Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase [25]

Journal of the American Chemical Society

Volumn 123, Issue 9, 2001, Pages 2107-2108

  Dinsmore, C J ^a   Bogusky, M J ^a   Culberson, J C ^a   Bergman, J M ^a   Homnick, C F ^a   Zartman, C B ^a   Mosser, S D ^a   Schaber, M D ^a   Robinson, R G ^a   Koblan, K S ^a   Huber, H E ^a   Graham, S L ^a   Hartman, G D ^a   Huff, J R ^a   Williams, T M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; MACROCYCLIC COMPOUND;

CONFORMATION; ENANTIOMER; ENZYME INHIBITION; ENZYME STRUCTURE; LETTER; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035819989     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja003673q     Document Type: Letter

References (28)