-
1
-
-
0029066110
-
Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs
-
Ou, S. H., Wu, F., Harrich, D., Garcfa-Martfnez, L. F., and Gaynor, R. B. (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. Virol. 69, 3584-3596
-
(1995)
Virol.
, vol.69
, pp. 3584-3596
-
-
Ou, S.H.1
Wu, F.2
Harrich, D.3
Garcfa-Martfnez, L.F.4
Gaynor, R.B.5
-
2
-
-
0344256486
-
Structural diversity and functional implications of the eukaryotic TDP gene family
-
Wang, H. Y., Wang, I. F., Bose, J., and Shen, C. K. (2004) Structural diversity and functional implications of the eukaryotic TDP gene family. Genomics 83, 130-139
-
(2004)
Genomics
, vol.83
, pp. 130-139
-
-
Wang, H.Y.1
Wang, I.F.2
Bose, J.3
Shen, C.K.4
-
3
-
-
47949086625
-
Phosphorylated TDP-43 in fron-totemporal lobar degeneration and amyotrophic lateral sclerosis
-
Hasegawa, M., Arai, T., Nonaka, T., Kametani, F., Yoshida, M., Hashi-zume, Y., Beach, T. G., Buratti, E., Baralle, F., Morita, M., Nakano, I., Oda, T., Tsuchiya, IC, and Akiyama, H. (2008) Phosphorylated TDP-43 in fron-totemporal lobar degeneration and amyotrophic lateral sclerosis. Ann. Neurol. 64, 60-70
-
(2008)
Ann. Neurol.
, vol.64
, pp. 60-70
-
-
Hasegawa, M.1
Arai, T.2
Nonaka, T.3
Kametani, F.4
Yoshida, M.5
Hashi-Zume, Y.6
Beach, T.G.7
Buratti, E.8
Baralle, F.9
Morita, M.10
Nakano, I.11
Oda, T.12
Tsuchiya, I.C.13
Akiyama, H.14
-
4
-
-
34249946466
-
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
-
Mackenzie, I. R., Bigio, E. H., Ince, P. G., Geser, F., Neumann, M., Cairns, N. J., Kwong, L. IC, Forman, M. S., Ravits, J., Stewart, H., Eisen, A., Mc-Clusky, L., Kretzschmar, H. A., Monoranu, C. M., Highley, J. R., Kirby, J., Siddique, T., Shaw, P. J., Lee, V. M., and Trojanowski, J. Q. (2007) Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann. Neurol. 61, 427-434
-
(2007)
Ann. Neurol.
, vol.61
, pp. 427-434
-
-
MacKenzie, I.R.1
Bigio, E.H.2
Ince, P.G.3
Geser, F.4
Neumann, M.5
Cairns, N.J.6
Kwong, L.I.C.7
Forman, M.S.8
Ravits, J.9
Stewart, H.10
Eisen, A.11
Mc-Clusky, L.12
Kretzschmar, H.A.13
Monoranu, C.M.14
Highley, J.R.15
Kirby, J.16
Siddique, T.17
Shaw, P.J.18
Lee, V.M.19
Trojanowski, J.Q.20
more..
-
5
-
-
35348853257
-
TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Protein misfolding diseases without amyloidosis
-
Neumann, M., Kwong, L. IC, Sampathu, D. M., Trojanowski, J. Q., and Lee, V. M. (2007) TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Protein misfolding diseases without amyloidosis. Arch. Neurol. 64, 1388-1394
-
(2007)
Arch. Neurol.
, vol.64
, pp. 1388-1394
-
-
Neumann, M.1
Kwong, L.I.C.2
Sampathu, D.M.3
Trojanowski, J.Q.4
Lee, V.M.5
-
6
-
-
33846815066
-
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations
-
Neumann, M., Mackenzie, I. R., Cairns, N. J., Boyer, P. J., Markesbery, W. R., Smith, C. D., Taylor, J. P., Kretzschmar, H. A., Kimonis, V. E., and Forman, M. S. (2007) TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations, J. Neuropathol. Exp. Neurol. 66, 152-157
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 152-157
-
-
Neumann, M.1
MacKenzie, I.R.2
Cairns, N.J.3
Boyer, P.J.4
Markesbery, W.R.5
Smith, C.D.6
Taylor, J.P.7
Kretzschmar, H.A.8
Kimonis, V.E.9
Forman, M.S.10
-
7
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann, M., Sampathu, D. M., Kwong, L. IC, Truax, A. C, Micsenyi, M. C, Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., McCluskey, L. F., Miller, B. L., Masliah, E., Mackenzie, I. R., Feldman, H., Feiden, W., Kretzschmar, H. A., Trojanowski, J. Q., and Lee, V. M. (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130-133
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.I.C.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
MacKenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.19
-
8
-
-
66149114101
-
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
-
Zhang, Y. J., Xu, Y. F., Cook, C, Gendron, T. F., Roettges, P., Link, C. D., Lin, W. L., Tong, J., Castanedes-Casey, M., Ash, P., Gass, J., Rangachari, V., Buratti, E., Baralle, F., Golde, T. E., Dickson, D. W., and Petrucelli, L. (2009) Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc. Natl. Acad. Sei. U.S.A. 106, 7607-7612
-
(2009)
Proc. Natl. Acad. Sei. U.S.A.
