Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 929-933

  Smaill, Jeff B ^a   Lee, Ho H ^a   Palmer, Brian D ^a   Thompson, Andrew M ^a   Squire, Christopher J ^b   Baker, Edward N ^b   Booth, R John ^c   Kraker, Alan ^c   Hook, Ken ^c   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c PFIZER INC   (United States)

Author keywords

Checkpoint inhibitor; Chk1 kinase inhibitor; G2 M checkpoint abrogation; Pyrrolocarbazole; Wee1 kinase inhibitor

Indexed keywords

CARBAZOLE DERIVATIVE; CHECKPOINT KINASE 1; ENZYME INHIBITOR; UNCLASSIFIED DRUG; WEE1 KINASE;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME BINDING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CARBAZOLES; CELL CYCLE PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38749138123     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.046     Document Type: Article

References (9)

1. Kawabe T. Mol. Cancer Ther. 3 (2004) 513
2. Palmer B.D., Thompson A.M., Booth J.R., Dobrusin E.M., Kraker A.J., Lee H.H., Lunney E.A., Mitchell L.H., Ortwine D.F., Smaill J.B., Swan L.M., and Denny W.A. J. Med. Chem. 49 (2006) 4896
3. Smaill, J. B.; Baker, E. N.; Booth, R. J.; Bridges, A. J.; Dickson, J. M.; Dobrusin, E. M.; Ivanovic, I.; Kraker, A. J.; Lee, H. H.; Lunney, E. A.; Ortwine, D. F.; Palmer, B. D.; Quin, J.; Squire, C. J.; Thompson, A. M.; Denny, W. A. Eur. J. Med. Chem., Posted online 6th August, 2007. Available from doi:10.1016/j.ejmech.2007.07.016.
4. Squire C., Dickson J.M., Ivanovic I., and Baker E.N. Structure 13 (2005) 541
5. Booth, R. J.; Denny, W. A., Dobrusin, E. M.; Kraker, A. J.; Mitchell, L. H.; Smaill, J. B.; Thompson, A. M.; Lee, H. H.; McCarthy, F. O. J.; Palmer, B. D. PCT Int. Appl. WO 03091255 A1, Published 6 November, 2003, 356 pp.
6. Suganuma M., Kawabe T., Hori H., Funabiki T., and Okamoto T. Cancer Res. 59 (1999) 5887
7. Davies S.P., Reddy H., Caivano M., and Cohen P. Biochem. J. 351 (2000) 95
8. El-Galley R., Keane T.E., and Sun C. Urol. Oncol. 21 (2003) 49
9. Hardman W.E., Moyer M.P., and Cameron I.L. Br. J. Cancer 81 (1999) 440