Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism

Neurogastroenterology and Motility

Volumn 21, Issue 2, 2009, Pages 215-222

  Chaumette, T ^a,b,c   Lebouvier, T ^a,b,c   Aubert, P ^a,b,c   Lardeux, B ^a,b,c   Qin, C ^d   Li, Q ^d   Accary, D ^e   Bezard E ^e   Bruley Des Varannes, S ^a,b,c   Derkinderen, P ^a,b,c   Neunlist, M ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c NANTES UNIVERSITY HOSPITAL   (France)

^d INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^e CNRS   (France)

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Colon; Enteric nervous system; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; NITRIC OXIDE SYNTHASE; TYROSINE 3 MONOOXYGENASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; GLIA CELL; INTESTINE INNERVATION; MALE; MONKEY; MYENTERIC PLEXUS; NERVE CELL PLASTICITY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; DISEASE MODELS, ANIMAL; ENTERIC NERVOUS SYSTEM; HUMANS; MACACA MULATTA; MALE; MYENTERIC PLEXUS; NEURONS; NEUROTRANSMITTER AGENTS; PARKINSONIAN DISORDERS;

EID: 58849098133     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01226.x     Document Type: Article

References (34)

1. Hornykiewicz O. Dopamine (3-hydroxytyramine) in the central nervous system and its relation to the Parkinson syndrome in man. Dtsch Med Wochenschr 1962 87 : 1807 10.
2. Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006 5 : 235 45.
3. Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease. Lancet Neurol 2003 2 : 107 16.
4. Sakakibara R, Uchiyama T, Yamanishi T, Shirai K, Hattori T. Bladder and bowel dysfunction in Parkinson's disease. J Neural Transm 2008 115 : 443 60.
5. Kaye J, Gage H, Kimber A, Storey L, Trend P. Excess burden of constipation in Parkinson's disease: a pilot study. Mov Disord 2006 21 : 1270 3.
6. Natale G, Pasquali L, Ruggieri S, Paparelli A, Fornai F. Parkinson's disease and the gut: a well known clinical association in need of an effective cure and explanation. Neurogastroenterol Motil 2008 20 : 741 9.
7. Cersosimo MG, Benarroch EE. Neural control of the gastrointestinal tract: implications for Parkinson disease. Mov Disord 2008 23 : 1065 75.
8. Schemann M, Neunlist M. The human enteric nervous system. Neurogastroenterol Motil 2004 16 (Suppl. 1 55 9.
9. Benarroch EE. Enteric nervous system: functional organization and neurologic implications. Neurology 2007 69 : 1953 7.
10. Li ZS, Schmauss C, Cuenca A, Ratcliffe E, Gershon MD. Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. J Neurosci 2006 26 : 2798 807.
11. Bassotti G, Villanacci V. Slow transit constipation: a functional disorder becomes an enteric neuropathy. World J Gastroenterol 2006 12 : 4609 13.
12. Bruley des Varannes S, Chevalier J, Pimont S et al. Serum from achalasia patients alters neurochemical coding in the myenteric plexus and nitric oxide mediated motor response in normal human fundus. Gut 2006 55 : 319 26.
13. Neunlist M, Aubert P, Toquet C et al. Changes in chemical coding of myenteric neurones in ulcerative colitis. Gut 2003 52 : 84 90.
14. Savidge TC, Newman P, Pothoulakis C et al. Enteric glia regulate intestinal barrier function and inflammation via release of S- nitrosoglutathione. Gastroenterology 2007 132 : 1344 58.
15. Wakabayashi K, Takahashi H, Ohama E, Ikuta F. Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol 1990 79 : 581 3.
16. Singaram C, Ashraf W, Gaumnitz EA et al. Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation. Lancet 1995 346 : 861 4.
17. Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006 396 : 67 72.
18. Qualman SJ, Haupt HM, Yang P, Hamilton SR. Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology 1984 87 : 848 56.
19. Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F. Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses. Acta Neuropathol 1988 76 : 217 21.
20. Smeyne RJ, Jackson-Lewis V. The MPTP model of Parkinson's disease. Brain Res Mol Brain Res 2005 134 : 57 66.
21. Bezard E, Dovero S, Prunier C et al. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J Neurosci 2001 21 : 6853 61.
22. Anderson G, Noorian AR, Taylor G et al. Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Exp Neurol 2007 207 : 4 12.
23. Bezard E, Ferry S, Mach U et al. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nat Med 2003 9 : 762 7.
24. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006 130 : 1480 91.
25. Wattchow D, Brookes S, Murphy E, Carbone S, de Fontgalland D, Costa M. Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterol Motil 2008 Epub ahead of print M, Schafer MK, Eiden L, Weihe E. Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes. J Comp Neurol 2003 459 : 90 111.
26. Hoff S, Zeller F, von Weyhern CW et al. Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol 2008 509 : 356 71.
27. Li ZS, Pham TD, Tamir H, Chen JJ, Gershon MD. Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation. J Neurosci 2004 24 : 1330 9.
28. Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 1995 4 : 257 69.
29. Hirsch EC, Hunot S, Damier P et al. Glial cell participation in the degeneration of dopaminergic neurons in Parkinson's disease. Adv Neurol 1999 80 : 9 18.
30. Serra PA, Sciola L, Delogu MR et al. The neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes. J Biol Chem 2002 277 : 34451 61.
31. Ferri GL, Probert L, Cocchia D, Michetti F, Marangos PJ, Polak JM. Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system. Nature 1982 297 : 409 10.
32. Jessen KR, Mirsky R. Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Nature 1980 286 : 736 7.
33. Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F. Lewy bodies in the enteric nervous system in Parkinson's disease. Arch Histol Cytol 1989 52 : 191 4.
34. Lebouvier T, Chaumette T, Damier P et al. Pathological lesions in colonic biopsies during Parkinson's disease. Gut 2008 in press H, Del Tredici K. Invited article: nervous system pathology in sporadic Parkinson disease. Neurology 2008 70 : 1916 25.