메뉴 건너뛰기




Volumn 50, Issue 2, 2013, Pages 179-191

Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer

Author keywords

Cancer; Cryptic exon; Ghrelin; Insulin; Prostate; Splicing; Testis

Indexed keywords

AMINO ACID; GHRELIN; INSULIN;

EID: 84874084911     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0150     Document Type: Article
Times cited : (19)

References (93)
  • 1
    • 84874102233 scopus 로고    scopus 로고
    • Insulin-like growth factor pathway: A link between androgen deprivation therapy (ADT), insulin resistance, and disease progression in patients with prostate cancer?
    • In press. (doi:10.1016/j.urolonc.2011.05.001)
    • Aggarwal RR, Ryan CJ & Chan JM 2013 Insulin-like growth factor pathway: a link between androgen deprivation therapy (ADT), insulin resistance, and disease progression in patients with prostate cancer? Urologic Oncology. In press. (doi:10.1016/j.urolonc.2011.05.001)
    • (2013) Urologic Oncology
    • Aggarwal, R.R.1    Ryan, C.J.2    Chan, J.M.3
  • 2
    • 17844406634 scopus 로고    scopus 로고
    • Relationship between obesity and prostate cancer
    • (doi:10.1097/01.mou.0000165550. 94663.fb)
    • Amling CL 2005 Relationship between obesity and prostate cancer. Current Opinion in Urology 15 167-171. (doi:10.1097/01.mou.0000165550. 94663.fb)
    • (2005) Current Opinion In Urology , vol.15 , pp. 167-171
    • Amling, C.L.1
  • 3
    • 79958082780 scopus 로고    scopus 로고
    • The effects of ghrelin on inflammation and the immune system
    • (doi:10.1016/j.mce.2011.04.019)
    • Baatar D, Patel K & Taub DD 2011 The effects of ghrelin on inflammation and the immune system. Molecular and Cellular Endocrinology 340 44-58. (doi:10.1016/j.mce.2011.04.019)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 44-58
    • Baatar, D.1    Patel, K.2    Taub, D.D.3
  • 7
    • 0034326362 scopus 로고    scopus 로고
    • Analysis of canonical and non-canonical splice sites in mammalian genomes
    • (doi:10.1093/nar/28.21.4364)
    • Burset M, Seledtsov IA & Solovyev VV 2000 Analysis of canonical and non-canonical splice sites in mammalian genomes. Nucleic Acids Research 28 4364-4375. (doi:10.1093/nar/28.21.4364)
    • (2000) Nucleic Acids Research , vol.28 , pp. 4364-4375
    • Burset, M.1    Seledtsov, I.A.2    Solovyev, V.V.3
  • 8
    • 34250745251 scopus 로고    scopus 로고
    • Obesity and prostate cancer: Epidemiology and clinical implications
    • (doi:10.1016/j.eururo.2007.04.069)
    • Buschemeyer WC III & Freedland SJ 2007 Obesity and prostate cancer: epidemiology and clinical implications. European Urology 52 331-343. (doi:10.1016/j.eururo.2007.04.069)
    • (2007) European Urology , vol.52 , pp. 331-343
    • Buschemeyer III, W.C.1    Freedland, S.J.2
  • 9
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • (doi:10.1210/jc.86.4.1738)
    • Cassoni P, Papotti M, Ghe C, Catapano F, Sapino A, Graziani A, Deghenghi R, Reissmann T, Ghigo E & Muccioli G 2001 Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. Journal of Clinical Endocrinology and Metabolism 86 1738-1745. (doi:10.1210/jc.86.4.1738)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 1738-1745
    • Cassoni, P.1    Papotti, M.2    Ghe, C.3    Catapano, F.4    Sapino, A.5    Graziani, A.6    Deghenghi, R.7    Reissmann, T.8    Ghigo, E.9    Muccioli, G.10
  • 10
    • 12144290080 scopus 로고    scopus 로고
    • Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines
    • (doi:10.1530/eje.0.1500173)
    • Cassoni P, Ghe C, Marrocco T, Tarabra E, Allia E, Catapano F, Deghenghi R, Ghigo E, Papotti M & Muccioli G 2004 Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. European Journal of Endocrinology 150 173-184. (doi:10.1530/eje.0.1500173)
    • (2004) European Journal of Endocrinology , vol.150 , pp. 173-184
    • Cassoni, P.1    Ghe, C.2    Marrocco, T.3    Tarabra, E.4    Allia, E.5    Catapano, F.6    Deghenghi, R.7    Ghigo, E.8    Papotti, M.9    Muccioli, G.10
  • 12
    • 84870995025 scopus 로고    scopus 로고
    • The ghrelin axis-does it have an appetite for cancer progression?
