Soy isoflavones mitigate long-term femoral and lumbar vertebral bone loss in middle-aged ovariectomized mice

Journal of Medicinal Food

Volumn 12, Issue 3, 2009, Pages 536-541

  Kim, Dae Won ^a   Yoo, Ki Yeon ^a   Lee, Yoon Bok ^b   Lee, Keun Ha ^b   Sohn, Heon Soo ^b   Lee, Sung Joon ^c   Cho, Kyung Hwan ^d   Shin, Yong Kook ^e   Hwang, In Koo ^f   Won, Moo Ho ^a   Kim, Dong Woo ^a,g  

^a Hallym University   (South Korea)

^b Dr Chung's Food Co Ltd   (South Korea)

^c Korea University   (South Korea)

^d Korea University College of Medicine   (South Korea)

^e Chungbuk Technopark   (South Korea)

^f Seoul National University   (South Korea)

^g Research Center   (South Korea)

Author keywords

Alkaline phosphatase; Bone mineral density; Mice; Ovariectomy; Soy isoflavones; Tartrate resistant acid phosphatase

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; ESTRADIOL; ISOFLAVONE DERIVATIVE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE TURNOVER; CONTROLLED STUDY; FEMALE; FEMUR; LEYDIG CELL; LUMBAR VERTEBRA; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; SOYBEAN; TRABECULAR BONE;

ACID PHOSPHATASE; AGING; ALKALINE PHOSPHATASE; ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; ESTRADIOL; FEMALE; FEMUR; ISOFLAVONES; LUMBAR VERTEBRAE; MICE; MICE, INBRED ICR; OSTEOPOROSIS; OVARIECTOMY; PHYTOTHERAPY; PLANT EXTRACTS; SOYBEANS;

MUS;

EID: 68149124037     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.1027     Document Type: Article

References (47)