, vol.106
, pp. 7607-7612
-
-
Zhang, Y.J.1
Xu, Y.F.2
Cook, C.3
Gendron, T.F.4
Roettges, P.5
Link, C.D.6
Lin, W.L.7
Tong, J.8
Castanedes-Casey, M.9
Ash, P.10
Gass, J.11
Rangachari, V.12
Buratti, E.13
Baralle, F.14
Golde, T.E.15
Dickson, D.W.16
Petrucelli, L.17
-
9
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopa-thy mouse model
-
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S. M., Iwata, N., Saido, T. C, Maeda, J., Suhara, T., Trojanowski, I. Q., and Lee, V. M. (2007) Synapse loss and microglial activation precede tangles in a P301S tauopa-thy mouse model. Neuron 53, 337-351
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
Maeda, J.7
Suhara, T.8
Trojanowski, I.Q.9
Lee, V.M.10
-
10
-
-
0025729489
-
Ubiquitin-immu-noreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity
-
Leigh, P. N., Whitwell, H., Garofalo, O., Buller, J., Swash, M., Martin, J. E., Gallo, J. M., Weiler, R. O., and Anderton, B. H. (1991) Ubiquitin-immu-noreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. Brain 114, 775-788
-
(1991)
Brain
, vol.114
, pp. 775-788
-
-
Leigh, P.N.1
Whitwell, H.2
Garofalo, O.3
Buller, J.4
Swash, M.5
Martin, J.E.6
Gallo, J.M.7
Weiler, R.O.8
Anderton, B.H.9
-
11
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive T-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Arai, T., Hasegawa, M., Akiyama, H, Ikeda, IC, Nonaka, T., Mori, H, Mann, D., Tsuchiya, IC, Yoshida, M., Hashizume, Y., and Oda, T. (2006) TDP-43 is a component of ubiquitin-positive T-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 351, 602-611
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.351
, pp. 602-611
-
-
Arai, T.1
Hasegawa, M.2
Akiyama, H.3
Ikeda, I.C.4
Nonaka, T.5
Mori, H.6
Mann, D.7
Tsuchiya, I.C.8
Yoshida, M.9
Hashizume, Y.10
Oda, T.11
-
12
-
-
77956850818
-
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
-
Mackenzie, I. R., Rademakers, R., and Neumann, M. (2010) TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 9, 995-1007
-
(2010)
Lancet Neurol.
, vol.9
, pp. 995-1007
-
-
MacKenzie, I.R.1
Rademakers, R.2
Neumann, M.3
-
13
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
Gitcho, M. A., Baloh, R. H, Chakraverty, S., Mayo, IC, Norton, J. B., Lev-itch, D., Hatanpaa, ICJ., White, C. L., 3rd, Bigio, E.H., Caselli, R., Baker, M., Al-Lozi, M. T., Morris, I. C, Pestronk, A., Rademakers, R., Goate, A. M., and Cairns, N. J. (2008) TDP-43 A315T mutation in familial motor neuron disease. Ann. Neurol. 63, 535-538
-
(2008)
Ann. Neurol.
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, I.C.4
Norton, J.B.5
Lev-Itch, D.6
Hatanpaa, I.C.J.7
White Iii., C.L.8
Bigio, E.H.9
Caselli, R.10
Baker, M.11
Al-Lozi, M.T.12
Morris, I.C.13
Pestronk, A.14
Rademakers, R.15
Goate, A.M.16
Cairns, N.J.17
-
14
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
Yokoseki, A., Shiga, A., Tan, C. F., Tagawa, A., Kaneko, H, Koyama, A., Eguchi, H, Tsujino, A., Ikeuchi, T., Kakita, A., Okamoto, IC, Nishizawa, M., Takahashi, H, and Onodera, O. (2008) TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann. Neurol. 63, 538-542
-
(2008)
Ann. Neurol.
, vol.63
, pp. 538-542
-
-
Yokoseki, A.1
Shiga, A.2
Tan, C.F.3
Tagawa, A.4
Kaneko, H.5
Koyama, A.6
Eguchi, H.7
Tsujino, A.8
Ikeuchi, T.9
Kakita, A.10
Okamoto, I.C.11
Nishizawa, M.12
Takahashi, H.13
Onodera, O.14
-
15
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi, E., Valdmanis, P. N., Dion, P., Spiegelman, D., McConkey, B. J., Vande Velde, C, Bouchard, J. P., Lacomblez, L., Pochigaeva, IC, Salachas, F., Pradat, P. F., Camu, W., Meininger, V., Dupre, N., and Rouleau, G. A. (2008) TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat. Genet. 40, 572-574
-
(2008)
Nat. Genet.
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Vande Velde, C.6
Bouchard, J.P.7
Lacomblez, L.8
Pochigaeva, I.C.9
Salachas, F.10
Pradat, P.F.11
Camu, W.12
Meininger, V.13
Dupre, N.14
Rouleau, G.A.15
-
16
-
-
41949100148
-
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology. A genetic and histopathological analysis
-
Van Deerlin, V M., Leverenz, J. B., Bekris, L. M., Bird, T. D., Yuan, W., Elman, L. B., Clay, D., Wood, E. M., Chen-Plotkin, A. S., Martinez-Lage, M., Steinbart, E., McCluskey, L., Grossman, M., Neumann, M., Wu, I. L., Yang, W. S., Kalb, R., Galasko, D. R., Montine, T. J., Trojanowski, J. Q., Lee, V. M., Schellenberg, G. D., and Yu, C. E. (2008) TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology. A genetic and histopathological analysis. Lancet Neurol. 7, 409-416
-
(2008)
Lancet Neurol.
, vol.7
, pp. 409-416
-
-
Van Deerlin, V.M.1
Leverenz, J.B.2
Bekris, L.M.3
Bird, T.D.4
Yuan, W.5
Elman, L.B.6
Clay, D.7
Wood, E.M.8
Chen-Plotkin, A.S.9
Martinez-Lage, M.10
Steinbart, E.11
McCluskey, L.12
Grossman, M.13
Neumann, M.14
Wu, I.L.15
Yang, W.S.16
Kalb, R.17
Galasko, D.R.18
Montine, T.J.19
Trojanowski, J.Q.20
Lee, V.M.21
Schellenberg, G.D.22
Yu, C.E.23
more..
