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Volumn 28, Issue 1, 2013, Pages 31-40

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

Author keywords

sheet formation; Lewy like pathology; Misfolded synuclein; Prions; Toxic oligomers

Indexed keywords

ALPHA SYNUCLEIN; OLIGOMER; PRION PROTEIN;

EID: 84873458538     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25373     Document Type: Review
Times cited : (320)

References (70)
  • 1
    • 84862620376 scopus 로고    scopus 로고
    • A unifying role for prions in neurodegenerative diseases
    • Cell biology.
    • Prusiner SB. Cell biology. A unifying role for prions in neurodegenerative diseases. Science 2012;336:1511-1513.
    • (2012) Science , vol.336 , pp. 1511-1513
    • Prusiner, S.B.1
  • 2
    • 0035902194 scopus 로고    scopus 로고
    • Shattuck lecture-neurodegenerative diseases and prions
    • Prusiner SB. Shattuck lecture-neurodegenerative diseases and prions. N Engl J Med 2001;344:1516-1526.
    • (2001) N Engl J Med , vol.344 , pp. 1516-1526
    • Prusiner, S.B.1
  • 4
    • 0001509014 scopus 로고
    • Paralysis agitans. I. Pathologische Anatomie
    • Lewandowsky M, ed. Berlin: Springer
    • Lewy FH. Paralysis agitans. I. Pathologische Anatomie. In: Lewandowsky M, ed. Handbuch de Neurologie. Berlin: Springer; 1912:920-933.
    • (1912) Handbuch de Neurologie , pp. 920-933
    • Lewy, F.H.1
  • 5
    • 7844245247 scopus 로고
    • Contribution a l'etude de l'anatomie pathologique du locus niger de Soemmering avec quelques deductions relatives a la pathogenie des troubles du tonus musculaires et de la maladie de Parkinson
    • Paris
    • Tretiakoff C. Contribution a l'etude de l'anatomie pathologique du locus niger de Soemmering avec quelques deductions relatives a la pathogenie des troubles du tonus musculaires et de la maladie de Parkinson. Rev Neurol (Paris) 1921;28:592-600.
    • (1921) Rev Neurol , vol.28 , pp. 592-600
    • Tretiakoff, C.1
  • 6
    • 3142540683 scopus 로고    scopus 로고
    • Lewy-body formation is an aggresome-related process: a hypothesis
    • Olanow CW, Perl DP, DeMartino GN, McNaught K. Lewy-body formation is an aggresome-related process: a hypothesis. Lancet Neurol 2004;3:496-503.
    • (2004) Lancet Neurol , vol.3 , pp. 496-503
    • Olanow, C.W.1    Perl, D.P.2    DeMartino, G.N.3    McNaught, K.4
  • 8
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 10
    • 4644290985 scopus 로고    scopus 로고
    • Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
    • Chartier-Harlin MC, Kacherus J, Roumier C, et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004;364:1167-1169.
    • (2004) Lancet , vol.364 , pp. 1167-1169
    • Chartier-Harlin, M.C.1    Kacherus, J.2    Roumier, C.3
  • 11
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
    • Ibanez P, Bonnet AM, Debarges B, et al. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004;364:1169-1171.
    • (2004) Lancet , vol.364 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.M.2    Debarges, B.3
  • 12
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-synuclein locus triplication causes Parkinson's disease [serial online]
    • Singleton AB, Farrer M, Johnson J, et al. Alpha-synuclein locus triplication causes Parkinson's disease [serial online]. Science 2003;302:841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 13
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    • Satake W, Nakabayashi Y, Mizuta I, et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet. 2009;41:1303-1307.
    • (2009) Nat Genet. , vol.41 , pp. 1303-1307
    • Satake, W.1    Nakabayashi, Y.2    Mizuta, I.3
  • 14
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • Simon-Sanchez J, Schulte C, Bras JM, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009;41:1308-1312.
    • (2009) Nat Genet. , vol.41 , pp. 1308-1312
    • Simon-Sanchez, J.1    Schulte, C.2    Bras, J.M.3
  • 15
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    • Masliah E, Rockenstein E, Veinbergs I, et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 2000;287:1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3
