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Volumn 19, Issue 6, 2007, Pages 372-376

The link between IL-23 and Th17 cell-mediated immune pathologies

Author keywords

Autoimmunity; IL 17; IL 6; Inflammation; T cell lineage commitment; TGF

Indexed keywords

INTERLEUKIN 23;

EID: 39449110445     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2007.10.012     Document Type: Review
Times cited : (129)

References (60)
  • 1
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25 (2007) 821-852
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 2
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • Bettelli E., Oukka M., and Kuchroo V.K. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8 (2007) 345-350
    • (2007) Nat Immunol , vol.8 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 3
    • 33645318217 scopus 로고    scopus 로고
    • Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
    • Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6 (2006) 329-333
    • (2006) Nat Rev Immunol , vol.6 , pp. 329-333
    • Dong, C.1
  • 5
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 6
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue S., Ahern P., Buonocore S., Kullberg M.C., Cua D.J., McKenzie B.S., et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 203 (2006) 2473-2483
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3    Kullberg, M.C.4    Cua, D.J.5    McKenzie, B.S.6
  • 7
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D., Cheung J., Scheerens H., Poulet F., McClanahan T., McKenzie B., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 (2006) 1310-1316
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3    Poulet, F.4    McClanahan, T.5    McKenzie, B.6
  • 8
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198 (2003) 1951-1957
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 9
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • Amadi-Obi A., Yu C.R., Liu X., Mahdi R.M., Clarke G.L., Nussenblatt R.B., et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13 (2007) 711-718
    • (2007) Nat Med , vol.13 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6
  • 11
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 12
    • 0030587910 scopus 로고    scopus 로고
    • IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg D.O., Fordham S., Bernard C.C., Cowden W.B., and Ramshaw I.A. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157 (1996) 3223-3227
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 13
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B., Zhang G.X., Yu S., Li J., Chen X.H., Ventura E.S., et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 169 (2002) 7104-7110
    • (2002) J Immunol , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6
  • 14
    • 0037442020 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
    • Zhang G.X., Gran B., Yu S., Li J., Siglienti I., Chen X., et al. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 170 (2003) 2153-2160
    • (2003) J Immunol , vol.170 , pp. 2153-2160
    • Zhang, G.X.1    Gran, B.2    Yu, S.3    Li, J.4    Siglienti, I.5    Chen, X.6
  • 17
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., and Gurney A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278 (2003) 1910-1914
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 18
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 19
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 20
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 22
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 23
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 24
    • 0035999828 scopus 로고    scopus 로고
    • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes
    • Guo J., Hawwari A., Li H., Sun Z., Mahanta S.K., Littman D.R., et al. Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol 3 (2002) 469-476
    • (2002) Nat Immunol , vol.3 , pp. 469-476
    • Guo, J.1    Hawwari, A.2    Li, H.3    Sun, Z.4    Mahanta, S.K.5    Littman, D.R.6
  • 26
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • Brustle A., Heink S., Huber M., Rosenplanter C., Stadelmann C., Yu P., et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 8 (2007) 958-966
    • (2007) Nat Immunol , vol.8 , pp. 958-966
    • Brustle, A.1    Heink, S.2    Huber, M.3    Rosenplanter, C.4    Stadelmann, C.5    Yu, P.6
  • 27
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., and Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8 (2007) 942-949
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 28
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6
  • 31
    • 1642278750 scopus 로고    scopus 로고
    • Identification of a TLR4- and TRIF-dependent activation program of dendritic cells
    • Weighardt H., Jusek G., Mages J., Lang R., Hoebe K., Beutler B., et al. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur J Immunol 34 (2004) 558-564
