and M. B. Segal. The electrical potential across the ovine nasal mucosa. J. Physiol. (Lond.) 293: 34P-35P, 1979.
4. Boucher, R. C. Human airway ion transport. Part one. Am. J. Respir. Crit. Care Med. 150: 271-281, 1994.
5. + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J. Clin. Invest. 78: 1245-1252, 1986.
6. DeAngelis, C., S. Farrace, L. Urbani, S. Porcu, C. Ferri, R. D'Amelio, A. Santucci, and F. Balsano. Effects of high altitude exposure on plasma and urinary digoxin-like immunoreactive substance. Am. J. Hypertens. 5: 600-607, 1992.
7. + channel along rat respiratory tract. Am. J. Physiol. 272 (Cell Physiol. 41): C131-C141, 1997.
8. 2 in man. Clin. Sci. (Colch.) 87: 447-451, 1994.
9. Ghosal, S., C. J. Taylor, and J. McGaw. Modification of nasal membrane potential difference with inhaled amiloride and loperamide in the cystic fibrosis (CF) mouse. Thorax 51: 1229-1232, 1996.
10. Knowles, M., G. Murray, J. Shallal, F. Askin, V. Ranga, J. Gatzy, and R. C. Boucher. Bioelectric properties and ion flow across excised human bronchi. J. Appl. Physiol. 56: 868-877, 1984.
11. Knowles, M. R., J. L. Carson, A. M. Collier, J. T. Gatzy, and R. C. Boucher. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am. Rev. Respir. Dis. 124: 484-490, 1981.
12. Knowles, M. R., M. J. Stutts, A. Spock, N. Fischer, J. T. Gatzy, and R. C. Boucher. Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science 221: 1067-1070, 1983.
13. Matsushita, K., P. B. McCray, Jr., R. D. Sigmund, M. J. Welsh, and J. B. Stokes. Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L332-L339, 1996.
14. Melville, G. N. Chloride and sodium fluxes across rat tracheal epithelium in health and disease. Respiration 43: 432-435, 1982.
15. Otulakowski, G., S. Fluecker-Staub, L. Ellis, K. Ramlall, O. Staub, D. Smith, P. Durie, and H. O'Brodovich. Relation between α, β, and γ human amiloride-sensitive epithelial Na channel mRNA levels and nasal epithelial potential difference in healthy men. Am. J. Respir. Crit. Care Med. 157: 1213-1220, 1998.
16. Ou, L. C., S. Salceda, S. J. Schuster, L. M. Dunnack, T. Brink-Johnsen, J. Chen, and J. C. Leiter. Polycythemic responses to hypoxia: molecular and genetic mechanisms of chronic mountain sickness. J. Appl. Physiol. 84: 1242-1251, 1998.
17. Pinter, E., J. A. Peyman, K. Snow, J. D. Jamieson, and J. B. Warshaw. Effects of maternal diabetes on fetal rat lung ion transport. Contribution of alveolar and bronchiolar epithelial cells to Na+,K(+)-ATPase expression. J. Clin. Invest. 87: 821-830, 1991.
18. Planes, C., B. Escoubet, M. Blot-Chabaud, G. Friedlander, N. Farman, and C. Clerici. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 17: 508-518, 1997.
19. Planes, C., G. Friedlander, A. Loiseau, C. Amiel, and C. Clerici. Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L70-L78, 1996.
20. Stewart, E. J., M. J. Cinnamond, P. Nicholls, and C. F. Stanford. The effects of diuretics on nasal transmucosal potential difference. Clin. Otolaryngol. 17: 351-353, 1992.
21. Suzuki, S., T. Sakuma, M. Sugita, Y. Hoshikawa, M. Noda, S. Ono, T. Tanita, and S. Fujimura. Subacute hypoxic challenge decreases alveolar fluid clearance (Abstract). Am. J. Respir. Cell Mol. Biol. 153: A505, 1996.
22. Talbot, C., D. Bosworth, E. Briley, D. Fenstermacher, R. C. Boucher, S. Gabriel, and P. Barker. Quantitation and localization of ENaC subunit expression in fetal, newborn, and adult mouse lung. Am. J. Respir. Cell Mol. Biol. 20: 398-406, 1998.