Cytokinergic IgE action in mast cell activation

Frontiers in Immunology

Volumn 3, Issue AUG, 2012, Pages

  Bax, Heather J ^a   Keeble, Anthony H ^a   Gould, Hannah J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Allergy; Asthma; Conformational isomerism; Cytokinergic; IgE; Mast cell; SPE 7

Indexed keywords

EID: 84874206492     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00229     Document Type: Article

References (142)

1. Aalberse, R. C., Akkerdaas, J., and Van Ree, R. (2001). Cross-reactivity of IgE antibodies to allergens. Allergy 56, 478-490.
2. Abhinandan, K. R., and Martin, A. C. (2010). Analysis and prediction of VH/VL packing in antibodies. Protein Eng. Des. Sel. 23, 689-697.
3. Aloisi, F., and Pujol-Borrell, R. (2006). Lymphoid neogenesis in chronic inflammatory diseases. Nat. Rev. Immunol. 6, 205-217.
4. Asai,K.,Kitaura,J.,Kawakami,Y.,Yamagata, N., Tsai, M., Carbone, D. P., Liu, F. T., Galli, S. J., and Kawakami, T. (2001). Regulation of mast cell survival by IgE. Immunity 14, 791-800.
5. Barthelemy, P. A., Raab, H.,Appleton, B. A., Bond, C. J.,Wu, P.,Wiesmann, C., and Sidhu, S. S. (2008). Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. J. Biol. Chem. 283, 3639-3654.
6. Beeh, K. M., Ksoll, M., and Buhl, R. (2000). Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individ-uals. Eur. Respir. J. 16, 609-614.
7. Bentley, G. A., Boulot, G., Riottot, M. M., and Poljak, R. J. (1990). Three-dimensional structure of an idiotope-anti-idiotope complex. Nature 348, 254-257.
8. Boehm, M. K., Corper, A. L., Wan, T., Sohi, M. K., Sutton, B. J., Thorn-ton, J. D., Keep, P. A., Chester, K. A., Begent, R. H., and Perkins, S. J. (2000). Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts. Biochem. J. 346(Pt 2), 519-528.
9. Brightbill, H. D., Jeet, S., Lin, Z., Yan, D., Zhou, M., Tan, M., Nguyen, A., Yeh, S., Delarosa, D., Leong, S. R., Wong, T., Chen, Y., Ultsch, M., Luis, E.,Ramani,S. R.,Jackman,J.,Gonza-lez, L., Dennis, M. S., Chuntharapai, A., Deforge, L., Meng, Y. G., Xu, M., Eigenbrot, C., Lee, W. P., Refino, C. J., Balazs, M., and Wu, L. C. (2010). Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J. Clin. Invest. 120, 2218-2229.
10. Bryce, P. J., Miller, M. L., Miyajima, I., Tsai, M., Galli, S. J., and Oettgen, H. C. (2004). Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immu-nity 20, 381-392.
11. Burrows, B., Martinez, F. D., Halonen, M., Barbee, R. A., and Cline, M. G. (1989). Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 320, 271-277.
12. Calarese, D. A., Scanlan, C. N., Zwick, M. B., Deechongkit, S., Mimura, Y., Kunert, R., Zhu, P., Wormald, M. R., Stanfield, R. L., Roux, K. H., Kelly, J. W., Rudd, P. M., Dwek, R. A., Katinger, H., Burton, D. R., and Wilson, I. A. (2003). Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 300,2065-2071.
13. Cameron, L., Gounni, A. S., Frenkiel, S., Lavigne, F., Vercelli, D., and Hamid, Q. (2003). S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination. J. Immunol. 171, 3816-3822.
14. Caravella, J. A., Wang, D., Glaser, S. M., and Lugovskoy, A. (2010). Structure-guided design of antibod-ies. Curr. Comput. Aided Drug Des. 6, 128-138.
15. Charles, N., Monteiro, R. C., and Benhamou, M. (2004). p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its lig-and in mast cells. J. Biol. Chem. 279, 12312-12318.
16. Chatellier, J., Van Regenmortel, M. H., Vernet, T., and Altschuh, D. (1996). Functional mapping of conserved residues located at the VL and VH domain interface of a Fab. J. Mol. Biol. 264, 1-6.
