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Volumn 56, Issue 2, 2009, Pages 261-270

A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system

Author keywords

Bone mechanical properties; Bone mineralization; Estradiol; Genistein; Osteoblasts; Osteoclasts; Raloxifene

Indexed keywords

MURINAE; RATTUS; RATTUS NORVEGICUS;

EID: 68249120572     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2009_2458     Document Type: Article
Times cited : (33)

References (48)
  • 1
    • 0031955293 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 stimulates the fusion process in osteoclasts
    • Amano H, Yamada S, Felix R (1998) Colony-stimulating factor-1 stimulates the fusion process in osteoclasts. J Bone Miner Res 13: 846-853.
    • (1998) J Bone Miner Res , vol.13 , pp. 846-853
    • Amano, H.1    Yamada, S.2    Felix, R.3
  • 2
    • 0033883022 scopus 로고    scopus 로고
    • Selective estrogen re-ceptor modulators in reproductive medicine and biology
    • Baker VL, Leitman D, Jaffe RB (2000) Selective estrogen re-ceptor modulators in reproductive medicine and biology. Obstet Gynecol Surv 55 (Suppl 2): S21-S47.
    • (2000) Obstet Gynecol Surv , vol.55 , Issue.SUPPL. 2
    • Baker, V.L.1    Leitman, D.2    Jaffe, R.B.3
  • 3
    • 0031816540 scopus 로고    scopus 로고
    • Differential response of estrogen receptor α and estrogen receptor β to partial estrogen agonists/antagonists
    • Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson JA, Nilsson S (1998) Differential response of estrogen receptor α and estrogen receptor β to partial estrogen agonists/antagonists. Mol Pharmacol 54: 105-112.
    • (1998) Mol Pharmacol , vol.54 , pp. 105-112
    • Barkhem, T.1    Carlsson, B.2    Nilsson, Y.3    Enmark, E.4    Gustafsson, J.A.5    Nilsson, S.6
  • 4
    • 0029945381 scopus 로고    scopus 로고
    • Variable effects of tyrosine kinase inhibitors on avian osteo-clastic activity and reduction of bone loss in ovariecto-mized rats
    • Blair HC, Jordan SE, Peterson TG, Barnes S (1996) Variable effects of tyrosine kinase inhibitors on avian osteo-clastic activity and reduction of bone loss in ovariecto-mized rats. J Cell Biochem 61: 629-637.
    • (1996) J Cell Biochem , vol.61 , pp. 629-637
    • Blair, H.C.1    Jordan, S.E.2    Peterson, T.G.3    Barnes, S.4
  • 6
    • 0036064771 scopus 로고    scopus 로고
    • Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway
    • Chen XW, Garner SC, Anderson JJ (2002) Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 295: 417-422.
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 417-422
    • Chen, X.W.1    Garner, S.C.2    Anderson, J.J.3
  • 7
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS (2006) Estrogen receptors and human disease. J Clin Invest 116: 561-570.
    • (2006) J Clin Invest , vol.116 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 8
    • 21344448186 scopus 로고    scopus 로고
    • Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice
    • Erlandsson MC, Islander U, Moverare S, Ohlsson C, Carlsten H (2005) Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice. APMIS 113: 317-323.
    • (2005) APMIS , vol.113 , pp. 317-323
    • Erlandsson, M.C.1    Islander, U.2    Moverare, S.3    Ohlsson, C.4    Carlsten, H.5
  • 9
    • 0029759978 scopus 로고    scopus 로고
    • Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia
    • Evans GL, Bryant HU, Magee DE, Turner RT (1996) Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia. Endocrinology 137: 4139-4144.
    • (1996) Endocrinology , vol.137 , pp. 4139-4144
    • Evans, G.L.1    Bryant, H.U.2    Magee, D.E.3    Turner, R.T.4
  • 10
    • 0042362024 scopus 로고    scopus 로고
    • Ectonucleotidases of the rabbit ciliary body nonpigmented epithelium
    • Farahbakhsh NA (2003) Ectonucleotidases of the rabbit ciliary body nonpigmented epithelium. Invest Ophthalmol Vis Sci 44: 3952-3960.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3952-3960
    • Farahbakhsh, N.A.1
  • 11
