Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells

Cancer Investigation

Volumn 28, Issue 4, 2010, Pages 350-356

  Li, Jing ^a   Xu, Meixiang ^a   Yang, Zhen ^a   Li, Albert ^a   Dong, Jianli ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Apoptosis; CDK4 inhibitor; MEK inhibitor; Melanoma

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 219476; BIM PROTEIN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BIRC5; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; PRIORITY JOURNAL; UPREGULATION;

APOPTOSIS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 4; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; MELANOMA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950557554     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357900903286966     Document Type: Article

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