메뉴 건너뛰기




Volumn 97, Issue 4, 2013, Pages 1489-1500

Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health

Author keywords

Antiosteoporosis; Ovariectomized model; Phytoestrogens; Postmenopausal

Indexed keywords

ALKALINE PHOSPHATASE; ANTI-ESTROGENIC; ANTIOSTEOPOROSIS; BENEFICIAL EFFECTS; BIOACTIVE COMPOUNDS; BONE FORMATION; BONE MINERAL DENSITY; BONE RESORPTION; IN-VITRO; INTERVENTION STUDIES; LIGAND RATIO; MC3T3-E1; MECHANISTIC STUDIES; MICE MODELS; MICROFLORA; MODE OF ACTION; MURINE MODEL; NUCLEAR FACTOR KAPPAB; OSTEOBLAST-LIKE CELLS; OSTEOCALCIN; OSTEOPONTIN; OSTEOPROTEGERIN; PHYTOESTROGENS; POSTMENOPAUSAL; PROTEIN SYNTHESIS; PYRIDINOLINE; TARTRATE-RESISTANT ACID PHOSPHATASE;

EID: 84874353020     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4675-y     Document Type: Review
Times cited : (43)

References (104)
  • 1
    • 80052596093 scopus 로고    scopus 로고
    • Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells
    • 1:CAS:528:DC%2BC3MXhtlaqtLrP
    • Alcantara EH, Shin MY, Sohn HY, Park YM, Kim T, Lim JH, Jeong HJ, Kwon ST, Kwun IS (2011) Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. J Nutr Biochem 22:1055-1063
    • (2011) J Nutr Biochem , vol.22 , pp. 1055-1063
    • Alcantara, E.H.1    Shin, M.Y.2    Sohn, H.Y.3    Park, Y.M.4    Kim, T.5    Lim, J.H.6    Jeong, H.J.7    Kwon, S.T.8    Kwun, I.S.9
  • 3
    • 0034674705 scopus 로고    scopus 로고
    • Absorption and metabolism of genistin in the isolated rat small intestine
    • 1:CAS:528:DC%2BD3cXktVSntbY%3D
    • Andlauer W, Kolb J, Fürst P (2000a) Absorption and metabolism of genistin in the isolated rat small intestine. FEBS Lett 475:127-130
    • (2000) FEBS Lett , vol.475 , pp. 127-130
    • Andlauer, W.1    Kolb, J.2    Fürst, P.3
  • 4
    • 0034019760 scopus 로고    scopus 로고
    • Absorption and metabolism of genistein in isolated rat small intestine
    • 1:CAS:528:DC%2BD3cXit1KnurY%3D
    • Andlauer W, Kolb J, Stehle P, Fürst P (2000b) Absorption and metabolism of genistein in isolated rat small intestine. J Nutr 130:843-846
    • (2000) J Nutr , vol.130 , pp. 843-846
    • Andlauer, W.1    Kolb, J.2    Stehle, P.3    Fürst, P.4
  • 5
    • 0036895683 scopus 로고    scopus 로고
    • Beneficial role of dietary phytoestrogens in obesity and diabetes
    • 1:CAS:528:DC%2BD38Xpt1emtrs%3D
    • Bhathena SJ, Velasquez MT (2002) Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 76:1191-1201
    • (2002) Am J Clin Nutr , vol.76 , pp. 1191-1201
    • Bhathena, S.J.1    Velasquez, M.T.2
  • 7
    • 0348107337 scopus 로고    scopus 로고
    • Dietary phyto-oestrogens and bone health
    • 1:CAS:528:DC%2BD2cXmt1Grsw%3D%3D
    • Branca F (2003) Dietary phyto-oestrogens and bone health. Proc Nutr Soc 62:877-887
    • (2003) Proc Nutr Soc , vol.62 , pp. 877-887
    • Branca, F.1
  • 8
    • 43249086703 scopus 로고    scopus 로고
    • Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice
    • 1:CAS:528:DC%2BD1cXltFyjtbc%3D
    • Cano A, Dapía S, Noguera I, Pineda B, Hermenegildo C, del Val R, Caeiro JR, García-Pérez MA (2008) Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice. Osteoporos Int 19:793-800
    • (2008) Osteoporos Int , vol.19 , pp. 793-800
    • Cano, A.1    Dapía, S.2    Noguera, I.3    Pineda, B.4    Hermenegildo, C.5    Del Val, R.6    Caeiro, J.R.7    García-Pérez, M.A.8
  • 9
    • 80053469650 scopus 로고    scopus 로고
    • Estimated dietary phytoestrogen intake and major food sources among women during the year before pregnancy
    • 1:CAS:528:DC%2BC3MXhs1ensLjP
    • Carmichael SL, Gonzalez-Feliciano AG, Ma C, Shaw GM, Cogswell ME (2011) Estimated dietary phytoestrogen intake and major food sources among women during the year before pregnancy. Nutr J 10:105-114
    • (2011) Nutr J , vol.10 , pp. 105-114
    • Carmichael, S.L.1    Gonzalez-Feliciano, A.G.2    Ma, C.3    Shaw, G.M.4    Cogswell, M.E.5
  • 10
    • 0037626862 scopus 로고    scopus 로고
    • Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation
    • 1:CAS:528:DC%2BD3sXlsVahu7w%3D
    • Chen X, Garner SC, Quarles LD, Anderson JJ (2003) Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation. J Nutr Biochem 14:342-349
    • (2003) J Nutr Biochem , vol.14 , pp. 342-349
    • Chen, X.1    Garner, S.C.2    Quarles, L.D.3    Anderson, J.J.4
  • 11
    • 12144271052 scopus 로고    scopus 로고
