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Volumn 9, Issue 6, 2008, Pages 658-671

Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors

Author keywords

[No Author keywords available]

Indexed keywords

ABT 869; ANTHRACYCLINE; ANTIHYPERTENSIVE AGENT; AXITINIB; BEVACIZUMAB; CARBOPLATIN; CISPLATIN; CP 868596; CYCLOPHOSPHAMIDE; CYTOKINE; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; INDAZOLE DERIVATIVE; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PLACEBO; RABEPRAZOLE; SORAFENIB; SUNITINIB;

EID: 44649151405     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (72)

References (119)
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    • 826225 Product update: New product: Sutent. Pfizer Inc MIMS (LONDON) 2007 October 01
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    • 843107 Axitinib (AG-013736; AG) in combination with paclitaxel (P)/carboplatin (C) in patients (pts) with advanced solid tumors. Cohen B, Kozloff F, Starr A, Pithavala Y, Tortorici M, Liau F, Tarazi JC, Olszanski J AACR-NCI-EORTC INT CONGRESS 2007 19 Abs A157
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    • 846096 A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, Louie SG et al BLOOD 2005 105 3 986-993
    • 846096 A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, Louie SG et al BLOOD 2005 105 3 986-993
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    • 852707 FDA approves Nexavar for hepatocellular carcinoma. Bayer HealthCare Pharmaceuticals; Onyx Pharmaceuticals Inc PRESS RELEASE 2007 November 19
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    • 870794 Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study Rixe O, Bukowski RM, Michaelson MD, Wilding G, Hudes GR, Bolte O, Motzer RJ, Bycott P, Liau KF, Freddo J, Trask PC et al LANCET ONCOL 2007 8 11 975-984 • Data showing an impressive activity of axitinib in metastatic RCC patients failing immunotherapy are discussed. The time to progression of 15.7 months is the longest reported to date in this patient population
    • 870794 Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study Rixe O, Bukowski RM, Michaelson MD, Wilding G, Hudes GR, Bolte O, Motzer RJ, Bycott P, Liau KF, Freddo J, Trask PC et al LANCET ONCOL 2007 8 11 975-984 • Data showing an impressive activity of axitinib in metastatic RCC patients failing immunotherapy are discussed. The time to progression of 15.7 months is the longest reported to date in this patient population.
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    • 870806 The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Fenton BM, Paoni SF CANCER RES 2008 67 20 9921-9928
    • 870806 The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Fenton BM, Paoni SF CANCER RES 2008 67 20 9921-9928
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    • 870808 AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging. Wilmes LJ, Pallavicini MG, Fleming LM, Gibbs J, Wang D, Li KL, Partridge SC, Henry RG, Shalinsky DR, Hu-Lowe D, Park JW et al MAGN RESON IMAGING 2007 25 3 319-327
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    • 870810 The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome MDS, Giles FJ, Bellamy WT, Estrov Z, O'Brien SM, Verstovsek S, Ravandi F, Beran M, Bycott P, Pithavala Y, Steinfeldt H, Reich SD et al LEUK RES 2006 30 7 801-811
    • 870810 The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Giles FJ, Bellamy WT, Estrov Z, O'Brien SM, Verstovsek S, Ravandi F, Beran M, Bycott P, Pithavala Y, Steinfeldt H, Reich SD et al LEUK RES 2006 30 7 801-811
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    • 870811 Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results Rugo HS, Herbst RS, Liu G, Park JW, Kies MS, Steinfeldt HM, Pithavala YK, Reich SD, Freddo JL, Wilding G J CLIN ONCOL 2005 23 24 5474-5483 • A phase I clinical trial that demonstrated the pharmacokinetics and safety of axitinib in patients with advanced solid tumors and identified the dose for phase II clinical testing.
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    • 870815 AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a phase 2 study of cytokine-refractory, metastatic renal cell cancer RCC, Rini B, Rixe O, Bukowski R, Michaelson MD, Wilding G, Hudes G, Bolte O, Steinfeldt H, Reich SD, Motzer R J CLIN ONCOL 2005 23 16 S4509
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    • 870816 A phase I/II study of AG-013736, an oral anti-angiogenesis agent, in combination with docetaxel in patients (pts) with metastatic breast cancer MBC, Rugo HS, Stopeck A, Badorf A, Pithavala YK, Steinfeldt HM BREAST CANCER RES TREAT 2005 94 S1 S62
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    • 871432 Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma. Zhu AX CANCER 2008 112 2 250-259
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    • 889603 Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Hicklin DJ, Ellis LM J CLIN ONOL 2005 23 5 1011-1027
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    • 889620 Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-Fms in mammary glands of transgenic mice results in hyperplasia and tumor formation. Kirma N, Luthra R, Jones J, Liu YG, Nair HB, Mandava U, Tekmal RR CANCER RES 2004 64 12 4162-4170
