메뉴 건너뛰기




Volumn 156, Issue 6, 2007, Pages 1204-1213

Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment

Author keywords

AKT; ERK; MAPK; Melanoma; PI3K; Signalling

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SORAFENIB; WORTMANNIN;

EID: 34447104362     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.07821.x     Document Type: Article
Times cited : (111)

References (29)
  • 1
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002 417: 949 54.
    • (2002) Nature , vol.417 , pp. 949-54
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 2
    • 21344456180 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    • Meier F, Schittek B, Busch S et al. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci 2005 10: 2986 3001.
    • (2005) Front Biosci , vol.10 , pp. 2986-3001
    • Meier, F.1    Schittek, B.2    Busch, S.3
  • 3
    • 0242658523 scopus 로고    scopus 로고
    • Reciprocal regulation of MelCAM and AKT in human melanoma
    • Li G, Kalabis J, Xu X et al. Reciprocal regulation of MelCAM and AKT in human melanoma. Oncogene 2003 22: 6891 9.
    • (2003) Oncogene , vol.22 , pp. 6891-9
    • Li, G.1    Kalabis, J.2    Xu, X.3
  • 4
    • 0036796781 scopus 로고    scopus 로고
    • Get a ligand, get a life: Integrins, signaling and cell survival
    • Stupack DG, Cheresh DA. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 2002 115: 3729 38.
    • (2002) J Cell Sci , vol.115 , pp. 3729-38
    • Stupack, D.G.1    Cheresh, D.A.2
  • 5
    • 0034744538 scopus 로고    scopus 로고
    • Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway
    • Woods D, Cherwinski H, Venetsanakos E et al. Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol 2001 21: 3192 205.
    • (2001) Mol Cell Biol , vol.21 , pp. 3192-205
    • Woods, D.1    Cherwinski, H.2    Venetsanakos, E.3
  • 6
    • 4344584872 scopus 로고    scopus 로고
    • B-RAF is a therapeutic target in melanoma
    • Karasarides M, Chiloeches A, Hayward R et al. B-RAF is a therapeutic target in melanoma. Oncogene 2004 23: 6292 8.
    • (2004) Oncogene , vol.23 , pp. 6292-8
    • Karasarides, M.1    Chiloeches, A.2    Hayward, R.3
  • 7
    • 13144281830 scopus 로고    scopus 로고
    • BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience
    • Ahmad T, Marais R, Pyle L et al. BAY 43-9006 in patients with advanced melanoma: the Royal Marsden experience. J Clin Oncol 2004 22: 7506.
    • (2004) J Clin Oncol , vol.22 , pp. 7506
    • Ahmad, T.1    Marais, R.2    Pyle, L.3
  • 8
    • 0022473621 scopus 로고
    • New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns
    • Pittelkow MR, Scott RE. New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns. Mayo Clin Proc 1986 61: 771 7.
    • (1986) Mayo Clin Proc , vol.61 , pp. 771-7
    • Pittelkow, M.R.1    Scott, R.E.2
  • 9
    • 0033883797 scopus 로고    scopus 로고
    • Human melanoma progression in skin reconstructs: Biological significance of bFGF
    • Meier F, Nesbit M, Hsu MY et al. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol 2000 156: 193 200.
    • (2000) Am J Pathol , vol.156 , pp. 193-200
    • Meier, F.1    Nesbit, M.2    Hsu, M.Y.3
  • 10
    • 0026168653 scopus 로고
    • A fluorometric rapid microassay to identify anti-proliferative compounds for human melanoma cells in vitro
    • Zouboulis CC, Garbe C, Krasagakis K et al. A fluorometric rapid microassay to identify anti-proliferative compounds for human melanoma cells in vitro. Melanoma Res 1991 1: 91 5.
    • (1991) Melanoma Res , vol.1 , pp. 91-5
    • Zouboulis, C.C.1    Garbe, C.2    Krasagakis, K.3
  • 11
    • 1942442169 scopus 로고    scopus 로고
    • Topical treatment with inhibitors of the phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice
    • Bedogni B, O'Neill MS, Welford SM et al. Topical treatment with inhibitors of the phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Cancer Res 2004 64: 2552 60.
    • (2004) Cancer Res , vol.64 , pp. 2552-60
    • Bedogni, B.1    O'Neill, M.S.2    Welford, S.M.3
  • 12
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004 64: 7099 109.
    • (2004) Cancer Res , vol.64 , pp. 7099-109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 13
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit DB, Garraway LA, Pratilas CA et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006 439: 358 62.
    • (2006) Nature , vol.439 , pp. 358-62
    • Solit, D.B.1    Garraway, L.A.2    Pratilas, C.A.3
  • 14
    • 0037531526 scopus 로고    scopus 로고
    • Exclusion of BRAFV599E as a melanoma susceptibility mutation
    • Meyer P, Klaes R, Schmitt C et al. Exclusion of BRAFV599E as a melanoma susceptibility mutation. Int J Cancer 2003 106: 78 80.
    • (2003) Int J Cancer , vol.106 , pp. 78-80
