-
1
-
-
22544463094
-
Cutaneous melanoma: Update on prevention, screening, diagnosis, and treatment
-
Rager EL, Bridgeford EP, Ollila DW. Cutaneous melanoma: Update on prevention, screening, diagnosis, and treatment. Am Fam Physician. 2005;72(2):269-76.
-
(2005)
Am Fam Physician
, vol.72
, Issue.2
, pp. 269-276
-
-
Rager, E.L.1
Bridgeford, E.P.2
Ollila, D.W.3
-
2
-
-
0037093947
-
Annual report to the nation on the status of cancer 1973-1999, featuring implications of age and aging on u.s. cancer burden
-
Edwards BK, Howe HL, Ries LA, Thun MJ, Rosenberg HM, Yancik R, et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer. 2002;94(10):2766-92.
-
(2002)
Cancer
, vol.94
, Issue.10
, pp. 2766-2792
-
-
Edwards, B.K.1
Howe, H.L.2
Ries, L.A.3
Thun, M.J.4
Rosenberg, H.M.5
Yancik, R.6
-
3
-
-
0035144754
-
Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies
-
Whiteman DC, Whiteman CA, Green AC. Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies. Cancer Causes Control. 2001;12(1):69-82.
-
(2001)
Cancer Causes Control
, vol.12
, Issue.1
, pp. 69-82
-
-
Whiteman, D.C.1
Whiteman, C.A.2
Green, A.C.3
-
4
-
-
0014884119
-
Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma
-
Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970;172(5):902-8.
-
(1970)
Ann Surg
, vol.172
, Issue.5
, pp. 902-908
-
-
Breslow, A.1
-
5
-
-
0027115924
-
Diagnosis and treatment of early melanoma
-
NIH Consensus conference268
-
NIH Consensus conference. Diagnosis and treatment of early melanoma. JAMA. 9;268(10):1314-9.
-
JAMA
, vol.9
, Issue.10
, pp. 1314-1319
-
-
-
6
-
-
0027169738
-
Efficacy of 2-cm surgical margins for intermediate-Thickness melanomas (1 to 4 mm Results of a multiinstitutional randomized surgical trial
-
discussion 7-9
-
Balch CM, Urist MM, Karakousis CP, Smith TJ, Temple WJ, Drzewiecki K, et al. Efficacy of 2-cm surgical margins for intermediate-Thickness melanomas (1 to 4 mm). Results of a multiinstitutional randomized surgical trial. Ann Surg. 1993;218(3):262-7. discussion 7-9
-
(1993)
Ann Surg
, vol.218
, Issue.3
, pp. 262-267
-
-
Balch, C.M.1
Urist, M.M.2
Karakousis, C.P.3
Smith, T.J.4
Temple, W.J.5
Drzewiecki, K.6
-
7
-
-
0023886429
-
Thin stage I primary cutaneous malignant melanoma Comparison of excision with margins of 1 or 3 cm
-
Veronesi U, Cascinelli N, Adamus J, Balch C, Bandiera D, Barchuk A, et al. Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm. N Engl J Med. 1988;318(18):1159-62.
-
(1988)
N Engl J Med
, vol.318
, Issue.18
, pp. 1159-1162
-
-
Veronesi, U.1
Cascinelli, N.2
Adamus, J.3
Balch, C.4
Bandiera, D.5
Barchuk, A.6
-
8
-
-
0019933831
-
A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma
-
Veronesi U, Adamus J, Aubert C, Bajetta E, Beretta G, Bonadonna G, et al. A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma. N Engl J Med. 1982;307(15):913-6.
-
(1982)
N Engl J Med
, vol.307
, Issue.15
, pp. 913-916
-
-
Veronesi, U.1
Adamus, J.2
Aubert, C.3
Bajetta, E.4
Beretta, G.5
Bonadonna, G.6
-
9
-
-
33646261668
-
Targeting the mitogen-Activated protein kinase pathway in the treatment of malignant melanoma
-
Panka DJ, Atkins MB, Mier JW. Targeting the mitogen-Activated protein kinase pathway in the treatment of malignant melanoma. Clin Cancer Res. 2006;12(7 PT2):2371s-5.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.7 PART 2
-
-
Panka, D.J.1
Atkins, M.B.2
Mier, J.W.3
-
11
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer KE, Pritchard CA. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta. 2003;1653(1):25-40.
-
(2003)
Biochim Biophys Acta
, vol.1653
, Issue.1
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
12
-
-
67649415934
-
Melanoma: Molecular pathogenesis and emerging target therapies (review
-
Russo AE, Torrisi E, Bevelacqua Y, Perrotta R, Libra M, McCubrey JA, et al. Melanoma: Molecular pathogenesis and emerging target therapies (review). Int J Oncol. 2009;34(6):1481-9.
-
(2009)
Int J Oncol
, vol.34
, Issue.6
, pp. 1481-1489
-
-
Russo, A.E.1
Torrisi, E.2
Bevelacqua, Y.3
Perrotta, R.4
Libra, M.5
McCubrey, J.A.6
-
13
-
-
49849086366
-
PBIse, a novel selenium containing drug for the treatment of malignant melanoma
-
Madhunapantula SV, Desai D, Sharma A, Huh S, Amin S, Robertson GP. PBIse, a novel selenium containing drug for the treatment of malignant melanoma. Mol Cancer Ther. 2008;7(5):1297-308.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.5
, pp. 1297-1308
-
-
Madhunapantula, S.V.1
Desai, D.2
Sharma, A.3
Huh, S.4
Amin, S.5
Robertson, G.P.6
-
14
-
-
65649090993
-
BRAF signaling and targeted therapies in melanoma
-
Dhomen N, Marais R. BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am. 2009;23(3):529-45. ix.
-
(2009)
Hematol Oncol Clin North A.m.
, vol.23
, Issue.3
, pp. 529-545
-
-
Dhomen, N.1
Marais, R.2
-
15
-
-
33746565515
-
Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
-
Gollob JA, Wilhelm S, Carter C, Kelley SL. Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 2006; 33(4):392-406.
-
(2006)
Semin Oncol
, vol.33
, Issue.4
, pp. 392-406
-
-
Gollob, J.A.1
Wilhelm, S.2
Carter, C.3
Kelley, S.L.4
-
16
-
-
33645575146
-
A trip through the signaling pathways of melanoma
-
Fensterle J. A trip through the signaling pathways of melanoma. J Dtsch Dermatol Ges. 2006;4(3):205-17.
-
(2006)
J Dtsch Dermatol Ges
, vol.4
, Issue.3
, pp. 205-217
-
-
Fensterle, J.1
-
17
-
-
21344456180
-
The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
-
Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K, et al. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci. 2005;10:2986-3001.
-
(2005)
Front Biosci
, vol.10
, pp. 2986-3001
-
-
Meier, F.1
Schittek, B.2
Busch, S.3
Garbe, C.4
Smalley, K.5
Satyamoorthy, K.6
-
18
-
-
38349138856
-
Recent discoveries in the genetics of melanoma and their therapeutic implications
-
Marquette A, Bagot M, Bensussan A, Dumaz N. Recent discoveries in the genetics of melanoma and their therapeutic implications. Arch Immunol Ther Exp (Warsz). 2007;55(6):363-72.
-
(2007)
Arch Immunol Ther Exp (Warsz
, vol.55
, Issue.6
, pp. 363-372
-
-
Marquette, A.1
Bagot, M.2
Bensussan, A.3
Dumaz, N.4
-
19
-
-
0034085811
-
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
-
Tsao H, Zhang X, Fowlkes K, Haluska FG. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res. 2000;60(7):1800-4.
-
(2000)
Cancer Res
, vol.60
, Issue.7
, pp. 1800-1804
-
-
Tsao, H.1
Zhang, X.2
Fowlkes, K.3
Haluska, F.G.4
-
20
-
-
36549085004
-
The genome and epigenome of malignant melanoma
-
Dahl C, Guldberg P. The genome and epigenome of malignant melanoma. APMIS. 2007;115(10):1161-76.
-
(2007)
APMIS
, vol.115
, Issue.10
, pp. 1161-1176
-
-
Dahl, C.1
Guldberg, P.2
-
21
-
-
0030729474
-
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
-
Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, et al. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 1997;11(21):2822-34.
-
(1997)
Genes Dev
, vol.11
, Issue.21
, pp. 2822-2834
-
-
Chin, L.1
Pomerantz, J.2
Polsky, D.3
Jacobson, M.4
Cohen, C.5
Cordon-Cardo, C.6
-
22
-
-
77951620399
-
Dissection of RAS downstream pathways in melanomagenesis: A role for Ral in transformation
-
Mishra PJ, Ha L, Rieker J, Sviderskaya EV, Bennett DC, Oberst MD, et al. Dissection of RAS downstream pathways in melanomagenesis: A role for Ral in transformation. Oncogene. 2010;29(16):2449-56.
-
(2010)
Oncogene
, vol.29
, Issue.16
, pp. 2449-2456
-
-
Mishra, P.J.1
Ha, L.2
Rieker, J.3
Sviderskaya, E.V.4
Bennett, D.C.5
Oberst, M.D.6
-
23
-
-
20144375230
-
Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background
-
Ackermann J, Frutschi M, Kaloulis K, McKee T, Trumpp A, Beermann F. Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 2005;65(10):4005-11.
-
(2005)
Cancer Res
, vol.65
, Issue.10
, pp. 4005-4011
-
-
Ackermann, J.1
Frutschi, M.2
Kaloulis, K.3
McKee, T.4
Trumpp, A.5
Beermann, F.6
-
24
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, et al. Essential role for oncogenic Ras in tumour maintenance. Nature. 1999;400(6743):468-72.
-
(1999)
Nature
, vol.400
, Issue.6743
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
-
25
-
-
0035216833
-
Farnesyltransferase inhibitors: Mechanism and applications
-
Prendergast GC, Rane N. Farnesyltransferase inhibitors: Mechanism and applications. Expert Opin Investig Drugs. 2001;10(12):2105-16.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, Issue.12
, pp. 2105-2116
-
-
Prendergast, G.C.1
Rane, N.2
-
26
-
-
0037431539
-
Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-Apoptotic and enhances chemosensitivity to cisplatin in melanoma cells
-
Smalley KS, Eisen TG. Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-Apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. Int J Cancer. 2003; 105(2):165-75.