    • (doi:10.1210/er.2011-1007)
    • Chopin LK, Seim I, Walpole CM & Herington AC 2012 The ghrelin axis-does it have an appetite for cancer progression? Endocrine Reviews 33 849-891. (doi:10.1210/er.2011-1007)
    • (2012) Endocrine Reviews , vol.33 , pp. 849-891
    • Chopin, L.K.1    Seim, I.2    Walpole, C.M.3    Herington, A.C.4
  • 14
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone releasing acylated peptide is synthesised in a distinct endocrine cell type in gastrointestinal tracts of rats and humans
    • (doi:10.1210/en.141.11.4255)
    • Date Y, Kojima M, Hosada H, Sawaguchi A, Mondal M, Suganama T, Matsukura S, Kangawa K & Nakazato M 2000 Ghrelin, a novel growth hormone releasing acylated peptide is synthesised in a distinct endocrine cell type in gastrointestinal tracts of rats and humans. Endocrinology 141 4255-4261. (doi:10.1210/en.141.11.4255)
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosada, H.3    Sawaguchi, A.4    Mondal, M.5    Suganama, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 15
    • 79958134198 scopus 로고    scopus 로고
    • Ghrelin and cachexia: Will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?
    • (doi:10.1016/j.mce.2011.02.012)
    • Deboer MD 2011 Ghrelin and cachexia: will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes? Molecular and Cellular Endocrinology 340 97-105. (doi:10.1016/j.mce.2011.02.012)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 97-105
    • Deboer, M.D.1
  • 16
    • 9244225118 scopus 로고    scopus 로고
    • Ghrelin degradation by serum and tissue homogen-ates: Identification of the cleavage sites
    • (doi:10.1210/en.2004-0569)
    • De Vriese C, Gregoire F, Lema-Kisoka R, Waelbroeck M, Robberecht P & Delporte C 2004 Ghrelin degradation by serum and tissue homogen-ates: identification of the cleavage sites. Endocrinology 145 4997-5005. (doi:10.1210/en.2004-0569)
    • (2004) Endocrinology , vol.145 , pp. 4997-5005
    • de Vriese, C.1    Gregoire, F.2    Lema-Kisoka, R.3    Waelbroeck, M.4    Robberecht, P.5    Delporte, C.6
  • 19
    • 67349097700 scopus 로고    scopus 로고
    • Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons
    • (doi:10.1159/000167698)
    • Fick LJ, Cai F & Belsham DD 2009 Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons. Neuroendocrinology 89 267-275. (doi:10.1159/000167698)
    • (2009) Neuroendocrinology , vol.89 , pp. 267-275
    • Fick, L.J.1    Cai, F.2    Belsham, D.D.3
  • 23
    • 79961174491 scopus 로고    scopus 로고
    • A novel human ghrelin variant (in1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: Potential pathophysiological relevance
    • (doi:10.1371/journal.pone.0023302)
    • Gahete MD, Cordoba-Chacon J, Hergueta-Redondo M, Mart́inez-Fuentes AJ, Kineman RD, Moreno-Bueno G, Luque RM & Castano JP 2011 A novel human ghrelin variant (in1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. PLoS ONE 6 e23302. (doi:10.1371/journal.pone.0023302)
    • (2011) PLoS ONE , vol.6
    • Gahete, M.D.1    Cordoba-Chacon, J.2    Hergueta-Redondo, M.3    Mart́inez-Fuentes, A.J.4    Kineman, R.D.5    Moreno-Bueno, G.6    Luque, R.M.7    Castano, J.P.8
  • 30
    • 28244481524 scopus 로고    scopus 로고
    • Hyperinsulinaemia: A prospective risk factor for lethal clinical prostate cancer
    • (doi:10.1016/j.ejca.2005.09.003)
    • Hammarsten J & Hogstedt B 2005 Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. European Journal of Cancer 41 2887-2895. (doi:10.1016/j.ejca.2005.09.003)
    • (2005) European Journal of Cancer , vol.41 , pp. 2887-2895
    • Hammarsten, J.1    Hogstedt, B.2
  • 31
