Preproghrelin expression is a key target for insulin action on adipogenesis

Journal of Endocrinology

Volumn 210, Issue 2, 2011, Pages

  Gurriarán Rodríguez, Uxía ^a,b   Al Massadi, Omar ^a,b   Crujeiras, Ana Belén ^a,b   Mosteiro, Carlos S ^a,b   Amil Diz, María ^a,b   Beiroa, Daniel ^b,c   Nogueiras, Rubén ^b,c   Seoane, Luisa María ^a,b   Gallego, Rosalía ^c   Pazos, Yolanda ^a,b   Casanueva, Felipe F ^a,b,c   Camiña, Jesús P ^a,b  

^a Santiago University Clinical Hospital   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PEPTIDES AND PROTEINS; PREPROGHRELIN; UNCLASSIFIED DRUG; PEPTIDE HORMONE; PROTEIN PRECURSOR; SMALL INTERFERING RNA;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL STRAIN 3T3; CYTOLOGY; METABOLISM; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; INSULIN; MALE; MICE; PEPTIDE HORMONES; PROTEIN PRECURSORS; RNA, SMALL INTERFERING;

EID: 80052563387     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0233     Document Type: Article

References (26)

1. An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C et al. 2010 Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cellular Physiology and Biochemistry 26 707-716.
2. Berggreen C, Gormand A, Omar B, Degerman E & Göransson O 2009 Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. American Journal of Physiology. Endocrinology and Metabolism 296 E635-E646.
3. Castañeda TR, Tong J, Datta R, CullerM& TschöpMH 2010 Ghrelin in the regulation of body weight and metabolism. Frontiers in Neuroendocrinology 31 44-60.
4. Cho H,Thorvaldsen JL,Chu Q, Feng F&Birnbaum MJ 2001 Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. Journal of Biological Chemistry 276 38349-38352.
5. Delhanty PJ, Sun Y, Visser JA, van Kerkwijk A, Huisman M, van Ijcken WF, Swagemakers S, Smith RG, Themmen AP & van der Lely AJ 2010 Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice. PLoS ONE 5 e11749.
6. Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR et al. 2003 Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. Journal of Clinical Investigation 112 197-208.
7. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB & Korbonits M 2002 The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. Journal of Clinical Endocrinology and Metabolism 87 2988.
8. Gurriaran-Rodriguez U, Al-Massadi O, Roca-Rivada A, Crujeiras AB, Gallego R, Pardo M, Seoane LM, Pazos Y, Casanueva FF & Camiña JP 2010 Obestatin as a regulator of adipocyte metabolism and adipogenesis. Journal of Cellular and Molecular Medicine (in press).
9. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE & Hale JE 2008 Ghrelin octanoylation mediated by an orphan lipid transferase. PNAS 105 6320-6325.
10. Knerr I, Herzog D, Rauh M, Rascher W & Horbach T 2006 Leptin and ghrelin expression in adipose tissues and serum levels in gastric banding patients. European Journal of Clinical Investigation 36 389-394.
11. Laplante M & Sabatini DM 2009 mTOR signaling at a glance. Journal of Cell Science 122 3589-3594.
12. Lodeiro M, Theodoropoulou M, Pardo M, Casanueva FF & Camiña JP 2009 c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS ONE 4 e4686.
13. Manning BD & Cantley LC 2007 AKT/PKB signaling: navigating downstream. Cell 129 1261-1274.
14. Rodriguez A, Gomez-Ambrosi J, Catalan V, Gil MJ, Becerril S, Sainz N, Silva C, Salvador J, Colina I & Frühbeck G 2009 Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. International Journal of Obesity 33 541-552.
15. Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL & Sabatini DM 2006 Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Molecular Cell 22 159-168.
16. Scherer PE 2006 Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55 1537-1545.
17. Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC & Wells T 2004 Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 234-242.
18. Trujillo ME & Scherer PE 2006 Adipose tissue-derived factors: impact on health and disease. Endocrine Reviews 27 762-778.
19. Virtue S & Vidal-Puig A 2010 Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective. Biochimica et Biophysica Acta 1801 338-349.
20. Wells T 2009 Ghrelin - defender of fat. Progress in Lipid Research 48 257-274.
21. Xu G, Li Y, AnW, Li S, Guan Y,Wang N, Tang C,Wang X, Zhu Y, Li X et al. 2009 Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 150 3637-3644.
22. Xu J & Liao K 2004 Protein kinase B/AKT1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-LI adipocyte differentiation. Journal of Biological Chemistry 279 35914-35922.
23. Yang J, Brown MS, Liang G, Grishin NV & Goldstein JL 2008 Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 387-396.
24. Zhang W, Chai B, Li JY,Wang H & Mulholland MW 2008 Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 149 4710-4716.
25. Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL & Manning BD 2009 Insulin stimulates adipogenesis through the Akt-TSC2- mTORC1 pathway. PLoS ONE 4 e6189.
26. Zhu X, Cao Y, Voogd K & Steiner DF 2006 On the processing of proghrelin to ghrelin. Journal of Biological Chemistry 281 38867-38870.