-
(2003)
Int J Cancer
, vol.105
, Issue.2
, pp. 165-175
-
-
Smalley, K.S.1
Eisen, T.G.2
-
27
-
-
0037244511
-
Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo
-
Halaschek-Wiener J, Kloog Y, Wacheck V, Jansen B. Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. J Invest Dermatol. 2003;120(1):109-15.
-
(2003)
J Invest Dermatol
, vol.120
, Issue.1
, pp. 109-115
-
-
Halaschek-Wiener, J.1
Kloog, Y.2
Wacheck, V.3
Jansen, B.4
-
28
-
-
77954212583
-
Effect of the farnesyl transferase inhibitor lonafarnib on sensitivity of melanoma cells to multikinase inhibitor sorafenib and opn Rheb farnesylation and mTOR signaling
-
Abstract Supplement abstract 9077
-
Meier F, Niessner H, Flaherty K, Schadendorf D, Sinnberg T, Schittek B, Garbe C. Effect of the farnesyl transferase inhibitor lonafarnib on sensitivity of melanoma cells to multikinase inhibitor sorafenib and opn Rheb farnesylation and mTOR signaling. J Clin Oncol. [Abstract]. 2009;27(15S (Supplement abstract 9077).
-
(2009)
J Clin Oncol
, vol.27
-
-
Meier, F.1
Niessner, H.2
Flaherty, K.3
Schadendorf, D.4
Sinnberg, T.5
Schittek, B.6
Garbe, C.7
-
29
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
-
End DW, Smets G, Todd AV, Applegate TL, Fuery CJ, Angibaud P, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001;61(1):131-7.
-
(2001)
Cancer Res
, vol.61
, Issue.1
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
Applegate, T.L.4
Fuery, C.J.5
Angibaud, P.6
-
30
-
-
33646262911
-
Molecular targets in melanoma from angiogenesis to apoptosis
-
Sosman JA, Puzanov I. Molecular targets in melanoma from angiogenesis to apoptosis. Clin Cancer Res. 2006;12(7 PT2):2376s-83.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.7 PART 2
-
-
Sosman, J.A.1
Puzanov, I.2
-
31
-
-
71649098951
-
Emerging Raf inhibitors
-
McCubrey JA, Steelman LS, Abrams SL, Chappell WH, Russo S, Ove R, et al. Emerging Raf inhibitors. Expert Opin Emerg Drugs. 2009;14(4):633-48.
-
(2009)
Expert Opin Emerg Drugs
, vol.14
, Issue.4
, pp. 633-648
-
-
McCubrey, J.A.1
Steelman, L.S.2
Abrams, S.L.3
Chappell, W.H.4
Russo, S.5
Ove, R.6
-
32
-
-
33947390695
-
Phase-II study of farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB500104
-
Abstract].18S, June 20 Supplement, Abstract #8014
-
Gajewsky T, Niedezwiecki D, Johnson J, Linette G, Bucher C, Blakovich M, et al. Phase-II study of farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB500104. J Clin Oncol. [Abstract]. 2006;24(18S, June 20 Supplement, Abstract #8014).
-
(2006)
J Clin Oncol
, vol.24
-
-
Gajewsky, T.1
Niedezwiecki, D.2
Johnson, J.3
Linette, G.4
Bucher, C.5
Blakovich, M.6
-
33
-
-
0141765782
-
Melanoma chemoprevention a role for statins orfibrates?
-
Dellavalle RP, Nicholas MK, Schilling LM. Melanoma chemoprevention: A role for statins orfibrates? Am J Ther. 2003;10(3):203-10.
-
(2003)
Am J Ther
, vol.10
, Issue.3
, pp. 203-210
-
-
Dellavalle, R.P.1
Nicholas, M.K.2
Schilling, L.M.3
-
34
-
-
0037340739
-
Farnesyl transferase inhibitors in the treatment of breast cancer
-
Kelland LR. Farnesyl transferase inhibitors in the treatment of breast cancer. Expert Opin Emerg Drugs. 2003;12(3):413-21.
-
(2003)
Expert Opin Emerg Drugs
, vol.12
, Issue.3
, pp. 413-421
-
-
Kelland, L.R.1
-
35
-
-
0035886842
-
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
-
Rose WC, Lee FY, Fairchild CR, Lynch M, Monticello T, Kramer RA, et al. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 2001;61(20):7507-17.
-
(2001)
Cancer Res
, vol.61
, Issue.20
, pp. 7507-7517
-
-
Rose, W.C.1
Lee, F.Y.2
Fairchild, C.R.3
Lynch, M.4
Monticello, T.5
Kramer, R.A.6
-
36
-
-
0034778514
-
Preclinical pharmacology of BMS-275183, an orally active taxane
-
Rose WC, Long BH, Fairchild CR, Lee FY, Kadow JF. Preclinical pharmacology of BMS-275183, an orally active taxane. Clin Cancer Res. 2001;7(7):2016-21.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.7
, pp. 2016-2021
-
-
Rose, W.C.1
Long, B.H.2
Fairchild, C.R.3
Lee, F.Y.4
Kadow, J.F.5
-
37
-
-
0035819989
-
Conformational restriction of fl exible ligands guided by the transferred noe experiment: Potent macrocyclic inhibitors of farnesyltransferase
-
Dinsmore CJ, Bogusky MJ, Culberson JC, Bergman JM, Homnick CF, Zartman CB, et al. Conformational restriction of fl exible ligands guided by the transferred noe experiment: Potent macrocyclic inhibitors of farnesyltransferase. J Am Chem Soc. 2001;123(9):2107-8.
-
(2001)
J Am Chem Soc
, vol.123
, Issue.9
, pp. 2107-2108
-
-
Dinsmore, C.J.1
Bogusky, M.J.2
Culberson, J.C.3
Bergman, J.M.4
Homnick, C.F.5
Zartman, C.B.6
-
38
-
-
0003236113
-
Dose escalation study of oral farnesyl transferase inhibitor (FTI) BMS-214662 in patients with solid tumors
-
Abstract
-
Camacho LH SS, Pezzulli S, et al. Dose escalation study of oral farnesyl transferase inhibitor (FTI) BMS-214662 in patients with solid tumors. Proc Annu Meet Am Soc Clin Oncol. 2001;20:311 [Abstract].
-
(2001)
Proc Annu Meet Am Soc Clin Oncol
, vol.20
, pp. 311
-
-
Camacho, L.H.S.S.1
Pezzulli, S.2
-
39
-
-
0000322353
-
Phase I trial of the farnesyl protein transferase inhibitor L-778123 on 14- or 28-day dosing schedule
-
Abstract
-
Rubin EAJ, Morrison BW, et al. Phase I trial of the farnesyl protein transferase inhibitor L-778123 on 14- or 28-day dosing schedule. Proc Annu Meet Am Soc Clin Oncol. 2000;19:689 [Abstract].
-
(2000)
Proc Annu Meet Am Soc Clin Oncol
, vol.19
, pp. 689
-
-
Rubin, E.A.J.1
Morrison, B.W.2
-
40
-
-
0001133883
-
A Phase I trial and PK study of farnesyl transferase inhibitor L-778123 administered as a seven day continuous infusion in combination with paclitaxel
-
Abstract
-
Sharma SBC, Spriggs D, et al. A Phase I trial and PK study of farnesyl transferase inhibitor L-778123 administered as a seven day continuous infusion in combination with paclitaxel. Proc Annu Meet Am Soc Clin Oncol. 2000;19:719 [Abstract].
-
(2000)
Proc Annu Meet Am Soc Clin Oncol
, vol.19
, pp. 719
-
-
Sharma, S.B.C.1
Spriggs, D.2
-
41
-
-
0000322356
-
Phase I trial of farnesyl transferase inhibitor L-778123 in combination with radio-Therapy
-
Abstract
-
Hahn SMKK, Morrison BW, et al. Phase I trial of farnesyl transferase inhibitor L-778123 in combination with radio-Therapy. Proc Annu Meet Am Soc Clin Oncol. 2000;19:906 [Abstract].
-
(2000)
Proc Annu Meet Am Soc Clin Oncol
, vol.19
, pp. 906
-
-
Hahn, S.M.K.K.1
Morrison, B.W.2
-
42
-
-
0035908493
-
Blocking oncogenic Ras signaling for cancer therapy
-
Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst. 2001;93(14):1062-74.
-
(2001)
J Natl Cancer Inst
, vol.93
, Issue.14
, pp. 1062-1074
-
-
Adjei, A.A.1
-
43
-
-
33749832543
-
Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein
-
Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M. Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein. Oncogene. 2006;25(47):6262-76.
-
(2006)
Oncogene
, vol.25
, Issue.47
, pp. 6262-6276
-
-
Brummer, T.1
Martin, P.2
Herzog, S.3
Misawa, Y.4
Daly, R.J.5
Reth, M.6
-
44
-
-
70349438995
-
A dimerization-dependent mechanism drives RAF catalytic activation
-
Rajakulendran T, Sahmi M, Lefrancois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 2009;461(7263):542-5.
-
(2009)
Nature
, vol.461
, Issue.7263
, pp. 542-545
-
-
Rajakulendran, T.1
Sahmi, M.2
Lefrancois, M.3
Sicheri, F.4
Therrien, M.5
-
46
-
-
38949131824
-
BRAF (E600) in benign and malignant human tumours
-
Michaloglou C, Vredeveld LC, Mooi WJ, Peeper DS. BRAF(E600) in benign and malignant human tumours. Oncogene. 2008;27(7):877-95.
-
(2008)
Oncogene
, vol.27
, Issue.7
, pp. 877-895
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Mooi, W.J.3
Peeper, D.S.4
-
47
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54.