-
17
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan, J., Blair, I. P., Tripathi, V B., Hu, X., Vance, C, Rogelj, B., Ackerley, S., Durnall, J. C, Williams, IC L., Buratti, E., Baralle, F., de Bel-leroche, J., Mitchell, I. D., Leigh, P. N., Al-Chalabi, A., Miller, C. C, Nicholson, G., and Shaw, C E. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319, 1668-1672
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, I.C.L.9
Buratti, E.10
Baralle, F.11
De Bel-Leroche, J.12
Mitchell, I.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
18
-
-
77957966260
-
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
-
Geser, F., Robinson, J. L., Malunda, J. A., Xie, S. X., Clark, C. M., Kwong, L. IC, Moberg, P. J., Moore, E. M., Van Deerlin, V M., Lee, V M., Arnold, S. E., and Trojanowski, J. Q. (2010) Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Arch. Neurol. 67, 1238-1250
-
(2010)
Arch. Neurol.
, vol.67
, pp. 1238-1250
-
-
Geser, F.1
Robinson, J.L.2
Malunda, J.A.3
Xie, S.X.4
Clark, C.M.5
Kwong, L.I.C.6
Moberg, P.J.7
Moore, E.M.8
Van Deerlin, V.M.9
Lee, V.M.10
Arnold, S.E.11
Trojanowski, J.Q.12
-
19
-
-
58149398638
-
Colocalizationoftransactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease
-
Schwab, C, Arai, T., Hasegawa, M., Yu, S., and McGeer, P. L. (2008) Colocalizationoftransactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. Neuropathol. Exp. Neu-rol. 67, 1159-1165
-
(2008)
Neuropathol. Exp. Neu-rol.
, vol.67
, pp. 1159-1165
-
-
Schwab, C.1
Arai, T.2
Hasegawa, M.3
Yu, S.4
McGeer, P.L.5
-
20
-
-
34249709931
-
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains
-
Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., and Oyanagi, IC (2007) TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. Brain 130, 1386-1394
-
(2007)
Brain
, vol.130
, pp. 1386-1394
-
-
Hasegawa, M.1
Arai, T.2
Akiyama, H.3
Nonaka, T.4
Mori, H.5
Hashimoto, T.6
Yamazaki, M.7
Oyanagi, I.C.8
-
21
-
-
36949036676
-
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
-
Geser, F., Winton, M. J., Kwong, L. IC, Xu, Y., Xie, S. X., Igaz, L. M., Garruto, R. M., Perl, D. P., Galasko, D., Lee, V. M., and Trojanowski, J. Q. (2008) Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathol. 115, 133-145
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 133-145
-
-
Geser, F.1
Winton, M.J.2
Kwong, L.I.C.3
Xu, Y.4
Xie, S.X.5
Igaz, L.M.6
Garruto, R.M.7
Perl, D.P.8
Galasko, D.9
Lee, V.M.10
Trojanowski, J.Q.11
-
22
-
-
36348972414
-
Concurrence of TDP-43, T, and a-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies
-
Higashi, S., Iseki, E., Yamamoto, R., Minegishi, M., Hino, H, Fujisawa, IC, Togo, T., Katsuse, O., Uchikado, H., Furukawa, Y., Kosaka, K., and Arai, H. (2007) Concurrence of TDP-43, T, and a-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain Res. 1184, 284-294
-
(2007)
Brain Res.
, vol.1184
, pp. 284-294
-
-
Higashi, S.1
Iseki, E.2
Yamamoto, R.3
Minegishi, M.4
Hino, H.5
Fujisawa, I.C.6
Togo, T.7
Katsuse, O.8
Uchikado, H.9
Furukawa, Y.10
Kosaka, K.11
Arai, H.12
-
23
-
-
34249949338
-
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
-
Amador-Ortiz, C, Lin, W. L., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff-Radford, N. R., Hutton, M. L., and Dickson, D.W. (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann. Neurol. 61, 435-445
-
(2007)
Ann. Neurol.
, vol.61
, pp. 435-445
-
-
Amador-Ortiz, C.1
Lin, W.L.2
Ahmed, Z.3
Personett, D.4
Davies, P.5
Duara, R.6
Graff-Radford, N.R.7
Hutton, M.L.8
Dickson, D.W.9
-
24
-
-
77954149731
-
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease
-
King, A., Sweeney, F., Bodi, I., Troakes, C, Maekawa, S., and Al-Sarraj, S. (2010) Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease. Neuropathology 30, 408-419
-
(2010)
Neuropathology
, vol.30
, pp. 408-419
-
-
King, A.1
Sweeney, F.2
Bodi, I.3
Troakes, C.4
Maekawa, S.5
Al-Sarraj, S.6
-
25
-
-
79953882939
-
β-Amyloid triggers ALS-associated TDP-43 pathology in AD models
-
Herman, A. M., Khandelwal, P. J., Stanczyk, B. B., Rebeck, G. W., and Moussa, C. E. (2011) β-Amyloid triggers ALS-associated TDP-43 pathology in AD models. Brain Res. 1386, 191-199
-
(2011)
Brain Res.
, vol.1386
, pp. 191-199
-
-
Herman, A.M.1
Khandelwal, P.J.2
Stanczyk, B.B.3
Rebeck, G.W.4
Moussa, C.E.5
-
26
-
-
34547733547
-
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
-
Nakashima-Yasuda, H., Uryu, IC, Robinson, J., Xie, S. X., Hurtig, H., Duda, 1. E., Arnold, S. E., Siderowf, A., Grossman, M., Leverenz, J. B., Woltjer, R., Lopez, O. L., Hamilton, R., Tsuang, D. W., Galasko, D., Masliah, E., Kaye, 1., Clark, C. M., Montine, T. J., Lee, V. M., and Trojanowski, J. Q. (2007) Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathol. 114, 221-229
-
(2007)
Acta Neuropathol.
