Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Journal of Allergy and Clinical Immunology

Volumn 129, Issue 4, 2012, Pages 1102-1115

  Chu, Seung Y ^a   Horton, Holly M ^a   Pong, Erik ^a   Leung, Irene W L ^a   Chen, Hsing ^a   Nguyen, Duc Hanh ^a   Bautista, Cristina ^a   Muchhal, Umesh S ^a   Bernett, Matthew J ^a   Moore, Gregory L ^a   Szymkowski, David E ^a   Desjarlais, John R ^a  

^a Xencor Inc   (United States)

Author keywords

Allergy; asthma; Fc RIIb; Fc RI; humanized mice; IgE; inhibitory receptor; omalizumab; plasma cell; therapeutic antibody

Indexed keywords

B LYMPHOCYTE RECEPTOR; FC GAMMA R IIB; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; OMALIZUMAB; UNCLASSIFIED DRUG; XENP 6402; XENP 6727; XENP 6728; XENP 7196; XENP 8252; XENP 8253; XMAB 7195;

AFFINITY LABELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ARTICLE; BASOPHIL; BINDING AFFINITY; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOSUPPRESSIVE TREATMENT; MAST CELL; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA CELL; PRIORITY JOURNAL; RECEPTOR BINDING; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-ALLERGIC AGENTS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY AFFINITY; B-LYMPHOCYTES; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; PROTEIN BINDING; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGE; RECEPTORS, IGG;

EID: 84862777586     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.11.029     Document Type: Article

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