    • Meyer, P.1    Klaes, R.2    Schmitt, C.3
  • 15
    • 0037442752 scopus 로고    scopus 로고
    • Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
    • Satyamoorthy K, Li G, Gerrero MR et al. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 2003 63: 756 9.
    • (2003) Cancer Res , vol.63 , pp. 756-9
    • Satyamoorthy, K.1    Li, G.2    Gerrero, M.R.3
  • 16
    • 24944522719 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy
    • Tsurutani J, West KA, Sayyah J et al. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. Cancer Res 2005 65: 8423 32.
    • (2005) Cancer Res , vol.65 , pp. 8423-32
    • Tsurutani, J.1    West, K.A.2    Sayyah, J.3
  • 17
    • 0036729867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
    • Krystal GW, Sulanke G, Litz J. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 2002 1: 913 22.
    • (2002) Mol Cancer Ther , vol.1 , pp. 913-22
    • Krystal, G.W.1    Sulanke, G.2    Litz, J.3
  • 18
    • 23044445418 scopus 로고    scopus 로고
    • PED mediates AKT-dependent chemoresistance in human breast cancer cells
    • Stassi G, Garofalo M, Zerilli M et al. PED mediates AKT-dependent chemoresistance in human breast cancer cells. Cancer Res 2005 65: 6668 75.
    • (2005) Cancer Res , vol.65 , pp. 6668-75
    • Stassi, G.1    Garofalo, M.2    Zerilli, M.3
  • 19
    • 0442323485 scopus 로고    scopus 로고
    • LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism
    • Choi EK, Park HJ, Ma JS et al. LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Lett 2004 559: 141 4.
    • (2004) FEBS Lett , vol.559 , pp. 141-4
    • Choi, E.K.1    Park, H.J.2    Ma, J.S.3
  • 20
    • 6344222886 scopus 로고    scopus 로고
    • LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition
    • Tolloczko B, Turkewitsch P, Al-Chalabi M, Martin JG. LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition. J Pharmacol Exp Ther 2004 311: 787 93.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 787-93
    • Tolloczko, B.1    Turkewitsch, P.2    Al-Chalabi, M.3    Martin, J.G.4
  • 21
    • 0036690393 scopus 로고    scopus 로고
    • PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells
    • Stewart AL, Mhashilkar AM, Yang XH et al. PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells. Mol Med 2002 8: 451 61.
    • (2002) Mol Med , vol.8 , pp. 451-61
    • Stewart, A.L.1    Mhashilkar, A.M.2    Yang, X.H.3
  • 23
    • 0037400975 scopus 로고    scopus 로고
    • A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
    • Smalley KS. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003 104: 527 32.
    • (2003) Int J Cancer , vol.104 , pp. 527-32
    • Smalley, K.S.1
  • 24
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumorigenesis
    • Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001 98: 10983 5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10983-5
    • Testa, J.R.1    Bellacosa, A.2
  • 25
    • 0032749387 scopus 로고    scopus 로고
    • Matrix metalloproteinases in human melanoma cell lines and xenografts: Increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression
    • Hofmann UB, Westphal JR, Waas ET et al. Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression. Br J Cancer 1999 81: 774 82.
    • (1999) Br J Cancer , vol.81 , pp. 774-82
    • Hofmann, U.B.1    Westphal, J.R.2    Waas, E.T.3
  • 26
    • 0033597728 scopus 로고    scopus 로고
    • Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines
    • Kurschat P, Zigrino P, Nischt R et al. Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines. J Biol Chem 1999 274: 21056 62.
    • (1999) J Biol Chem , vol.274 , pp. 21056-62
    • Kurschat, P.1    Zigrino, P.2    Nischt, R.3
  • 27
    • 0035887436 scopus 로고    scopus 로고
    • Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells
    • Park BK, Zeng X, Glazer RI. Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 2001 61: 7647 53.
    • (2001) Cancer Res , vol.61 , pp. 7647-53
    • Park, B.K.1    Zeng, X.2    Glazer, R.I.3
  • 28
    • 0034654639 scopus 로고    scopus 로고
    • Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells
    • Welch DR, Sakamaki T, Pioquinto R et al. Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells. Cancer Res 2000 60: 1552 6.
    • (2000) Cancer Res , vol.60 , pp. 1552-6
    • Welch, D.R.1    Sakamaki, T.2    Pioquinto, R.3
  • 29
    • 33745075558 scopus 로고    scopus 로고
    • Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    • Smalley KS, Haass NK, Brafford PA et al. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 2006 5: 1136 44.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1136-44
    • Smalley, K.S.1    Haass, N.K.2    Brafford, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.