    • 80052717911 scopus 로고    scopus 로고
    • Urological aspects of the metabolic syndrome. Nature Reviews
    • (doi:10.1038/nrurol. 2011.112)
    • Hammarsten J & Peeker R 2011 Urological aspects of the metabolic syndrome. Nature Reviews. Urology 8 483-494. (doi:10.1038/nrurol. 2011.112)
    • (2011) Urology , vol.8 , pp. 483-494
    • Hammarsten, J.1    Peeker, R.2
  • 32
    • 77957220643 scopus 로고    scopus 로고
    • A higher prediagnostic insulin level is a prospective risk factor for incident prostate cancer
    • doi:10.1016/j.canep.2010.06.014)
    • Hammarsten J, Damber JE, Peeker R, Mellstrom D & Hogstedt B 2010 A higher prediagnostic insulin level is a prospective risk factor for incident prostate cancer. Cancer Epidemiology 34 574-579. (doi:10.1016/j.canep.2010.06.014)
    • (2010) Cancer Epidemiology , vol.34 , pp. 574-579
    • Hammarsten, J.1    Damber, J.E.2    Peeker, R.3    Mellstrom, D.4    Hogstedt, B.5
  • 33
    • 61649125623 scopus 로고    scopus 로고
    • Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells
    • doi:10.1186/gb-2009-10-1-r11
    • Hartmann B, Castelo R, Blanchette M, Boue S, Rio DC & Valcarcel J 2009 Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells. Genome Biology 10 R11. (doi:10.1186/gb-2009-10-1-r11)
    • (2009) Genome Biology , vol.10
    • Hartmann, B.1    Castelo, R.2    Blanchette, M.3    Boue, S.4    Rio, D.C.5    Valcarcel, J.6
  • 34
    • 62749098351 scopus 로고    scopus 로고
    • A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis
    • doi:10.1371/journal.pone.0004732
    • He C, Zhou F, Zuo Z, Cheng H & Zhou R 2009 A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS ONE 4 e4732. (doi:10.1371/journal.pone.0004732)
    • (2009) PLoS ONE , vol.4
    • He, C.1    Zhou, F.2    Zuo, Z.3    Cheng, H.4    Zhou, R.5
  • 35
    • 77951769605 scopus 로고    scopus 로고
    • Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer
    • doi:10.1016/j.clon.2010.02.001
    • Healy LA, Ryan AM, Carroll P, Ennis D, Crowley V, Boyle T, Kennedy MJ, Connolly E & Reynolds JV 2010 Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer. Clinical Oncology 22 281-288. (doi:10.1016/j.clon.2010.02.001)
    • (2010) Clinical Oncology , vol.22 , pp. 281-288
    • Healy, L.A.1    Ryan, A.M.2    Carroll, P.3    Ennis, D.4    Crowley, V.5    Boyle, T.6    Kennedy, M.J.7    Connolly, E.8    Reynolds, J.V.9
  • 36
    • 73449138387 scopus 로고    scopus 로고
    • Circulating ghrelin exists in both lipoprotein bound and free forms
    • doi:10.1258/acb.2009.008254)
    • Holmes E, Davies I, Lowe G & Ranganath LR 2009 Circulating ghrelin exists in both lipoprotein bound and free forms. Annals of Clinical Biochemistry 46 514-516. (doi:10.1258/acb.2009.008254)
    • (2009) Annals of Clinical Biochemistry , vol.46 , pp. 514-516
    • Holmes, E.1    Davies, I.2    Lowe, G.3    Ranganath, L.R.4
  • 37
    • 2642570058 scopus 로고    scopus 로고
    • Optimum collection and storage conditions for ghrelin measurements: Octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples
    • doi:10.1373/clinchem.2003.025841
    • Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M, Ono F & Kangawa K 2004 Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clinical Chemistry 50 1077-1080. (doi:10.1373/clinchem.2003.025841)
    • (2004) Clinical Chemistry , vol.50 , pp. 1077-1080
    • Hosoda, H.1    Doi, K.2    Nagaya, N.3    Okumura, H.4    Nakagawa, E.5    Enomoto, M.6    Ono, F.7    Kangawa, K.8
  • 39
    • 79958127428 scopus 로고    scopus 로고
    • Ghrelin in cardiovascular disease and atherogenesis
    • (doi:10.1016/j.mce.2011.03.006)