    • Absorption and metabolism of genistein and its five isoflavone analogs in human intestinal Caco-2 model
    • 1:CAS:528:DC%2BD2cXhtVGgtL3P
    • Chen J, Lin H, Hu M (2005) Absorption and metabolism of genistein and its five isoflavone analogs in human intestinal Caco-2 model. Cancer Chemother Pharmacol 55:159-169
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 159-169
    • Chen, J.1    Lin, H.2    Hu, M.3
  • 12
    • 70449708897 scopus 로고    scopus 로고
    • Site-specific bone loss in senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis
    • 1:CAS:528:DC%2BD1MXhsVynt7vK
    • Chen H, Zhou X, Emura S, Shoumura S (2009) Site-specific bone loss in senescence-accelerated mouse (SAMP6): a murine model for senile osteoporosis. Exp Gerontol 44:792-798
    • (2009) Exp Gerontol , vol.44 , pp. 792-798
    • Chen, H.1    Zhou, X.2    Emura, S.3    Shoumura, S.4
  • 13
    • 79960594662 scopus 로고    scopus 로고
    • Antiosteoporotic effects of Lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice
    • 1:CAS:528:DC%2BC3MXnslKjtLs%3D
    • Chiang SS, Pan TM (2011) Antiosteoporotic effects of Lactobacillus- fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice. J Agric Food Chem 59:7734-7742
    • (2011) J Agric Food Chem , vol.59 , pp. 7734-7742
    • Chiang, S.S.1    Pan, T.M.2
  • 14
    • 80052566343 scopus 로고    scopus 로고
    • Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis
    • 1:CAS:528:DC%2BC3MXpvFSnsLg%3D
    • Chiang SS, Chang SP, Pan TM (2011) Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis. J Agric Food Chem 59:9150-9157
    • (2011) J Agric Food Chem , vol.59 , pp. 9150-9157
    • Chiang, S.S.1    Chang, S.P.2    Pan, T.M.3
  • 15
    • 83255194119 scopus 로고    scopus 로고
    • Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice
    • 1:CAS:528:DC%2BC3MXhsFOitbjF
    • Chiang SS, Liao JW, Pan TM (2012) Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice. J Sci Food Agric 92:328-335
    • (2012) J Sci Food Agric , vol.92 , pp. 328-335
    • Chiang, S.S.1    Liao, J.W.2    Pan, T.M.3
  • 17
    • 0037042498 scopus 로고    scopus 로고
    • Treatment of postmenopausal osteoporosis
    • 1:CAS:528:DC%2BD38XksFKkt7g%3D
    • Delmas PD (2002) Treatment of postmenopausal osteoporosis. Lancet 359:2018-2026
    • (2002) Lancet , vol.359 , pp. 2018-2026
    • Delmas, P.D.1
  • 18
    • 0030921703 scopus 로고    scopus 로고
    • Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats
    • 1:CAS:528:DyaK2sXlvFGht70%3D
    • Draper CR, Edel MJ, Dick IM, Randall AG, Martin GB, Prince RL (1997) Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. J Nutr 127:1795-1799
    • (1997) J Nutr , vol.127 , pp. 1795-1799
    • Draper, C.R.1    Edel, M.J.2    Dick, I.M.3    Randall, A.G.4    Martin, G.B.5    Prince, R.L.6
  • 20
    • 26944488042 scopus 로고    scopus 로고
    • Animal models for fracture treatment in osteoporosis
    • Egermann M, Goldhahn J, Schneider E (2005) Animal models for fracture treatment in osteoporosis. Osteoporos Int 16:S129-S138
    • (2005) Osteoporos Int , vol.16
    • Egermann, M.1    Goldhahn, J.2    Schneider, E.3
  • 21
    • 0035543669 scopus 로고    scopus 로고
    • Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage
    • 1:CAS:528:DC%2BD38XivVymsA%3D%3D
    • Emmanuel S, Amalraj T, Ignacimuthu S (2001) Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage. Indian J Exp Biol 39:1305-1307
    • (2001) Indian J Exp Biol , vol.39 , pp. 1305-1307
    • Emmanuel, S.1    Amalraj, T.2    Ignacimuthu, S.3
  • 23
    • 3242661873 scopus 로고    scopus 로고
    • Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice
    • 1:CAS:528:DC%2BD2cXmtVWit7Y%3D
    • Fonseca D, Ward WE (2004) Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Bone 35:489-497
    • (2004) Bone , vol.35 , pp. 489-497
    • Fonseca, D.1    Ward, W.E.2
  • 26
    • 0035985804 scopus 로고    scopus 로고
    • The role of statins as potential targets for bone formation
    • Garrett IR, Mundy GR (2002) The role of statins as potential targets for bone formation. Arthritis Res 4:237-240
    • (2002) Arthritis Res , vol.4 , pp. 237-240
    • Garrett, I.R.1    Mundy, G.R.2
  • 27
    • 0032900043 scopus 로고    scopus 로고
    • Calcitonin, bone-active isoflavones and vitamin D metabolites
    • Gennari C (1999) Calcitonin, bone-active isoflavones and vitamin D metabolites. Osteoporos Int 9:S81-S90