    • (2004) Eur J Immunol , vol.34 , pp. 558-564
    • Weighardt, H.1    Jusek, G.2    Mages, J.3    Lang, R.4    Hoebe, K.5    Beutler, B.6
  • 32
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen M., Hocking R.J., Flavell R.A., and Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 7 (2006) 1151-1156
    • (2006) Nat Immunol , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 33
    • 34249026701 scopus 로고    scopus 로고
    • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann S., Gross O., Robinson M.J., Osorio F., Slack E.C., Tsoni S.V., et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8 (2007) 630-638
    • (2007) Nat Immunol , vol.8 , pp. 630-638
    • LeibundGut-Landmann, S.1    Gross, O.2    Robinson, M.J.3    Osorio, F.4    Slack, E.C.5    Tsoni, S.V.6
  • 34
    • 18644364701 scopus 로고    scopus 로고
    • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    • Gautier G., Humbert M., Deauvieau F., Scuiller M., Hiscott J., Bates E.E., et al. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 201 (2005) 1435-1446
    • (2005) J Exp Med , vol.201 , pp. 1435-1446
    • Gautier, G.1    Humbert, M.2    Deauvieau, F.3    Scuiller, M.4    Hiscott, J.5    Bates, E.E.6
  • 35
    • 33751571417 scopus 로고    scopus 로고
    • Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta
    • Touil T., Fitzgerald D., Zhang G.X., Rostami A., and Gran B. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol 177 (2006) 7505-7509
    • (2006) J Immunol , vol.177 , pp. 7505-7509
    • Touil, T.1    Fitzgerald, D.2    Zhang, G.X.3    Rostami, A.4    Gran, B.5
  • 36
    • 33846922783 scopus 로고    scopus 로고
    • Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs
    • Yarilina A., DiCarlo E., and Ivashkiv L.B. Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs. J Immunol 178 (2007) 2204-2211
    • (2007) J Immunol , vol.178 , pp. 2204-2211
    • Yarilina, A.1    DiCarlo, E.2    Ivashkiv, L.B.3
  • 37
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    • Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16 (2002) 779-790
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5    Gilbert, J.6
  • 38
    • 35648988381 scopus 로고    scopus 로고
    • Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    • Fitzgerald D.C., Ciric B., Touil T., Harle H., Grammatikopolou J., Das Sarma J., et al. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 179 (2007) 3268-3275
    • (2007) J Immunol , vol.179 , pp. 3268-3275
    • Fitzgerald, D.C.1    Ciric, B.2    Touil, T.3    Harle, H.4    Grammatikopolou, J.5    Das Sarma, J.6
  • 39
    • 9644279571 scopus 로고    scopus 로고
    • The role of IL-27 in the development of T-cell responses during parasitic infections
    • Hunter C.A., Villarino A., Artis D., and Scott P. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunol Rev 202 (2004) 106-114
    • (2004) Immunol Rev , vol.202 , pp. 106-114
    • Hunter, C.A.1    Villarino, A.2    Artis, D.3    Scott, P.4
  • 40
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7 (2006) 929-936
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6
  • 41
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7 (2006) 937-945
    • (2006) Nat Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6
  • 42
    • 0041931076 scopus 로고    scopus 로고
    • Foxp3 and natural regulatory T cells: key to a cell lineage?
    • Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage?. Immunity 19 (2003) 165-168
    • (2003) Immunity , vol.19 , pp. 165-168
    • Ramsdell, F.1
  • 43
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4 + CD25-T cells through Foxp3 induction and down-regulation of Smad 7
    • Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., and Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4 + CD25-T cells through Foxp3 induction and down-regulation of Smad 7. J Immunol 172 (2004) 5149-5153
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 44
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function
    • Thornton A.M., Donovan E.E., Piccirillo C.A., and Shevach E.M. Cutting edge: IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function. J Immunol 172 (2004) 6519-6523
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 45
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26 (2007) 371-381
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 46
    • 34249026701 scopus 로고    scopus 로고
    • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • Leibundgut-Landmann S., Gross O., Robinson M.J., Osorio F., Slack E.C., Tsoni S.V., et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol (2007)
    • (2007) Nat Immunol
    • Leibundgut-Landmann, S.1    Gross, O.2    Robinson, M.J.3    Osorio, F.4    Slack, E.C.5    Tsoni, S.V.6
  • 47
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    • Li M.O., Wan Y.Y., and Flavell R.A. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26 (2007) 579-591
