Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 36, 2005, Pages 12730-12735

  James, Leo C ^a   Tawfik, Dan S ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Conformational diversity; Induced fit; Multispecificity; Promiscuity

Indexed keywords

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION; HYDROGEN BOND; ISOMER; ISOMERIZATION; KINETICS; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTHRACENES; ANTIBODY SPECIFICITY; ANTIGENS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; IMMUNOGLOBULIN E; ISOMERISM; KINETICS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY;

EID: 24644521419     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500909102     Document Type: Article

References (28)

1. Mason, D. (1998) Immunol. Today 19, 395-404.
2. Kriwacki, R. W., Hengst, L., Tennant, L., Reed, S. I. & Wright, P. E. (1996) Proc. Natl. Acad. Sci. USA 93, 11504-11509.
3. Sprang, S. R. (1997) Annu. Rev. Biochem. 66, 639-678.
4. Goh, C. S., Milburn, D. & Gerstein, M. (2004) Curr. Opin. Struct. Biol. 14, 104-109.
5. De Guzman, R. N., Martinez-Yamout, M. A., Dyson, H. J. & Wright, P. E. (2004) J. Biol. Chem. 279, 3042-3049.
6. Holler, P. D. & Kranz, D. M. (2004) Mol. Immunol. 40, 1027-1031.
7. James, L. C., Roversi, P. & Tawfik, D. S. (2003) Science 299, 1362-1367.
8. Wright, P. E. & Dyson, H. J. (1999) J. Mol. Biol. 293, 321-331.
9. Del Carmine, R., Molinari, P., Sbraccia, M., Ambrosio, C. & Costa, T. (2004) Mol. Pharmacol. 66, 356-363.
10. Karbstein, K. & Herschlag, D. (2003) Proc. Natl. Acad. Sci. USA 100, 2300-2305.
11. Varga, J. M., Kalchschmid, G., Klein, G. F. & Fritsch, P. (1991) Mol. Immunol. 28, 641-654.
12. James, L. C. & Tawfik, D. S. (2003) Protein Sci. 12, 2183-2193.
13. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. D 50, 760-763.
14. DeLano, W. L. (2002) The PYMOL Molecular Graphics System (DeLano Scientific, San Carlos, CA).
15. Fersht, A. (1985) Enzyme Structure and Mechanism (Freeman, New York).
16. Foote, J. & Milstein, C. (1994) Proc. Natl. Acad. Sci. USA 91, 10370-10374.
17. Sundberg, E. J. & Mariuzza, R. A. (2002) Adv. Protein Chem. 61, 119-160.
18. Rini, J. M., Schulze-Gahmen, U. & Wilson, I. A. (1992) Science 255, 959-965.
19. Krebs, W. G. & Gerstein, M. (2000) Nucleic Acids Res. 28, 1665-1675.
20. Jimenez, R., Salazar, G., Yin, J., Joo, T. & Romesberg, F. E. (2004) Proc. Natl. Acad. Sci. USA 101, 3803-3808.
21. Lawrence, M. C. & Colman, P. M. (1993) J. Mol. Biol. 234, 946-950.
22. Stanfield, R. L., Takimoto-Kamimura, M., Rini, J. M., Profy, A. T. & Wilson, I. A. (1993) Structure (London) 1, 83-93.
23. Wilson, I. A. & Stanfield, R. L. (1994) Curr. Opin. Struct. Biol. 4, 857-867.
24. Li, Y., Li, H., Yang, F., Smith-Gill, S. J. & Mariuzza, R. A. (2003) Nat. Struct. Biol. 10, 482-488.
25. Jimenez, R., Salazar, G., Baldridge, K. K. & Romesberg, F. E. (2003) Proc. Natl. Acad. Sci. USA 100, 92-97.
26. Manivel, V., Sahoo, N. C., Salunke, D. M. & Rao, K. V. S. (2000) Immunity 13, 611-620.
27. Foote, J. & Milstein, C. (1991) Nature 352, 530-532.
28. Roost, H. P., Bachmann, M. F., Haag, A., Kalinke, U., Pliska, V., Hengartner, H. & Zinkernagel, R. M. (1995) Proc. Natl. Acad. Sci. USA 92, 1257-1261.