    • (1999) Osteoporos Int , vol.9
    • Gennari, C.1
  • 28
    • 79955006421 scopus 로고    scopus 로고
    • Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo
    • Gong G, Qin Y, Huang W (2011) Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo. Phytomedicine 18:456-463
    • (2011) Phytomedicine , vol.18 , pp. 456-463
    • Gong, G.1    Qin, Y.2    Huang, W.3
  • 30
    • 58649096568 scopus 로고    scopus 로고
    • Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats
    • 1:CAS:528:DC%2BD1MXhtVCgtLs%3D
    • Hertrampf T, Schleipen B, Offermanns C, Velders M, Laudenbach U, Diel P (2009) Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats. Toxicol Lett 184:198-203
    • (2009) Toxicol Lett , vol.184 , pp. 198-203
    • Hertrampf, T.1    Schleipen, B.2    Offermanns, C.3    Velders, M.4    Laudenbach, U.5    Diel, P.6
  • 31
    • 33645160437 scopus 로고    scopus 로고
    • Statins and bone metabolism
    • Horiuchi N, Maeda T (2006) Statins and bone metabolism. Oral Dis 15:85-101
    • (2006) Oral Dis , vol.15 , pp. 85-101
    • Horiuchi, N.1    Maeda, T.2
  • 32
    • 47349108514 scopus 로고    scopus 로고
    • Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats
    • Hsu KH, Chang CC, Tsai HD, Tsai FJ, Hsieh YY (2008) Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats. Taiwan J Obstet Gynecol 47:180-186
    • (2008) Taiwan J Obstet Gynecol , vol.47 , pp. 180-186
    • Hsu, K.H.1    Chang, C.C.2    Tsai, H.D.3    Tsai, F.J.4    Hsieh, Y.Y.5
  • 33
    • 77954082015 scopus 로고    scopus 로고
    • Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy
    • 1:CAS:528:DC%2BC3cXlvFOjsLs%3D
    • Huang CH, Liu DZ, Jan TR (2010) Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy. J Nat Prod 73:1033-1037
    • (2010) J Nat Prod , vol.73 , pp. 1033-1037
    • Huang, C.H.1    Liu, D.Z.2    Jan, T.R.3
  • 34
    • 67650242711 scopus 로고    scopus 로고
    • Soybean isoflavones in bone health
    • 1:CAS:528:DC%2BD1MXhtFegsbfL
    • Ishimi Y (2009) Soybean isoflavones in bone health. Forum Nutr Basel Karger 61:104-116
    • (2009) Forum Nutr Basel Karger , vol.61 , pp. 104-116
    • Ishimi, Y.1
  • 35
    • 77953738875 scopus 로고    scopus 로고
    • Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice
    • 1:CAS:528:DC%2BC3cXot1agur4%3D
    • Ishimi Y (2010) Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice. J Nutr 140:1373S-1376S
    • (2010) J Nutr , vol.140
    • Ishimi, Y.1
  • 37
    • 33745488185 scopus 로고    scopus 로고
    • Strain-dependent variations in the response of cancellous bone to ovariectomy in mice
    • 1:CAS:528:DC%2BD28XntlWqurg%3D
    • Iwaniec UT, Yuan D, Power RA, Wronski TJ (2006) Strain-dependent variations in the response of cancellous bone to ovariectomy in mice. J Bone Miner Res 21:1068-1074
    • (2006) J Bone Miner Res , vol.21 , pp. 1068-1074
    • Iwaniec, U.T.1    Yuan, D.2    Power, R.A.3    Wronski, T.J.4
  • 38
    • 0030964587 scopus 로고    scopus 로고
    • The socioeconomic burden of fractures: Today and in the 21st century
    • 1:STN:280:DyaK2svkvVGlug%3D%3D
    • Johnell O (1997) The socioeconomic burden of fractures: today and in the 21st century. Am J Med 103:20S-26S
    • (1997) Am J Med , vol.103
    • Johnell, O.1
  • 39
    • 1242338858 scopus 로고    scopus 로고
    • Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells
    • 1:CAS:528:DC%2BD2cXhtV2ltbg%3D
    • Kanno S, Hirano S, Kayama F (2004) Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells. Toxicology 196:137-145
    • (2004) Toxicology , vol.196 , pp. 137-145
    • Kanno, S.1    Hirano, S.2    Kayama, F.3
  • 41
    • 33847660965 scopus 로고    scopus 로고
    • Osteoporosis: Strategies for prevention and management
    • Keen R (2007) Osteoporosis: strategies for prevention and management. Best Pract Res Clin Rheumatol 21:109-122
    • (2007) Best Pract Res Clin Rheumatol , vol.21 , pp. 109-122
    • Keen, R.1
  • 42
    • 36448972263 scopus 로고    scopus 로고
    • Effect of safflower seeds supplementation on stimulation of the proliferation, differentiation and mineralization of osteoblastic MC3T3-E1 cells
    • Kim KW, Suh SJ, Lee TK, Ha KT, Kim JK, Kim KH, Kim DI, Jeon JH, Moon TC, Kim CH (2008) Effect of safflower seeds supplementation on stimulation of the proliferation, differentiation and mineralization of osteoblastic MC3T3-E1 cells. J Ethnopharmacol 115:42-49