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
48
-
-
0041333110
-
BRAF mutations in metastatic melanoma: A possible association with clinical outcome
-
Kumar R, Angelini S, Czene K, Sauroja I, Hahka-Kemppinen M, Pyrhonen S, et al. BRAF mutations in metastatic melanoma: A possible association with clinical outcome. Clin Cancer Res. 2003;9(9):3362-8.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.9
, pp. 3362-3368
-
-
Kumar, R.1
Angelini, S.2
Czene, K.3
Sauroja, I.4
Hahka-Kemppinen, M.5
Pyrhonen, S.6
-
49
-
-
5444227865
-
Guilty as charged: B-RAF is a human oncogene
-
Garnett MJ, Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell. 2004;6(4):313-9.
-
(2004)
Cancer Cell
, vol.6
, Issue.4
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
50
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116(6):855-67.
-
(2004)
Cell
, vol.116
, Issue.6
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
-
51
-
-
1942506706
-
V599EB-RAF is an oncogene in melanocytes
-
Wellbrock C, Ogilvie L, Hedley D, Karasarides M, Martin J, Niculescu-Duvaz D, et al. V599EB-RAF is an oncogene in melanocytes. Cancer Res. 2004;64(7):2338-42
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2338-2342
-
-
Wellbrock, C.1
Ogilvie, L.2
Hedley, D.3
Karasarides, M.4
Martin, J.5
Niculescu-Duvaz, D.6
-
52
-
-
0042885906
-
BRAF as a potential therapeutic target in melanoma and other malignancies
-
Tuveson DA, Weber BL, Herlyn M. BRAF as a potential therapeutic target in melanoma and other malignancies. Cancer Cell. 2003;4(2):95-8.
-
(2003)
Cancer Cell
, vol.4
, Issue.2
, pp. 95-98
-
-
Tuveson, D.A.1
Weber, B.L.2
Herlyn, M.3
-
53
-
-
31544442670
-
Oncogenic BRAF is required for tumor growth and maintenance in melanoma models
-
Hoe fl ich KP, Gray DC, Eby MT, Tien JY, Wong L, Bower J, et al. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Cancer Res. 2006;66(2):999-1006.
-
(2006)
Cancer Res
, vol.66
, Issue.2
, pp. 999-1006
-
-
Hoeflich, K.P.1
Gray, D.C.2
Eby, M.T.3
Tien, J.Y.4
Wong, L.5
Bower, J.6
-
54
-
-
34250816365
-
Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation
-
Liang S, Sharma A, Peng HH, Robertson G, Dong C. Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Res. 2007;67(12):5814-20.
-
(2007)
Cancer Res
, vol.67
, Issue.12
, pp. 5814-5820
-
-
Liang, S.1
Sharma, A.2
Peng, H.H.3
Robertson, G.4
Dong, C.5
-
55
-
-
33748030422
-
Targeting mitogen-Activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases
-
Sharma A, Tran MA, Liang S, Sharma AK, Amin S, Smith CD, et al. Targeting mitogen-Activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res. 2006;66(16):8200-9.
-
(2006)
Cancer Res
, vol.66
, Issue.16
, pp. 8200-8209
-
-
Sharma, A.1
Tran, M.A.2
Liang, S.3
Sharma, A.K.4
Amin, S.5
Smith, C.D.6
-
56
-
-
58449129853
-
Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity
-
Boyle GM, Pedley J, Martyn AC, Banducci KJ, Strutton GM, Brown DA, et al. Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity. J Invest Dermatol. 2009;129(2):383-91.
-
(2009)
J Invest Dermatol
, vol.129
, Issue.2
, pp. 383-391
-
-
Boyle, G.M.1
Pedley, J.2
Martyn, A.C.3
Banducci, K.J.4
Strutton, G.M.5
Brown, D.A.6
-
57
-
-
16844362816
-
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
-
Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP. Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. 2005;65(6):2412-21.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2412-2421
-
-
Sharma, A.1
Trivedi, N.R.2
Zimmerman, M.A.3
Tuveson, D.A.4
Smith, C.D.5
Robertson, G.P.6
-
58
-
-
44849096481
-
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development
-
Cheung M, Sharma A, Madhunapantula SV, Robertson GP. Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res. 2008;68(9):3429-39.
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3429-3439
-
-
Cheung, M.1
Sharma, A.2
Madhunapantula, S.V.3
Robertson, G.P.4
-
59
-
-
38849168162
-
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
-
Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008;132(3):363-74.
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 363-374
-
-
Wajapeyee, N.1
Serra, R.W.2
Zhu, X.3
Mahalingam, M.4
Green, M.R.5
-
60
-
-
63249105225
-
Oncogenic Braf induces melanocyte senescence and melanoma in mice
-
Dhomen N, Reis-Filho JS, da Rocha Dias S, Hayward R, Savage K, Delmas V, et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell. 2009;15(4):294-303.
-
(2009)
Cancer Cell
, vol.15
, Issue.4
, pp. 294-303
-
-
Dhomen, N.1
Reis-Filho, J.S.2
Da Rocha Dias, S.3
Hayward, R.4
Savage, K.5
Delmas, V.6
-
61
-
-
23244447037
-
BRAFE600-Associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, et al. BRAFE600-Associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436(7051):720-4.
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
Van Der Horst, C.M.6
-
62
-
-
76949091228
-
BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi
-
Nguyen LP, Emley A, Wajapeyee N, Green MR, Mahalingam M. BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi. Br J Dermatol. 2009;162(3):677-80.
-
(2009)
Br J Dermatol
, vol.162
, Issue.3
, pp. 677-680
-
-
Nguyen, L.P.1
Emley, A.2
Wajapeyee, N.3
Green, M.R.4
Mahalingam, M.5
-
63
-
-
42749085117
-
Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis
-
Zhao Y, Zhang Y, Yang Z, Li A, Dong J. Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis. Biochem Biophys Res Commun. 2008;370(3):509-13.
-
(2008)
Biochem Biophys Res Commun
, vol.370
, Issue.3
, pp. 509-513
-
-
Zhao, Y.1
Zhang, Y.2
Yang, Z.3
Li, A.4
Dong, J.5
-
64
-
-
65649147543
-
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
-
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky Jr. WE, et al. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009;41(5):544-52.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 544-552
-
-
Dankort, D.1
Curley, D.P.2
Cartlidge, R.A.3
Nelson, B.4
Karnezis, A.N.5
Damsky Jr., W.E.6
-
65
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
-
Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005;15(3):249-54.
-
(2005)
Curr Biol
, vol.15
, Issue.3
, pp. 249-254
-
-
Patton, E.E.1
Widlund, H.R.2
Kutok, J.L.3
Kopani, K.R.4
Amatruda, J.F.5
Murphey, R.D.6
-
66
-
-
67049168909
-
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes
-
Yu H, McDaid R, Lee J, Possik P, Li L, Kumar SM, et al. The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. Am J Pathol. 2009;174(6):2367-77.
-
(2009)
Am J Pathol
, vol.174
, Issue.6
, pp. 2367-2377
-
-
Yu, H.1
McDaid, R.2
Lee, J.3
Possik, P.4
Li, L.5
Kumar, S.M.6
-
67
-
-
55849122635
-
P16ink4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors
-
Gallagher SJ, Thompson JF, Indsto J, Scurr LL, Lett M, Gao BF, et al. p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors. Neoplasia. 2008;10(11):1231-9.
-
(2008)
Neoplasia
, vol.10
, Issue.11
, pp. 1231-1239
-
-
Gallagher, S.J.1
Thompson, J.F.2
Indsto, J.3
Scurr, L.L.4
Lett, M.5
Gao, B.F.6
-
68
-
-
33644774541
-
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
-
Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG. Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol. 2006;126(1):154-60.
-
(2006)
J Invest Dermatol
, vol.126
, Issue.1
, pp. 154-160
-
-
Goel, V.K.1
Lazar, A.J.2
Warneke, C.L.3
Redston, M.S.4
Haluska, F.G.5
-
69
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099-109.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
-
70
-
-
33748325763
-
Sorafenib in advanced melanoma: A phase II randomised discontinuation trial analysis
-
Eisen T, Ahmad T, Flaherty KT, Gore M, Kaye S, Marais R, et al. Sorafenib in advanced melanoma: A phase II randomised discontinuation trial analysis. Br J Cancer. 2006;95(5):581-6.
-
(2006)
Br J Cancer
, vol.95
, Issue.5
, pp. 581-586
-
-
Eisen, T.1
Ahmad, T.2
Flaherty, K.T.3
Gore, M.4
Kaye, S.5
Marais, R.6
-
71
-
-
38049019119
-
Safety and anti-Tumor activity of sorafenib (nexavar) in combination with other anti-cancer agents: A review of clinical trials
-
Takimoto CH, Awada A. Safety and anti-Tumor activity of sorafenib (nexavar) in combination with other anti-cancer agents: A review of clinical trials. Cancer Chemother Pharmacol. 2008;61(4):535-48.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.4
, pp. 535-548
-
-
Takimoto, C.H.1
Awada, A.2
-
72
-
-
4344584872
-
B-RAF is a therapeutic target in melanoma
-
Karasarides M, Chiloeches A, Hayward R, Niculescu-Duvaz D, Scanlon I, Friedlos F, et al. B-RAF is a therapeutic target in melanoma. Oncogene. 2004;23(37):6292-8.
-
(2004)
Oncogene
, vol.23
, Issue.37
, pp. 6292-6298
-
-
Karasarides, M.1
Chiloeches, A.2
Hayward, R.3
Niculescu-Duvaz, D.4
Scanlon, I.5
Friedlos, F.6
-
73
-
-
39149133664
-
Is B-Raf a good therapeutic target for melanoma and other malignancies?
-
Madhunapantula SV, Robertson GP. Is B-Raf a good therapeutic target for melanoma and other malignancies? Cancer Res. 2008;68(1):5-8.
-
(2008)
Cancer Res
, vol.68
, Issue.1
, pp. 5-8
-
-
Madhunapantula, S.V.1
Robertson, G.P.2
-
74
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA. 2008;105(8):3041-6.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.8
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Cho, H.5
Mamo, S.6
-
75
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010;467(7315):596-9.
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
-
76
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363(9):809-19.
-
(2010)
N Engl J Med
, vol.363
, Issue.9
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
77
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-16.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
78
-
-
79960233861
-
Overcoming metastatic melanoma with BRAF inhibitors
-
Hong S, Han SB. Overcoming metastatic melanoma with BRAF inhibitors. Arch Pharm Res. 2011;34(5):699-701.