, vol.114
, pp. 221-229
-
-
Nakashima-Yasuda, H.1
Uryu, I.C.2
Robinson, J.3
Xie, S.X.4
Hurtig, H.5
Duda, L.E.6
Arnold, S.E.7
Siderowf, A.8
Grossman, M.9
Leverenz, J.B.10
Woltjer, R.11
Lopez, O.L.12
Hamilton, R.13
Tsuang, D.W.14
Galasko, D.15
Masliah, E.16
Kaye, L.17
Clark, C.M.18
Montine, T.J.19
Lee, V.M.20
Trojanowski, J.Q.21
more..
-
27
-
-
44649137415
-
Concomitant TAR-DNA-bind-ing protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
-
Uryu, IC, Nakashima-Yasuda, H., Forman, M. S., Kwong, L. IC, Clark, C. M., Grossman, M., Miller, B. L., Kretzschmar, H. A., Lee, V. M., Trojanowski, I. Q., and Neumann, M. (2008) Concomitant TAR-DNA-bind-ing protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. J. Neuropathol. Exp. Neurol. 67, 555-564
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 555-564
-
-
Uryu, I.C.1
Nakashima-Yasuda, H.2
Forman, M.S.3
Kwong, L.I.C.4
Clark, C.M.5
Grossman, M.6
Miller, B.L.7
Kretzschmar, H.A.8
Lee, V.M.9
Trojanowski, I.Q.10
Neumann, M.11
-
28
-
-
77953870659
-
Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy
-
Yokota, O., Davidson, Y., Bigio, E. H, Ishizu, H, Terada, S., Arai, T., Hasegawa, M., Akiyama, H., Sikkink, S., Pickering-Brown, S., and Mann, D. M. (2010) Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta Neuropathol. 120, 55-66
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 55-66
-
-
Yokota, O.1
Davidson, Y.2
Bigio, E.H.3
Ishizu, H.4
Terada, S.5
Arai, T.6
Hasegawa, M.7
Akiyama, H.8
Sikkink, S.9
Pickering-Brown, S.10
Mann, D.M.11
-
29
-
-
79953185674
-
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
-
Polymenidou, M., Lagier-Tourenne, C, Hutt, K. R., Huelga, S. C, Moran, J., Liang, T. Y., Ling, S. C, Sun, E., Wancewicz, E., Mazur, C, Kordasiewicz, H, Sedaghat, Y., Donohue, J. P., Shiue, L., Bennett, C. F., Yeo, G. W., and Cleveland, D.W. (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat. Neurosci. 14, 459-468
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 459-468
-
-
Polymenidou, M.1
Lagier-Tourenne, C.2
Hutt, K.R.3
Huelga, S.C.4
Moran, J.5
Liang, T.Y.6
Ling, S.C.7
Sun, E.8
Wancewicz, E.9
Mazur, C.10
Kordasiewicz, H.11
Sedaghat, Y.12
Donohue, J.P.13
Shiue, L.14
Bennett, C.F.15
Yeo, G.W.16
Cleveland, D.W.17
-
30
-
-
84868152371
-
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
-
Lagier-Tourenne, C, Polymenidou, M., Hutt, K. R., Vu, A. Q., Baughn, M., Huelga, S. C, Clutario, K. M., Ling, S. C, Liang, T. Y., Mazur, C, Wancewicz, E., Kim, A. S., Watt, A., Freier, S., Hicks, G. G., Donohue, J. P., Shiue, L., Bennett, C. F., Ravits, J., Cleveland, D. W., and Yeo, G. W. (2012) Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat. Neurosci. 15, 1488-1497
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1488-1497
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Hutt, K.R.3
Vu, A.Q.4
Baughn, M.5
Huelga, S.C.6
Clutario, K.M.7
Ling, S.C.8
Liang, T.Y.9
Mazur, C.10
Wancewicz, E.11
Kim, A.S.12
Watt, A.13
Freier, S.14
Hicks, G.G.15
Donohue, J.P.16
Shiue, L.17
Bennett, C.F.18
Ravits, J.19
Cleveland, D.W.20
Yeo, G.W.21
more..
-
31
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura, H., Hattori, N, Kubo Si, Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, IC, and Suzuki, T. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25, 302-305
-
(2000)
Nat. Genet.
, vol.25
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Si, K.3
Mizuno, Y.4
Asakawa, S.5
Minoshima, S.6
Shimizu, N.7
Iwai, K.8
Chiba, T.9
Tanaka, I.C.10
Suzuki, T.11
-
32
-
-
77953890085
-
Parkinson's disease. Insights from pathways
-
Cookson, M. R., and Bandmann, O. (2010) Parkinson's disease. Insights from pathways. Hum. Mol. Genet. 19, R21-27
-
(2010)
Hum. Mol. Genet.
, vol.19
-
-
Cookson, M.R.1
Bandmann, O.2
-
33
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T., Asakawa, S., Hattori, N, Matsumine, H, Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
34
-
-
0342368772
-
Association between early-onset Parkinson's disease and mutations in the parkin gene
-
Lucking, C. B., Dürr, A., Bonifati, V., Vaughan, J., De Michèle, G., Gasser, T., Harhangi, B. S., Meco, G., Denèfle, P., Wood, N. W., Agid, Y., Brice, A., French Parkinson's Disease Genetics Study Group, and European Consortium on Genetic Susceptibility in Parkinson's Disease (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl. J. Med. 342, 1560-1567
-
(2000)
N Engl. J. Med.