17. Chen, J. B., Wu, P. C., Hung, A. F., Chu, C. Y., Tsai, T. F.,Yu, H. M., Chang, H. Y., and Chang, T. W. (2010). Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applic-able for targeting IgE-committed B cells. J. Immunol. 184, 1748-1756.
18. Chu, S. Y., Horton, H. M., Pong, E., Leung, I. W., Chen, H., Nguyen, D. H., Bautista, C., Muchhal, U. S., Bernett, M. J., Moore, G. L., Szymkowski, D. E., and Desjarlais, J. R. (2012). Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcgammaRIIb with Fc-engineered antibody. J. Allergy Clin. Immunol. 129, 1102-1115.
19. Chung, K. F., and Marwick, J. A. (2010). Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease. Ann. N. Y. Acad. Sci. 1203, 85-91.
20. Coker, H. A., Durham, S. R., and Gould, H. J. (2003). Local somatic hyper-mutation and class switch recombi-nation in the nasal mucosa of allergic rhinitis patients. J. Immunol. 171, 5602-5610.
21. Coker, H. A., Harries, H. E., Banfield, G. K., Carr, V. A., Durham, S. R., Chevretton, E., Hobby, P., Sutton, B. J., and Gould, H. J. (2005). Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis. J. Allergy Clin. Immunol. 116,445-452.
22. Conrad, D. H., Wingard, J. R., and Ishizaka, T. (1983). The interac-tion of human and rodent IgE with the human basophil IgE receptor. J. Immunol. 130, 327-333.
23. Conroy, M. C., Adkinson, N. F. Jr., and Lichtenstein, L. M. (1977). Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release. J. Immunol. 118, 1317-1321.
24. Corper, A. L., Sohi, M. K., Bonagura, V. R., Steinitz, M., Jefferis, R., Fein-stein, A., Beale, D., Taussig, M. J., and Sutton, B. J. (1997). Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction. Nat. Struct. Biol. 4, 374-381.
25. Cruse, G., Cockerill, S., and Bradding, P. (2008). IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. BMC Immunol. 9, 2. doi:10.1186/1471-2172-9-2
26. Cruse, G., Kaur, D., Yang, W., Duffy, S. M., Brightling, C. E., and Bradding, P. (2005). Activation of human lung mast cells by monomeric immunoglobulin E. Eur. Respir. J. 25, 858-863.
27. DeLisi, C. (1981). The magnitude of signal amplification by ligand-induced receptor clustering. Nature 289, 322-323.
28. Drazen, J. M. (2012). Asthma: the para-dox of heterogeneity. J. Allergy Clin. Immunol. 129, 1200-1201.
29. Eckl-Dorna, J., Pree, I., Reisinger, J., Marth, K., Chen, K.-W., Vrtala, S., Spitzauer,S.,Valenta,R.,and Nieder-berger, V. (2012). The majority of allergen-specific IgE in the blood of allergic patients does not origi-nate from blood-derived B cells or plasma cells. Clin. Exp. Allergy. doi: 10.1111/j.1365-2222.2012.04030.x.
30. Ehrlich, P. (1900). Croonian lecture: on immunity with special reference to cell life. Proc. R. Soc. Lond. B Biol. Sci. 66, 424-448.
31. Eisenberg, R. A. (2012). Secondary receptor editing in the generation of autoimmunity. Autoimmun. Rev. doi: 10.1016/j.autrev.2012.02.004
32. Eshhar, Z., Ofarim, M., and Waks, T. (1980). Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J. Immunol. 124, 775-780.
33. Feichtner, S., Infuhr, D., Achatz-Straussberger, G., Schmid, D., Karnowski, A., Lamers, M., Rhyner, C., Crameri, R., and Achatz, G. (2008). Targeting the extracellular membrane-proximal domain of membrane-bound IgE by passive immunization blocks IgE synthesis in vivo. J. Immunol. 180, 5499-5505.
34. Fewtrell, C., and Metzger, H. (1980). Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. J. Immunol. 125, 701-710.
35. Field, K. A., Holowka, D., and Baird, B. (1997). Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J. Biol. Chem. 272, 4276-4280.
36. Foote, J., and Milstein, C. (1991). Kinetic maturation of an immune response. Nature 352, 530-532.
37. Foote, J., and Milstein, C. (1994). Conformational isomerism and the diversity of antibodies. Proc. Natl. Acad. Sci. U.S.A. 91, 10370-10374.