-
(2011)
Arch Pharm Res
, vol.34
, Issue.5
, pp. 699-701
-
-
Hong, S.1
Han, S.B.2
-
79
-
-
77956323144
-
Meeting report from the third global workshop on melanoma
-
Agarwala SS, di Pietro A, Flaherty KT, Garbe C, Grob JJ, Kashani-Sabet M, et al. Meeting report from the third global workshop on melanoma. Pigment Cell Melanoma Res. 2010;23(5):e1-7.
-
(2010)
Pigment Cell Melanoma Res
, vol.23
, Issue.5
-
-
Agarwala, S.S.1
Di Pietro, A.2
Flaherty, K.T.3
Garbe, C.4
Grob, J.J.5
Kashani-Sabet, M.6
-
80
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468(7326):973-7.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
Lee, H.6
-
81
-
-
79951961755
-
Resistance to BRAF inhibition in melanomas
-
Solit DB, Rosen N. Resistance to BRAF inhibition in melanomas. N Engl J Med. 2011;364(8):772-4.
-
(2011)
N Engl J Med
, vol.364
, Issue.8
, pp. 772-774
-
-
Solit, D.B.1
Rosen, N.2
-
82
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Dec 16 2010
-
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468(7326):968-72. Dec 16 2010.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
-
83
-
-
78751648455
-
Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells
-
Kaplan FM, Shao Y, Mayberry MM, Aplin AE. Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells. Oncogene. 2011;30(3):366-71.
-
(2011)
Oncogene
, vol.30
, Issue.3
, pp. 366-371
-
-
Kaplan, F.M.1
Shao, Y.2
Mayberry, M.M.3
Aplin, A.E.4
-
84
-
-
77949421744
-
BRAF inhibitors: Research accelerates in wake of positivefindings
-
Brower V. BRAF inhibitors: Research accelerates in wake of positivefindings. J Natl Cancer Inst. 2010;102(4):214-5.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.4
, pp. 214-215
-
-
Brower, V.1
-
85
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;439(7074):358-62.
-
(2006)
Nature
, vol.439
, Issue.7074
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
-
86
-
-
34548097240
-
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-Activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: Mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
-
Davies BR, Logie A, McKay JS, Martin P, Steele S, Jenkins R, et al. AZD6244 (ARRY-142886), a potent inhibitor of mitogen-Activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: Mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther. 2007;6(8):2209-19.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.8
, pp. 2209-2219
-
-
Davies, B.R.1
Logie, A.2
McKay, J.S.3
Martin, P.4
Steele, S.5
Jenkins, R.6
-
87
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-Activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei AA, Cohen RB, Franklin W, Morris C, Wilson D, Molina JR, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-Activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008;26(13):2139-46.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
Morris, C.4
Wilson, D.5
Molina, J.R.6
-
88
-
-
73949091523
-
Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models
-
Daouti S, Higgins B, Kolinsky K, Packman K, Wang H, Rizzo C, et al. Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models. Mol Cancer Ther. 2010;9(1):134-44.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.1
, pp. 134-144
-
-
Daouti, S.1
Higgins, B.2
Kolinsky, K.3
Packman, K.4
Wang, H.5
Rizzo, C.6
-
89
-
-
0035135510
-
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis
-
Mandic A, Viktorsson K, Heiden T, Hansson J, Shoshan MC. The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis. Melanoma Res. 2001;11(1):11-9.
-
(2001)
Melanoma Res
, vol.11
, Issue.1
, pp. 11-19
-
-
Mandic, A.1
Viktorsson, K.2
Heiden, T.3
Hansson, J.4
Shoshan, M.C.5
-
90
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA. 2009;106(48):20411-6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
Sawyer, A.M.4
Niu, L.5
Kim, J.J.6
-
91
-
-
34247606483
-
Rewired ERKJNK signaling pathways in melanoma
-
Lopez-Bergami P, Huang C, Goydos JS, Yip D, Bar-Eli M, Herlyn M, et al. Rewired ERKJNK signaling pathways in melanoma. Cancer Cell. 2007;11(5):447-60.
-
(2007)
Cancer Cell
, vol.11
, Issue.5
, pp. 447-460
-
-
Lopez-Bergami, P.1
Huang, C.2
Goydos, J.S.3
Yip, D.4
Bar-Eli, M.5
Herlyn, M.6
-
92
-
-
34547875411
-
ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatinmediated apoptosis
-
Mirmohammadsadegh A, Mota R, Gustrau A, Hassan M, Nambiar S, Marini A, et al. ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatinmediated apoptosis. J Invest Dermatol. 2007;127(9):2207-15. Current and Future Trials of Targeted Therapies in Cutaneous Melanoma 2511
-
(2007)
J Invest Dermatol
, vol.127
, Issue.9
, pp. 2207-2215
-
-
Mirmohammadsadegh, A.1
Mota, R.2
Gustrau, A.3
Hassan, M.4
Nambiar, S.5
Marini, A.6
-
93
-
-
0035891347
-
Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells
-
Pardo OE, Arcaro A, Salerno G, Tetley TD, Valovka T, Gout I, et al. Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells. Oncogene. 2001;20(52):7658-67.
-
(2001)
Oncogene
, vol.20
, Issue.52
, pp. 7658-7667
-
-
Pardo, O.E.1
Arcaro, A.2
Salerno, G.3
Tetley, T.D.4
Valovka, T.5
Gout, I.6
-
94
-
-
24044543035
-
Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma
-
Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Palmer AA, Zhang XD, et al. Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma. J Clin Pathol. 2005;58(11):1163-9.
-
(2005)
J Clin Pathol
, vol.58
, Issue.11
, pp. 1163-1169
-
-
Zhuang, L.1
Lee, C.S.2
Scolyer, R.A.3
McCarthy, S.W.4
Palmer, A.A.5
Zhang, X.D.6
-
95
-
-
0013202857
-
Pharmacological inhibitors of the ERK signaling pathway: Applications as anticancer drugs
-
Chapter 22
-
Kohno MJP. Pharmacological inhibitors of the ERK signaling pathway: Applications as anticancer drugs. Prog Cell Cycle Res. 2003;5(Chapter 22):219-24.
-
(2003)
Prog Cell Cycle Res
, vol.5
, pp. 219-224
-
-
Kohno, M.J.P.1
-
96
-
-
70249098518
-
Clinical experience with aurora kinase inhibitors: A review
-
Boss DS, Beijnen JH, Schellens JH. Clinical experience with aurora kinase inhibitors: A review. Oncologist. 2009;14(8):780-93.
-
(2009)
Oncologist
, vol.14
, Issue.8
, pp. 780-793
-
-
Boss, D.S.1
Beijnen, J.H.2
Schellens, J.H.3
-
97
-
-
70549105789
-
Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteins
-
Carmena M, Ruchaud S, Earnshaw WC. Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol. 2009;21(6):796-805.
-
(2009)
Curr Opin Cell Biol
, vol.21
, Issue.6
, pp. 796-805
-
-
Carmena, M.1
Ruchaud, S.2
Earnshaw, W.C.3
-
98
-
-
78349283089
-
Aurora A and B kinases - Targets of novel anticancer drugs
-
Libertini S, Abagnale A, Passaro C, Botta G, Portella G. Aurora A and B kinases - Targets of novel anticancer drugs. Recent Pat Anticancer Drug Discov. 2010;5(3):219-41.
-
(2010)
Recent Pat Anticancer Drug Discov
, vol.5
, Issue.3
, pp. 219-241
-
-
Libertini, S.1
Abagnale, A.2
Passaro, C.3
Botta, G.4
Portella, G.5
-
99
-
-
58149189433
-
Aurora kinases: Structure, functions and their association with cancer
-
Kollareddy M, Dzubak P, Zheleva D, Hajduch M. Aurora kinases: Structure, functions and their association with cancer. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008;152(1):27-33.
-
(2008)
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
, vol.152
, Issue.1
, pp. 27-33
-
-
Kollareddy, M.1
Dzubak, P.2
Zheleva, D.3
Hajduch, M.4
-
101
-
-
51649095569
-
The Aurora kinase family in cell division and cancer
-
Vader G, Lens SM. The Aurora kinase family in cell division and cancer. Biochim Biophys Acta. 2008;1786(1):60-72.
-
(2008)
Biochim Biophys Acta
, vol.1786
, Issue.1
, pp. 60-72
-
-
Vader, G.1
Lens, S.M.2
-
102
-
-
34948901399
-
Aurora-A: The maker and breaker of spindle poles
-
Barr AR, Gergely F. Aurora-A: The maker and breaker of spindle poles. J Cell Sci. 2007;120(PT17):2987-96.
-
(2007)
J Cell Sci
, vol.120
, Issue.PART 17
, pp. 2987-2996
-
-
Barr, A.R.1
Gergely, F.2
-
103
-
-
34548248276
-
Detection and correction of merotelic kinetochore orientation by Aurora B and its partners
-
Cimini D. Detection and correction of merotelic kinetochore orientation by Aurora B and its partners. Cell Cycle. 2007;6(13):1558-64.
-
(2007)
Cell Cycle
, vol.6
, Issue.13
, pp. 1558-1564
-
-
Cimini, D.1
-
104
-
-
61549083089
-
Aurora-B kinase inhibitors for cancer chemotherapy
-
Yeung SC, Gully C, Lee MH. Aurora-B kinase inhibitors for cancer chemotherapy. Mini Rev Med Chem. 2008;8(14):1514-25.
-
(2008)
Mini Rev Med Chem
, vol.8
, Issue.14
, pp. 1514-1525
-
-
Yeung, S.C.1
Gully, C.2
Lee, M.H.3
-
105
-
-
76649120544
-
Aurora kinase inhibitorsrising stars in cancer therapeutics?
-
Dar AA, Goff LW, Majid S, Berlin J, El-Rifai W. Aurora kinase inhibitors - rising stars in cancer therapeutics? Mol Cancer Ther. 2010;9(2):268-78.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.2
, pp. 268-278
-
-
Dar, A.A.1
Goff, L.W.2
Majid, S.3
Berlin, J.4
El-Rifai, W.5
-
106
-
-
77449151205
-
Physiological and oncogenic Aurora-A pathway
-
Saeki T, Ouchi M, Ouchi T. Physiological and oncogenic Aurora-A pathway. Int J Biol Sci. 2009;5(7):758-62.