    • (2008) J Ethnopharmacol , vol.115 , pp. 42-49
    • Kim, K.W.1    Suh, S.J.2    Lee, T.K.3    Ha, K.T.4    Kim, J.K.5    Kim, K.H.6    Kim, D.I.7    Jeon, J.H.8    Moon, T.C.9    Kim, C.H.10
  • 44
    • 78649931136 scopus 로고    scopus 로고
    • The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss
    • 1:CAS:528:DC%2BC3cXhsFGhtbnI
    • Kim TH, Jung JW, Ha BG, Hong JM, Park EK, Kim HJ, Kim SY (2011) The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem 22:8-15
    • (2011) J Nutr Biochem , vol.22 , pp. 8-15
    • Kim, T.H.1    Jung, J.W.2    Ha, B.G.3    Hong, J.M.4    Park, E.K.5    Kim, H.J.6    Kim, S.Y.7
  • 45
    • 84865996852 scopus 로고    scopus 로고
    • Synergistic effect of isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats
    • 1:CAS:528:DC%2BC38Xhs1ars7fL
    • Kimira Y, Tajima K, Ohta A, Ishimi Y, Katsumata S, Suzuki K, Adlercreutz H, Uehara M (2012) Synergistic effect of isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats. J Clin Biochem Nutr 51:156-160
    • (2012) J Clin Biochem Nutr , vol.51 , pp. 156-160
    • Kimira, Y.1    Tajima, K.2    Ohta, A.3    Ishimi, Y.4    Katsumata, S.5    Suzuki, K.6    Adlercreutz, H.7    Uehara, M.8
  • 46
    • 50949113691 scopus 로고    scopus 로고
    • The magnitude and rate of bone loss in ovariectomized mice differs among inbred strains as determined by longitudinal in vivo micro-computed tomography
    • 1:CAS:528:DC%2BD1cXhtVSgurjI
    • Klinck J, Boyd SK (2008) The magnitude and rate of bone loss in ovariectomized mice differs among inbred strains as determined by longitudinal in vivo micro-computed tomography. Cif Tissue Int 83:70-79
    • (2008) Cif Tissue Int , vol.83 , pp. 70-79
    • Klinck, J.1    Boyd, S.K.2
  • 49
    • 26444612089 scopus 로고    scopus 로고
    • Biochanin A stimulates osteoblastic differentiation and inhibits hydrogen peroxide-induced production of inflammatory mediators in MC3T3-E1 cells
    • 1:CAS:528:DC%2BD2MXht1Wqt7bJ
    • Lee KH, Choi EM (2005) Biochanin A stimulates osteoblastic differentiation and inhibits hydrogen peroxide-induced production of inflammatory mediators in MC3T3-E1 cells. Biol Pharm Bull 28:1948-1953
    • (2005) Biol Pharm Bull , vol.28 , pp. 1948-1953
    • Lee, K.H.1    Choi, E.M.2
  • 52
    • 0036201358 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perfused rat intestinal model
    • 1:CAS:528:DC%2BD38Xis1Ols7Y%3D
    • Liu Y, Hu M (2002) Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perfused rat intestinal model. Drug Metab Dispos 30:370-377
    • (2002) Drug Metab Dispos , vol.30 , pp. 370-377
    • Liu, Y.1    Hu, M.2
  • 55
    • 0032839807 scopus 로고    scopus 로고
    • Legumes and soybeans: Overview of their nutritional profiles and health effects
    • 1:CAS:528:DyaK1MXmtVaju7s%3D
    • Messina MJ (1999) Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr 70:439S-450S
    • (1999) Am J Clin Nutr , vol.70
    • Messina, M.J.1
  • 56
    • 84930481252 scopus 로고    scopus 로고
    • Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway
    • 1:CAS:528:DC%2BC38XhtVegt7%2FI
    • Michihara S, Tanaka T, Uzawa Y, Moriyama T, Kawamura Y (2012) Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. J Nutr Sci Vitaminol 58:202-209
    • (2012) J Nutr Sci Vitaminol , vol.58 , pp. 202-209
    • Michihara, S.1    Tanaka, T.2    Uzawa, Y.3    Moriyama, T.4    Kawamura, Y.5
  • 58
    • 11844251380 scopus 로고    scopus 로고
    • Office of the Surgeon General (US) Office of the Surgeon General (US) Rockville, MD
    • Office of the Surgeon General (US) (2004) Bone health and osteoporosis: a report of the surgeon general. Office of the Surgeon General (US), Rockville, MD, pp 1-404
    • (2004) Bone Health and Osteoporosis: A Report of the Surgeon General , pp. 1-404
  • 59
    • 48749084087 scopus 로고    scopus 로고
    • Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures
    • 1:CAS:528:DC%2BD1cXhtFWmsLnP
    • Ohtomo T, Uehara M, Peñalvo JL, Adlercreutz H, Katsumata S, Suzuki K, Takeda K, Masuyama R, Ishimi Y (2008) Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures. Eur J Nutr 47:273-279
    • (2008) Eur J Nutr , vol.47 , pp. 273-279
    • Ohtomo, T.1    Uehara, M.2    Peñalvo, J.L.3    Adlercreutz, H.4    Katsumata, S.5    Suzuki, K.6    Takeda, K.7    Masuyama, R.8    Ishimi, Y.9
