메뉴 건너뛰기




Volumn 174, Issue 6, 2009, Pages 2234-2245

Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CELL NUCLEUS RECEPTOR ROR; INTERLEUKIN 10; INTERLEUKIN 17; RETINOIC ACID; TAMIBAROTENE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 67049137416     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.081084     Document Type: Article
Times cited : (80)

References (55)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R: Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747 (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 0036219003 scopus 로고    scopus 로고
    • T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    • DOI 10.1146/annurev.immunol.20.081701.141316
    • Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB: T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol 2002, 20:101-123 (Pubitemid 34293422)
    • (2002) Annual Review of Immunology , vol.20 , pp. 101-123
    • Kuchroo, V.K.1    Anderson, A.C.2    Waldner, H.3    Munder, M.4    Bettelli, E.5    Nicholson, L.B.6
  • 3
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 Years of merits and culprits in experimental autoimmune encephalomyelitis research
    • DOI 10.1093/brain/awl075
    • Gold R, Linington C, Lassmann H: Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129:1953-1971 (Pubitemid 44289062)
    • (2006) Brain , vol.129 , Issue.8 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 5
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil SS, Steinman L: The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 1990, 8:579-621 (Pubitemid 20135640)
    • (1990) Annual Review of Immunology , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 9
    • 39449110445 scopus 로고    scopus 로고
    • The link between IL-23 and Th17 cell-mediated immune pathologies
    • DOI 10.1016/j.smim.2007.10.012, PII S1044532307000875
    • McGeachy MJ, Cua DJ: The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol 2007, 19:372-376 (Pubitemid 351274049)
    • (2007) Seminars in Immunology , vol.19 , Issue.6 , pp. 372-376
    • McGeachy, M.J.1    Cua, D.J.2
  • 10
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, Link H: Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999, 5:101-104 (Pubitemid 29186827)
    • (1999) Multiple Sclerosis , vol.5 , Issue.2 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 11
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • DOI 10.2353/ajpath.2008.070690
    • Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L: Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008, 172:146-155 (Pubitemid 351186376)
    • (2008) American Journal of Pathology , vol.172 , Issue.1 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 12
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189 (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 13
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 21
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • DOI 10.1016/j.immuni.2005.01.016
    • Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY: Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22:329-341 (Pubitemid 40387475)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 26
    • 33144488245 scopus 로고    scopus 로고
    • Function of retinoid nuclear receptors: Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    • DOI 10.1146/annurev.pharmtox.46.120604.141156
    • Mark M, Ghyselinck NB, Chambon P: Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol 2006, 46:451-480 (Pubitemid 43271197)
    • (2006) Annual Review of Pharmacology and Toxicology , vol.46 , pp. 451-480
    • Mark, M.1    Ghyselinck, N.B.2    Chambon, P.3
  • 27
    • 34548762585 scopus 로고    scopus 로고
    • Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation
    • DOI 10.1002/eji.200737621
    • Schambach F, Schupp M, Lazar MA, Reiner SL: Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol 2007, 37:2396-2399 (Pubitemid 47423609)
    • (2007) European Journal of Immunology , vol.37 , Issue.9 , pp. 2396-2399
    • Schambach, F.1    Schupp, M.2    Lazar, M.A.3    Reiner, S.L.4
  • 28
    • 38949164425 scopus 로고    scopus 로고
    • Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
    • DOI 10.1182/blood-2007-06-096438
    • Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ: Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 2008, 111:1013-1020 (Pubitemid 351213378)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1013-1020
    • Elias, K.M.1    Laurence, A.2    Davidson, T.S.3    Stephens, G.4    Kanno, Y.5    Shevach, E.M.6    O'Shea, J.J.7
  • 29
    • 34447503805 scopus 로고    scopus 로고
    • H17 and regulatory T cell differentiation mediated by retinoic acid
    • DOI 10.1126/science.1145697
    • Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317:256-260 (Pubitemid 47076203)
    • (2007) Science , vol.317 , Issue.5835 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6    Cheroutre, H.7
  • 30
    • 53149137849 scopus 로고    scopus 로고
    • Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    • Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, Kuchroo VK: Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 2008, 181:2277-2284