-
(2009)
Int J Biol Sci
, vol.5
, Issue.7
, pp. 758-762
-
-
Saeki, T.1
Ouchi, M.2
Ouchi, T.3
-
107
-
-
33749264040
-
Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression
-
Ju H, Cho H, Kim YS, Kim WH, Ihm C, Noh SM, et al. Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression. Cancer Lett. 2006;242(2):273-9.
-
(2006)
Cancer Lett
, vol.242
, Issue.2
, pp. 273-279
-
-
Ju, H.1
Cho, H.2
Kim, Y.S.3
Kim, W.H.4
Ihm, C.5
Noh, S.M.6
-
108
-
-
33846924624
-
Aurora kinases A and B and familial breast cancer risk
-
Tchatchou S, Wirtenberger M, Hemminki K, Sutter C, Meindl A, Wappenschmidt B, et al. Aurora kinases A and B and familial breast cancer risk. Cancer Lett. 2007;247(2):266-72.
-
(2007)
Cancer Lett
, vol.247
, Issue.2
, pp. 266-272
-
-
Tchatchou, S.1
Wirtenberger, M.2
Hemminki, K.3
Sutter, C.4
Meindl, A.5
Wappenschmidt, B.6
-
109
-
-
24944573674
-
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: A meta-Analysis of multiple cancer types
-
Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, et al. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: A meta-Analysis of multiple cancer types. Carcinogenesis. 2005;26(8):1368-73.
-
(2005)
Carcinogenesis
, vol.26
, Issue.8
, pp. 1368-1373
-
-
Ewart-Toland, A.1
Dai, Q.2
Gao, Y.T.3
Nagase, H.4
Dunlop, M.G.5
Farrington, S.M.6
-
110
-
-
75749121467
-
SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-Tumor activity and dosing fl exibility in vivo
-
Arbitrario JP, Belmont BJ, Evanchik MJ, Flanagan WM, Fucini RV, Hansen SK, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-Tumor activity and dosing fl exibility in vivo. Cancer Chemother Pharmacol. 2010;65(4):707-17.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, Issue.4
, pp. 707-717
-
-
Arbitrario, J.P.1
Belmont, B.J.2
Evanchik, M.J.3
Flanagan, W.M.4
Fucini, R.V.5
Hansen, S.K.6
-
111
-
-
78649864566
-
Aurora kinase inhibitors as anticancer molecules
-
Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta. 2010;1799(10-12):829-39.
-
(2010)
Biochim Biophys Acta
, vol.1799
, Issue.10-12
, pp. 829-839
-
-
Katayama, H.1
Sen, S.2
-
112
-
-
78649476052
-
Shared and separate functions of polo-like kinases and aurora kinases in cancer
-
Lens SM, Voest EE, Medema RH. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer. 2010;10(12):825-41.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.12
, pp. 825-841
-
-
Lens, S.M.1
Voest, E.E.2
Medema, R.H.3
-
113
-
-
78649497606
-
Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465
-
Pirker C, Lotsch D, Spiegl-Kreinecker S, Jantscher F, Sutterluty H, Micksche M, et al. Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465. Exp Dermatol. 2010;19(12):1040-7.
-
(2010)
Exp Dermatol
, vol.19
, Issue.12
, pp. 1040-1047
-
-
Pirker, C.1
Lotsch, D.2
Spiegl-Kreinecker, S.3
Jantscher, F.4
Sutterluty, H.5
Micksche, M.6
-
114
-
-
79954448918
-
Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors
-
Dees EC, Infante JR, Cohen RB, O'Neil BH, Jones S, von Mehren M, et al. Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2010;67(4):945-54.
-
(2010)
Cancer Chemother Pharmacol
, vol.67
, Issue.4
, pp. 945-954
-
-
Dees, E.C.1
Infante, J.R.2
Cohen, R.B.3
O'Neil, B.H.4
Jones, S.5
Von Mehren, M.6
-
115
-
-
77958042173
-
Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: Safety, pharmacokinetics, and pharmacodynamics
-
Macarulla T, Cervantes A, Elez E, Rodriguez-Braun E, Baselga J, Rosello S, et al. Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: Safety, pharmacokinetics, and pharmacodynamics. Mol Cancer Ther. 2010;9(10):2844-52.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2844-2852
-
-
Macarulla, T.1
Cervantes, A.2
Elez, E.3
Rodriguez-Braun, E.4
Baselga, J.5
Rosello, S.6
-
116
-
-
82455192242
-
Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
-
Carol H, Boehm I, Reynolds CP, Kang MH, Maris JM, Morton CL, et al. Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. Cancer Chemother Pharmacol. 2011;68(5):1291-304.
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, Issue.5
, pp. 1291-1304
-
-
Carol, H.1
Boehm, I.2
Reynolds, C.P.3
Kang, M.H.4
Maris, J.M.5
Morton, C.L.6
-
117
-
-
58449113003
-
Macrophage inhibitory cytokine-1: A new player in melanoma development
-
Yamashita T, Yoneta A, Hida T. Macrophage inhibitory cytokine-1: A new player in melanoma development. J Invest Dermatol. 2009;129(2):262-4.
-
(2009)
J Invest Dermatol
, vol.129
, Issue.2
, pp. 262-264
-
-
Yamashita, T.1
Yoneta, A.2
Hida, T.3
-
118
-
-
77953217053
-
Macrophage inhibitory cytokine-1 regulates melanoma vascular development
-
Huh SJ, Chung CY, Sharma A, Robertson GP. Macrophage inhibitory cytokine-1 regulates melanoma vascular development. Am J Pathol. 2010;176(6):2948-57.
-
(2010)
Am J Pathol
, vol.176
, Issue.6
, pp. 2948-2957
-
-
Huh, S.J.1
Chung, C.Y.2
Sharma, A.3
Robertson, G.P.4
-
119
-
-
0033913570
-
IL-8 expression in malignant melanoma: Implications in growth and metastasis
-
Singh RK, Varney ML. IL-8 expression in malignant melanoma: Implications in growth and metastasis. Histol Histopathol. 2000;15(3):843-9.
-
(2000)
Histol Histopathol
, vol.15
, Issue.3
, pp. 843-849
-
-
Singh, R.K.1
Varney, M.L.2
-
120
-
-
79953327929
-
IL8 And cathepsin B as melanoma serum biomarkers
-
Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, et al. IL8 And cathepsin B as melanoma serum biomarkers. Int J Mol Sci. 2011;12(3):1505-18.
-
(2011)
Int J Mol Sci
, vol.12
, Issue.3
, pp. 1505-1518
-
-
Zhang, H.1
Fu, T.2
McGettigan, S.3
Kumar, S.4
Liu, S.5
Speicher, D.6
-
121
-
-
77949840400
-
Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins alpha5 and beta1
-
Jovanovic M, Stefanoska I, Radojcic L, Vicovac L. Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins alpha5 and beta1. Reproduction. 2010;139(4):789-98.
-
(2010)
Reproduction
, vol.139
, Issue.4
, pp. 789-798
-
-
Jovanovic, M.1
Stefanoska, I.2
Radojcic, L.3
Vicovac, L.4
-
122
-
-
70450245233
-
Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8
-
Araki K, Shimura T, Yajima T, Tsutsumi S, Suzuki H, Okada K, et al. Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8. J Biol Chem. 2009;284(47): 32305-11.
-
(2009)
J Biol Chem
, vol.284
, Issue.47
, pp. 32305-32311
-
-
Araki, K.1
Shimura, T.2
Yajima, T.3
Tsutsumi, S.4
Suzuki, H.5
Okada, K.6
-
123
-
-
77955034793
-
Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development
-
Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 2010;70(14):6071-82.
-
(2010)
Cancer Res
, vol.70
, Issue.14
, pp. 6071-6082
-
-
Huh, S.J.1
Liang, S.2
Sharma, A.3
Dong, C.4
Robertson, G.P.5
-
124
-
-
72249093615
-
Tumor selfseeding by circulating cancer cells
-
Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, et al. Tumor selfseeding by circulating cancer cells. Cell. 2009;139(7):1315-26.
-
(2009)
Cell
, vol.139
, Issue.7
, pp. 1315-1326
-
-
Kim, M.Y.1
Oskarsson, T.2
Acharyya, S.3
Nguyen, D.X.4
Zhang, X.H.5
Norton, L.6
-
125
-
-
41649114134
-
A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
-
Crawford S, Belajic D, Wei J, Riley JP, Dunford PJ, Bembenek S, et al. A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker. Mol Cancer Ther. 2008;7(3):492-9.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.3
, pp. 492-499
-
-
Crawford, S.1
Belajic, D.2
Wei, J.3
Riley, J.P.4
Dunford, P.J.5
Bembenek, S.6
-
126
-
-
67650498443
-
Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations
-
Ciuffreda L, Del Bufalo D, Desideri M, Di Sanza C, Stoppacciaro A, Ricciardi MR, et al. Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations. Neoplasia. 2009;11(8):720-31.
-
(2009)
Neoplasia
, vol.11
, Issue.8
, pp. 720-731
-
-
Ciuffreda, L.1
Del Bufalo, D.2
Desideri, M.3
Di Sanza, C.4
Stoppacciaro, A.5
Ricciardi, M.R.6
-
127
-
-
77954852993
-
Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells
-
Oka M, Sakaguchi M, Okada T, Nagai H, Ozaki M, Yoshioka T, et al. Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells. Exp Dermatol. 2010;19(8):e50-5.
-
(2010)
Exp Dermatol
, vol.19
, Issue.8
-
-
Oka, M.1
Sakaguchi, M.2
Okada, T.3
Nagai, H.4
Ozaki, M.5
Yoshioka, T.6
-
128
-
-
55349098455
-
Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-Activated receptor-1 small interfering RNA
-
Villares GJ, Zigler M, Wang H, Melnikova VO, Wu H, Friedman R, et al. Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-Activated receptor-1 small interfering RNA. Cancer Res. 2008;68(21):9078-86.