    • 9144271735 scopus 로고    scopus 로고
    • Effects of heparin and low-molecular-weight heparins on bone mechanical properties in rats
    • Folwarczna J, Janiec W, Śliwiński L (2004) Effects of heparin and low-molecular-weight heparins on bone mechanical properties in rats. Thromb Haemost 92: 940-946.
    • (2004) Thromb Haemost , vol.92 , pp. 940-946
    • Folwarczna, J.1    Janiec, W.2    Śliwiński, L.3
  • 12
    • 25444482167 scopus 로고    scopus 로고
    • Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile
    • Gallo D, Zannoni GF, Apollonio P, Martinelli E, Ferlini C, Passetti G, Riva A, Morazzoni P, Bombardelli E, Scambia G (2005) Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile. Menopause 12: 589-600.
    • (2005) Menopause , vol.12 , pp. 589-600
    • Gallo, D.1    Zannoni, G.F.2    Apollonio, P.3    Martinelli, E.4    Ferlini, C.5    Passetti, G.6    Riva, A.7    Morazzoni, P.8    Bombardelli, E.9    Scambia, G.10
  • 13
    • 0032810114 scopus 로고    scopus 로고
    • Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures
    • Gao YH, Yamaguchi M (1999) Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures. Biochem Pharmacol 58: 767-772.
    • (1999) Biochem Pharmacol , vol.58 , pp. 767-772
    • Gao, Y.H.1    Yamaguchi, M.2
  • 14
    • 0034145709 scopus 로고    scopus 로고
    • Suppressive effect of genistein on rat bone osteoclasts: involvement of protein kinase inhibition and protein tyrosine phosphatase activation
    • Gao YH, Yamaguchi M (2000) Suppressive effect of genistein on rat bone osteoclasts: involvement of protein kinase inhibition and protein tyrosine phosphatase activation. Int J Mol Med 5: 261-267.
    • (2000) Int J Mol Med , vol.5 , pp. 261-267
    • Gao, Y.H.1    Yamaguchi, M.2
  • 15
    • 17144384732 scopus 로고    scopus 로고
    • Negative regulation of RANKL-induced osteoclastic differentiation in RAW264.7 cells by estrogen and phytoestrogens
    • García Palacios V, Robinson LJ, Borysenko CW, Lehmann T, Kalla SE, Blair HC (2005) Negative regulation of RANKL-induced osteoclastic differentiation in RAW264.7 cells by estrogen and phytoestrogens. J Biol Chem 280: 13720-13727.
    • (2005) J Biol Chem , vol.280 , pp. 13720-13727
    • García Palacios, V.1    Robinson, L.J.2    Borysenko, C.W.3    Lehmann, T.4    Kalla, S.E.5    Blair, H.C.6
  • 16
    • 1642313676 scopus 로고    scopus 로고
    • Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1, and Ank: an integrated model of the pathogenesis of miner-alization disorders
    • Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millán JL (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1, and Ank: an integrated model of the pathogenesis of miner-alization disorders. Am J Pathol 164: 1199-1209.
    • (2004) Am J Pathol , vol.164 , pp. 1199-1209
    • Harmey, D.1    Hessle, L.2    Narisawa, S.3    Johnson, K.A.4    Terkeltaub, R.5    Millán, J.L.6
  • 17
  • 19
    • 0034056092 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts
    • Kajiya H, Okabe K, Okamoto F, Tsuzuki T, Soeda H (2000) Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts. J Cell Physiol 183: 83-90.
    • (2000) J Cell Physiol , vol.183 , pp. 83-90
    • Kajiya, H.1    Okabe, K.2    Okamoto, F.3    Tsuzuki, T.4    Soeda, H.5
  • 20
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmen-opausal bone loss
    • Kalu DN (1991) The ovariectomized rat model of postmen-opausal bone loss. Bone Miner 15: 175-191.
    • (1991) Bone Miner , vol.15 , pp. 175-191
    • Kalu, D.N.1
  • 21
    • 84885785208 scopus 로고    scopus 로고
    • RANKL/RANK/OPG system and its importance in bone physiology and pathophysiology
    • Kryśkiewicz E, Lorenc RS (2006) RANKL/RANK/OPG system and its importance in bone physiology and pathophysiology. Terapia 3: 58-63.
    • (2006) Terapia , vol.3 , pp. 58-63
    • Kryśkiewicz, E.1    Lorenc, R.S.2
  • 22
    • 0036321005 scopus 로고    scopus 로고
    • p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function