    • (2008) J Immunol , vol.181 , pp. 2277-2284
    • Xiao, S.1    Jin, H.2    Korn, T.3    Liu, S.M.4    Oukka, M.5    Lim, B.6    Kuchroo, V.K.7
  • 31
    • 0023227105 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by retinoic acid
    • DOI 10.1016/0022-510X(87)90220-6
    • Massacesi L, Abbamondi AL, Giorgi C, Sarlo F, Lolli F, Amaducci L: Suppression of experimental allergic encephalomyelitis by retinoic acid. J Neurol Sci 1987, 80:55-64 (Pubitemid 17094624)
    • (1987) Journal of the Neurological Sciences , vol.80 , Issue.1 , pp. 55-64
    • Massacesi, L.1    Abbamondi, A.L.2    Giorgi, C.3
  • 32
    • 0028876611 scopus 로고
    • Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course
    • Racke MK, Burnett D, Pak SH, Albert PS, Cannella B, Raine CS, McFarlin DE, Scott DE: Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J Immunol 1995, 154:450-458
    • (1995) J Immunol , vol.154 , pp. 450-458
    • Racke, M.K.1    Burnett, D.2    Pak, S.H.3    Albert, P.S.4    Cannella, B.5    Raine, C.S.6    McFarlin, D.E.7    Scott, D.E.8
  • 37
    • 35348907310 scopus 로고    scopus 로고
    • PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia
    • DOI 10.1007/s10147-007-0694-6
    • Ohnishi K: PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. Int J Clin Oncol 2007, 12:313-317 (Pubitemid 47573414)
    • (2007) International Journal of Clinical Oncology , vol.12 , Issue.5 , pp. 313-317
    • Ohnishi, K.1
  • 38
    • 0036010727 scopus 로고    scopus 로고
    • Novel synthetic retinoids and separation of the pleiotropic retinoidal activities
    • Kagechika H: Novel synthetic retinoids and separation of the pleiotropic retinoidal activities. Curr Med Chem 2002, 9:591-608 (Pubitemid 34436436)
    • (2002) Current Medicinal Chemistry , vol.9 , Issue.5 , pp. 591-608
    • Kagechika, H.1
  • 42
    • 46049093364 scopus 로고    scopus 로고
    • Th17 cells and autoimmune encephalomyelitis (EAE/MS)
    • DOI 10.2332/allergolint.R-07-159
    • Aranami T, Yamamura T: Th17 Cells and autoimmune encephalomyelitis (EAE/MS). Allergol Int 2008, 57:115-120 (Pubitemid 351897665)
    • (2008) Allergology International , vol.57 , Issue.2 , pp. 115-120
    • Aranami, T.1    Yamamura, T.2
  • 45
    • 33645396955 scopus 로고    scopus 로고
    • Clinical experience with a new synthetic retinoid, tamibarotene (Am-80) for relapsed or refractory acute promyelocytic leukemia
    • Takeuchi M: Clinical experience with a new synthetic retinoid, tamibarotene (Am-80) for relapsed or refractory acute promyelocytic leukemia. Gan To Kagaku Ryoho 2006, 33:397-401
    • (2006) Gan to Kagaku Ryoho , vol.33 , pp. 397-401
    • Takeuchi, M.1
  • 48
    • 39449087338 scopus 로고    scopus 로고
    • Th17 cells: Effector T cells with inflammatory properties
    • DOI 10.1016/j.smim.2007.10.007, PII S1044532307000838
    • Korn T, Oukka M, Kuchroo V, Bettelli E: Th17 cells: effector T cells with inflammatory properties. Semin Immunol 2007, 19:362-371 (Pubitemid 351274046)
    • (2007) Seminars in Immunology , vol.19 , Issue.6 , pp. 362-371
    • Korn, T.1    Oukka, M.2    Kuchroo, V.3    Bettelli, E.4
  • 50
    • 42649135852 scopus 로고    scopus 로고
    • Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: Implications for multiple sclerosis
    • Herrero-Herranz EPL, Gold R, Linker RA: Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neurobiol Dis 2008, 30:162-173
    • (2008) Neurobiol Dis , vol.30 , pp. 162-173
    • Herrero-Herranz, E.P.L.1    Gold, R.2    Linker, R.A.3
  • 51
    • 0041522463 scopus 로고    scopus 로고
    • h2 development via retinoic acid receptors
    • DOI 10.1093/intimm/dxg101
    • Iwata M, Eshima Y, Kagechika H: Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol 2003, 15:1017-1025 (Pubitemid 36987299)
    • (2003) International Immunology , vol.15 , Issue.8 , pp. 1017-1025
    • Iwata, M.1    Eshima, Y.2    Kagechika, H.3
  • 52
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    • DOI 10.1084/jem.192.7.1075
    • Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD: Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med 2000, 192:1075-1080 (Pubitemid 30765700)
    • (2000) Journal of Experimental Medicine , vol.192 , Issue.7 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 53
    • 47249098928 scopus 로고    scopus 로고
    • Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells
    • Dogan RN, Elhofy A, Karpus WJ: Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J Immunol 2008, 180:7376-7384
    • (2008) J Immunol , vol.180 , pp. 7376-7384
    • Dogan, R.N.1    Elhofy, A.2    Karpus, W.J.3
  • 54
    • 34250196774 scopus 로고    scopus 로고
    • Cutting edge: Human Th17 cells are identified as bearing CCR2+CCR5- phenotype
    • Sato W, Aranami T, Yamamura T: Cutting edge: human Th17 cells are identified as bearing CCR2+CCR5- phenotype. J Immunol 2007, 178:7525-7529
    • (2007) J Immunol , vol.178 , pp. 7525-7529
    • Sato, W.1    Aranami, T.2    Yamamura, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.