-
(2008)
Cancer Res
, vol.68
, Issue.21
, pp. 9078-9086
-
-
Villares, G.J.1
Zigler, M.2
Wang, H.3
Melnikova, V.O.4
Wu, H.5
Friedman, R.6
-
129
-
-
2942688195
-
Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: A possible escape mechanism from chemotherapy
-
Lev DC, Ruiz M, Mills L, McGary EC, Price JE, Bar-Eli M. Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: A possible escape mechanism from chemotherapy. Mol Cancer Ther. 2003;2(8):753-63.
-
(2003)
Mol Cancer Ther
, vol.2
, Issue.8
, pp. 753-763
-
-
Lev, D.C.1
Ruiz, M.2
Mills, L.3
McGary, E.C.4
Price, J.E.5
Bar-Eli, M.6
-
130
-
-
2942696482
-
Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo
-
Lev DC, Onn A, Melinkova VO, Miller C, Stone V, Ruiz M, et al. Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo. J Clin Oncol. 2004;22(11):2092-100.
-
(2004)
J Clin Oncol
, vol.22
, Issue.11
, pp. 2092-2100
-
-
Lev, D.C.1
Onn, A.2
Melinkova, V.O.3
Miller, C.4
Stone, V.5
Ruiz, M.6
-
131
-
-
79957800994
-
Melanoma prevention using topical PBISe
-
Chung CY, Madhunapantula SV, Desai D, Amin S, Robertson GP. Melanoma prevention using topical PBISe. Cancer Prev Res (Phila Pa). 2011;4(6):935-48.
-
(2011)
Cancer Prev Res (Phila Pa
, vol.4
, Issue.6
, pp. 935-948
-
-
Chung, C.Y.1
Madhunapantula, S.V.2
Desai, D.3
Amin, S.4
Robertson, G.P.5
-
132
-
-
0036310021
-
Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma
-
Huang S, Mills L, Mian B, Tellez C, McCarty M, Yang XD, et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002;161(1):125-34.
-
(2002)
Am J Pathol
, vol.161
, Issue.1
, pp. 125-134
-
-
Huang, S.1
Mills, L.2
Mian, B.3
Tellez, C.4
McCarty, M.5
Yang, X.D.6
-
133
-
-
50049089470
-
Tumor immunotherapy in melanoma: Strategies for overcoming mechanisms of resistance and escape
-
Zigler M, Villares GJ, Lev DC, Melnikova VO, Bar-Eli M. Tumor immunotherapy in melanoma: Strategies for overcoming mechanisms of resistance and escape. Am J Clin Dermatol. 2008;9(5):307-11.
-
(2008)
Am J Clin Dermatol
, vol.9
, Issue.5
, pp. 307-311
-
-
Zigler, M.1
Villares, G.J.2
Lev, D.C.3
Melnikova, V.O.4
Bar-Eli, M.5
-
134
-
-
77955655940
-
Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome
-
Murrow LM, Garimella SV, Jones TL, Caplen NJ, Lipkowitz S. Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome. Breast Cancer Res Treat. 2010;122(2):347-57.
-
(2010)
Breast Cancer Res Treat
, vol.122
, Issue.2
, pp. 347-357
-
-
Murrow, L.M.1
Garimella, S.V.2
Jones, T.L.3
Caplen, N.J.4
Lipkowitz, S.5
-
135
-
-
0034058071
-
Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts
-
Walter SA, Guadagno SN, Ferrell Jr. JE. Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts. Mol Biol Cell. 2000;11(3):887-96.
-
(2000)
Mol Biol Cell
, vol.11
, Issue.3
, pp. 887-896
-
-
Walter, S.A.1
Guadagno, S.N.2
Ferrell Jr., J.E.3
-
136
-
-
79960339454
-
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
-
De Witt Hamer PC, Mir SE, Noske D, Van Noorden CJ, Wurdinger T. WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe. Clin Cancer Res. 2011;17:4200-7.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4200-4207
-
-
De Witt Hamer, P.C.1
Mir, S.E.2
Noske, D.3
Van Noorden, C.J.4
Wurdinger, T.5
-
137
-
-
77953711939
-
MK-1775, a small molecule Wee1 inhibitor, enhances anti-Tumor efficacy of various DNA-damaging agents, including 5- fl uorouracil
-
Hirai H, Arai T, Okada M, Nishibata T, Kobayashi M, Sakai N, et al. MK-1775, a small molecule Wee1 inhibitor, enhances anti-Tumor efficacy of various DNA-damaging agents, including 5- fl uorouracil. Cancer Biol Ther. 2010;9(7):514-22.
-
(2010)
Cancer Biol Ther
, vol.9
, Issue.7
, pp. 514-522
-
-
Hirai, H.1
Arai, T.2
Okada, M.3
Nishibata, T.4
Kobayashi, M.5
Sakai, N.6
-
138
-
-
38749138123
-
Synthesis and structure-Activityrelationshipsofsoluble8-substituted4-(2- chlorophenyl 9-hydroxypyrrolo [3,4-c]carbazole-1 3(2H6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases
-
Smaill JB, Lee HH, Palmer BD, Thompson AM, Squire CJ, Baker EN, et al. Synthesis and structure-Activityrelationshipsofsoluble8-substituted4-(2- chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg Med Chem Lett. 2008;18(3):929-33.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, Issue.3
, pp. 929-933
-
-
Smaill, J.B.1
Lee, H.H.2
Palmer, B.D.3
Thompson, A.M.4
Squire, C.J.5
Baker, E.N.6
-
139
-
-
0035890610
-
Radiosensitization of p53 mutant cells by PD0166285 a novel G (2) checkpoint abrogator
-
Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res. 2001;61(22):8211-7.
-
(2001)
Cancer Res
, vol.61
, Issue.22
, pp. 8211-8217
-
-
Wang, Y.1
Li, J.2
Booher, R.N.3
Kraker, A.4
Lawrence, T.5
Leopold, W.R.6
-
140
-
-
33846608696
-
Cell cycle regulation by the Wee1 inhibitor PD0166285 pyrido [2,3-d] pyrimidine, in the B16 mouse melanoma cell line
-
Hashimoto O, Shinkawa M, Torimura T, Nakamura T, Selvendiran K, Sakamoto M, et al. Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyrimidine, in the B16 mouse melanoma cell line. BMC Cancer. 2006;6:292.
-
(2006)
BMC Cancer
, vol.6
, pp. 292
-
-
Hashimoto, O.1
Shinkawa, M.2
Torimura, T.3
Nakamura, T.4
Selvendiran, K.5
Sakamoto, M.6
-
141
-
-
77952289449
-
Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate
-
Park K, Lee MY, Kim KS, Hahn SK. Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate. Biomaterials. 2010;31(19):5258-65.
-
(2010)
Biomaterials
, vol.31
, Issue.19
, pp. 5258-5265
-
-
Park, K.1
Lee, M.Y.2
Kim, K.S.3
Hahn, S.K.4
-
142
-
-
49249137986
-
Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2
-
Molhoek KR, Griesemann H, Shu J, Gershenwald JE, Brautigan DL, Slingluff Jr. CL. Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. Cancer Res. 2008;68(11):4392-7.
-
(2008)
Cancer Res
, vol.68
, Issue.11
, pp. 4392-4397
-
-
Molhoek, K.R.1
Griesemann, H.2
Shu, J.3
Gershenwald, J.E.4
Brautigan, D.L.5
Slingluff Jr., C.L.6
-
143
-
-
80051688309
-
GPR56 regulates VEGF production and angiogenesis during melanoma progression
-
Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, et al. GPR56 regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011;71(16):5558-68.
-
(2011)
Cancer Res
, vol.71
, Issue.16
, pp. 5558-5568
-
-
Yang, L.1
Chen, G.2
Mohanty, S.3
Scott, G.4
Fazal, F.5
Rahman, A.6
-
144
-
-
19344370532
-
B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-Associated herpesvirus-infected human B cells
-
Akula SM, Ford PW, Whitman AG, Hamden KE, Bryan BA, Cook PP, et al. B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-Associated herpesvirus-infected human B cells. Blood. 2005;105(11):4516-22.
-
(2005)
Blood
, vol.105
, Issue.11
, pp. 4516-4522
-
-
Akula, S.M.1
Ford, P.W.2
Whitman, A.G.3
Hamden, K.E.4
Bryan, B.A.5
Cook, P.P.6
-
145
-
-
79957553592
-
Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker
-
Niers TM, Richel DJ, Meijers JC, Schlingemann RO. Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker. PLoS One. 2011;6(5): E19873.
-
(2011)
PLoS One
, vol.6
, Issue.5
-
-
Niers, T.M.1
Richel, D.J.2
Meijers, J.C.3
Schlingemann, R.O.4
-
146
-
-
79952825157
-
Targeting angiogenesis in melanoma: Prospects for the future
-
Corrie PG, Basu B, Zaki KA. Targeting angiogenesis in melanoma: Prospects for the future. Ther Adv Med Oncol. 2010;2(6):367-80.
-
(2010)
Ther Adv Med Oncol
, vol.2
, Issue.6
, pp. 367-380
-
-
Corrie, P.G.1
Basu, B.2
Zaki, K.A.3
-
148
-
-
44649151405
-
Axitinib, a novel anti-Angiogenic drug with promising activity in various solid tumors
-
Choueiri TK. Axitinib, a novel anti-Angiogenic drug with promising activity in various solid tumors. Curr Opin Investig Drugs. 2008;9(6):658-71.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, Issue.6
, pp. 658-671
-
-
Choueiri, T.K.1
-
149
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA. 2002;99(17):11393-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
-
150
-
-
77949385731
-
AlphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells
-
Hu R, Aplin AE. AlphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells. Pigment Cell Melanoma Res. 2010;23:201-9.
-
(2010)
Pigment Cell Melanoma Res
, vol.23
, pp. 201-209
-
-
Hu, R.1
Aplin, A.E.2
-
151
-
-
79954579925
-
Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: An immunohistochemical study and analysis of prognostic value
-
Oba J, Nakahara T, Abe T, Hagihara A, Moroi Y, Furue M. Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: An immunohistochemical study and analysis of prognostic value. J Dermatol Sci. 2011;62(2):116-23.