  • 60
    • 45749138429 scopus 로고    scopus 로고
    • Beneficial effects of Ajuga decumbens on osteoporosis and arthritis
    • 1:CAS:528:DC%2BD1cXpsVyjtLc%3D
    • Ono Y, Fukaya Y, Imai S, Yamakuni T (2008) Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol Pharm Bull 31:1199-1204
    • (2008) Biol Pharm Bull , vol.31 , pp. 1199-1204
    • Ono, Y.1    Fukaya, Y.2    Imai, S.3    Yamakuni, T.4
  • 61
    • 0031719627 scopus 로고    scopus 로고
    • Effects of calcium and vitamin D insufficiency on the skeleton
    • 1:CAS:528:DyaK1cXmvFahtb0%3D
    • Peacock M (1998) Effects of calcium and vitamin D insufficiency on the skeleton. Osteoporos Int 8:S45-S51
    • (1998) Osteoporos Int , vol.8
    • Peacock, M.1
  • 63
    • 36048990376 scopus 로고    scopus 로고
    • Effects of dietary equol administration on ovariectomy induced bone loss in Sprague-Dawley rats
    • Rachoń D, Seidlová-Wuttke D, Vortherms T, Wuttke W (2007) Effects of dietary equol administration on ovariectomy induced bone loss in Sprague-Dawley rats. Maturitas 58:308-315
    • (2007) Maturitas , vol.58 , pp. 308-315
    • Rachoń, D.1    Seidlová-Wuttke, D.2    Vortherms, T.3    Wuttke, W.4
  • 64
    • 34247356121 scopus 로고    scopus 로고
    • Protective effects of sodium daidzein sulfonate on trabecular bone in ovariectomized rats
    • 1:CAS:528:DC%2BD2sXktlSlt7s%3D
    • Ren P, Ji H, Shao Q, Chen X, Han J, Sun Y (2007) Protective effects of sodium daidzein sulfonate on trabecular bone in ovariectomized rats. Pharmacology 79:129-136
    • (2007) Pharmacology , vol.79 , pp. 129-136
    • Ren, P.1    Ji, H.2    Shao, Q.3    Chen, X.4    Han, J.5    Sun, Y.6
  • 65
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: Estrogen deficiency causes both type i and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
    • 1:STN:280:DyaK1c3nt1aksg%3D%3D
    • Riggs BL, Khosla S, Melton LJ (1998) A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13:763-773
    • (1998) J Bone Miner Res , vol.13 , pp. 763-773
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 66
    • 0033011895 scopus 로고    scopus 로고
    • Dietary isoflavones: Biological effects and relevance to human health
    • 1:CAS:528:DyaK1MXhvFals70%3D
    • Setchell KD, Cassidy A (1999) Dietary isoflavones: biological effects and relevance to human health. J Nutr 129:758S-767S
    • (1999) J Nutr , vol.129
    • Setchell, K.D.1    Cassidy, A.2
  • 67
    • 84864754756 scopus 로고    scopus 로고
    • Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)
    • 1:CAS:528:DC%2BC38XhtFSlsbnL
    • Simons R, Gruppen H, Bovee TF, Verbruggen MA, Vincken JP (2012) Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs). Food Funct 3:810-827
    • (2012) Food Funct , vol.3 , pp. 810-827
    • Simons, R.1    Gruppen, H.2    Bovee, T.F.3    Verbruggen, M.A.4    Vincken, J.P.5
  • 69
    • 37649008319 scopus 로고    scopus 로고
    • Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats
    • 1:CAS:528:DC%2BD1cXktVGqtQ%3D%3D
    • Son IS, Kim JH, Sohn HY, Son KH, Kim JS, Kwon CS (2007) Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci Biotechnol Biochem 71:3063-3071
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 3063-3071
    • Son, I.S.1    Kim, J.H.2    Sohn, H.Y.3    Son, K.H.4    Kim, J.S.5    Kwon, C.S.6
  • 70
    • 0033966168 scopus 로고    scopus 로고
    • Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells
    • 1:CAS:528:DC%2BD3cXltVGqsw%3D%3D
    • Sugimoto E, Yamaguchi M (2000) Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells. Biochem Pharmacol 59:471-475
    • (2000) Biochem Pharmacol , vol.59 , pp. 471-475
    • Sugimoto, E.1    Yamaguchi, M.2
  • 71
    • 0037652137 scopus 로고    scopus 로고
    • Soybean isoflavones inhibit tumor necrosis factor-alpha-induced apoptosis and the production of interleukin-6 and prostaglandin E2 in osteoblastic cells
    • 1:CAS:528:DC%2BD3sXjtFWhtbk%3D
    • Suh KS, Koh G, Park CY, Woo JT, Kim SW, Kim JW, Park IK, Kim YS (2003) Soybean isoflavones inhibit tumor necrosis factor-alpha-induced apoptosis and the production of interleukin-6 and prostaglandin E2 in osteoblastic cells. Phytochemistry 63:209-215
    • (2003) Phytochemistry , vol.63 , pp. 209-215
    • Suh, K.S.1    Koh, G.2    Park, C.Y.3    Woo, J.T.4    Kim, S.W.5    Kim, J.W.6    Park, I.K.7    Kim, Y.S.8