38. Furuichi, K., Rivera, J., and Isersky, C. (1985). The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc. Natl. Acad. Sci. U.S.A. 82, 1522-1525.
39. Galli, S. J., Grimbaldeston, M., and Tsai, M. (2008). Immunomodula-tory mast cells: negative, as well as positive, regulators of immunity. Nat. Rev. Immunol. 8, 478-486.
40. Galli, S. J., Maurer, M., and Lantz, C. S. (1999). Mast cells as sentinels of innate immunity. Curr. Opin. Immunol. 11, 53-59.
41. Genovese, A., Rossi, F. W., Spadaro, G., Galdiero, M. R., and Marone, G. (2010). Human cardiac mast cellsinanaphylaxis. Chem. Immunol. Allergy 95, 98-109.
42. Gilchrest, H., Cheewatrakoolpong, B., Billah, M., Egan, R. W., Anthes, J. C., and Greenfeder, S. (2003). Human cord blood-derived mast cells syn-thesize and release I-309 in response to IgE. Life Sci. 73, 2571-2581.
43. Gould, H. J., and Sutton, B. J. (2008). IgE in allergy and asthma today. Nat. Rev. Immunol. 8, 205-217.
44. Gould, H. J., Sutton, B. J., Beavil, A. J., Beavil, R. L., Mccloskey, N., Coker, H. A., Fear, D., and Smurthwaite, L. (2003). The biology of IgE and the basis of allergic disease. Annu. Rev. Immunol. 21, 579-628.
45. Gould, H. J., Takhar, P., Harries, H. E., Durham, S. R., and Corrigan, C. J. (2006). Germinalcentre reactions in allergic inflammation. Trends Immunol. 27, 446-452.
46. Harnett,W., and Harnett, M. M. (2010). Helminth-derived immunomodula-tors: can understanding the worm produce the pill? Nat. Rev. Immunol. 10, 278-284.
47. Hillion, S., Dueymes, M., Youinou, P., and Jamin, C. (2007a). IL-6 contributes to the expression of RAGs in human mature B cells. J. Immunol. 179, 6790-6798.
48. Hillion, S., Youinou, P., and Jamin, C. (2007b). Peripheral expression of RAG in human B lymphocytes in normal and pathological condi-tions is dependent on interleukin-6. Autoimmun. Rev. 6, 415-420.
49. Holdom, M. D., Davies, A. M., Nettle-ship, J. E., Bagby, S. C., Dhaliwal, B., Girardi, E., Hunt, J., Gould, H. J., Beavil, A. J., Mcdonnell, J. M., Owens, R. J.,and Sutton, B. J. (2011). Conformational changes in IgE con-tribute to its uniquely slow dissociation rate from receptor FcvarepsilonRI. Nat. Struct. Mol. Biol. 18, 571-576.
50. Hsu, C., and MacGlashan, D. Jr. (1996). IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells. Immunol. Lett. 52, 129-134.
51. Huff, T. F., Uede, T., Iwata, M., and Ishizaka, K. (1983). Modulation of the biologic activities of IgE-binding factors. III. Switching of a T cell hybrid clone from the formation of IgE-suppressive factor to the for-mation of IgE-potentiating factor. J. Immunol. 131, 1090-1095.
52. Hunt, J., Keeble, A. H., Dale, R. E., Corbett, M. K., Beavil, R. L., Levitt, J., Swann, M. J., Suhling, K., Ameer-Beg, S., Sutton, B. J., and Beavil, A. J. (2012). A fluorescent biosen-sor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition. J. Biol. Chem. 287, 17459-17470.
53. Igawa, T., Tsunoda, H., Kikuchi, Y., Yoshida, M., Tanaka, M., Koga, A., Sekimori, Y., Orita, T., Aso, Y., Hattori, K., and Tsuchiya, M. (2010). VH/VL interface engineer-ing to promote selective expression and inhibit conformational isomer-ization of thrombopoietin receptor agonistsingle-chaindiabody. Protein Eng. Des. Sel. 23, 667-677.
54. James, L. C., Roversi, P., and Tawfik, D. S. (2003). Antibody multispeci-ficity mediated by conformational diversity. Science 299, 1362-1367.
55. James, L. C., and Tawfik, D. S. (2003a). Conformational diversity and protein evolution -a 60-year-old hypothesis revisited. Trends Biochem. Sci. 28, 361-368.
