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Volumn 22, Issue 11, 2011, Pages 1055-1063

Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells

Author keywords

ALP activity; Diosgenin; MC3T3 E1 cells; Mineralization; Osteopontin; Runx2; Type 1 collagen

Indexed keywords

ALIZARIN RED S; ALKALINE PHOSPHATASE; CALCIUM; CELL PROTEIN; COLLAGEN TYPE 1; DIOSGENIN; OSTEOPONTIN; TRANSCRIPTION FACTOR RUNX2;

EID: 80052596093     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.09.003     Document Type: Article
Times cited : (53)

References (30)
  • 1
    • 0032983542 scopus 로고    scopus 로고
    • Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential
    • Wang D., Christensen K., Chawla K., Xioa G., Krebsbach P.H., Franceschi R.T. Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res 1999, 14:893-903.
    • (1999) J Bone Miner Res , vol.14 , pp. 893-903
    • Wang, D.1    Christensen, K.2    Chawla, K.3    Xioa, G.4    Krebsbach, P.H.5    Franceschi, R.T.6
  • 2
    • 0036090228 scopus 로고    scopus 로고
    • Regulatory mechanisms of osteoblast and osteoclast differentiation
    • Katagiri T., Nakahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 2002, 8:147-159.
    • (2002) Oral Dis , vol.8 , pp. 147-159
    • Katagiri, T.1    Nakahashi, N.2
  • 3
    • 41149150641 scopus 로고    scopus 로고
    • Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression
    • Lee S.U., Shin H.K., Min Y.K., Kim S.H. Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression. Int Immunopharmacol 2008, 8:741-747.
    • (2008) Int Immunopharmacol , vol.8 , pp. 741-747
    • Lee, S.U.1    Shin, H.K.2    Min, Y.K.3    Kim, S.H.4
  • 4
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan G., Martin J.T. Therapeutic approaches to bone diseases. Science 2000, 289:1508-1514.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.1    Martin, J.T.2
  • 5
    • 34547945104 scopus 로고    scopus 로고
    • Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells
    • Raju J., Bird R.P. Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Lett 2007, 255:194-204.
    • (2007) Cancer Lett , vol.255 , pp. 194-204
    • Raju, J.1    Bird, R.P.2
  • 6
    • 36849074161 scopus 로고    scopus 로고
    • Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
    • Chiang C.T., Way T.D., Tsai S.J., Kin J.K. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett 2007, 581:5735-5742.
    • (2007) FEBS Lett , vol.581 , pp. 5735-5742
    • Chiang, C.T.1    Way, T.D.2    Tsai, S.J.3    Kin, J.K.4
  • 7
    • 46849084316 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells
    • Cailleteau C., Battu S., Jayat-Vignoles C., Beneytout J.L. Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells. Anal Biochem 2008, 380:26-34.
    • (2008) Anal Biochem , vol.380 , pp. 26-34
    • Cailleteau, C.1    Battu, S.2    Jayat-Vignoles, C.3    Beneytout, J.L.4
  • 8
    • 0035850836 scopus 로고    scopus 로고
    • A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells
    • Moalic S., Liagre B., Corbiere C., Bianchi A., Dauca M., Bordji K., et al. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett 2001, 506:225-230.
    • (2001) FEBS Lett , vol.506 , pp. 225-230
    • Moalic, S.1    Liagre, B.2    Corbiere, C.3    Bianchi, A.4    Dauca, M.5    Bordji, K.6
  • 9
    • 8844245483 scopus 로고    scopus 로고
    • Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring
    • Leger D.Y., Liagre B., Cardot P.J.P., Beneytout J.L., Battu S. Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring. Anal Biochem 2004, 335:267-278.
    • (2004) Anal Biochem , vol.335 , pp. 267-278
