Soybean isoflavones in bone health

Forum of Nutrition

Volumn 61, Issue , 2009, Pages 104-116

  Ishimi, Yoshiko ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLAVONE DERIVATIVE;

ANIMAL; BONE; CHEMISTRY; DRUG EFFECT; FEMALE; HEALTH STATUS; HUMAN; MALE; METABOLISM; MOUSE; OSTEOPOROSIS; REVIEW; SOYBEAN;

ANIMALS; BONE AND BONES; FEMALE; HEALTH STATUS; HUMANS; ISOFLAVONES; MALE; MICE; OSTEOPOROSIS; SOY FOODS; SOYBEANS;

EID: 67650242711     PISSN: 16600347     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000212743     Document Type: Article

References (31)

1. Adlercreutz H, Mazur W: Phyto-oestrogens and Western diseases. Ann Med 1997;29:95-120.
2. Adlercreutz H: Phyto-oestrogens and cancer. Lancet Oncol 2002;3:364-373.
3. Lampe JW: Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr 2003;133:956S-964S.
4. Magee RJ, Rowland IR: Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 2004;91:513-531.
5. Messina M, Kucuk O, Lampe JW: An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 2006;89:1121-1134.
6. Inzerillo AM, Zaidi M: Osteoporosis: trends and intervention. Mt Sinai J Med 2002;69:220-231.
7. Beral V, Bull D, Reeves G: Endometrial cancer and hormone-replacement therapy in the Million Women Study. Lancet 2005;365:1543-1551.
8. Messina MJ: Soy foods and soy isoflavones and menopausal health. Nutr Clin Care 2002;5:272-282.
9. Ma DF, Qin LQ, Wang PY, Katoh R: Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clin Nutr 2008;27:57-64.
10. Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F: Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 2008;87: 761-770.
11. Setchell KDR, Brown NM, Lydeking-Olsen E: The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr 2002;132:3577-3584.
12. Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S: Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995;125:2307-2315.
13. Heinone S, Wähälä K, Adlercreutz H: Identification of isoflavone metabolites dihydrodaidzein, dihydro-genistein, 6′-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds. Anal Biochem 1999;274:211-219.
14. Frankenfeld CL, McTiernan A, Tworoger SS, Atkinson C, Thomas WK, Stanczyk FZ, Marcovina SM, Weigle, DS, Weiss NS, Holt VL, Schwartz SM, Lampe JW: Serum steroid hormones, sex hormone-binding globulin concentrations, and urinary hydroxylated estrogen metabolites in post-meno-pausal women in relation to daidzein-metabolizing phenotypes. J Steroid Biochem Mol Biol 2004;88: 399-408.
15. Uchiyama S, Ueno T, Suzuki T: Identification of a newly isolated equol-producing lactic acid bacterium from the human feces. J Intestinal Microbiol (Tokyo) 2007;21:217-220.
16. Setchell KD, Lydeking-Olsen E: Dietary phytoestro-gens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 2003;78(suppl):593S- 609S.
17. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyama Y, Ito M, Wang X, Suda T, Ikegami S: Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999;140:1893-1900.
18. Fujioka M, Uehara M, Wu J, Adlercreutz H, Suzuki K, Kanazawa K, Takeda K, Yamada K, Ishimi Y: Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized mice. J Nutr 2004;134:2623-2627.
19. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S: Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 2007;130:811-823.
20. Frost HM: On our age-related bone loss: insights from a new paradigm. J Bone Miner Res 1997;12: 1539-1546.
21. Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y: Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res 2006;21:780-789.
22. Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y: Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial. Menopause 2007;14:866-874.
23. Ishimi Y, Oka J, Tabata I, Ohtomo T, Ezaki J, Ueno T, Uchiyama S, Toda T, Uehara M, Higuchi M, Yamada K, Wu J: Effects of soybean isoflavones on bone health and its safety in postmenopausal Japanese women J Clin Biochem Nutr 2008;43(suppl 1):48-52.
24. Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T, Okada H: Urinary excretion of lignans and isoflavonoid phytoestro-gens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 1991;54: 1093-1100.
25. Rowland IR, Wisemen H, Sanders TAB, Adlercreutz H, Bowey EA: Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut micro-flora. Nutr Cancer 2000;36:27-32.
26. Lampe J W, Skor HE, Li S, Wähälä K, Howald WN, Chen C: Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in pre-menopausal women. J Nutr 2001;131:740-744.
27. Bolca S, Possemiers S, Herregat A, Huybrechts I, Heyerick A, De Vriese S, Verbruggen M, Depypere H, De Keukeleire D, Bracke M, De Henauw S, Verstraete W, Van de Wiele T: Microbial and dietary factors are associated with the equol producer phe-notype in healthy postmenopausal women. J Nutr 2007;137:2242-2246.
28. Uehara M, Ohta A, Sakai K, Suzuki K, Watanabe S, Adlercreutz H: Dietary fructooligosaccharides modify intestinal bioavailability of a single dose of genistein and daidzein and affect their urinary excretion and kinetics in blood of rats. J Nutr 2001; 131:787-795.
29. Ohta A, Uehara M, Sakai K, Takasaki M, Adlercreutz H, Morohashi T, Ishimi Y: A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice. J Nutr 2002;132: 2048-2054.
30. The Japanese Food Safety Commission of the Cabinet: Basic approaches to evaluating the safety of Food for Specified Health Uses containing soy iso-flavones (in Japanese). 2006; http://www.fsc.go.jp/ hyouka/hy/hy-singi- isoflavone-kihon.pdf.
31. Marini H, Bitto A, Altavilla D, Burnett B P, Polito F, Di Stefano V, Minutoli L, Atteritano M, Levy RM, D'Anna R, Frisina N, Mazzaferro S, Cancellieri F, Cannata ML, Corrado F, Frisina A, Adamo V, Lubrano C, Sansotta C, Marini R, Adamo EB, Squadrito F: Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008;93:4787-4796.