56. James, L. C., and Tawfik, D. S. (2003b). The specificity of cross-reactivity: promiscuous antibody binding involves specific hydro-gen bonds rather than nonspecific hydrophobic stickiness. Protein Sci. 12, 2183-2193.
57. James, L. C., and Tawfik, D. S. (2005). Structure and kinetics of a tran-sient antibody binding intermedi-ate reveal a kinetic discrimination mechanism in antigen recognition. Proc. Natl. Acad. Sci. U.S.A. 102, 12730-12735.
58. Kalesnikoff, J., Huber, M., Lam, V., Damen, J. E., Zhang, J., Siragan-ian, R. P., and Krystal, G. (2001). Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14, 801-811.
59. Kashiwakura, J., Kawakami, Y., Yuki, K., Zajonc, D. M., Hasegawa, S., Tomi-mori,Y., Caplan, B., Saito, H., Furue, M., Oettgen, H. C., Okayama, Y., and Kawakami, T. (2009). Polyclonal IgE induces mast cell survival and cytokine production. Allergol. Int. 58, 411-419.
60. Kashiwakura, J., Otani, I. M., and Kawakami, T. (2011). Monomeric IgE and mast cell development, sur-vival and function. Adv. Exp. Med. Biol. 716, 29-46.
61. Kashiwakura, J. C., Ando, T., Matsumoto, K., Kimura, M., Kitaura, J., Matho, M. H., Zajonc, D. M., Ozeki, T., Ra, C., Macdonald, S. M., Siraganian, R. P., Broide, D. H., Kawakami, Y., and Kawakami, T. (2012a). Histamine-releasing factor has a proinflamma-tory role in mouse models of asthma and allergy. J. Clin. Invest. 122, 218-228.
62. Kashiwakura, J. C., Okayama, Y., Furue, M., Kabashima, K., Shimada, S., Ra, C., Siraganian, R. P., Kawakami, Y., and Kawakami, T. (2012b). Most highlycytokinergicIgEshavepolyre-activity to autoantigens. Allergy Asthma Immunol. Res. 4, e124.
63. Kawakami, T., and Galli, S. J. (2002). Regulation of mastcell and basophil function and survival by IgE. Nat. Rev. Immunol. 2, 773-786.
64. Kawakami, T., and Kitaura, J. (2005). Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mech-anisms and relevance. J. Immunol. 175, 4167-4173.
65. Kawakami, Y., Yumoto, K., and Kawakami, T. (2007). An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of Tec family kinases. Allergol. Int. 56, 403-409.
66. Khan, T., and Salunke, D. M. (2012). Structural elucidation of the mecha-nistic basis of degeneracy in the primary humoral response. J. Immunol. 188, 1819-1827.
67. Kinet, J. P. (1999). The highaffinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol. 17, 931-972.
68. Kitamura, Y., and Ito, A. (2005). Mast cell-committed progenitors. Proc. Natl. Acad. Sci. U.S.A. 102, 11129-11130.
69. Kitaura, J., Eto, K., Kinoshita, T., Kawakami, Y., Leitges, M., Lowell, C. A., and Kawakami, T. (2005). Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J. Immunol. 174, 4495-4504.
70. Kitaura, J., Song, J., Tsai, M., Asai, K., Maeda-Yamamoto, M., Mocsai, A., Kawakami, Y., Liu, F. T., Lowell, C. A., Barisas, B. G., Galli, S. J., and Kawakami, T. (2003). Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the Fcep-silonRI. Proc. Natl. Acad. Sci. U.S.A. 100, 12911-12916.
71. Kitaura, J., Xiao, W., Maeda-Yamamoto, M., Kawakami, Y., Lowell, C. A., and Kawakami, T. (2004). Early diver-gence of Fc epsilon receptor I sig-nals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J. Immunol. 173, 4317-4323.
72. KleinJan, A., Vinke, J. G., Severijnen, L. W., and Fokkens, W. J. (2000). Local production and detection of (spe-cific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur. Respir. J. 15, 491-497.
73. Kohno, M., Yamasaki, S., Tybulewicz, V. L., and Saito, T. (2005). Rapid and large amount of autocrine IL-3 pro-duction is responsible for mast cell survival by IgE in the absence of antigen. Blood 105, 2059-2065.
