Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts

Biochemical Journal

Volumn 346, Issue 2, 2000, Pages 519-528

  Boehm, Mark K ^a,b   Corper, Adam L ^c   Wan, Tommy ^c   Sohi, Maninder K ^c   Sutton, Brian J ^c   Thornton, Jeremy D ^b   Keep, Patricia A ^b   Chester, Kerry A ^b   Begent, Richard H J ^b   Perkins, Stephen J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antibody combining site; Dimerization; Humanization; Immunoglobulin

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; THREONINE;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; HYDROPHOBICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; CARCINOEMBRYONIC ANTIGEN; EPITOPES; IMMUNOGLOBULIN FC FRAGMENTS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

EID: 0034161846     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3460519     Document Type: Article

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