    • (2007) Immunity , vol.26 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 48
    • 33645225611 scopus 로고    scopus 로고
    • Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4 + LAP+ and CD4 + CD25 + T cells
    • Zhang X., Reddy J., Ochi H., Frenkel D., Kuchroo V.K., and Weiner H.L. Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4 + LAP+ and CD4 + CD25 + T cells. Int Immunol 18 (2006) 495-503
    • (2006) Int Immunol , vol.18 , pp. 495-503
    • Zhang, X.1    Reddy, J.2    Ochi, H.3    Frenkel, D.4    Kuchroo, V.K.5    Weiner, H.L.6
  • 49
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering
    • Miller A., Lider O., Roberts A.B., Sporn M.B., and Weiner H.L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 89 (1992) 421-425
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 50
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1
    • Racke M.K., Dhib-Jalbut S., Cannella B., Albert P.S., Raine C.S., and McFarlin D.E. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1. J Immunol 146 (1991) 3012-3017
    • (1991) J Immunol , vol.146 , pp. 3012-3017
    • Racke, M.K.1    Dhib-Jalbut, S.2    Cannella, B.3    Albert, P.S.4    Raine, C.S.5    McFarlin, D.E.6
  • 51
    • 34548734314 scopus 로고    scopus 로고
    • The inflamed central nervous system drives the activation and rapid proliferation of Foxp3 + regulatory T cells
    • O'Connor R.A., Malpass K.H., and Anderton S.M. The inflamed central nervous system drives the activation and rapid proliferation of Foxp3 + regulatory T cells. J Immunol 179 (2007) 958-966
    • (2007) J Immunol , vol.179 , pp. 958-966
    • O'Connor, R.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 52
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson C.F., Oukka M., Kuchroo V.J., and Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204 (2007) 285-297
    • (2007) J Exp Med , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 53
    • 33847144180 scopus 로고    scopus 로고
    • Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    • Jankovic D., Kullberg M.C., Feng C.G., Goldszmid R.S., Collazo C.M., Wilson M., et al. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204 (2007) 273-283
    • (2007) J Exp Med , vol.204 , pp. 273-283
    • Jankovic, D.1    Kullberg, M.C.2    Feng, C.G.3    Goldszmid, R.S.4    Collazo, C.M.5    Wilson, M.6
  • 54
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • Elson C.O., Cong Y., Weaver C.T., Schoeb T.R., McClanahan T.K., Fick R.B., et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132 (2007) 2359-2370
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1    Cong, Y.2    Weaver, C.T.3    Schoeb, T.R.4    McClanahan, T.K.5    Fick, R.B.6
  • 55
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg M.C., Jankovic D., Feng C.G., Hue S., Gorelick P.L., McKenzie B.S., et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 203 (2006) 2485-2494
    • (2006) J Exp Med , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1    Jankovic, D.2    Feng, C.G.3    Hue, S.4    Gorelick, P.L.5    McKenzie, B.S.6
  • 56
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig H.H., McKenzie B.S., Hue S., Thompson C., Joyce-Shaikh B., Stepankova R., et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25 (2006) 309-318
    • (2006) Immunity , vol.25 , pp. 309-318
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3    Thompson, C.4    Joyce-Shaikh, B.5    Stepankova, R.6
  • 57
    • 34249059942 scopus 로고    scopus 로고
    • Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    • Michel M.L., Keller A.C., Paget C., Fujio M., Trottein F., Savage P.B., et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med 204 (2007) 995-1001
    • (2007) J Exp Med , vol.204 , pp. 995-1001
    • Michel, M.L.1    Keller, A.C.2    Paget, C.3    Fujio, M.4    Trottein, F.5    Savage, P.B.6
  • 58
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • Becker C., Wirtz S., Blessing M., Pirhonen J., Strand D., Bechthold O., et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 112 (2003) 693-706
    • (2003) J Clin Invest , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3    Pirhonen, J.4    Strand, D.5    Bechthold, O.6
  • 59
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • Kinugasa T., Sakaguchi T., Gu X., and Reinecker H.C. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118 (2000) 1001-1011
    • (2000) Gastroenterology , vol.118 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 60
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • Ogawa A., Andoh A., Araki Y., Bamba T., and Fujiyama Y. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 110 (2004) 55-62
    • (2004) Clin Immunol , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5


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