    • Isgaard J & Granata R 2011 Ghrelin in cardiovascular disease and atherogenesis. Molecular and Cellular Endocrinology 340 59-64. (doi:10.1016/j.mce.2011.03.006)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 59-64
    • Isgaard, J.1    Granata, R.2
  • 40
    • 33947245127 scopus 로고    scopus 로고
    • Ghrelin expression in human testis and serum testosterone level
    • (doi:10.2164/jandrol.106.000810)
    • Ishikawa T, Fujioka H, Ishimura T, Takenaka A & Fujisawa M 2007 Ghrelin expression in human testis and serum testosterone level. Journal of Andrology 28 320-324. (doi:10.2164/jandrol.106.000810)
    • (2007) Journal of Andrology , vol.28 , pp. 320-324
    • Ishikawa, T.1    Fujioka, H.2    Ishimura, T.3    Takenaka, A.4    Fujisawa, M.5
  • 41
    • 0036123510 scopus 로고    scopus 로고
    • Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines
    • (doi:10.1677/ joe.0.172R007)
    • Jeffery PL, Herington AC & Chopin LK 2002 Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. Journal of Endocrinology 172 R7-R11. (doi:10.1677/ joe.0.172R007)
    • (2002) Journal of Endocrinology , vol.172
    • Jeffery, P.L.1    Herington, A.C.2    Chopin, L.K.3
  • 42
    • 28544446509 scopus 로고    scopus 로고
    • Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines
    • (doi:10.1677/erc.1.00984)
    • Jeffery P, Murray R, Yeh A, McNamara J, Duncan RP, Francis G, Herington A & Chopin L 2005 Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocrine-Related Cancer 12 839-850. (doi:10.1677/erc.1.00984)
    • (2005) Endocrine-Related Cancer , vol.12 , pp. 839-850
    • Jeffery, P.1    Murray, R.2    Yeh, A.3    McNamara, J.4    Duncan, R.P.5    Francis, G.6    Herington, A.7    Chopin, L.8
  • 45
    • 34347391255 scopus 로고    scopus 로고
    • Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress
    • (doi:10.1677/JME-06-0026)
    • Kineman RD, Gahete MD & Luque RM 2007 Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress. Journal of Molecular Endocrinology 38 511-521. (doi:10.1677/JME-06-0026)
    • (2007) Journal of Molecular Endocrinology , vol.38 , pp. 511-521
    • Kineman, R.D.1    Gahete, M.D.2    Luque, R.M.3
  • 47
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • (doi:10.1038/45230)
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660. (doi:10.1038/45230)
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 48
    • 57149146434 scopus 로고    scopus 로고
    • The role of endocrine insulin-like growth factor-I and insulin in breast cancer
    • doi:10.1007/s10911-008-9100-x
    • Lann D & LeRoith D 2008 The role of endocrine insulin-like growth factor-I and insulin in breast cancer. Journal of Mammary Gland Biology and Neoplasia 13 371-379. (doi:10.1007/s10911-008-9100-x)
    • (2008) Journal of Mammary Gland Biology and Neoplasia , vol.13 , pp. 371-379
    • Lann, D.1    Leroith, D.2
  • 49
    • 78049470371 scopus 로고    scopus 로고
    • Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: Evidence from mouse models
    • doi:10.1002/dmrr.1139
    • LeRoith D 2010 Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models. Diabetes/Metabolism Research and Reviews 26 599-601. (doi:10.1002/dmrr.1139)
    • (2010) Diabetes/Metabolism Research and Reviews , vol.26 , pp. 599-601
    • Leroith, D.1
  • 50
    • 80054866128 scopus 로고    scopus 로고
    • The ghrelin/GOAT/GHS-R system and energy metabolism
    • doi:10.1007/s11154-011-9169-1
    • Lim CT, Kola B & Korbonits M 2011 The ghrelin/GOAT/GHS-R system and energy metabolism. Reviews in Endocrine & Metabolic Disorders 12 173-186. (doi:10.1007/s11154-011-9169-1)