    • Leger, D.Y.1    Liagre, B.2    Cardot, P.J.P.3    Beneytout, J.L.4    Battu, S.5
  • 10
    • 0642348024 scopus 로고    scopus 로고
    • Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin, and tigogenin, on human 1547 osteosarcoma cells
    • Corbiare C., Liagre B., Bianchi A., Bordji K., Dauca M., Netter P., et al. Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin, and tigogenin, on human 1547 osteosarcoma cells. Int J Oncol 2003, 22(4):899-905.
    • (2003) Int J Oncol , vol.22 , Issue.4 , pp. 899-905
    • Corbiare, C.1    Liagre, B.2    Bianchi, A.3    Bordji, K.4    Dauca, M.5    Netter, P.6
  • 11
    • 0018343957 scopus 로고
    • Effect of diosgenin on lipid metabolism in rats
    • Cayen M.N., Dvornik D. Effect of diosgenin on lipid metabolism in rats. J Lipid Res 1979, 20:163-174.
    • (1979) J Lipid Res , vol.20 , pp. 163-174
    • Cayen, M.N.1    Dvornik, D.2
  • 12
    • 0035030588 scopus 로고    scopus 로고
    • The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model
    • Higdon K., Scott A., Tucci M., Benghuzzi H., Tsao A., Puckett A., et al. The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model. Biomed Sci Instrum 2001, 37:281-286.
    • (2001) Biomed Sci Instrum , vol.37 , pp. 281-286
    • Higdon, K.1    Scott, A.2    Tucci, M.3    Benghuzzi, H.4    Tsao, A.5    Puckett, A.6
  • 13
    • 25144462239 scopus 로고    scopus 로고
    • Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts
    • Yen M.L., Su J.L., Chien C.L., Tseng K.W., Yang C.Y., Chen W.F., et al. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol Pharmacol 2005, 68:1061-1073.
    • (2005) Mol Pharmacol , vol.68 , pp. 1061-1073
    • Yen, M.L.1    Su, J.L.2    Chien, C.L.3    Tseng, K.W.4    Yang, C.Y.5    Chen, W.F.6
  • 14
    • 33846996015 scopus 로고    scopus 로고
    • Natural products as an alternative treatments for metabolic bone disorders and for maintenance of bone health
    • Putnam S., Scutt A., Bicknell K., Priestly C., Williamson E. Natural products as an alternative treatments for metabolic bone disorders and for maintenance of bone health. Phytother Res 2006, 21:99-112.
    • (2006) Phytother Res , vol.21 , pp. 99-112
    • Putnam, S.1    Scutt, A.2    Bicknell, K.3    Priestly, C.4    Williamson, E.5
  • 15
    • 77951562679 scopus 로고    scopus 로고
    • Stimulatory effect of undecylenic acid on mouse osteoblast differentiation
    • Kim M.H., Shim K.S., Lee S.U., Kim Y.S., Min Y.K., Kim S.H. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res 2009, 24:559-564.
    • (2009) Phytother Res , vol.24 , pp. 559-564
    • Kim, M.H.1    Shim, K.S.2    Lee, S.U.3    Kim, Y.S.4    Min, Y.K.5    Kim, S.H.6
  • 17
    • 34447578609 scopus 로고    scopus 로고
    • Mending the bones with natural products
    • Sethi G., Aggarwal B. Mending the bones with natural products. Chem Biol 2007, 14:738-740.
    • (2007) Chem Biol , vol.14 , pp. 738-740
    • Sethi, G.1    Aggarwal, B.2
  • 19
    • 0034805319 scopus 로고    scopus 로고
    • Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells
    • Maeda T., Matsunuma A., Kawane T., Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 2001, 280:874-877.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 874-877
    • Maeda, T.1    Matsunuma, A.2    Kawane, T.3    Horiuchi, N.4
  • 20
    • 77950021664 scopus 로고    scopus 로고
    • Icariin isolated from Epimedium pubescens regulates osteoblast anabolism through BMP-2, SMAD4, and Cbfa1 expression
    • Hsieh T.P., Sheu S.Y., Sun J.S., Chen M.H., Liu M.H. Icariin isolated from Epimedium pubescens regulates osteoblast anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine 2010, 17:414-423.