-
(2011)
J Dermatol Sci
, vol.62
, Issue.2
, pp. 116-123
-
-
Oba, J.1
Nakahara, T.2
Abe, T.3
Hagihara, A.4
Moroi, Y.5
Furue, M.6
-
152
-
-
34249738595
-
The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions
-
Lebe B, Pabuccuoglu U, Ozer E. The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions. Appl Immunohistochem Mol Morphol. 2007;15(2):160-4.
-
(2007)
Appl Immunohistochem Mol Morphol
, vol.15
, Issue.2
, pp. 160-164
-
-
Lebe, B.1
Pabuccuoglu, U.2
Ozer, E.3
-
153
-
-
34147167723
-
P276-00, a novel cyclindependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
-
Joshi KS, Rathos MJ, Mahajan P, Wagh V, Shenoy S, Bhatia D, et al. P276-00, a novel cyclindependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007;6(3):926-34.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.3
, pp. 926-934
-
-
Joshi, K.S.1
Rathos, M.J.2
Mahajan, P.3
Wagh, V.4
Shenoy, S.5
Bhatia, D.6
-
154
-
-
85047691355
-
Chemotherapy for metastatic melanoma
-
Mandara M, Nortilli R, Sava T, Cetto GL. Chemotherapy for metastatic melanoma. Expert Rev Anticancer Ther. 2006;6(1):121-30.
-
(2006)
Expert Rev Anticancer Ther
, vol.6
, Issue.1
, pp. 121-130
-
-
Mandara, M.1
Nortilli, R.2
Sava, T.3
Cetto, G.L.4
-
155
-
-
0035136793
-
Single-Agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: A meta-Analysis of 3273 patients from 20 randomized trials
-
Huncharek M, Caubet JF, McGarry R. Single-Agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: A meta-Analysis of 3273 patients from 20 randomized trials. Melanoma Res. 2001;11(1):75-81.
-
(2001)
Melanoma Res
, vol.11
, Issue.1
, pp. 75-81
-
-
Huncharek, M.1
Caubet, J.F.2
McGarry, R.3
-
156
-
-
33745075558
-
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
-
Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther. 2006;5(5):1136-44.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.5
, pp. 1136-1144
-
-
Smalley, K.S.1
Haass, N.K.2
Brafford, P.A.3
Lioni, M.4
Flaherty, K.T.5
Herlyn, M.6
-
157
-
-
54849373400
-
Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development
-
Tran MA, Gowda R, Sharma A, Park EJ, Adair J, Kester M, et al. Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development. Cancer Res. 2008;68(18):7638-49.
-
(2008)
Cancer Res
, vol.68
, Issue.18
, pp. 7638-7649
-
-
Tran, M.A.1
Gowda, R.2
Sharma, A.3
Park, E.J.4
Adair, J.5
Kester, M.6
-
158
-
-
77954215697
-
Temozolomide combined with the PI3K inhibitor LY294002 or the mTOR inhibitor rapamycin inhibits melanoma cell growth, survival and invasion
-
Abstract]. rftxt June 20 Suppl) Abstract 8559
-
Meier FE, Lasithiotakis K, Schittek B, Sinnberg T, Garbe C. Temozolomide combined with the PI3K inhibitor LY294002 or the mTOR inhibitor rapamycin inhibits melanoma cell growth, survival and invasion. J Clin Oncol. [Abstract]. 2007;25(18S (June 20 Suppl) Abstract 8559).
-
(2007)
J Clin Oncol
, vol.25
-
-
Meier, F.E.1
Lasithiotakis, K.2
Schittek, B.3
Sinnberg, T.4
Garbe, C.5
-
159
-
-
77950557554
-
Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells
-
Li J, Xu M, Yang Z, Li A, Dong J. Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. Cancer Invest. 2009;28(4):350-6.
-
(2009)
Cancer Invest
, vol.28
, Issue.4
, pp. 350-356
-
-
Li, J.1
Xu, M.2
Yang, Z.3
Li, A.4
Dong, J.5
-
160
-
-
34447104362
-
Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment
-
Meier F, Busch S, Lasithiotakis K, Kulms D, Garbe C, Maczey E, et al. Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br J Dermatol. 2007;156(6):1204-13.
-
(2007)
Br J Dermatol
, vol.156
, Issue.6
, pp. 1204-1213
-
-
Meier, F.1
Busch, S.2
Lasithiotakis, K.3
Kulms, D.4
Garbe, C.5
Maczey, E.6
-
161
-
-
55749112156
-
Melanoma and the tumor microenvironment
-
Villanueva J, Herlyn M. Melanoma and the tumor microenvironment. Curr Oncol Rep. 2008;10(5):439-46.
-
(2008)
Curr Oncol Rep
, vol.10
, Issue.5
, pp. 439-446
-
-
Villanueva, J.1
Herlyn, M.2
-
162
-
-
82955172970
-
Fibroblasts contribute to melanoma tumor growth and drug resistance
-
Flach EH, Rebecca VW, Herlyn M, Smalley KS, Anderson AR. Fibroblasts contribute to melanoma tumor growth and drug resistance. Mol Pharm. 2011;8(6):2039-49.
-
(2011)
Mol Pharm
, vol.8
, Issue.6
, pp. 2039-2049
-
-
Flach, E.H.1
Rebecca, V.W.2
Herlyn, M.3
Smalley, K.S.4
Anderson, A.R.5
-
163
-
-
33744461302
-
Melanoma cell extravasation under fl ow conditions is modulated by leukocytes and endogenously produced interleukin 8
-
Dong C, Slattery MJ, Liang S, Peng HH. Melanoma cell extravasation under fl ow conditions is modulated by leukocytes and endogenously produced interleukin 8. Mol Cell Biomech. 2005;2(3):145-59.
-
(2005)
Mol Cell Biomech
, vol.2
, Issue.3
, pp. 145-159
-
-
Dong, C.1
Slattery, M.J.2
Liang, S.3
Peng, H.H.4
-
164
-
-
77952999313
-
Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling
-
Liang S, Hoskins M, Dong C. Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling. Mol Cell Biomech. 2010;7(2):77-91.
-
(2010)
Mol Cell Biomech
, vol.7
, Issue.2
, pp. 77-91
-
-
Liang, S.1
Hoskins, M.2
Dong, C.3
-
165
-
-
84859762704
-
Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions
-
Ozdemir T, Zhang P, Fu C, Dong C. Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions. Am J Physiol Cell Physiol. 2012;302(8):C1189-201.
-
(2012)
Am J Physiol Cell Physiol
, vol.302
, Issue.8
-
-
Ozdemir, T.1
Zhang, P.2
Fu, C.3
Dong, C.4
-
166
-
-
79251537741
-
Sequential binding of alphaVbeta3 and ICAM-1 determinesfibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils
-
Zhang P, Ozdemir T, Chung CY, Robertson GP, Dong C. Sequential binding of alphaVbeta3 and ICAM-1 determinesfibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils. J Immunol. 2011;186(1):242-54.
-
(2011)
J Immunol
, vol.186
, Issue.1
, pp. 242-254
-
-
Zhang, P.1
Ozdemir, T.2
Chung, C.Y.3
Robertson, G.P.4
Dong, C.5
-
167
-
-
70349096379
-
Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development
-
Dong C, Robertson GP. Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development. Biorheology. 2009;46(4):265-79.
-
(2009)
Biorheology
, vol.46
, Issue.4
, pp. 265-279
-
-
Dong, C.1
Robertson, G.P.2
-
168
-
-
34249860062
-
Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China
-
Liang S, Seto EY, Remais JV, Zhong B, Yang C, Hubbard A, et al. Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China. Proc Natl Acad Sci USA. 2007;104(17):7110-5.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.17
, pp. 7110-7115
-
-
Liang, S.1
Seto, E.Y.2
Remais, J.V.3
Zhong, B.4
Yang, C.5
Hubbard, A.6
-
169
-
-
38749090569
-
Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma
-
van Kempen LC, Rijntjes J, Mamor-Cornelissen I, Vincent-Naulleau S, Gerritsen MJ, Ruiter DJ, et al. Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma. Int J Cancer. 2008;122(5):1019-29.
-
(2008)
Int J Cancer
, vol.122
, Issue.5
, pp. 1019-1029
-
-
Van Kempen, L.C.1
Rijntjes, J.2
Mamor-Cornelissen, I.3
Vincent-Naulleau, S.4
Gerritsen, M.J.5
Ruiter, D.J.6
-
170
-
-
77955462823
-
KLF6 gene and early melanoma development in a collagen I-rich extracellular environment
-
Huh SJ, Chen YL, Friedman SL, Liao J, Huang HJ, Cavenee WK, et al. KLF6 gene and early melanoma development in a collagen I-rich extracellular environment. J Natl Cancer Inst. 2010;102(15):1131-47.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.15
, pp. 1131-1147
-
-
Huh, S.J.1
Chen, Y.L.2
Friedman, S.L.3
Liao, J.4
Huang, H.J.5
Cavenee, W.K.6
-
171
-
-
0035139062
-
Expression of cyclooxygenase 2 in human malignant melanoma
-
Denkert C, Kobel M, Berger S, Siegert A, Leclere A, Trefzer U, et al. Expression of cyclooxygenase 2 in human malignant melanoma. Cancer Res. 2001;61(1):303-8.
-
(2001)
Cancer Res
, vol.61
, Issue.1
, pp. 303-308
-
-
Denkert, C.1
Kobel, M.2
Berger, S.3
Siegert, A.4
Leclere, A.5
Trefzer, U.6
-
172
-
-
3142587657
-
Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression
-
Goulet AC, Einsphar JG, Alberts DS, Beas A, Burk C, Bhattacharyya A, et al. Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. Cancer Biol Ther. 2003;2(6):713-8.
-
(2003)
Cancer Biol Ther
, vol.2
, Issue.6
, pp. 713-718
-
-
Goulet, A.C.1
Einsphar, J.G.2
Alberts, D.S.3
Beas, A.4
Burk, C.5
Bhattacharyya, A.6
-
173
-
-
59549097545
-
COX-2 expression in malignant melanoma: A novel prognostic marker?