1. Anderson J, Garner SC: The effect of phytoestrogens on bone. Nutr Res 1997;17:1617-1632.
2. Gallagher JC: Effect of early menopause on bone mineral density and fractures. Menopause 2007;14:567-571.
3. Gambacciani M, Pepe A: Menopause and related problems. Minerva Med 2007;98:191-201.
4. Rice JC, Cowin SC, Bowman JA: On the dependence of the elasticity and strength of cancellous bone on apparent density. J Bio- mech 1988;21:155-168.
5. Hui SL, Slemenda CW, Johnston CCJ: Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 1988;81: 1804-1809.
6. Xu M, Dick IM, Day R, Randall D, Prince RL: Effects of a herbal extract on the bone density, strength and markers of bone turnover of mature ovariectomized rats. Am J Chin Med 2003;31:87-101.
7. Kim MS, Lee YS: Effects of soy isoflavone and/or estrogen treatments on bone metabolism in ovariectomized rats. J Med Food 2005;8:439-145.
8. Paik MK, Lee HO, Chung HS, Yang SO, Kim JH, Om AS: Genis- tein may prevent cadmium-induced bone loss in ovariectomized rats. J Med Food 2003;6:337-343.
9. Ima-Nirwana S, Suhaniza S: Effects of tocopherols and to- cotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone. J Med Food 2004;7:45-51.
10. Liu ZP, Li WX, Yu B, Huang J, Sun J, Huo JS, Liu CX: Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. J Med Food 2005;8:14-19.
11. Tsai MH, Huang GS, Hung YC, Bin L, Liao LT, Lin LW: Pso- ralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats. Am J Chin Med 2007;35:669-680.
12. Chang TS, Ding HY, Tai SS, Wu CY: Metabolism of the soy isoflavones daidzein and genistein by fungi used in the preparation of various fermented soybean foods. Biosci Biotechnol Biochem 2007;71:1330-1333.
13. Ososki AL, Kennelly EJ: Phytoestrogens: a review of the present state of research. Phytother Res 2003;17:845-869.
14. Valachovicova T, Slivova V, Sliva D: Cellular and physiological effects of soy flavonoids. Mini Rev Med Chem 2004;4:881-887.
15. Song WO, Chun OK, Hwang I, Shin HS, Kim BG, Kim KS, Lee SY, Shin D, Lee SG: Soy isoflavones as safe functional ingredients. J Med Food 2007;10:571-580.
16. Barnes S: Phyto-oestrogens and osteoporosis: what is a safe dose? Br J Nutr 2003;89(Suppl):S101-S108.
17. Richard AD: Phytoestrogens. Annu Rev Plant Biol 2004;55:225- 261.
18. Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz- Sapuntzakis M, Guo P, Kukreja SC: Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 1996;126:161-167.
19. Hidaka S, Okamoto Y, Miyazaki K, Uesugi T: Evaluating of a soybean product fujiflavone P40 as an antiosteoporotic agent in rats. Phytother Res 2003;17:112-119.
20. Lee YB, Lee JH, Kim KS, Lee JY, Nam SY, Cheon SH, Sohn HS: Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci Biotechnol Biochem 2004;68:1040-1045.
21. Mathy J, Puel C, Kati-Coulibaly S, Bennetau-Pelissero C, Davicco MJ, Lebecque P, Horcajada MN, Coxam V: Fructooligosaccha- rides maximize bone-sparing effects of soy isoflavone-enriched diet in the ovarioectomized rat. Calcif Tiss Int 2004;75:169-179.
22. Song WO, Chun OK, Hwang I, Shin HS, Kim BG, Kim KS, Lee SY, Shin D, Lee SG: Soy isoflavones as safe functional ingredients. J Med Food 2007;10:571-580.
23. Nishimoto SK, Chang CH, Gendler E, Stryker WF, Nimni ME: The effect of aging on bone formation in rats: biochemical and histological evidence for decreased bone formation capacity. Cal- cif Tissue Int 1985;37:617-624.
24. Schapira D, Linn S, Sarid M, Mokadi S, Kabala A, Silbermann M: Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats. Bone 1995; 16:575-582.
25. Cooper C, Melton LJ III: Epidemiology of osteoporosis. Trends Endocrinol Metab 1992;3:224-229.
26. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ: Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985;7:178-208.
27. Yao W, Farmer R, Cooper R, Chmielewski PA, Tian XY, Set-terberg RB, Jee WSS, Lundy MW: Simvastatin did not prevent nor restore ovariectomy-induced bone loss in adult rats. J Mus- culoskelet Neuronal Interact 2006;6:277-283.
28. Guide for the Care and Use of Laboratory Animals, revised. NIH Publication Number 85-23. National Institutes of Health, Bethesda, MD, 1996.
29. Andersch MA, Szecypinski AJ: Use of p-nitrophenyl phosphate as the substrate for determination of serum acid phosphatase. Am J Clin Pathol 1947;17:571-574.
30. Tenniswood M, Bind CE, Clake AF: Acid phosphatases: andro- gen dependent markers of rat prostate. Can J Biochem 1976; 54:350-357.
31. Pastoureau P, Chomel A, Bonnet J: Specific evaluation of localized bone mass and bone loss in the rat using dual-energy X-ray absorptiometry subregional analysis. Osteoporos Int 1995;5: 143-149.
32. rd: Epidemiology worldwide. Endocrinol Metab Clin North Am 2003;32:1-13.
33. Dennison E, Yoshimura N, Hashimoto T, Cooper C: Bone loss in Great Britain and Japan: a comparative longitudinal study. Bone 1998;23:379-382.
34. rd: A comparison of hip fracture incidence among native Japanese, Japanese Americans, and American Caucasians. Am J Epidemiol 1991; 133:801-809.
35. Kim J, Kwon C: Estimated dietary isoflavone intake of Korean population based on National Nutrition Survey. Nutr Res 2001;21:947-953.
36. Setchell KD, Cassidy A: Dietary isoflavones: biological effects and relevance to human health. J Nutr 1999;129(Suppl):758S- 767S.
37. Kimira M, Arai Y, Shimoi K, Watanabe S: Japanese intake of flavonoids and isoflavonoids from foods. J Epidemiol 1998;8: 168-175.
38. Whitten PL, Patisaul HB: Cross-species and interassay comparisons of phytoestrogen action. Environ Health Perspect 2001;109(Suppl 1):5-20.
39. Kyoko T, Shinji F, Kazutoshi N, Satoshi K, Koichiro T: Comparison of incadronate and alfacalcidol on increased bone turnover caused by ovariectomy in rats. Eur J Pharmacol 2002;449: 191-196.
40. Kyoko T, Shinji F, Takaya I, Kazotoshi N, Satoshi K, Koichiro T: Incadronate inhibits oteoporosis in ovariectomized rats. Eur J Pharmacol 2002;457:51-56.
41. Igarashi Y, Lee MY, Matsuzaki S: Acid phosphatases as markers of bone metabolism. J Chromatogr B Analyt Technol Biomed Life Sci 2002;781:345-358.
42. Goyal N, Getlinger MJ, Sun P: Effect of soy protein, with and without isoflavonoids, on bone in ovariectomized rats [abstract]. J Bone Miner Res 1995;10(Suppl):S453.
43. Vatanparast H, Chilibeck PD: Does the effect of soy phytoestro- gens on bone in postmenopausal women depend on the equol-producing phenotype? Nutr Rev 2007;65:294-299.
44. Fanti P, Monier-Faugere MC, Geng Z, Schmidt J, Morris PE, Cohen D, Malluche HH: The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporosis Int 1998;8:274-281.
45. Ishimi Y, Arai N, Wang X, Wu J, Umegaki K, Miyaura C, Takeda A, Ikegami S: Diffference in effective dosage of genistein on bone and uterus in ovariectomized mice. Biochem Biophys Res Com- mun 2000;274:697-701.
46. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyama Y, Ito M, Wang X, Suda T, Ikegami S: Selective effects of genis- tein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999;140:1893-1900.
47. Adlercreutz H, Hamalainen E, Gorbach S, Goldin B: Dietary phy- toestrogens and the menopause in Japan [letter]. Lancet 1992;339:1233.