74. Lancet, D., and Pecht, I. (1976). Kinetic evidence for hapten-induced con-formational transition in immuno-globin MOPC 460. Proc. Natl. Acad. Sci. U.S.A. 73, 3549-3553.
75. Lee, Y. C., Boehm, M. K., Chester, K. A., Begent, R. H., and Perkins, S. J. (2002). Reversible dimer forma-tion and stability of the anti-tumor single-chain Fv antibody MFE-23 by neutron scattering, analytical ultra-centrifugation, and NMR and FT-IR spectroscopy. J. Mol. Biol. 320, 107-127.
76. Li, M., Gustchina, A., Alexandratos, J., Wlodawer, A., Wunschmann, S., Kepley, C. L., Chapman, M. D., and Pomes, A. (2008). Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a mono-clonal antibody. J. Biol. Chem. 283, 22806-22814.
77. Liu, F. T. (2005). Regulatory roles of galectins in the immune response. Int. Arch. Allergy Immunol. 136, 385-400.
78. Liu, F. T., Bohn, J. W., Ferry, E. L., Yamamoto, H., Molinaro, C. A., Sherman, L. A., Klinman, N. R., and Katz, D. H. (1980). Monoclonal dinitrophenyl-specific murine IgE antibody: preparation,isolation,and characterization. J. Immunol. 124, 2728-2737.
79. Lorentz,A.,Wilke,M.,Sellge,G.,Worth-mann, H., Klempnauer, J., Manns, M. P., and Bischoff, S. C. (2005). IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine genera-tion is reversible and associated with increased activity of ERK1/2 and c-Fos. J. Immunol. 174, 6751-6756.
80. Luger, E. O., Fokuhl, V., Wegmann, M., Abram, M., Tillack, K., Achatz, G., Manz, R. A., Worm, M., Radbruch, A.,and Renz,H. (2009). Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge. J. Allergy Clin. Immunol. 124,819-826, e814.
81. MacDonald, S. M. (1996). Histamine-releasing factors. Curr. Opin. Immunol. 8, 778-783.
82. MacDonald, S. M., Lichtenstein, L. M., Proud, D., Plaut, M., Naclerio, R. M., Macglashan, D. W., and Kagey-Sobotka, A. (1987). Studies of IgE-dependent histamine releas-ing factors: heterogeneity of IgE. J. Immunol. 139, 506-512.
83. MacDonald, S. M., Rafnar, T., Langdon, J., and Lichtenstein, L. M. (1995). Molecular identification of an IgE-dependent histamine-releasing factor. Science 269, 688-690.
84. MacGlashan, D. Jr. (2005). IgE and FcepsilonRI regulation. Clin. Rev. Allergy Immunol. 29, 49-60.
85. Manivel, V., Sahoo, N. C., Salunke, D. M., and Rao, K. V. (2000). Matu-ration of an antibody response is governed by modulations in flexi-bility of the antigen-combining site. Immunity 13, 611-620.
86. Matsuda, K., Piliponsky, A. M., Iikura, M., Nakae, S., Wang, E. W., Dutta, S. M., Kawakami, T., Tsai, M., and Galli, S. J. (2005). Monomeric IgE enhances human mast cell chemokine production: IL-4 aug-ments and dexamethasone suppresses the response. J. Allergy Clin. Immunol. 116, 1357-1363.
87. Nakanishi, T., Tsumoto, K., Yokota, A., Kondo, H., and Kumagai, I. (2008). Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10. Protein Sci. 17, 261-270.
88. Nemazee, D. (2006). Receptor editing in lymphocyte development and cen-tral tolerance. Nat. Rev. Immunol. 6, 728-740.
89. Niemi, M., Jylha, S., Laukkanen, M. L., Soderlund, H., Makinen-Kiljunen, S., Kallio, J. M., Hakulinen, N., Haahtela, T., Takkinen,x K., and Rouvinen, J. (2007). Molecular interac-tions between a recombinant IgE antibody and the beta-lactoglobulin allergen. Structure 15, 1413-1421.
90. Nunomura, S., Gon, Y., Yoshimaru, T., Suzuki, Y., Nishimoto, H., Kawakami, T., and Ra, C. (2005). Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int. Immunol. 17, 685-694.