    • Li X, Udagawa N, Itoh K, Suda K, Murase Y, Nishihara T, Suda T, Takahashi N (2002) p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology 143: 3105-3113.
    • (2002) Endocrinology , vol.143 , pp. 3105-3113
    • Li, X.1    Udagawa, N.2    Itoh, K.3    Suda, K.4    Murase, Y.5    Nishihara, T.6    Suda, T.7    Takahashi, N.8
  • 23
    • 0031790401 scopus 로고    scopus 로고
    • Conditionally immortalized murine bone marrow stromal cells mediate parathyroid hormone-dependent osteoclastogenesis in vitro
    • Liu BY, Guo J, Lanske B, Divieti P, Kronenberg HM, Bringhurst FR (1998) Conditionally immortalized murine bone marrow stromal cells mediate parathyroid hormone-dependent osteoclastogenesis in vitro. Endocrinology 139: 1952-1964.
    • (1998) Endocrinology , vol.139 , pp. 1952-1964
    • Liu, B.Y.1    Guo, J.2    Lanske, B.3    Divieti, P.4    Kronenberg, H.M.5    Bringhurst, F.R.6
  • 24
    • 0017236217 scopus 로고
    • Effects of parathormone and calcitonin on citrate and hyaluronate metabolism in cultured bone
    • Luben RA, Cohn DV (1976) Effects of parathormone and calcitonin on citrate and hyaluronate metabolism in cultured bone. Endocrinology 98: 413-419.
    • (1976) Endocrinology , vol.98 , pp. 413-419
    • Luben, R.A.1    Cohn, D.V.2
  • 25
    • 39049113293 scopus 로고    scopus 로고
    • Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials
    • Ma DF, Qin LQ, Wang PY, Katoh R (2008) Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr 62: 155-161.
    • (2008) Eur J Clin Nutr , vol.62 , pp. 155-161
    • Ma, D.F.1    Qin, L.Q.2    Wang, P.Y.3    Katoh, R.4
  • 27
    • 33645213907 scopus 로고    scopus 로고
    • Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits
    • McCarty MF (2006) Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits. Med Hypotheses 66: 1093-1114.
    • (2006) Med Hypotheses , vol.66 , pp. 1093-1114
    • McCarty, M.F.1
  • 29
    • 0041705966 scopus 로고    scopus 로고
    • Isoflavones and skeletal health: are these molecules ready for clinical application?
    • Migliaccio S, Anderson JJ (2003) Isoflavones and skeletal health: are these molecules ready for clinical application? Osteoporos Int 14: 361-368
    • (2003) Osteoporos Int , vol.14 , pp. 361-368
    • Migliaccio, S.1    Anderson, J.J.2
  • 30
    • 33646435803 scopus 로고    scopus 로고
    • The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts
    • Morris C, Thorpe J, Ambrosio L, Santin M (2006) The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts. J Nutr 136: 1166-1170.
    • (2006) J Nutr , vol.136 , pp. 1166-1170
    • Morris, C.1    Thorpe, J.2    Ambrosio, L.3    Santin, M.4
  • 31
    • 30844435292 scopus 로고    scopus 로고
    • Bone formation-promoting effect of genistein on marrow mesenchymal cell culture
    • Okumura N, Yoshikawa T, Iida J, Nonomura A, Takakura Y (2006) Bone formation-promoting effect of genistein on marrow mesenchymal cell culture. Biomed Mater Eng 16: 23-32.
    • (2006) Biomed Mater Eng , vol.16 , pp. 23-32
    • Okumura, N.1    Yoshikawa, T.2    Iida, J.3    Nonomura, A.4    Takakura, Y.5
  • 32
    • 35348851973 scopus 로고    scopus 로고
    • Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats
    • Om A-S, Shim J-Y (2007) Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats. Acta Biochim Polon 54: 641-646.
    • (2007) Acta Biochim Polon , vol.54 , pp. 641-646
    • Om, A.-S.1    Shim, J.-Y.2
  • 35
    • 4944229454 scopus 로고    scopus 로고
    • Effects of doxy-cycline on mechanical properties of bones in rats with ovariectomy-induced osteopenia
    • Pytlik M, Folwarczna J, Janiec W (2004) Effects of doxy-cycline on mechanical properties of bones in rats with ovariectomy-induced osteopenia. Calcif Tissue Int 75: 225-230.
    • (2004) Calcif Tissue Int , vol.75 , pp. 225-230
    • Pytlik, M.1    Folwarczna, J.2    Janiec, W.3
  • 36
    • 33646027300 scopus 로고    scopus 로고
    • Soy isoflavones and bone health: a double-edged sword?