, vol.342
, pp. 1560-1567
-
-
Lucking, C.B.1
Dürr, A.2
Bonifati, V.3
Vaughan, J.4
De Michèle, G.5
Gasser, T.6
Harhangi, B.S.7
Meco, G.8
Denèfle, P.9
Wood, N.W.10
Agid, Y.11
Brice, A.12
-
35
-
-
33745589773
-
Drosophila pinkl is required for mitochondrial function and interacts genetically with parkin
-
Clark, I. E., Dodson, M. W., Jiang, C, Cao, J. H, Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., and Guo, M. (2006) Drosophila pinkl is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
36
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J. C, Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., and Pallanck, L. J. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl. Acad. Sei. U.S.A. 100, 4078-4083
-
(2003)
Proc. Natl. Acad. Sei. U.S.A.
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
Whitworth, A.J.2
Kuo, I.3
Andrews, L.A.4
Feany, M.B.5
Pallanck, L.J.6
-
37
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J. M., and Chung, J. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.M.10
Chung, J.11
-
38
-
-
0037422010
-
Parkin is a component of an SCF-like ubiquitinligase complex and protects postmitotic neurons from kainate excitotox-icity
-
Staropoli, J. F., McDermott, C, Martinat, C, Schulman, B., Demireva, E., and Abeliovich, A. (2003) Parkin is a component of an SCF-like ubiquitinligase complex and protects postmitotic neurons from kainate excitotox-icity. Neuron 37, 735-749
-
(2003)
Neuron
, vol.37
, pp. 735-749
-
-
Staropoli, J.F.1
McDermott, C.2
Martinat, C.3
Schulman, B.4
Demireva, E.5
Abeliovich, A.6
-
39
-
-
0036345454
-
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
-
Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, IC I., and Takahashi, R. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol. Cell 10, 55-67
-
(2002)
Mol. Cell
, vol.10
, pp. 55-67
-
-
Imai, Y.1
Soda, M.2
Hatakeyama, S.3
Akagi, T.4
Hashikawa, T.5
Nakayama, I.C.I.6
Takahashi, R.7
-
40
-
-
68749107083
-
Parkin promotes intracellular A/31-42 clearance
-
Burns, M. P., Zhang, L., Rebeck, G. W., Querfurth, H. W., and Moussa, C. E. (2009) Parkin promotes intracellular A/31-42 clearance. Hum. Mol. Genet. 18, 3206-3216
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3206-3216
-
-
Burns, M.P.1
Zhang, L.2
Rebeck, G.W.3
Querfurth, H.W.4
Moussa, C.E.5
-
41
-
-
78049368074
-
Parkinson-related parkin reduces a-synuclein phosphorylation in a gene transfer model
-
Khandelwal, P. J., Dumanis, S. B., Feng, L. R., Maguire-Zeiss, IC, Rebeck, G., Lashuel, H. A., and Moussa, C. E. (2010) Parkinson-related parkin reduces a-synuclein phosphorylation in a gene transfer model. Mol. Neu-rodegener 5, 47
-
(2010)
Mol. Neu-rodegener
, vol.5
, pp. 47
-
-
Khandelwal, P.J.1
Dumanis, S.B.2
Feng, L.R.3
Maguire-Zeiss, I.C.4
Rebeck, G.5
Lashuel, H.A.6
Moussa, C.E.7
-
42
-
-
73949083524
-
Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function
-
Rosen, K. M., Moussa, C. E., Lee, H. IC, Kumar, P., Kitada, T., Qin, G., Fu, Q., and Querfurth, H. W. (2010) Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function. Neurosci. Res. 88, 167-178
-
(2010)
Neurosci. Res.
, vol.88
, pp. 167-178
-
-
Rosen, K.M.1
Moussa, C.E.2
Lee, H.I.C.3
Kumar, P.4
Kitada, T.5
Qin, G.6
Fu, Q.7
Querfurth, H.W.8
-
43
-
-
84859913759
-
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
-
Herman, A. M., Khandelwal, P. J., Rebeck, G. W., and Moussa, C. E. (2012) Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models. Exp. Neurol. 235, 297-305
-
(2012)
Exp. Neurol.
, vol.235
, pp. 297-305
-
-
Herman, A.M.1
Khandelwal, P.J.2
Rebeck, G.W.3
Moussa, C.E.4
-
44
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
Wegorzewska, I., Bell, S., Cairns, N. J., Miller, T. M., and Baloh, R. H. (2009) TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc. Natl. Acad. Sei. U.S.A. 106, 18809-18814
-
(2009)
Proc. Natl. Acad. Sei. U.S.A.
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
45
-
-
84872480032
-
Diminished Parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's Disease
-
Lonskaya, I., Shekoyan, A. R., Hebron, M. L., Desforges, N, Algarzae, N. IC, and Moussa, C. E. (2012) Diminished Parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's Disease, J. Alzheimers Dis. 33, 231-247
-
(2012)
J. Alzheimers Dis.
, vol.33
, pp. 231-247
-
-
Lonskaya, I.1
Shekoyan, A.R.2
Hebron, M.L.3
Desforges, N.4
Algarzae, N.I.C.5
Moussa, C.E.6
-
46
-
-
0030827862
-
Mammalian homologs of seven in absentia regulate DCC via the ubiqui-tin-proteasome pathway
-
Hu, G., Zhang, S., Vidal, M., Baer, J. L., Xu, T., and Fearon, E. R. (1997) Mammalian homologs of seven in absentia regulate DCC via the ubiqui-tin-proteasome pathway. Genes Dev. 11, 2701-2714
-
(1997)
Genes Dev.