91. Oka, T., Hori, M., Tanaka, A., Matsuda, H., Karaki, H., and Ozaki, H. (2004). IgE alone-induced actin assembly modifies calcium signaling and degranulation in RBL-2H3 mast cells. Am. J. Physiol. Cell Physiol. 286, C256-C263.
92. Oskeritzian, C. A., Zhao, W., Pozez, A. L., Cohen, N. M., Grimes, M., and Schwartz, L. B. (2004). Neutralizing endogenous IL-6 renders mast cells of the MCT type from lung, but not the MCTC type from skin and lung, susceptible to human recombinant IL-4-induced apoptosis. J. Immunol. 172, 593-600.
93. Paar, J. M., Harris, N. T., Holowka, D., and Baird, B. (2002). Bivalent ligands with rigid double-stranded DNA spacers reveal structural con-straints on signaling by Fc epsilon RI. J. Immunol. 169, 856-864.
94. Palm, N. W., Rosenstein, R. K., and Medzhitov, R. (2012). Allergic host defences. Nature 484, 465-472.
95. Pandey, V., Mihara, S., Fensome-Green, A., Bolsover, S., and Cockcroft, S. (2004). Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranu-lation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J. Immunol. 172, 4048-4058.
96. Peden, D. B. (2011). The role of oxidative stress and innate immu-nity in O(3) and endotoxin-induced human allergic airway disease. Immunol. Rev. 242, 91-105.
97. Raghunathan, G., Smart, J., Williams, J., and Almargo, J. C. (2012). Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens. J. Mol. Recognit. 25, 103-113.
98. Rashid, T., and Ebringer, A. (2012). Autoimmunity in rheumatic diseases is induced by microbial infections via crossreactivity or molecular mimicry. Autoimmune Dis. 2012, 539282.
99. Rini, J. M., Schulze-Gahmen, U., and Wilson, I. A. (1992). Structural evi-dence for induced fit as a mechanism for antibodyantigen recognition. Science 255, 959-965.
100. Sakurai, D., Yamasaki, S., Arase, K., Park, S. Y., Arase, H., Konno, A., and Saito, T. (2004). Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J. Immunol. 172, 2374-2381.
101. Schmid-Grendelmeier, P., Fluckiger, S., Disch, R., Trautmann, A., Wuthrich, B., Blaser, K., Scheynius, A., and Crameri, R. (2005). IgE-mediated and T cell-mediated autoimmu-nity against manganese superox-ide dismutase in atopic dermati-tis. J. Allergy Clin. Immunol. 115, 1068-1075.
102. Schweitzer-Stenner, R., and Pecht, I. (2005). Death of a dogma or enforcing the artificial: monomeric IgE binding may initiate mast cell response by inducing its recep-tor aggregation. J. Immunol. 174, 4461-4464.
103. Segal, D. M., Taurog, J. D., and Metzger, H. (1977). Dimeric immunoglobu-lin E serves as a unit signal for mast cell degranulation. Proc. Natl. Acad. Sci. U.S.A. 74, 2993-2997.
104. Sethi, D. K., Agarwal, A., Manivel, V., Rao, K. V., and Salunke, D. M. (2006). Differential epitope posi-tioning within the germline anti-body paratope enhances promiscu-ity in the primary immune response. Immunity 24, 429-438.
105. Sly, L. M., Kalesnikoff, J., Lam,V.,Wong, D., Song, C., Omeis, S., Chan, K., Lee, C. W., Siraganian, R. P., Rivera, J., and Krystal, G. (2008). IgE-induced mast cell survival requires the prolonged generation of reac-tive oxygen species. J. Immunol. 181, 3850-3860.
106. Smurthwaite, L., Walker, S. N., Wilson, D. R., Birch, D. S., Merrett, T. G., Durham, S. R., and Gould, H. J. (2001). Persistent IgE syn-thesis in the nasal mucosa of hay fever patients. Eur. J. Immunol. 31, 3422-3431.
107. Snow, R. E., Chapman, C. J., Frew, A. J., Holgate, S. T., and Stevenson, F. K. (1995). Analysis of Ig VH region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma. J. Immunol. 154, 5576-5581.
108. Snow, R. E., Chapman, C. J., Frew, A. J., Holgate, S. T., and Steven-son, F. K. (1997). Pattern of usage and somatic hypermutation in the V(H)5 gene segments of a patient with asthma: implications for IgE. Eur. J. Immunol. 27, 162-170.