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    • 889623 The current role of angiogenesis inhibitors in the treatment of renal cell carcinoma. Choueiri TK, Bukowski RM, Rini BI SEMIN ONCOL 2006 33 5 596-606
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    • 889627 Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. GEORGE S CURR ONCOL REP 2007 9 4 323-327
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    • 889889 WO-2006048745: Methods for preparing indazole compounds. Srinivasan B, Dagnino R Jr, Ouellette M, Shi A, Tian B, Zook Q, Edward S WORLD PATENT 2006 May 11
    • 889889 WO-2006048745: Methods for preparing indazole compounds. Srinivasan B, Dagnino R Jr, Ouellette M, Shi A, Tian B, Zook Q, Edward S WORLD PATENT 2006 May 11
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    • 892766 NCT00454649: Investigational agent AG-013736 in combinations with standard of care treatments for patient's with advanced solid tumor. Pfizer Inc CLINICALTRIALS.GOV 2008 April 03
    • 892766 NCT00454649: Investigational agent AG-013736 in combinations with standard of care treatments for patient's with advanced solid tumor. Pfizer Inc CLINICALTRIALS.GOV 2008 April 03
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    • 892768 NCT00447005: A phase 1 study of AG-013736 (axitinib) in Japanese patients with advanced solid tumors. CLINICALTRIALS.GOV 2008 April 03
    • 892768 NCT00447005: A phase 1 study of AG-013736 (axitinib) in Japanese patients with advanced solid tumors. CLINICALTRIALS.GOV 2008 April 03
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    • 892866 NCT00094055: Phase 2 study of the anti-angiogenesis agent AG-013736 in patients with metastatic thyroid cancer who are refractory to or not suitable candidates for 131I treatment. CLINICALTRIALS. GOV 2008 April 03
    • 131I treatment. CLINICALTRIALS. GOV 2008 April 03
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    • 892870 NCT00389441: A pivotal phase 2 study of the antiangiogenesis agent AG-013736 in patients with 131I-refractory metastatic or unresectable locally-advanced papillary, follicular, or hurthle-cell thyroid cancer who are also refractory to, or intolerant of, or have clinical contraindication to, doxorubicin treatment. CLINICALTRIALS.GOV 2008 April 03
    • 131I-refractory metastatic or unresectable locally-advanced papillary, follicular, or hurthle-cell thyroid cancer who are also refractory to, or intolerant of, or have clinical contraindication to, doxorubicin treatment. CLINICALTRIALS.GOV 2008 April 03
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    • 893454 NCT00569946: Phase 2 study Of AG-013736 as second-line treatment in patients with metastatic renal cell cancer. CLINICALTRIALS.GOV 2008 April 07
    • 893454 NCT00569946: Phase 2 study Of AG-013736 as second-line treatment in patients with metastatic renal cell cancer. CLINICALTRIALS.GOV 2008 April 07
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    • 893558 NCT00600821: Randomized phase 2 trial of AG013736 or bevacizumab in combination with paclitaxel and carboplatin as first line treatment for patients with advanced non small cell lung cancer. CLINICALTRIALS.GOV 2008 April 07
    • 893558 NCT00600821: Randomized phase 2 trial of AG013736 or bevacizumab in combination with paclitaxel and carboplatin as first line treatment for patients with advanced non small cell lung cancer. CLINICALTRIALS.GOV 2008 April 07
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    • 893671 NCT00071006: Phase 2 study of AG-013736 in patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome. CLINICALTRIALS.GOV 2008 April 07
    • 893671 NCT00071006: Phase 2 study of AG-013736 in patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome. CLINICALTRIALS.GOV 2008 April 07
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    • 893694 SAIC awarded DIA intelligence analysis contract. SAIC PRESS RELEASE 2008 April 07
    • 893694 SAIC awarded DIA intelligence analysis contract. SAIC PRESS RELEASE 2008 April 07
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    • 893804 NCT00094107: Anti-angiogenesis agent AG-013736 in patients with metastatic melanoma. CLINICALTRIALS.GOV 2008 April 07
    • 893804 NCT00094107: Anti-angiogenesis agent AG-013736 in patients with metastatic melanoma. CLINICALTRIALS.GOV 2008 April 07
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    • 893817 NCT00460603: Phase 2 study with AG-013736 combined with chemotherapy and bevacizumab in patients with metastatic colorectal cancer. CLINICALTRIALS.GOV 2008 April 07
    • 893817 NCT00460603: Phase 2 study with AG-013736 combined with chemotherapy and bevacizumab in patients with metastatic colorectal cancer. CLINICALTRIALS.GOV 2008 April 07
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    • 893837 NCT00615056: A study combining FOLFOX or FOLFIRI with AG-013736 or avastin in patients with metastatic colorectal cancer after failure of one first line regimen. CLINICALTRIALS.GOV 2008 April 07
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