  • 72
    • 65249110392 scopus 로고    scopus 로고
    • Kaempferol attenuates 2-deoxy-d-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells
    • 1:CAS:528:DC%2BD1MXmsVansL0%3D
    • Suh KS, Choi EM, Kwon M, Chon S, Oh S, Woo JT, Kim SW, Kim JW, Kim YS (2009) Kaempferol attenuates 2-deoxy-d-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol Pharm Bull 32:746-749
    • (2009) Biol Pharm Bull , vol.32 , pp. 746-749
    • Suh, K.S.1    Choi, E.M.2    Kwon, M.3    Chon, S.4    Oh, S.5    Woo, J.T.6    Kim, S.W.7    Kim, J.W.8    Kim, Y.S.9
  • 73
    • 33750112615 scopus 로고    scopus 로고
    • Comparative effects of milk and soymilk on bone loss in adult ovariectomized osteoporosis rat
    • 1:CAS:528:DC%2BD28XpvVOntrs%3D
    • Taguchi H, Chen H, Yano R, Shoumura S (2006) Comparative effects of milk and soymilk on bone loss in adult ovariectomized osteoporosis rat. Okajimas Folia Anat Jpn 83:53-59
    • (2006) Okajimas Folia Anat Jpn , vol.83 , pp. 53-59
    • Taguchi, H.1    Chen, H.2    Yano, R.3    Shoumura, S.4
  • 74
    • 0025745357 scopus 로고
    • Mammalian lignan production from various foods
    • 1:CAS:528:DyaK38Xht1Onu74%3D
    • Thompson LU, Robb P, Serraino M, Cheung F (1991) Mammalian lignan production from various foods. Nutr Cancer 16:43-52
    • (1991) Nutr Cancer , vol.16 , pp. 43-52
    • Thompson, L.U.1    Robb, P.2    Serraino, M.3    Cheung, F.4
  • 76
    • 33748188128 scopus 로고    scopus 로고
    • Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    • 1:CAS:528:DC%2BD28XpvFOluro%3D
    • Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N (2006) Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 54:184-201
    • (2006) Nutr Cancer , vol.54 , pp. 184-201
    • Thompson, L.U.1    Boucher, B.A.2    Liu, Z.3    Cotterchio, M.4    Kreiger, N.5
  • 77
    • 80052969466 scopus 로고    scopus 로고
    • Resistant starch promotes equol production and inhibits tibial bone loss in ovariectomized mice treated with daidzein
    • 1:CAS:528:DC%2BC3MXhtFyns7fF
    • Tousen Y, Abe F, Ishida T, Uehara M, Ishimi Y (2011) Resistant starch promotes equol production and inhibits tibial bone loss in ovariectomized mice treated with daidzein. Metabolism 60:1425-1432
    • (2011) Metabolism , vol.60 , pp. 1425-1432
    • Tousen, Y.1    Abe, F.2    Ishida, T.3    Uehara, M.4    Ishimi, Y.5
  • 79
    • 0032924732 scopus 로고    scopus 로고
    • Mice, estrogen and postmenopausal osteoporosis
    • 1:STN:280:DyaK1M7jt1Gguw%3D%3D
    • Turner RT (1999) Mice, estrogen and postmenopausal osteoporosis. J Bone Miner Res 14:187-191
    • (1999) J Bone Miner Res , vol.14 , pp. 187-191
    • Turner, R.T.1
  • 80
    • 33847781830 scopus 로고    scopus 로고
    • Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells
    • 1:CAS:528:DC%2BD2sXhvFClu7g%3D
    • Uchiyama S, Yamaguchi M (2007) Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells. Int J Mol Med 19:213-220
    • (2007) Int J Mol Med , vol.19 , pp. 213-220
    • Uchiyama, S.1    Yamaguchi, M.2
  • 81
    • 36949004530 scopus 로고    scopus 로고
    • Anabolic effect of beta-cryptoxanthin in osteoblastic MC3T3-E1 cells is enhanced with 17beta-estradiol, genistein, or zinc sulfate in vitro: The unique effect with zinc on Runx2 and alpha1(I) collagen mRNA expressions
    • 1:CAS:528:DC%2BD2sXhtlOqsLzL
    • Uchiyama S, Yamaguchi M (2008) Anabolic effect of beta-cryptoxanthin in osteoblastic MC3T3-E1 cells is enhanced with 17beta-estradiol, genistein, or zinc sulfate in vitro: the unique effect with zinc on Runx2 and alpha1(I) collagen mRNA expressions. Mol Cell Biochem 307:209-219
    • (2008) Mol Cell Biochem , vol.307 , pp. 209-219
    • Uchiyama, S.1    Yamaguchi, M.2
  • 82
    • 33645000494 scopus 로고    scopus 로고
    • Pharmaceutical prospects of phytoestrogens
    • 1:CAS:528:DC%2BD28XltVGhtL4%3D
    • Usui T (2006) Pharmaceutical prospects of phytoestrogens. Endocr J 53:7-20
    • (2006) Endocr J , vol.53 , pp. 7-20
    • Usui, T.1
  • 83
    • 33751158078 scopus 로고
    • Isoflavone content in commercial soybean foods
    • 1:CAS:528:DyaK2cXltVKqtbs%3D
    • Wang HJ, Murphy PA (1994) Isoflavone content in commercial soybean foods. J Agric Food Chem 42:1666-1673
    • (1994) J Agric Food Chem , vol.42 , pp. 1666-1673
    • Wang, H.J.1    Murphy, P.A.2
  • 84