    • (2011) Reviews In Endocrine & Metabolic Disorders , vol.12 , pp. 173-186
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 51
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(KDDC(T)) method
    • (doi:10.1006/meth.2001.1262)
    • Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(KDDC(T)) method. Methods 25 402-408. (doi:10.1006/meth.2001.1262)
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 54
    • 54349083481 scopus 로고    scopus 로고
    • Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: A long-term survival analysis
    • (doi:10.1016/S1470-2045(08)70235-3)
    • Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL, Gaziano JM, Pollak M & Stampfer MJ 2008 Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncology 9 1039-1047. (doi:10.1016/S1470-2045(08)70235-3)
    • (2008) Lancet Oncology , vol.9 , pp. 1039-1047
    • Ma, J.1    Li, H.2    Giovannucci, E.3    Mucci, L.4    Qiu, W.5    Nguyen, P.L.6    Gaziano, J.M.7    Pollak, M.8    Stampfer, M.J.9
  • 55
    • 72049098765 scopus 로고    scopus 로고
    • Elevated blood active ghrelin and unaltered total ghrelin and obestatin concentrations in prostate carcinoma
    • (doi:10.1159/000251190)
    • Malendowicz W, Ziolkowska A, Szyszka M & Kwias Z 2009 Elevated blood active ghrelin and unaltered total ghrelin and obestatin concentrations in prostate carcinoma. Urologia Internationalis 83 471-475. (doi:10.1159/000251190)
    • (2009) Urologia Internationalis , vol.83 , pp. 471-475
    • Malendowicz, W.1    Ziolkowska, A.2    Szyszka, M.3    Kwias, Z.4
  • 56
    • 79952753928 scopus 로고    scopus 로고
    • Genome-wide analysis of alternative splicing in medullo-blastoma identifies splicing patterns characteristic of normal cerebellar development
    • (doi:10.1158/0008-5472. CAN-10-2519)
    • Menghi F, Jacques TS, Barenco M, Schwalbe EC, Clifford SC, Hubank M & Ham J 2011 Genome-wide analysis of alternative splicing in medullo-blastoma identifies splicing patterns characteristic of normal cerebellar development. Cancer Research 71 2045-2055. (doi:10.1158/0008-5472. CAN-10-2519)
    • (2011) Cancer Research , vol.71 , pp. 2045-2055
    • Menghi, F.1    Jacques, T.S.2    Barenco, M.3    Schwalbe, E.C.4    Clifford, S.C.5    Hubank, M.6    Ham, J.7
  • 58
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • (doi:10.1038/nature08909)
    • Nilsen TW & Graveley BR 2010 Expansion of the eukaryotic proteome by alternative splicing. Nature 463 457-463. (doi:10.1038/nature08909)
    • (2010) Nature , vol.463 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 59
    • 0029859045 scopus 로고    scopus 로고
    • Regulation of gene expression by insulin
    • O'Brien RM & Granner DK 1996 Regulation of gene expression by insulin. Physiological Reviews 76 1109-1161.
    • (1996) Physiological Reviews , vol.76 , pp. 1109-1161
    • O'Brien, R.M.1    Granner, D.K.2
  • 61
    • 41449114267 scopus 로고    scopus 로고
    • Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin
    • (doi:10.1080/08977190801889313)
    • Pazos Y, Alvarez CJ, Camina JP & Casanueva FF 2007 Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. Growth Factors 25 373-381. (doi:10.1080/08977190801889313)
    • (2007) Growth Factors , vol.25 , pp. 373-381
    • Pazos, Y.1    Alvarez, C.J.2    Camina, J.P.3    Casanueva, F.F.4
  • 64
    • 51549115215 scopus 로고    scopus 로고
    • Targeting insulin and insulin-like growth factor signalling in oncology
    • (doi:10.1016/j.coph.2008.07.004)
    • Pollak M 2008 Targeting insulin and insulin-like growth factor signalling in oncology. Current Opinion in Pharmacology 8 384-392. (doi:10.1016/j.coph.2008.07.004)