    • (2010) Phytomedicine , vol.17 , pp. 414-423
    • Hsieh, T.P.1    Sheu, S.Y.2    Sun, J.S.3    Chen, M.H.4    Liu, M.H.5
  • 21
    • 57049118500 scopus 로고    scopus 로고
    • Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-κB pathways
    • Tang C.H., Huang T.H., Chang C.S., Fu W.M., Yang R.S. Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-κB pathways. Osteoporos Int 2009, 20:93-103.
    • (2009) Osteoporos Int , vol.20 , pp. 93-103
    • Tang, C.H.1    Huang, T.H.2    Chang, C.S.3    Fu, W.M.4    Yang, R.S.5
  • 22
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodelling, ossification and angiogenesis during endochondral bone formation
    • Gerber H.P., Vu T.H., Ryan A.M., Kowalski J., Werb Z., Ferrara N. VEGF couples hypertrophic cartilage remodelling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999, 56:623-628.
    • (1999) Nat Med , vol.56 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 23
    • 0026537256 scopus 로고
    • Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation
    • Lian J., Stein G. Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med 1992, 3:269-305.
    • (1992) Crit Rev Oral Biol Med , vol.3 , pp. 269-305
    • Lian, J.1    Stein, G.2
  • 24
    • 0028242767 scopus 로고
    • Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells
    • Franceschi R.T., Iyer B.S., Cui Y. Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res 1994, 9:843-854.
    • (1994) J Bone Miner Res , vol.9 , pp. 843-854
    • Franceschi, R.T.1    Iyer, B.S.2    Cui, Y.3
  • 25
    • 0028942119 scopus 로고
    • The influence of Type 1 collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization
    • Lynch M., Stein J., Stein G., Lian J. The influence of Type 1 collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Exp Cell Res 1995, 216:35-45.
    • (1995) Exp Cell Res , vol.216 , pp. 35-45
    • Lynch, M.1    Stein, J.2    Stein, G.3    Lian, J.4
  • 26
    • 1942420158 scopus 로고    scopus 로고
    • Stimulation of differentiation in sodium-dependent vitamin C transporter 2 overexpressing MC3T3-E1 osteoblasts
    • Wu X., Itoh N., Taniguchi T., Hirano J., Nakanishi T., Tanaka K. Stimulation of differentiation in sodium-dependent vitamin C transporter 2 overexpressing MC3T3-E1 osteoblasts. Biochem Biophys Res Commun 2004, 317:1159-1164.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 1159-1164
    • Wu, X.1    Itoh, N.2    Taniguchi, T.3    Hirano, J.4    Nakanishi, T.5    Tanaka, K.6
  • 28
    • 34548525045 scopus 로고    scopus 로고
    • ATP-mediated mineralization of MC3T3-E1 osteoblast cultures
    • Nakano Y., Addison W., Kaartinen M.T. ATP-mediated mineralization of MC3T3-E1 osteoblast cultures. Bone 2007, 41:549-561.
    • (2007) Bone , vol.41 , pp. 549-561
    • Nakano, Y.1    Addison, W.2    Kaartinen, M.T.3
  • 29
    • 18244392685 scopus 로고    scopus 로고
    • Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone
    • Murshed M., Harmey D., Millan J.L., McKee M.D., Karsenty G. Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 2005, 19:1093-1104.
    • (2005) Genes Dev , vol.19 , pp. 1093-1104
    • Murshed, M.1    Harmey, D.2    Millan, J.L.3    McKee, M.D.4    Karsenty, G.5
  • 30
    • 0033560784 scopus 로고    scopus 로고
    • A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    • Ducy P., Starbuck M., Priemel M., Shen J., Pinero R., Geoffroy V., et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 1999, 13:1025-1036.
    • (1999) Genes Dev , vol.13 , pp. 1025-1036
    • Ducy, P.1    Starbuck, M.2    Priemel, M.3    Shen, J.4    Pinero, R.5    Geoffroy, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.