  • 16
    • 0038015531 scopus 로고    scopus 로고
    • Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
    • Kirik D, Bjorklund A. Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors. Trends Neurosci 2003;26:386-392.
    • (2003) Trends Neurosci , vol.26 , pp. 386-392
    • Kirik, D.1    Bjorklund, A.2
  • 17
    • 84855972240 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts
    • Jellinger KA. Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov Disord 2012;27:8-30.
    • (2012) Mov Disord , vol.27 , pp. 8-30
    • Jellinger, K.A.1
  • 19
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson's disease
    • Burke RE, Dauer WT, Vonsattel JP. A critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol 2008;64:485-491.
    • (2008) Ann Neurol , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.3
  • 20
    • 0042837887 scopus 로고    scopus 로고
    • A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    • Olanow CW, Goetz CG, Kordower JH, et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003;54:403-414.
    • (2003) Ann Neurol , vol.54 , pp. 403-414
    • Olanow, C.W.1    Goetz, C.G.2    Kordower, J.H.3
  • 21
    • 0027977759 scopus 로고
    • Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease
    • Lindvall O, Sawle G, Widner H, et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 1994;35:172-180.
    • (1994) Ann Neurol , vol.35 , pp. 172-180
    • Lindvall, O.1    Sawle, G.2    Widner, H.3
  • 22
    • 0028911848 scopus 로고
    • Neuropathologic evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease
    • Kordower JH, Freeman TB, Snow BJ, et al. Neuropathologic evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124.
    • (1995) N Engl J Med , vol.332 , pp. 1118-1124
    • Kordower, J.H.1    Freeman, T.B.2    Snow, B.J.3
  • 23
    • 43249114934 scopus 로고    scopus 로고
    • Parkinson's disease pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Parkinson's disease pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008;14:504-506.
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 24
    • 43249110200 scopus 로고    scopus 로고
    • Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    • Li JY, Englund E, Holton JL, et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008;14:501-503.
    • (2008) Nat Med , vol.14 , pp. 501-503
    • Li, J.Y.1    Englund, E.2    Holton, J.L.3
  • 25
    • 79958227103 scopus 로고    scopus 로고
    • Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease
    • Kurowska Z, Englund E, Widner H, Lindvall O, Li J-Y, Brudin Pl. Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. J Parkinsons Dis 2011;1:83-92.
    • (2011) J Parkinsons Dis , vol.1 , pp. 83-92
    • Kurowska, Z.1    Englund, E.2    Widner, H.3    Lindvall, O.4    Li, J.-Y.5    Brudin, P.6
  • 29
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee H-J, Patel S, Lee S-J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 2005;25:6016-6024.
    • (2005) J Neurosci , vol.25 , pp. 6016-6024
    • Lee, H.-J.1    Patel, S.2    Lee, S.-J.3
  • 31
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • Desplats P, Lee HJ, Bae EJ, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 2009;106:13010-13015.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13010-13015
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3
  • 32
    • 79551519276 scopus 로고    scopus 로고
    • α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    • Hansen C, Angot E, Bergstrom A-L, et al. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011;121:715-725.
    • (2011) J Clin Invest , vol.121 , pp. 715-725
    • Hansen, C.1    Angot, E.2    Bergstrom, A.-L.3
  • 33
    • 79960285197 scopus 로고    scopus 로고
    • Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat
    • Kordower JH, Dodiya HB, Kordower AM, et al. Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis 2011;43:552-557.
    • (2011) Neurobiol Dis , vol.43 , pp. 552-557
    • Kordower, J.H.1    Dodiya, H.B.2    Kordower, A.M.3
  • 34
    • 72149119358 scopus 로고    scopus 로고
    • Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    • Luk KC, Song C, O'Brien P, et al. Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. PNAS 2009;106:20051-20056.
    • (2009) PNAS , vol.106 , pp. 20051-20056
    • Luk, K.C.1    Song, C.2    O'Brien, P.3
  • 35
    • 80053613574 scopus 로고    scopus 로고
    • Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    • Volpicelli-Daley LA, Luk KC, Patel TP, et al. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 2011;72:57-71.
    • (2011) Neuron , vol.72 , pp. 57-71
    • Volpicelli-Daley, L.A.1    Luk, K.C.2    Patel, T.P.3
  • 36
    • 84868148328 scopus 로고    scopus 로고
    • Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
    • Freundt EC, Maynard N, Clancy EK, et al. Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport. Ann Neurol. 2012;72:517-524.
    • (2012) Ann Neurol. , vol.72 , pp. 517-524
    • Freundt, E.C.1    Maynard, N.2    Clancy, E.K.3
  • 37
    • 84863433677 scopus 로고    scopus 로고
    • Prion-like acceleration of a synucleinopathy in a transgenic mouse model
    • Mougenot AL, Nicot S, Bencsik A, et al. Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging 2012;33:2225-2228.
    • (2012) Neurobiol Aging , vol.33 , pp. 2225-2228
    • Mougenot, A.L.1    Nicot, S.2    Bencsik, A.3
  • 38
    • 84869109864 scopus 로고    scopus 로고
    • Pathological a-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm K, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM-Y. Pathological a-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012;338:949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, K.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.-Y.7
  • 40
    • 77952648551 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    • Emmanouilidou E, Melachroinou K, Roumeliotis T, et al. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 2010;30:6838-6851.
    • (2010) J Neurosci , vol.30 , pp. 6838-6851
    • Emmanouilidou, E.1    Melachroinou, K.2    Roumeliotis, T.3
  • 41
    • 84865307818 scopus 로고    scopus 로고
    • Exosomal cell-to-cell transmission of alpha synuclein oligomers [serial online]
    • Danzer KM, Kranich LR, Ruf WP, et al. Exosomal cell-to-cell transmission of alpha synuclein oligomers [serial online]. Mol Neurodegener 2012;7:42.
    • (2012) Mol Neurodegener , vol.7 , pp. 42
    • Danzer, K.M.1    Kranich, L.R.2    Ruf, W.P.3
  • 43
    • 84861563520 scopus 로고    scopus 로고
    • Direct observation of the interconversion of normal and toxic forms of α-synuclein
    • Cremades N, Cohen SI, Deas E, et al. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 2012;149:1048-1059.
    • (2012) Cell , vol.149 , pp. 1048-1059
    • Cremades, N.1    Cohen, S.I.2    Deas, E.3
  • 44
    • 80052398365 scopus 로고    scopus 로고
    • α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T, Choi JG, Selkoe DJ. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011;477:107-110.
    • (2011) Nature , vol.477 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 45
    • 2642514788 scopus 로고    scopus 로고
    • Alpha-synuclein: normal function and role in neurodegenerative diseases
    • Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr Top Dev Biol. 2004;60:17-54.
    • (2004) Curr Top Dev Biol. , vol.60 , pp. 17-54
    • Norris, E.H.1    Giasson, B.I.2    Lee, V.M.3
  • 46
    • 6944227811 scopus 로고    scopus 로고
    • Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
    • Chandra S, Fornai F, Kwon HB, et al. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 2004;101:14966-14971.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14966-14971
    • Chandra, S.1    Fornai, F.2    Kwon, H.B.3
  • 47
    • 1442275729 scopus 로고    scopus 로고
    • Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway
    • Lee HJ, Khoshaghideh F, Patel S, Lee SJ. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 2004;24:1888-1896.
    • (2004) J Neurosci , vol.24 , pp. 1888-1896
    • Lee, H.J.1    Khoshaghideh, F.2    Patel, S.3    Lee, S.J.4
  • 48
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008;283:23542-23556.
    • (2008) J Biol Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 50
    • 20744442130 scopus 로고    scopus 로고