    • Reinwald S, Weaver CM (2006) Soy isoflavones and bone health: a double-edged sword? J Nat Prod 69: 450-459
    • (2006) J Nat Prod , vol.69 , pp. 450-459
    • Reinwald, S.1    Weaver, C.M.2
  • 37
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    • Raisz LG (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115: 3318-3325.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 38
    • 0038360744 scopus 로고    scopus 로고
    • Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β
    • Rickard DJ, Monroe DG, Ruesink TJ, Khosla S, Riggs BL, Spelsberg TC (2003) Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β. J Cell Biochem 89: 633-646.
    • (2003) J Cell Biochem , vol.89 , pp. 633-646
    • Rickard, D.J.1    Monroe, D.G.2    Ruesink, T.J.3    Khosla, S.4    Riggs, B.L.5    Spelsberg, T.C.6
  • 39
    • 0026050042 scopus 로고
    • Overview of osteoporosis
    • Riggs BL (1991) Overview of osteoporosis. West J Med 154: 63-77.
    • (1991) West J Med , vol.154 , pp. 63-77
    • Riggs, B.L.1
  • 40
    • 0042785118 scopus 로고    scopus 로고
    • Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies
    • Setchell KDR, Lydeking-Olsen E (2003) Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 78 (3 Suppl): 593S-609S.
    • (2003) Am J Clin Nutr , vol.78 , Issue.SUPPL. 3
    • Setchell, K.D.R.1    Lydeking-Olsen, E.2
  • 41
    • 33144467452 scopus 로고    scopus 로고
    • Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration
    • Soucy NV, Parkinson HD, Sochaski MA, Borghoff SJ (2006) Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol Sci 90: 230-240.
    • (2006) Toxicol Sci , vol.90 , pp. 230-240
    • Soucy, N.V.1    Parkinson, H.D.2    Sochaski, M.A.3    Borghoff, S.J.4
  • 42
    • 22744432029 scopus 로고    scopus 로고
    • Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro
    • Śliwiński L, Folwarczna J, Janiec W, Grynkiewicz G, Kuzyk K (2005) Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro. Pharmacol Rep 57: 352-359.
    • (2005) Pharmacol Rep , vol.57 , pp. 352-359
    • Śliwiński, L.1    Folwarczna, J.2    Janiec, W.3    Grynkiewicz, G.4    Kuzyk, K.5
  • 44
    • 0036157227 scopus 로고    scopus 로고
    • Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts
    • Viereck V, Gründker C, Blaschke S, Siggelkow H, Emons G, Hofbauer LC (2002) Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts. J Cell Biochem 84: 725-735.
    • (2002) J Cell Biochem , vol.84 , pp. 725-735
    • Viereck, V.1    Gründker, C.2    Blaschke, S.3    Siggelkow, H.4    Emons, G.5    Hofbauer, L.C.6
  • 45
    • 18344381664 scopus 로고    scopus 로고
    • Soy isoflavones and bone health: the relationship is still unclear
    • Weaver CM, Cheong JM (2005) Soy isoflavones and bone health: the relationship is still unclear. J Nutr 135: 1243-1237.
    • (2005) J Nutr , vol.135 , pp. 1243-1237
    • Weaver, C.M.1    Cheong, J.M.2
  • 46
    • 0031795623 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor effects on avian osteoclastic acid transport
    • Williams JP, Jordan SE, Barnes S, Blair HC (1998) Tyrosine kinase inhibitor effects on avian osteoclastic acid transport. Am J Clin Nutr 68 (6 Suppl): 1369S-1374S.
    • (1998) Am J Clin Nutr , vol.68 , Issue.SUPPL. 6
    • Williams, J.P.1    Jordan, S.E.2    Barnes, S.3    Blair, H.C.4
  • 47
    • 0002081094 scopus 로고
    • The ovariectomized rat as an animal model for postmenopausal bone loss
    • Wronski TJ, Yen C-F (1991) The ovariectomized rat as an animal model for postmenopausal bone loss. Cells Materials Suppl 1: 69-74.
    • (1991) Cells Materials Suppl , vol.1 , pp. 69-74
    • Wronski, T.J.1    Yen, C.-F.2
  • 48
    • 0034926517 scopus 로고    scopus 로고
    • Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis
    • Yamagishi T, Otsuka E, Hagiwara H (2001) Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis. Endocrinology 142: 3632-3637.
    • (2001) Endocrinology , vol.142 , pp. 3632-3637
    • Yamagishi, T.1    Otsuka, E.2    Hagiwara, H.3


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