, vol.11
, pp. 2701-2714
-
-
Hu, G.1
Zhang, S.2
Vidal, M.3
Baer, J.L.4
Xu, T.5
Fearon, E.R.6
-
47
-
-
0036118452
-
The ubiquitin ligase component Siahla is required for completion of meiosis i in male mice
-
Dickins, R. A., Frew, I. J., House, C. M., O'Bryan, M. IC, Holloway, A. J., Haviv, L, Traficante, N, de Kretser, D. M., and Bowtell, D. D. (2002) The ubiquitin ligase component Siahla is required for completion of meiosis I in male mice. Mol. Cell. Biol. 22, 2294-2303
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2294-2303
-
-
Dickins, R.A.1
Frew, I.J.2
House, C.M.3
O'Bryan, M.I.C.4
Holloway, A.J.5
Haviv, L.6
Traficante, N.7
De Kretser, D.M.8
Bowtell, D.D.9
-
48
-
-
0032933351
-
Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligo-merization and binding to target proteins
-
Hu, G., and Fearon, E. R. (1999) Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligo-merization and binding to target proteins. Mol. Cell. Biol. 19, 724-732
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 724-732
-
-
Hu, G.1
Fearon, E.R.2
-
49
-
-
79956027131
-
The Siah2-HIF-FoxA2 axis in prostate cancer-new markers and therapeutic opportunities
-
Qi, J., Pellecchia, M., and Ronai, Z. A. (2010) The Siah2-HIF-FoxA2 axis in prostate cancer-new markers and therapeutic opportunities. Oncotarget 1, 379-385
-
(2010)
Oncotarget
, vol.1
, pp. 379-385
-
-
Qi, J.1
Pellecchia, M.2
Ronai, Z.A.3
-
50
-
-
77954291438
-
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors
-
Qi, J., Nakayama, IC, Cardiff, R. D., Borowsky, A. D., Kaul, IC, Williams, R., Krajewski, S., Mercola, D., Carpenter, P. M., Bowtell, D., and Ronai, Z. A. (2010) Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18, 23-38
-
(2010)
Cancer Cell
, vol.18
, pp. 23-38
-
-
Qi, J.1
Nakayama, I.C.2
Cardiff, R.D.3
Borowsky, A.D.4
Kaul, I.C.5
Williams, R.6
Krajewski, S.7
Mercola, D.8
Carpenter, P.M.9
Bowtell, D.10
Ronai, Z.A.11
-
51
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIFla abundance, and modulates physiological responses to hypoxia
-
Nakayama, IC, Frew, I. J., Hagensen, M., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P. B., Bowtell, D. D., and Ronai, Z. (2004) Siah2 regulates stability of prolyl-hydroxylases, controls HIFla abundance, and modulates physiological responses to hypoxia. Cell 117, 941-952
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, I.C.1
Frew, I.J.2
Hagensen, M.3
Skals, M.4
Habelhah, H.5
Bhoumik, A.6
Kadoya, T.7
Erdjument-Bromage, H.8
Tempst, P.9
Frappell, P.B.10
Bowtell, D.D.11
Ronai, Z.12
-
52
-
-
58149393853
-
Direct binding with histone deacety-lase 6 mediates the reversible recruitment of parkin to the centrosome
-
Jiang, Q., Ren, Y., and Feng, J. (2008) Direct binding with histone deacety-lase 6 mediates the reversible recruitment of parkin to the centrosome. Neurosci. 28, 12993-13002
-
(2008)
Neurosci.
, vol.28
, pp. 12993-13002
-
-
Jiang, Q.1
Ren, Y.2
Feng, J.3
-
53
-
-
38049014824
-
Parkin-mediated K63-linked poly-ubiquitination. A signal for targeting misfolded proteins to the ag-gresome-autophagy pathway
-
Olzmann, J. A., and Chin, L. S. (2008) Parkin-mediated K63-linked poly-ubiquitination. A signal for targeting misfolded proteins to the ag-gresome-autophagy pathway. Autophagy 4, 85-87
-
(2008)
Autophagy
, vol.4
, pp. 85-87
-
-
Olzmann, J.A.1
Chin, L.S.2
-
54
-
-
13544266179
-
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
-
Yamamoto, A., Friedlein, A., Imai, Y., Takahashi, R., Kahle, P. J., and Haass, C. (2005) Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. Biol. Chem. 280, 3390-3399
-
(2005)
Biol. Chem.
, vol.280
, pp. 3390-3399
-
-
Yamamoto, A.1
Friedlein, A.2
Imai, Y.3
Takahashi, R.4
Kahle, P.J.5
Haass, C.6
-
55
-
-
34250344611
-
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
-
Avraham, E., Rott, R., Liani, E., Szargel, R., and Engelender, S. (2007) Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. Biol. Chem. 282, 12842-12850
-
(2007)
Biol. Chem.
, vol.282
, pp. 12842-12850
-
-
Avraham, E.1
Rott, R.2
Liani, E.3
Szargel, R.4
Engelender, S.5
-
56
-
-
60549088301
-
Combined kinase inhibition modulates parkin inactivation
-
Rubio de la Torre, E., Luzón-Toro, B., Forte-Lago, I., Minguez-Castella-nos, A., Ferrer, I., and Hilfiker, S. (2009) Combined kinase inhibition modulates parkin inactivation. Hum. Mol. Genet. 18, 809-823
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 809-823
-
-
Rubio De La Torre, E.1
Luzón-Toro, B.2
Forte-Lago, I.3
Minguez-Castella-Nos, A.4
Ferrer, I.5
Hilfiker, S.6
-
57
-
-
78049275348
-
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
-
Ko, H. S., Lee, Y., Shin, J. H., Karuppagounder, S. S., Gadad, B. S., Koleske, A. J., Pletnikova, O., Troncoso, J. C, Dawson, V. L., and Dawson, T. M. (2010) Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc. Natl. Acad. Sei. U.S.A. 107, 16691-16696
-
(2010)
Proc. Natl. Acad. Sei. U.S.A.
