Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5277-5289

  Aminake, Makoah N ^a   Mahajan, Aman ^b   Kumar, Vipan ^c   Hans, Renate ^d   Wiesner, Lubbe ^b   Taylor, Dale ^b   De Kock, Carmen ^b   Grobler, Anne ^e   Smith, Peter J ^b   Kirschner, Marc ^a   Rethwilm, Axel ^a   Pradel, Gabriele ^a   Chibale, Kelly ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c GURU NANAK DEV UNIVERSITY   (India)

^d UNIVERSITY OF NAMIBIA   (Namibia)

^e NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Combination therapy; Drug metabolism; HIV AIDS; Hybrid drugs; Malaria; Medicinal chemistry; Pharmacokinetics

Indexed keywords

1 (4 AZIDO 5 DECAHYDRO 3,6,9 TRIMETHYL 3,12 EPOXY 12H PYRANO[4,3 J] 1,2 BENZODIOXEPIN 10 OXYMETHYL TETRAMETHYL TETRAHYDRO FURAN 2 YL) 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 (4 AZIDO 5 HYDROXYMETHYL TETRAHYDRO FURAN 2 YL) 3 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 (4 AZIDO 5 HYDROXYMETHYL TETRAHYDRO FURAN 2 YL) 3 [3 (7 CHLORO QUINOLIN 4 YLAMINO) BENZYL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 3 [2 HYDROXYMETHYL 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H 2 PYRIMIDIN 1 YL)TETRAHYDRO FURAN 3 YL]UREA; 1 [2 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 5 [5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL]TETRAHYDROFURAN 3 YL] 3 [2 [7 CHLOROQUINOLIN 4 YLAMINO]ETHYL]UREA; 1 [2 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 5 [5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL]TETRAHYDROFURAN 3 YL] 3 [2 [7 CHLOROQUINOLIN 4 YLAMINO]PENTYL]UREA; 1 [5 (7 CHLORO QUINOLIN 4 YLAMINO) PENTYL] 3 [2 HYDROXYMETHYL 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)TETRAHYDRO FURAN 3 YL]UREA; 1 [5 (7 CHLORO QUINOLIN 4 YLAMINO) PENTYL] N [2 HYDROXYMETHYL 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)TETRAHYDRO FURAN 3 YL]OXALAMIDE; ANTIMALARIAL AGENT; ANTIVIRUS AGENT; ARTEMISININ; CHLOROQUINE; DIHYDROARTEMISININ; ETHYL 2 [2 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 5 [METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1 (2H) YL]TETRAHYDROFURAN 3 YLAMINO] 2 OXOACETATE; N [2 (TERT BUTYL DIPHENYL SILANYLOXYMETHYL) 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL) TETRAHYDROFURAN 3 YL] 2 (1,2,4,5 TETRAOXA 3 BICYCLO[3,3.1]NONANE SPIRO[5.5]UNDEC 9 YL)ACETAMIDE; N [2 HYDROXYMETHYL 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL) TETRAHYDROFURAN 3 YL] 2 (1,2,4,5 TETRAOXA 3 BICYCLO[3,3.1]NONANE SPIRO[5.5]UNDEC 9 YL)ACETAMIDE; N1 [2 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 5 [5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL]TETRAHYDROFURAN 3 YL] 3 [2 [7 CHLOROQUINOLIN 4 YLAMINO]PENTYL]OXALAMIDE; PHENYL 2 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1 (2H) YL)TETRAHYDROFURAN 3 YLCARBAMATE; TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DEALKYLATION; DESILYLATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; MALARIA; MALE; MOUSE; NONHUMAN; SILYLATION; TREATMENT RESPONSE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTI-HIV AGENTS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; MALARIA; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 84865043450     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.038     Document Type: Article

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