109. Snow, R. E., Chapman, C. J., Holgate, S. T.,and Stevenson,F. K. (1998). Clon-ally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing pat-terns of somatic mutation. Eur. J. Immunol. 28, 3354-3361.
110. Spencer, J., Barone, F., and Dunn-Walters, D. (2009). Generation of Immunoglobulin diversity in human gut-associated lymphoid tis-sue. Semin. Immunol. 21, 139-146.
111. Spitzauer, S., Schweiger, C., Sperr, W. R., Pandjaitan, B., Valent, P., Muhl, S., Ebner, C., Scheiner, O., Kraft, D., Rumpold, H., and Valenta, R. (1994). Molecular characterization of dog albumin as a cross-reactive allergen. J. Allergy Clin. Immunol. 93, 614-627.
112. Stallman, P. J., and Aalberse, R. C. (1977). Estimation of basophil-bound IgE by quantitative immuno-fluorescence microscopy. Int. Arch. Allergy Appl. Immunol. 54, 9-18.
113. Stanfield, R. L., Takimoto-Kamimura, M., Rini, J. M., Profy, A. T., and Wilson, I. A. (1993). Major antigen-induced domain rearrangements in an antibody. Structure 1, 83-93.
114. Stevens, F. J., Chang, C. H., and Schiffer, M. (1988). Dual conforma-tions of an immunoglobulin lightchain dimer: heterogeneity of antigen specificity and idiotope profile may result from multiple variable-domain interaction mechanisms. Proc. Natl. Acad. Sci. U.S.A. 85, 6895-6899.
115. Sunyer, J., Anto, J. M., Castellsague, J., Soriano, J. B., and Roca, J. (1996). Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. Eur. Respir. J. 9, 1880-1884.
116. Swindle, E. J., Coleman, J. W., Deleo, F. R., and Metcalfe, D. D. (2007). FcepsilonRI-and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase-and cyclooxygenase-dependent and NADPH oxidase-independent. J. Immunol. 179, 7059-7071.
117. Swindle, E. J., and Metcalfe, D. D. (2007). The role of reactive oxygen species and nitric oxide in mast cell-dependent inflammatory processes. Immunol. Rev. 217, 186-205.
118. Takhar, P., Corrigan, C. J., Smurthwaite, L., O'Connor, B. J., Durham, S. R., Lee, T. H., and Gould, H. J. (2007). Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. J. Allergy Clin. Immunol. 119, 213-218.
119. Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R., and Gould, H. J. (2005). Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. J. Immunol. 174, 5024-5032.
120. Teplyakov, A., Obmolova, G., Malia, T., and Gilliland, G. (2011). Anti-gen recognition by antibody C836 through adjustment of V(L)/V(H) packing. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67, 1165-1167.
121. Thielges, M. C., Zimmermann, J., Yu, W., Oda, M., and Romesberg, F. E. (2008). Exploring the energy landscape of antibody-antigen com-plexes: protein dynamics, flexibil-ity, and molecular recognition. Biochemistry 47, 7237-7247.
122. Thorpe, I. F., and Brooks, C. L. III (2007). Molecular evolution of affin-ity and flexibility in the immune sys-tem. Proc. Natl. Acad. Sci. U.S.A. 104, 8821-8826.
123. Turner, H., and Kinet, J. P. (1999). Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 402, B24-B30.
124. Valenta, R., Duchene, M., Pettenburger, K., Sillaber, C.,Valent, P., Bettelheim, P., Breitenbach, M., Rumpold, H., Kraft, D., and Scheiner, O. (1991). Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 253, 557-560.
125. Valenta, R., Mittermann, I., Werfel, T., Garn, H., and Renz, H. (2009). Linking allergy to autoim-mune disease. Trends Immunol. 30, 109-116.
126. Vargas-Madrazo, E., and Paz-Garcia, E. (2003). An improved model of asso-ciation for VH-VL immunoglobu-lin domains: asymmetries between VH and VL in the packing of some interface residues. J. Mol. Recognit. 16, 113-120.
127. Wan, T., Beavil, R. L., Fabiane, S. M., Beavil, A. J., Sohi, M. K., Keown, M., Young, R. J., Henry, A. J., Owens, R. J., Gould, H. J., and Sutton, B. J. (2002). The crystal structure of IgE Fc reveals an asymmetrically bent conformation. Nat. Immunol. 3, 681-686.