, vol.107
, pp. 16691-16696
-
-
Ko, H.S.1
Lee, Y.2
Shin, J.H.3
Karuppagounder, S.S.4
Gadad, B.S.5
Koleske, A.J.6
Pletnikova, O.7
Troncoso, J.C.8
Dawson, V.L.9
Dawson, T.M.10
-
58
-
-
78650881155
-
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation. Implications for Parkinson's disease
-
Imam, S. Z., Zhou, Q., Yamamoto, A., Valente, A. J., Ali, S. F., Bains, M., Roberts, J. L., Kahle, P. J., Clark, R. A., and Li, S. (2011) Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation. Implications for Parkinson's disease. Neurosci. 31, 157-163
-
(2011)
Neurosci.
, vol.31
, pp. 157-163
-
-
Imam, S.Z.1
Zhou, Q.2
Yamamoto, A.3
Valente, A.J.4
Ali, S.F.5
Bains, M.6
Roberts, J.L.7
Kahle, P.J.8
Clark, R.A.9
Li, S.10
-
59
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim, Y., Park, J., Kim, S., Song, S., Kwon, S. IC, Lee, S. H., Kitada, T., Kim, J. M., and Chung, J. (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377, 975-980
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
Song, S.4
Kwon, S.I.C.5
Lee, S.H.6
Kitada, T.7
Kim, J.M.8
Chung, J.9
-
60
-
-
77949478474
-
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-KB signaling
-
Sha, D., Chin, L. S., and Li, L. (2010) Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-KB signaling. Hum. Mol. Genet. 19, 352-363
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 352-363
-
-
Sha, D.1
Chin, L.S.2
Li, L.3
-
61
-
-
53349120013
-
Parkin deletion causes cerebral and systemic amyloidosis in human mutated T over-expressing mice
-
Rodriguez-Navarro, J. A., Gomez, A., Rodal, I., Perucho, J., Martinez, A., Furió, V., Ampuero, I., Casarejos, M. J., Solano, R. M., de Yébenes, J. G., and Mena, M. A. (2008) Parkin deletion causes cerebral and systemic amyloidosis in human mutated T over-expressing mice. Hum. Mol. Genet. 17, 3128-3143
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3128-3143
-
-
Rodriguez-Navarro, J.A.1
Gomez, A.2
Rodal, I.3
Perucho, J.4
Martinez, A.5
Furió, V.6
Ampuero, I.7
Casarejos, M.J.8
Solano, R.M.9
De Yébenes, J.G.10
Mena, M.A.11
-
62
-
-
0041706156
-
A proteomics approach to understanding protein ubiquitination
-
Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C, Cheng, D., Marsischky, G., Roelofs, J., Finley, D., and Gygi, S. P. (2003) A proteomics approach to understanding protein ubiquitination. Wat Biotechnol. 21, 921-926
-
(2003)
Wat Biotechnol.
, vol.21
, pp. 921-926
-
-
Peng, J.1
Schwartz, D.2
Elias, J.E.3
Thoreen, C.C.4
Cheng, D.5
Marsischky, G.6
Roelofs, J.7
Finley, D.8
Gygi, S.P.9
-
63
-
-
44649101850
-
Atypical ubiquitin chains. New molecular signals. Protein modifications. beyond the usual suspects' review series
-
Ikeda, F., and Dikic, I. (2008) Atypical ubiquitin chains. New molecular signals. Protein modifications. Beyond the usual suspects' review series. EMBORep. 9, 536-542
-
(2008)
EMBORep.
, vol.9
, pp. 536-542
-
-
Ikeda, F.1
Dikic, I.2
-
64
-
-
33846240526
-
Sequestosome l/p62-more than just a scaffold
-
Seibenhener, M. L., Geetha, T., and Wooten, M. W. (2007) Sequestosome l/p62-more than just a scaffold. F£SS Lett. 581, 175-179
-
(2007)
F£SS Lett.
, vol.581
, pp. 175-179
-
-
Seibenhener, M.L.1
Geetha, T.2
Wooten, M.W.3
-
65
-
-
78049495046
-
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: A potential role for protein aggregation in autophagic substrate selection
-
Riley, B. E., Kaiser, S. E., Shaler, T. A., Ng, A. C, Hara, T., Hipp, M. S., Lage, IC, Xavier, R. J., Ryu, K. Y., Taguchi, IC, Yamamoto, M., Tanaka, IC, Miz-ushima, N, Komatsu, M., and Kopito, R. R. (2010) Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. Cell Biol. 191, 537-552
-
(2010)
Cell Biol.
, vol.191
, pp. 537-552
-
-
Riley, B.E.1
Kaiser, S.E.2
Shaler, T.A.3
Ng, A.C.4
Hara, T.5
Hipp, M.S.6
Lage7
Ic8
Xavier, R.J.9
Ryu, K.Y.10
Taguchi, I.C.11
Yamamoto, M.12
Tanaka, I.C.13
Mizushima, N.14
Komatsu, M.15
Kopito, R.R.16
-
66
-
-
34547130325
-
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
-
Kim, H. T., Kim, K. P., Lledias, F., Kisselev, A.F., Scaglione, K. M., Skowyra, D., Gygi, S. P., and Goldberg, A. L. (2007) Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. Biol. Chem. 282, 17375-17386
-
(2007)
Biol. Chem.