    • (2008) Current Opinion In Pharmacology , vol.8 , pp. 384-392
    • Pollak, M.1
  • 65
    • 77957165656 scopus 로고    scopus 로고
    • Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray
    • (doi:10.1186/1471-2407-10-482)
    • Rahman FA, Aziz N & Coverley D 2010 Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray. BMC Cancer 10 482. (doi:10.1186/1471-2407-10-482)
    • (2010) BMC Cancer , vol.10 , pp. 482
    • Rahman, F.A.1    Aziz, N.2    Coverley, D.3
  • 67
    • 0038724906 scopus 로고    scopus 로고
    • Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp
    • (doi:10.1074/jbc.M300293200)
    • Rome S, Clement K, Rabasa-Lhoret R, Loizon E, Poitou C, Barsh GS, Riou JP, Laville M & Vidal H 2003 Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. Journal of Biological Chemistry 278 18063-18068. (doi:10.1074/jbc.M300293200)
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 18063-18068
    • Rome, S.1    Clement, K.2    Rabasa-Lhoret, R.3    Loizon, E.4    Poitou, C.5    Barsh, G.S.6    Riou, J.P.7    Laville, M.8    Vidal, H.9
  • 69
    • 77957266562 scopus 로고    scopus 로고
    • Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
    • (doi:10.1210/en.2010-0412)
    • Satou M, Nishi Y, Yoh J, Hattori Y & Sugimoto H 2010 Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology 151 4765-4775. (doi:10.1210/en.2010-0412)
    • (2010) Endocrinology , vol.151 , pp. 4765-4775
    • Satou, M.1    Nishi, Y.2    Yoh, J.3    Hattori, Y.4    Sugimoto, H.5
  • 71
    • 35248827576 scopus 로고    scopus 로고
    • Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts
    • (doi:10.1186/1471-2164-8-298)
    • Seim I, Collet C, Herington AC & Chopin LK 2007 Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 8 298. (doi:10.1186/1471-2164-8-298)
    • (2007) BMC Genomics , vol.8 , pp. 298
    • Seim, I.1    Collet, C.2    Herington, A.C.3    Chopin, L.K.4
  • 72
    • 69249229780 scopus 로고    scopus 로고
    • New insights into the molecular complexity of the ghrelin gene locus
    • (doi:10.1016/j.cytogfr.2009.07.006)
    • Seim I, Herington AC & Chopin LK 2009 New insights into the molecular complexity of the ghrelin gene locus. Cytokine & Growth Factor Reviews 20 297-304. (doi:10.1016/j.cytogfr.2009.07.006)
    • (2009) Cytokine & Growth Factor Reviews , vol.20 , pp. 297-304
    • Seim, I.1    Herington, A.C.2    Chopin, L.K.3
  • 73
    • 79958156703 scopus 로고    scopus 로고
    • Ghrelin axis genes, peptides and receptors: Recent findings and future challenges
    • (doi:10.1016/j.mce. 2011.05.002)
    • Seim I, Josh P, Cunningham P, Herington A & Chopin L 2011a Ghrelin axis genes, peptides and receptors: recent findings and future challenges. Molecular and Cellular Endocrinology 340 3-9. (doi:10.1016/j.mce. 2011.05.002)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 3-9
    • Seim, I.1    Josh, P.2    Cunningham, P.3    Herington, A.4    Chopin, L.5
  • 74
    • 79958170443 scopus 로고    scopus 로고
    • The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease
    • (doi:10.1016/j.mce.2011.03.018)
    • Seim I, Walpole C, Amorim L, Josh P, Herington A & Chopin L 2011b The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Molecular and Cellular Endocrinology 340 111-117. (doi:10.1016/j.mce.2011.03.018)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 111-117
    • Seim, I.1    Walpole, C.2    Amorim, L.3    Josh, P.4    Herington, A.5    Chopin, L.6
  • 75
    • 34447106755 scopus 로고    scopus 로고
    • Alternative splicing in cancer: Noise, functional, or systematic?