-
Becker MR, Siegelin MD, Rompel R, Enk AH, Gaiser T. COX-2 expression in malignant melanoma: A novel prognostic marker? Melanoma Res. 2009;19(1):8-16.
-
(2009)
Melanoma Res
, vol.19
, Issue.1
, pp. 8-16
-
-
Becker, M.R.1
Siegelin, M.D.2
Rompel, R.3
Enk, A.H.4
Gaiser, T.5
-
174
-
-
70349962950
-
NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma
-
Flockhart RJ, Armstrong JL, Reynolds NJ, Lovat PE. NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. Br J Cancer. 2009;101(8):1448-55.
-
(2009)
Br J Cancer
, vol.101
, Issue.8
, pp. 1448-1455
-
-
Flockhart, R.J.1
Armstrong, J.L.2
Reynolds, N.J.3
Lovat, P.E.4
-
175
-
-
33645456543
-
Expression of cyclooxygenase-2 in benign naevi and during human cutaneous melanoma progression
-
Kuzbicki L, Sarnecka A, Chwirot BW. Expression of cyclooxygenase-2 in benign naevi and during human cutaneous melanoma progression. Melanoma Res. 2006;16(1):29-36.
-
(2006)
Melanoma Res
, vol.16
, Issue.1
, pp. 29-36
-
-
Kuzbicki, L.1
Sarnecka, A.2
Chwirot, B.W.3
-
176
-
-
80052032423
-
Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2
-
Current and Future Trials of Targeted Therapies in Cutaneous Melanoma 2555
-
Valcarcel M, Mendoza L, Hernandez JJ, Carrascal T, Salado C, Crende O, et al. Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. J Transl Med. 2011;9:142. Current and Future Trials of Targeted Therapies in Cutaneous Melanoma 2555
-
(2011)
J Transl Med
, vol.9
, pp. 142
-
-
Valcarcel, M.1
Mendoza, L.2
Hernandez, J.J.3
Carrascal, T.4
Salado, C.5
Crende, O.6
-
177
-
-
33749431821
-
Cyclooxygenase-2 inhibition and regression of metastatic melanoma
-
Wilson KS. Cyclooxygenase-2 inhibition and regression of metastatic melanoma. Melanoma Res. 2006;16(5):465.
-
(2006)
Melanoma Res
, vol.16
, Issue.5
, pp. 465
-
-
Wilson, K.S.1
-
178
-
-
37549072028
-
A study of malignant lymphomas and leukemias III Stem cell, blast cell, and monocytic leukemias (with reference to their lymphogenous or myelogenous origin
-
Goldberg GM, Rubenstone AI, Saphir O. A study of malignant lymphomas and leukemias. III. Stem cell, blast cell, and monocytic leukemias (with reference to their lymphogenous or myelogenous origin). Cancer. 1961;14:21-9.
-
(1961)
Cancer
, vol.14
, pp. 21-29
-
-
Goldberg, G.M.1
Rubenstone, A.I.2
Saphir, O.3
-
179
-
-
79960572950
-
Cancer stem cells and cancer therapy
-
Soltanian S, Matin MM. Cancer stem cells and cancer therapy. Tumour Biol. 2011;32(3): 425-40.
-
(2011)
Tumour Biol
, vol.32
, Issue.3
, pp. 425-440
-
-
Soltanian, S.1
Matin, M.M.2
-
180
-
-
41049111969
-
Cancer stem cells and human malignant melanoma
-
Schatton T, Frank MH. Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res. 2008;21(1):39-55.
-
(2008)
Pigment Cell Melanoma Res
, vol.21
, Issue.1
, pp. 39-55
-
-
Schatton, T.1
Frank, M.H.2
-
181
-
-
68849109234
-
Stem cells, melanoma and cancer stem cells: The good, the bad and the evil?
-
Menaa F, Houben R, Eyrich M, Broecker EB, Becker JC, Wischhusen J. Stem cells, melanoma and cancer stem cells: The good, the bad and the evil? G Ital Dermatol Venereol. 2009;144(3):287-96.
-
(2009)
G Ital Dermatol Venereol
, vol.144
, Issue.3
, pp. 287-296
-
-
Menaa, F.1
Houben, R.2
Eyrich, M.3
Broecker, E.B.4
Becker, J.C.5
Wischhusen, J.6
-
182
-
-
35648999534
-
Recent advances in cancer stem/progenitor cell research: Therapeutic implications for overcoming resistance to the most aggressive cancers
-
Mimeault M, Hauke R, Mehta PP, Batra SK. Recent advances in cancer stem/progenitor cell research: Therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med. 2007;11(5):981-1011.
-
(2007)
J Cell Mol Med
, vol.11
, Issue.5
, pp. 981-1011
-
-
Mimeault, M.1
Hauke, R.2
Mehta, P.P.3
Batra, S.K.4
-
183
-
-
79956002779
-
Dermis-derived stem cells: A source of epidermal melanocytes and melanoma?
-
Zabierowski SE, Fukunaga-Kalabis M, Li L, Herlyn M. Dermis-derived stem cells: A source of epidermal melanocytes and melanoma? Pigment Cell Melanoma Res. 2011;24(3):422-9.
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, Issue.3
, pp. 422-429
-
-
Zabierowski, S.E.1
Fukunaga-Kalabis, M.2
Li, L.3
Herlyn, M.4
-
184
-
-
27144557960
-
A tumorigenic subpopulation with stem cell properties in melanomas
-
Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005;65(20):9328-37.
-
(2005)
Cancer Res
, vol.65
, Issue.20
, pp. 9328-9337
-
-
Fang, D.1
Nguyen, T.K.2
Leishear, K.3
Finko, R.4
Kulp, A.N.5
Hotz, S.6
-
185
-
-
84860420791
-
Erythropoietin receptor contributes to melanoma cell survival in vivo
-
Kumar SM, Zhang G, Bastian BC, Arcasoy MO, Karande P, Pushparajan A, et al. Erythropoietin receptor contributes to melanoma cell survival in vivo. Oncogene. 2012;31(13):1649-60.
-
(2012)
Oncogene
, vol.31
, Issue.13
, pp. 1649-1660
-
-
Kumar, S.M.1
Zhang, G.2
Bastian, B.C.3
Arcasoy, M.O.4
Karande, P.5
Pushparajan, A.6
-
186
-
-
67749135874
-
Use of liposomes as drug delivery vehicles for treatment of melanoma
-
Tran MA, Watts RJ, Robertson GP. Use of liposomes as drug delivery vehicles for treatment of melanoma. Pigment Cell Melanoma Res. 2009;22(4):388-99.
-
(2009)
Pigment Cell Melanoma Res
, vol.22
, Issue.4
, pp. 388-399
-
-
Tran, M.A.1
Watts, R.J.2
Robertson, G.P.3
-
187
-
-
66049083487
-
Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy
-
Basu S, Harfouche R, Soni S, Chimote G, Mashelkar RA, Sengupta S. Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. Proc Natl Acad Sci USA. 2009;106(19):7957-61.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.19
, pp. 7957-7961
-
-
Basu, S.1
Harfouche, R.2
Soni, S.3
Chimote, G.4
Mashelkar, R.A.5
Sengupta, S.6
-
188
-
-
10844220559
-
Clinical phase II study of pegylated liposomal doxorubicin as second-line treatment in disseminated melanoma
-
Fink W, Zimpfer-Rechner C, Thoelke A, Figl R, Kaatz M, Ugurel S, et al. Clinical phase II study of pegylated liposomal doxorubicin as second-line treatment in disseminated melanoma. Onkologie. 2004;27(6):540-4.
-
(2004)
Onkologie
, vol.27
, Issue.6
, pp. 540-544
-
-
Fink, W.1
Zimpfer-Rechner, C.2
Thoelke, A.3
Figl, R.4
Kaatz, M.5
Ugurel, S.6
-
189
-
-
26244441643
-
Nanostructure-mediated drug delivery
-
Hughes GA. Nanostructure-mediated drug delivery. Nanomedicine. 2005;1(1):22-30.
-
(2005)
Nanomedicine
, vol.1
, Issue.1
, pp. 22-30
-
-
Hughes, G.A.1
-
190
-
-
47949086963
-
Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development
-
Tran MA, Smith CD, Kester M, Robertson GP. Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res. 2008;14(11):3571-81.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.11
, pp. 3571-3581
-
-
Tran, M.A.1
Smith, C.D.2
Kester, M.3
Robertson, G.P.4
-
191
-
-
33847769265
-
Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas
-
Hwang TL, Lee WR, Hua SC, Fang JY. Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas. J Dermatol Sci. 2007;46(1):11-20.
-
(2007)
J Dermatol Sci
, vol.46
, Issue.1
, pp. 11-20
-
-
Hwang, T.L.1
Lee, W.R.2
Hua, S.C.3
Fang, J.Y.4
-
192
-
-
51449117728
-
Nanoparticle-based therapeutics in humans: A survey
-
Bawa R. Nanoparticle-based therapeutics in humans: A survey. Nanotechnol Law Bus. 2008;5(2):135-55.
-
(2008)
Nanotechnol Law Bus
, vol.5
, Issue.2
, pp. 135-155
-
-
Bawa, R.1
-
193
-
-
33645691940
-
Engineered nanoparticles as precise drug delivery systems
-
Yih TC, Al-Fandi M. Engineered nanoparticles as precise drug delivery systems. J Cell Biochem. 2006;97(6):1184-90.
-
(2006)
J Cell Biochem
, vol.97
, Issue.6
, pp. 1184-1190
-
-
Yih, T.C.1
Al-Fandi, M.2
-
194
-
-
84866374885
-
Curiously strong lipidoids science-business exchange "cover story: Targets and mechanisms" featured in nature
-
Fulmer T. Curiously strong lipidoids. Science-Business exchange, "Cover story: Targets and mechanisms" featured in nature. Nature. 2010;3(2):1-2.
-
(2010)
Nature
, vol.3
, Issue.2
, pp. 1-2
-
-
Fulmer, T.1
-
195
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature. 2010;464(7291):1067-70.
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
Seligson, D.4
Tolcher, A.5
Alabi, C.A.6
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