, vol.282
, pp. 17375-17386
-
-
Kim, H.T.1
Kim, K.P.2
Lledias, F.3
Kisselev, A.F.4
Scaglione, K.M.5
Skowyra, D.6
Gygi, S.P.7
Goldberg, A.L.8
-
67
-
-
38349114036
-
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
-
Tan, J. M., Wong, E. S., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., Ho, M. W., Troncoso, J., Gygi, S. P., Lee, M. K., Dawson, V. L., Dawson, T. M., and Lim, K. L. (2008) Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum. Mol. Genet. 17, 431-439
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 431-439
-
-
Tan, J.M.1
Wong, E.S.2
Kirkpatrick, D.S.3
Pletnikova, O.4
Ko, H.S.5
Tay, S.P.6
Ho, M.W.7
Troncoso, J.8
Gygi, S.P.9
Lee, M.K.10
Dawson, V.L.11
Dawson, T.M.12
Lim, K.L.13
-
68
-
-
34447094657
-
TDP-43 in differential diagnosis of motor neuron disorders
-
Dickson, D. W., Josephs, K. A., and Amador-Ortiz, C. (2007) TDP-43 in differential diagnosis of motor neuron disorders. Acta Neuropathol. 114, 71-79
-
(2007)
Acta Neuropathol.
, vol.114
, pp. 71-79
-
-
Dickson, D.W.1
Josephs, K.A.2
Amador-Ortiz, C.3
-
69
-
-
43549091368
-
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis
-
Geser, F., Brandmeir, N. J., Kwong, L. IC, Martinez-Lage, M., Elman, L., McCluskey, L., Xie, S. X., Lee, V. M., and Trojanowski, I. Q. (2008) Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Arch. Neurol. 65, 636-641
-
(2008)
Arch. Neurol.
, vol.65
, pp. 636-641
-
-
Geser, F.1
Brandmeir, N.J.2
Kwong, L.I.C.3
Martinez-Lage, M.4
Elman, L.5
McCluskey, L.6
Xie, S.X.7
Lee, V.M.8
Trojanowski, I.Q.9
-
70
-
-
58449089306
-
Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology
-
McCluskey, L. F., Elman, L. B., Martinez-Lage, M., Van Deerlin, V., Yuan, W, Clay, D., Siderowf, A., and Trojanowski, J. Q. (2009) Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology. Arch. Neurol. 66, 121-124
-
(2009)
Arch. Neurol.
, vol.66
, pp. 121-124
-
-
McCluskey, L.F.1
Elman, L.B.2
Martinez-Lage, M.3
Van Deerlin, V.4
Yuan, W.5
Clay, D.6
Siderowf, A.7
Trojanowski, J.Q.8
-
71
-
-
34250209501
-
Amyotrophic lateral sclerosis
-
Mitchell, J. D., and Borasio, G. D. (2007) Amyotrophic lateral sclerosis. Lancet 369, 2031-2041
-
(2007)
Lancet
, vol.369
, pp. 2031-2041
-
-
Mitchell, J.D.1
Borasio, G.D.2
-
72
-
-
80155157847
-
The seeds of neurodegen-eration: Prion-like spreading in ALS
-
Polymenidou, M., and Cleveland, D. W. (2011) The seeds of neurodegen-eration: prion-like spreading in ALS. Cell 147, 498-508
-
(2011)
Cell
, vol.147
, pp. 498-508
-
-
Polymenidou, M.1
Cleveland, D.W.2
-
73
-
-
77953890823
-
TDP-43 and FUS/TLS. Emerging roles in RNA processing and neurode-generation
-
Lagier-Tourenne, C, Polymenidou, M., and Cleveland, D. W. (2010) TDP-43 and FUS/TLS. Emerging roles in RNA processing and neurode-generation. Hum. Mol. Genet. 19, R46-64
-
(2010)
Hum. Mol. Genet.
, vol.19
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Cleveland, D.W.3
-
74
-
-
80052136588
-
TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
-
Fiesel, F. C, Schurr, C, Weber, S. S., and Kahle, P. J. (2011) TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6. Mol. Neurodegener 6, 64
-
(2011)
Mol. Neurodegener
, vol.6
, pp. 64
-
-
Fiesel, F.C.1
Schurr, C.2
Weber, S.S.3
Kahle, P.J.4
-
75
-
-
43749102944
-
A-Synuclein aggregates interfere with Parkin solubility and distribution. Role in the pathogenesis of Parkinson disease
-
Kawahara, IC, Hashimoto, M., Bar-On, P., Ho, G. J., Crews, L., Mizuno, H, Rockenstein, E., Imam, S. Z., and Masliah, E. (2008) a-Synuclein aggregates interfere with Parkin solubility and distribution. Role in the pathogenesis of Parkinson disease. Biol. Chem. 283, 6979-6987
-
(2008)
Biol. Chem.
, vol.283
, pp. 6979-6987
-
-
Kawahara, I.C.1
Hashimoto, M.2
Bar-On, P.3
Ho, G.J.4
Crews, L.5
Mizuno, H.6
Rockenstein, E.7
Imam, S.Z.8
Masliah, E.9
-
76
-
-
0034895295
-
Parkin and Parkinson's disease
-
Mizuno, Y., Hattori, N, Mori, H, Suzuki, T., and Tanaka, IC (2001) Parkin and Parkinson's disease. Curr. Opin. Neurol. 14, 477-482
-
(2001)
Curr. Opin. Neurol.
, vol.14
, pp. 477-482
-
-
Mizuno, Y.1
Hattori, N.2
Mori, H.3
Suzuki, T.4
Tanaka, I.C.5
-
77
-
-
79953180492
-
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
-
Tollervey, J. R., Curk, T., Rogelj, B., Briese, M., Cereda, M., Kayikci, M., König, J., Hortobâgyi, T., Nishimura, A. L., Zupunski, V., Patani, R., Chan-dran, S., Rot, G., Zupan, B., Shaw, C. E., and Ule, J. (2011) Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat. Neurosci. 14, 452-458
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 452-458
-
-
Tollervey, J.R.1
Curk, T.2
Rogelj, B.3
Briese, M.4
Cereda, M.5
Kayikci, M.6
König, J.7
Hortobâgyi, T.8
Nishimura, A.L.9
Zupunski, V.10
Patani, R.11
Chan-Dran, S.12
Rot, G.13
Zupan, B.14
Shaw, C.E.15
Ule, J.16
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