    • doi:10.1016/j.biocel.2007.02.016
    • Skotheim RI & Nees M 2007 Alternative splicing in cancer: noise, functional, or systematic? International Journal of Biochemistry & Cell Biology 39 1432-1449. (doi:10.1016/j.biocel.2007.02.016)
    • (2007) International Journal of Biochemistry & Cell Biology , vol.39 , pp. 1432-1449
    • Skotheim, R.I.1    Nees, M.2
  • 76
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • Eds. R Gentleman, V Carey, S Dudoit, R Irizarry, W Huber. New York: Springer
    • Smyth G 2005 Limma: linear models for microarray data. In Bioinformatics and Computational Biology Solutions using R and Bioconductor, pp 397-420. Eds. R Gentleman, V Carey, S Dudoit, R Irizarry, W Huber. New York: Springer
    • (2005) Bioinformatics and Computational Biology Solutions Using R and Bioconductor , pp. 397-420
    • Smyth, G.1
  • 78
    • 80054700909 scopus 로고    scopus 로고
    • Long-term effects of insulin glargine on the risk of breast cancer
    • (doi:10.1007/s00125-011-2190-9)
    • Suissa S, Azoulay L, Dell'aniello S, Evans M, Vora J & Pollak M 2011 Long-term effects of insulin glargine on the risk of breast cancer. Diabetologia 54 2254-2262. (doi:10.1007/s00125-011-2190-9)
    • (2011) Diabetologia , vol.54 , pp. 2254-2262
    • Suissa, S.1    Azoulay, L.2    Dell'aniello, S.3    Evans, M.4    Vora, J.5    Pollak, M.6
  • 79
    • 70449632792 scopus 로고    scopus 로고
    • Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid
    • (doi:10.1093/jb/mvp112)
    • Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsuji A & Kojima M 2009 Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. Journal of Biochemistry 146 675-682. (doi:10.1093/jb/mvp112)
    • (2009) Journal of Biochemistry , vol.146 , pp. 675-682
    • Takahashi, T.1    Ida, T.2    Sato, T.3    Nakashima, Y.4    Nakamura, Y.5    Tsuji, A.6    Kojima, M.7
  • 82
    • 79958080521 scopus 로고    scopus 로고
    • Ghrelin in type 2 diabetes mellitus and metabolic syndrome
    • (doi:10.1016/j.mce.2011.02.009)
    • Ukkola O 2011 Ghrelin in type 2 diabetes mellitus and metabolic syndrome. Molecular and Cellular Endocrinology 340 26-28. (doi:10.1016/j.mce.2011.02.009)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 26-28
    • Ukkola, O.1
  • 85
    • 80052054096 scopus 로고    scopus 로고
    • Diabetes: Long-term use of insulin glargine might increase the risk of breast cancer. Nature Reviews
    • (doi:10.1038/nrendo.2011.112)
    • Wilson C 2011 Diabetes: long-term use of insulin glargine might increase the risk of breast cancer. Nature Reviews. Endocrinology 7 499. (doi:10.1038/nrendo.2011.112)
    • (2011) Endocrinology , vol.7 , pp. 499
    • Wilson, C.1
  • 87
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • (doi:10.1016/ j.cell.2008.01.017)
    • Yang J, Brown MS, Liang G, Grishin NV & Goldstein JL 2008 Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 387-396. (doi:10.1016/ j.cell.2008.01.017)
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 88
    • 28544441759 scopus 로고    scopus 로고
    • Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer
    • (doi:10.1158/1078-0432.CCR-05-0443)
    • Yeh A, Jeffery PL, Duncan RP, Herington A & Chopin L 2005 Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. Clinical Cancer Research 11 8295-8303. (doi:10.1158/1078-0432.CCR-05-0443)
    • (2005) Clinical Cancer Research , vol.11 , pp. 8295-8303
    • Yeh, A.1    Jeffery, P.L.2    Duncan, R.P.3    Herington, A.4    Chopin, L.5
  • 91
    • 69449084106 scopus 로고    scopus 로고
    • The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer
    • (doi:10.1038/aja.2008.44)
    • Yu SQ, Lai KP, Xia SJ, Chang HC, Chang C, Yeh S et al. 2009 The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer. Asian Journal of Andrology 11 39-48. (doi:10.1038/aja.2008.44)
    • (2009) Asian Journal of Andrology , vol.11 , pp. 39-48
    • Yu, S.Q.1    Lai, K.P.2    Xia, S.J.3    Chang, H.C.4    Chang, C.5    Yeh, S.6
  • 92
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin,apeptide encodedbytheghrelin gene, opposes ghrelin's effects on food intake
    • (doi:10.1126/science. 1117255)
    • Zhang J, Ren P-G, Avsian-Kretchmer O, Luo C-W, Raucg R, Klein C & Hsueh A 2005 Obestatin,apeptide encodedbytheghrelin gene, opposes ghrelin's effects on food intake. Science 310 996-999. (doi:10.1126/science. 1117255)
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.1    Ren, P.-G.2    Avsian-Kretchmer, O.3    Luo, C.-W.4    Raucg, R.5    Klein, C.6    Hsueh, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.