    • 21744450580 scopus 로고    scopus 로고
    • Genistein derivatives as selective estrogen receptor modulators: Sonochemical synthesis and in vivo anti-osteoporotic action
    • 1:CAS:528:DC%2BD2MXlvFaktbg%3D
    • Wang SF, Jiang Q, Ye YH, Li Y, Tan RX (2005) Genistein derivatives as selective estrogen receptor modulators: sonochemical synthesis and in vivo anti-osteoporotic action. Bioorg Med Chem 13:4880-4890
    • (2005) Bioorg Med Chem , vol.13 , pp. 4880-4890
    • Wang, S.F.1    Jiang, Q.2    Ye, Y.H.3    Li, Y.4    Tan, R.X.5
  • 85
    • 33750524252 scopus 로고    scopus 로고
    • Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis
    • 1:CAS:528:DC%2BD2sXpsF2ksg%3D%3D
    • Wang ZL, Sun JY, Wang DN, Xie YH, Wang SW, Zhao WM (2006) Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis. Phytomedicine 13:718-723
    • (2006) Phytomedicine , vol.13 , pp. 718-723
    • Wang, Z.L.1    Sun, J.Y.2    Wang, D.N.3    Xie, Y.H.4    Wang, S.W.5    Zhao, W.M.6
  • 86
    • 34249110626 scopus 로고    scopus 로고
    • Nitric oxide-donating genistein prodrug: Design, synthesis, and bioactivity on MC3T3-E1 cells
    • 1:CAS:528:DC%2BD2sXmt1Wrtrc%3D
    • Wang J, Shang F, Jiang R, Liu L, Wang S, Hou J, Huan M, Mei Q (2007a) Nitric oxide-donating genistein prodrug: design, synthesis, and bioactivity on MC3T3-E1 cells. J Pharmacol Sci 104:82-89
    • (2007) J Pharmacol Sci , vol.104 , pp. 82-89
    • Wang, J.1    Shang, F.2    Jiang, R.3    Liu, L.4    Wang, S.5    Hou, J.6    Huan, M.7    Mei, Q.8
  • 87
    • 35448981919 scopus 로고    scopus 로고
    • Locally applied simvastatin promotes fracture healing in ovariectomized rat
    • Wang JW, Xu SW, Yang DS, Lv RK (2007b) Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int 18:1641-1650
    • (2007) Osteoporos Int , vol.18 , pp. 1641-1650
    • Wang, J.W.1    Xu, S.W.2    Yang, D.S.3    Lv, R.K.4
  • 88
    • 54349096629 scopus 로고    scopus 로고
    • NO-donating genistein prodrug alleviates bone loss in ovariectomised rats
    • 1:CAS:528:DC%2BD1cXhtlGgtbnM
    • Wang J, Shang F, Mei Q, Wang J, Zhang R, Wang S (2008) NO-donating genistein prodrug alleviates bone loss in ovariectomised rats. Swiss Med Wkly 138:602-607
    • (2008) Swiss Med Wkly , vol.138 , pp. 602-607
    • Wang, J.1    Shang, F.2    Mei, Q.3    Wang, J.4    Zhang, R.5    Wang, S.6
  • 89
    • 27744508819 scopus 로고    scopus 로고
    • Serum equol, bone mineral density and biomechanical bone strength differ among four mouse strains
    • 1:CAS:528:DC%2BD2MXht1Sks73J
    • Ward WE, Kim S, Chan D, Fonseca D (2005) Serum equol, bone mineral density and biomechanical bone strength differ among four mouse strains. J Nutr Biochem 16:743-749
    • (2005) J Nutr Biochem , vol.16 , pp. 743-749
    • Ward, W.E.1    Kim, S.2    Chan, D.3    Fonseca, D.4
  • 90
    • 0024797888 scopus 로고
    • Long-term effects of ovariectomy and aging on the rat skeleton
    • 1:STN:280:DyaK3c%2FivFKkug%3D%3D
    • Wronski TJ, Dann LM, Scott KS, Cintrón M (1989) Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366
    • (1989) Calcif Tissue Int , vol.45 , pp. 360-366
    • Wronski, T.J.1    Dann, L.M.2    Scott, K.S.3    Cintrón, M.4
  • 91
    • 0034814093 scopus 로고    scopus 로고
    • Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice
    • 1:CAS:528:DC%2BD3MXnsVKqtL4%3D
    • Wu J, Wang XX, Takasaki M, Ohta A, Higuchi M, Ishimi Y (2001) Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice. J Bone Miner Res 16:1829-1836
    • (2001) J Bone Miner Res , vol.16 , pp. 1829-1836
    • Wu, J.1    Wang, X.X.2    Takasaki, M.3    Ohta, A.4    Higuchi, M.5    Ishimi, Y.6
  • 92
    • 3042523543 scopus 로고    scopus 로고
    • Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice
    • 1:CAS:528:DC%2BD2cXlt1eltbg%3D
    • Wu J, Wang X, Chiba H, Higuchi M, Nakatani T, Ezaki O, Cui H, Yamada K, Ishimi Y (2004) Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53:942-948
    • (2004) Metabolism , vol.53 , pp. 942-948
    • Wu, J.1    Wang, X.2    Chiba, H.3    Higuchi, M.4    Nakatani, T.5    Ezaki, O.6    Cui, H.7    Yamada, K.8    Ishimi, Y.9
  • 93
    • 67749127905 scopus 로고    scopus 로고
    • Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells
    • Wu XT, Wang B, Wei JN (2009) Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells. J Biomed Mater Res B Appl Biomater 90:621-628