128. Wang, J., Cheng, X., Xiang, M. X., Alanne-Kinnunen, M., Wang, J. A., Chen, H., He, A., Sun, X., Lin, Y., Tang, T. T., Tu, X., Sjoberg, S., Sukhova, G. K., Liao, Y. H., Conrad, D. H.,Yu,L.,Kawakami,T.,Kovanen, P. T., Libby, P., and Shi, G. P. (2011). IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atheroge-nesis in Apoe-/-mice. J. Clin. Invest. 121, 3564-3577.
129. Wantke,F.,Macglashan,D.W.,Langdon, J. M., and Macdonald, S. M. (1999). The human recombinant histamine releasing factor: functional evidence that it does not bind to the IgE mol-ecule. J. Allergy Clin. Immunol. 103, 642-648.
130. Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., and Nussenzweig, M. C. (2003). Pre-dominant autoantibody production by early human B cell precursors. Science 301, 1374-1377.
131. Wedemayer, G. J., Patten, P. A., Wang, L. H., Schultz, P. G., and Stevens, R. C. (1997). Structural insights into the evolution of an antibody combining site. Science 276, 1665-1669.
132. Xie, L., Schroeder, J. T., Langdon, J. M., Sora-Scott, R. S., Kawakami, T., and Macdonald, S. M. (2008). Human IgE+ and IgE-are not equiv-alent to mouse highly cytokinergic IgE. J. Allergy Clin. Immunol. 121, 1027-1033.
133. Yadav, S., Laue, T. M., Kalonia, D. S., and Shire, S. J. (2012). The influ-ence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions. Mol. Pharm. 9, 791-802.
134. Yamaguchi, M., Lantz, C. S., Oettgen, H. C., Katona, I. M., Fleming, T., Miyajima, I., Kinet, J. P., and Galli, S. J. (1997). IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185, 663-672.
135. Yamaguchi, M., Sayama, K., Yano, K., Lantz, C. S., Noben-Trauth, N., Ra, C., Costa, J. J., and Galli, S. J. (1999). IgE enhances Fc epsilon recep-tor I expression and IgE-dependent release of histamine and lipid medi-ators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. J. Immunol. 162, 5455-5465.
136. Yamasaki, S., Ishikawa, E., Kohno, M., and Saito, T. (2004). The quan-tity and duration of FcRgamma sig-nals determine mast cell degran-ulation and survival. Blood 103, 3093-3101.
137. Yamasaki, S., Ishikawa, E., Sakuma, M., Kanagawa, O., Cheng, A. M., Malissen, B., and Saito, T. (2007). LAT and NTAL medi-ate immunoglobulin E-induced sus-tained extracellular signal-regulated kinase activation critical for mast cell survival. Mol. Cell. Biol. 27, 4406-4415.
138. Yanagida, M., Fukamachi, H., Ohgami, K., Kuwaki, T., Ishii, H., Uzumaki, H.,Amano,K.,Tokiwa,T.,Mitsui,H., Saito, H., Iikura, Y., Ishizaka, T., and Nakahata, T. (1995). Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Blood 86, 3705-3714.
139. Yin, J., Beuscher, A. E. T., Andryski, S. E., Stevens, R. C., and Schultz, P. G. (2003). Structural plasticity and the evolution of antibody affinity and specificity. J. Mol. Biol. 330,651-656.
140. Zhang, N., Holtappels, G., Gevaert, P., Patou, J., Dhaliwal, B., Gould, H., and Bachert, C. (2011). Mucosal tis-sue polyclonal IgE is functional in response to allergen and SEB. Allergy 66, 141-148.
141. Zimmermann, J., Oakman, E. L., Thorpe, I. F., Shi, X., Abbyad, P., Brooks, C. L. III, Boxer, S. G., and Romesberg, F. E. (2006). Anti-body evolution constrains confor-mational heterogeneity by tailoring protein dynamics. Proc. Natl. Acad. Sci. U.S.A. 103, 13722-13727.
142. Zimmermann, J., Romesberg, F. E., Brooks, C. L. III, and Thorpe, I. F. (2010). Molecular description of flexibility in an antibody combin-ing site. J. Phys. Chem. B 114, 7359-7370.