In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin

Planta Medica

Volumn 70, Issue 3, 2004, Pages 220-226

  Yin, Jun ^a   Tezuka, Yasuhiro ^a   Kouda, Kyoji ^a   Le Tran, Quan ^a   Miyahara, Tatsuro ^a   Chen, Yingjie ^b   Kadota, Shigetoshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dioscorea spongiosa; Dioscoreaceae; Methylprotodioscin; Osteoporosis; pQCT

Indexed keywords

DIOSCOREA SPONGIOSA EXTRACT; METHYLPROTODIOSCIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERAL; BONE STRENGTH; CONTROLLED STUDY; DIOSCOREA SPONGIOSA; DRUG ISOLATION; FEMALE; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; RAT; RHIZOME; YAM;

ANIMALS; BONE DENSITY; DIOSCOREA; DIOSGENIN; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED STRAINS; OSTEOPOROSIS; OVARIECTOMY; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SAPONINS;

ANIMALIA; DIOSCOREA; DIOSCOREA ALATA; DIOSCOREACEAE;

EID: 1842484342     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815538     Document Type: Article

References (18)

1. Liu CC, Kalu DN. Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually matured ovariectomized rats. J Bone Miner Res 1990; 5: 973-82
2. Wronski TJ, Cintron M, Doherty AL, Dann LM. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 1988; 123: 823-31
3. Ziel HK, Finke WO. Increased risk of endometrial carcinoma among users of conjugated estrogens. N Engl J Med 1975; 293: 1167-70
4. Schnitzer T, Bone HG, Crepaldi G. Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Aging 2000; 12: 1-12
5. Rossini M, Gatti D, Braga V. Effects of two intermittent alendronate regimens in the treatment of postmenopausal osteoporosis. Osteoporosis Int 2000; 11: S170
6. Yin J, Kouda K, Tezuka Y, Tran LQ, Miyahara T, Chen Y et al. Steroidal glycosides from the rhizomes of Dioscorea spongiosa. J Nat Prod 2003; 66: 646-50
7. Zhao W, He J, Xi J. New species of Mian Bixie. China J Chin Materia Med 1994; 19: 199-200
8. Yin J, Kouda K, Tezuka Y, Tran LQ, Miyahara T, Chen Yet al. New diarylheptanoids from the rhizomes of Dioscorea spongiosa and their antiosteoporotic activity. Planta Med 2004; 2: in press
9. Wronski TJ, Yen CF. The ovariectomized rat as an animal model for postmenopausal bone loss. Cells Matr 1991; 1: 69-74
10. Nonaka K. Noninvasive assessment of mechanical properties in bone with pQCT. Clinical Calcium 2000; 10: 675-81
11. 2 inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. Bone 2002; 31: 571-81
12. Wu J, Wang XX, Takasaki M, Ohta A, Higuchi M, Ishimi Y. Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice. J Bone Miner Res 2002; 16: 1829-36
13. Gasser JA. Quantitative assessment of bone mass and geometry by pQCT in rats in vivo and site specificity of changes at different skeletal sites. J Jpn Soc Morphom 1997; 7: 107-14
14. Gasser JA. Assessing bone quantity by pQCT. Bone 1995; 17: 145-54
15. Wang L, Orhii PB, Banu J, Kalu DN. Effects of separate and combined therapy with growth hormone and parathyroid hormone on lumbar vertebral bone in aged ovariectomized osteopenic rats. Bone 2001; 28: 202-7
16. Mohan S, Kutilek S, Zhang C, Shen HG, Kodama Y, Srivastava AK et al. Comparison of bone formation responses to parathyroid hormone (1-34), (1-31), and (2-34) in mice. Bone 2000; 27: 471-78
17. Turner RT, Vandersteenhoven JJ, Bell NH. The effect of ovariectomy and 17β-estradiol, on cortical bone histomorphometry in growing rats. J Bone Miner Res 1987; 2: 115-22
18. Wronski TJ, Walsh CC, Ignaszewski LA. Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 1986; 7: 119-23