TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

Molecular Neurodegeneration

Volumn 6, Issue 1, 2011, Pages

  Fiesel, Fabienne C ^a   Schurr, Christine ^a   Weber, Stephanie S ^a   Kahle, Philipp J ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

amyotrophic lateral sclerosis; frontotemporal dementia; HDAC6; neurite outgrowth; RNAi; SH SY5Y neuroblastoma; TDP 43

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HISTONE DEACETYLASE 6; RETINOIC ACID; TAR DNA BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL;

EID: 80052136588     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-6-64     Document Type: Article

References (33)

1. TAR DNA-binding protein 43 in neurodegenerative disease. Chen-Plotkin AS, Lee VM-Y, Trojanowski JQ, Nat Rev Neurol 2010 6 211 220 10.1038/nrneurol.2010. 18 20234357
2. Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Pesiridis GS, Lee VM-Y, Trojanowski JQ, Hum Mol Genet 2009 18 156 R162 10.1093/hmg/ddp303 19808791
3. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. Ou S-HI, Wu F, Harrich D, García-Martínez LF, Gaynor RB, J Virol 1995 69 3584 3596 7745706
4. The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation. Buratti E, Baralle FE, RNA Biol 2010 7
5. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. Buratti E, Dörk T, Zuccato E, Pagani F, Romano M, Baralle FE, EMBO J 2001 20 1774 1784 10.1093/emboj/20.7.1774 11285240 (Pubitemid 32299413)
6. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE, Nucleic Acids Res 2005 33 6000 6010 10.1093/nar/gki897 16254078 (Pubitemid 41742619)
7. TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing. Bose JK, Wang I-F, Hung L, Tarn W-Y, Shen C-KJ, J Biol Chem 2008 283 28852 28859 10.1074/jbc.M805376200 18703504
8. Antagonistic factors control the unproductive splicing of SC35 terminal intron. Dreumont N, Hardy S, Behm-Ansmant I, Kister L, Branlant C, Stévenin J, Bourgeois CF, Nucleic Acids Res 2010 38 1353 1366 10.1093/nar/gkp1086 19965769
9. Nuclear factor TDP-43 can affect selected microRNA levels. Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F, FEBS J 2010 277 2268 2281 10.1111/j.1742-4658.2010.07643.x 20423455
10. TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C, Mol Cell Neurosci 2007 35 320 327 10.1016/j.mcn.2007.03.007 17481916 (Pubitemid 46843567)
11. Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. Fiesel FC, Voigt A, Weber SS, Van den Haute C, Waldenmaier A, Görner K, Walter M, Anderson ML, Kern JV, Rasse TM, Schmidt T, Springer W, Kirchner R, Bonin M, Neumann M, Baekelandt V, Alunni-Fabbroni M, Schulz JB, Kahle PJ, EMBO J 2010 29 209 221 10.1038/emboj.2009.324 19910924
12. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Chiang P-M, Ling J, Jeong YH, Price DL, Aja SM, Wong PC, Proc Natl Acad Sci USA 2010 107 16320 16324 10.1073/pnas.1002176107 20660762
13. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Tollervey JR, Curk T, Rogelj B, Briese M, Cereda M, Kayikci M, König J, Hortobágyi T, Nishimura AL, Zupunski V, Patani R, Chandran S, Rot G, Zupan B, Shaw CE, Ule J, Nat Neurosci 2011 14 452 458 10.1038/nn.2778 21358640
14. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling S-C, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW, Nat Neurosci 2011 14 459 468 10.1038/nn.2779 21358643
15. Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. Kim SH, Shanware NP, Bowler MJ, Tibbetts RS, J Biol Chem 2010 285 34097 34105 10.1074/jbc.M110.154831 20720006
16. HDAC6 a new cellular stress surveillance factor. Matthias P, Yoshida M, Khochbin S, Cell Cycle 2008 7 7 10 10.4161/cc.7.1.5186 18196966
17. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Watts GDJ, Wymer J, Kovach MJ, Mehta SG, Mumm S, Darvish D, Pestronk A, Whyte MP, Kimonis VE, Nat Genet 2004 36 377 381 10.1038/ng1332 15034582 (Pubitemid 38437260)
18. Exome sequencing reveals VCP mutations as a cause of familial ALS. Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang Y-D, Calvo A, Mora G, Sabatelli M, Monsurr MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G, Galassi G, Scholz SW, Taylor JP, Restagno G, Chi A, Traynor BJ, Neuron 2010 68 857 864 10.1016/j.neuron.2010.11.036 21145000
19. HDAC6-p97/VCP controlled polyubiquitin chain turnover. Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer-Klaucke W, Matthias P, Müller CW, Khochbin S, EMBO J 2006 25 3357 3366 10.1038/sj.emboj.7601210 16810319 (Pubitemid 44141793)
20. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Valenzuela-Fernández A, Cabrero JR, Serrador JM, Sánchez-Madrid F, Trends Cell Biol 2008 18 291 297 10.1016/j.tcb.2008.04. 003 18472263
21. TDP-43 regulates its mRNA levels through a negative feedback loop. Ayala YM, De Conti L, Avendão-Vázquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E, Baralle FE, EMBO J 2011 30 277 288 10.1038/emboj.2010.310 21131904
22. TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G, J Biol Chem 2009 284 22059 22066 10.1074/jbc.M109.012195 19535326
23. The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z, PLoS One 2010 5 15878 10.1371/journal.pone.0015878 21209826
24. Depletion of TDP-43 affects Drosophila motoneurons terminal synapses and locomotive behavior. Feiguin F, Godena VK, Romano G, D'Ambrogio A, Klima R, Baralle FE, FEBS Lett 2009 583 1586 1592 10.1016/j.febslet.2009.04.019 19379745
25. Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching. Lu Y, Ferris J, Gao F-B, Mol Brain 2009 2 30 10.1186/1756-6606-2-30 19781077
26. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM-Y, Science 2006 314 130 133 10.1126/science.1134108 17023659 (Pubitemid 44547757)
27. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng H-L, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P, Mol Cell Biol 2008 28 1688 1701 10.1128/MCB.01154-06 18180281
28. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. Lee J-Y, Koga H, Kawaguchi Y, Tang W, Wong E, Gao Y-S, Pandey UB, Kaushik S, Tresse E, Lu J, Taylor JP, Cuervo AM, Yao T-P, EMBO J 2010 29 969 980 10.1038/emboj.2009.405 20075865
29. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao T-P, Baehrecke EH, Taylor JP, Nature 2007 447 859 863 17568747 (Pubitemid 46920134)
30. Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. Tapia M, Wandosell F, Garrido JJ, PLoS One 2010 5 12908 10.1371/journal.pone.0012908 20886111
31. Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Gao Y-S, Hubbert CC, Lu J, Lee Y-S, Lee J-Y, Yao T-P, Mol Cell Biol 2007 27 8637 8647 10.1128/MCB.00393-07 17938201
32. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A, Cell 2009 136 322 336 10.1016/j.cell.2008.11.050 19167333
33. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. Encinas M, Iglesias M, Liu Y, Wang H, Muhaisen A, Cẽa V, Gallego C, Comella JX, J Neurochem 2000 75 991 1003 10936180 (Pubitemid 30660487)