    • (2009) J Biomed Mater Res B Appl Biomater , vol.90 , pp. 621-628
    • Wu, X.T.1    Wang, B.2    Wei, J.N.3
  • 94
    • 26444494894 scopus 로고    scopus 로고
    • Increase in bone mass and bone strength by Sambucus williamsii HANCE in ovariectomized rats
    • 1:CAS:528:DC%2BD2MXht1Wqt7nO
    • Xie F, Wu CF, Zhang Y, Yao XS, Cheung PY, Chan AS, Wong MS (2005) Increase in bone mass and bone strength by Sambucus williamsii HANCE in ovariectomized rats. Biol Pharm Bull 28:1879-1885
    • (2005) Biol Pharm Bull , vol.28 , pp. 1879-1885
    • Xie, F.1    Wu, C.F.2    Zhang, Y.3    Yao, X.S.4    Cheung, P.Y.5    Chan, A.S.6    Wong, M.S.7
  • 95
    • 0029146781 scopus 로고
    • Bioavailability of soybean isoflavones depends upon gut microflora in women
    • 1:CAS:528:DyaK2MXnvVCgsLk%3D
    • Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 125:2307-2315
    • (1995) J Nutr , vol.125 , pp. 2307-2315
    • Xu, X.1    Harris, K.S.2    Wang, H.J.3    Murphy, P.A.4    Hendrich, S.5
  • 96
    • 0034541399 scopus 로고    scopus 로고
    • Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase
    • 1:CAS:528:DC%2BD3MXjtVegtA%3D%3D
    • Yamaguchi M, Sugimoto E (2000) Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: activation of aminoacyl-tRNA synthetase. Mol Cell Biochem 214:97-102
    • (2000) Mol Cell Biochem , vol.214 , pp. 97-102
    • Yamaguchi, M.1    Sugimoto, E.2
  • 97
    • 0033112758 scopus 로고    scopus 로고
    • (2E,6R)-8-hydroxy-2,6-dimethyl-2-octenoic acid, a novel anti-osteoporotic monoterpene, isolated from Cistanche salsa
    • 1:CAS:528:DyaK1MXjtFeqtrY%3D
    • Yamaguchi K, Shinohara C, Kojima S, Sodeoka M, Tsuji T (1999) (2E,6R)-8-hydroxy-2,6-dimethyl-2-octenoic acid, a novel anti-osteoporotic monoterpene, isolated from Cistanche salsa. Biosci Biotechnol Biochem 63:731-735
    • (1999) Biosci Biotechnol Biochem , vol.63 , pp. 731-735
    • Yamaguchi, K.1    Shinohara, C.2    Kojima, S.3    Sodeoka, M.4    Tsuji, T.5
  • 98
    • 25144462239 scopus 로고    scopus 로고
    • Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts
    • 1:CAS:528:DC%2BD2MXhtVyhu7bI
    • Yen ML, Su JL, Chien CL, Tseng KW, Yang CY, Chen WF, Chang CC, Kuo ML (2005) Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol Pharmacol 68:1061-1073
    • (2005) Mol Pharmacol , vol.68 , pp. 1061-1073
    • Yen, M.L.1    Su, J.L.2    Chien, C.L.3    Tseng, K.W.4    Yang, C.Y.5    Chen, W.F.6    Chang, C.C.7    Kuo, M.L.8
  • 100
    • 1842484342 scopus 로고    scopus 로고
    • In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin
    • 1:CAS:528:DC%2BD2cXivFCht78%3D
    • Yin J, Tezuka Y, Kouda K, Tran QL, Miyahara T, Chen Y, Kadota S (2004b) In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin. Planta Med 70:220-226
    • (2004) Planta Med , vol.70 , pp. 220-226
    • Yin, J.1    Tezuka, Y.2    Kouda, K.3    Tran, Q.L.4    Miyahara, T.5    Chen, Y.6    Kadota, S.7
  • 101
    • 76049088059 scopus 로고    scopus 로고
    • The in vitro antiosteoporotic activity of some glycosides in Dioscorea spongiosa
    • 1:CAS:528:DC%2BC3cXos1Ontrc%3D
    • Yin J, Han N, Liu Z, Song S, Kadota S (2010) The in vitro antiosteoporotic activity of some glycosides in Dioscorea spongiosa. Biol Pharm Bull 33:316-320
    • (2010) Biol Pharm Bull , vol.33 , pp. 316-320
    • Yin, J.1    Han, N.2    Liu, Z.3    Song, S.4    Kadota, S.5
  • 102
    • 84863126263 scopus 로고    scopus 로고
    • Absorption and plasma disposition of genistin differ from those of genistein in healthy women
    • 1:CAS:528:DC%2BC38XosFajug%3D%3D
    • Yuan B, Zhen H, Jin Y, Xu L, Jiang X, Sun S, Li C, Xu H (2012) Absorption and plasma disposition of genistin differ from those of genistein in healthy women. J Agric Food Chem 60:1428-1436
    • (2012) J Agric Food Chem , vol.60 , pp. 1428-1436
    • Yuan, B.1    Zhen, H.2    Jin, Y.3    Xu, L.4    Jiang, X.5    Sun, S.6    Li, C.7    Xu, H.8
  • 104
    • 58449109469 scopus 로고    scopus 로고
    • Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring A
    • 1:CAS:528:DC%2BD1cXhsFWrs7rE
    • Zhang Y, Li XL, Yao XS, Wong MS (2008) Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring A. Arch Pharm Res 31:1534-1539
    • (2008) Arch Pharm Res , vol.31 , pp. 1534-1539
    • Zhang, Y.1    Li, X.L.2    Yao, X.S.3    Wong, M.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.