    • A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson's disease
    • Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson's disease. J Biol Chem 2005;280:22670-22678.
    • (2005) J Biol Chem , vol.280 , pp. 22670-22678
    • Liu, C.W.1    Giasson, B.I.2    Lewis, K.A.3    Lee, V.M.4    Demartino, G.N.5    Thomas, P.J.6
  • 54
    • 0036316947 scopus 로고    scopus 로고
    • Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
    • McNaught KS, Mytilineou C, Jnobaptiste R, Yabut J, Shashidharan P, Jennert P, Olanow CW. Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures. J Neurochem 2002;81:301-306.
    • (2002) J Neurochem , vol.81 , pp. 301-306
    • McNaught, K.S.1    Mytilineou, C.2    Jnobaptiste, R.3    Yabut, J.4    Shashidharan, P.5    Jennert, P.6    Olanow, C.W.7
  • 55
    • 0035870881 scopus 로고    scopus 로고
    • Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
    • Tanaka Y, Engelender S, Igarashi S, et al. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 2001;10:919-926.
    • (2001) Hum Mol Genet , vol.10 , pp. 919-926
    • Tanaka, Y.1    Engelender, S.2    Igarashi, S.3
  • 56
    • 0038413759 scopus 로고    scopus 로고
    • Aggregated and monomeric alpha-synuclein bind to the S6′ proteasomal protein and inhibit proteasomal function
    • Snyder H, Mensah K, Theisler C, et al. Aggregated and monomeric alpha-synuclein bind to the S6′ proteasomal protein and inhibit proteasomal function. J Biol Chem 2003;278:11753-11759.
    • (2003) J Biol Chem , vol.278 , pp. 11753-11759
    • Snyder, H.1    Mensah, K.2    Theisler, C.3
  • 57
    • 38849174979 scopus 로고    scopus 로고
    • Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    • Martinez-Vicente M, Talloczy Z, Kaushik S, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008;118:777-788.
    • (2008) J Clin Invest , vol.118 , pp. 777-788
    • Martinez-Vicente, M.1    Talloczy, Z.2    Kaushik, S.3
  • 58
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo AM, Stefanis L, Fredenburg R, et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004;305:1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3
  • 59
    • 79957620836 scopus 로고    scopus 로고
    • Parkinson's disease, proteins, and prions: milestones
    • Olanow CW, McNaught K. Parkinson's disease, proteins, and prions: milestones. Mov Disord 2011;26:1056-1071.
    • (2011) Mov Disord , vol.26 , pp. 1056-1071
    • Olanow, C.W.1    McNaught, K.2
  • 60
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinsons disease: relationship to alpha synuclein inclusions
    • Chu Y, Dodiya1 H, Aebischer P, et al. Alterations in lysosomal and proteasomal markers in Parkinsons disease: relationship to alpha synuclein inclusions. Neurobiol Dis 2009;35:385-398.
    • (2009) Neurobiol Dis , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya1, H.2    Aebischer, P.3
  • 61
    • 0035859865 scopus 로고    scopus 로고
    • Frequency of bowel movements and the future risk of Parkinson's disease
    • Abbott RD, Petrovitch H, White LR, et al. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology 2001;57:456-462.
    • (2001) Neurology , vol.57 , pp. 456-462
    • Abbott, R.D.1    Petrovitch, H.2    White, L.R.3
  • 62
    • 84861697687 scopus 로고    scopus 로고
    • Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases
    • Shannon KM, Keshavarzian A, Dodiya HB, et al. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Mov Disord 2012;27:716-719.
    • (2012) Mov Disord , vol.27 , pp. 716-719
    • Shannon, K.M.1    Keshavarzian, A.2    Dodiya, H.B.3
  • 63
    • 77649284470 scopus 로고    scopus 로고
    • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice [serial online]
    • Pan-Montojo F, Anichtchik O, Dening Y, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice [serial online]. PLoS One 2010;5(1):e8762.
    • (2010) PLoS One , vol.5 , Issue.1
    • Pan-Montojo, F.1    Anichtchik, O.2    Dening, Y.3
  • 64
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice [serial online]
    • Pan-Montojo F, Schwarz M, Winkler C, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice [serial online]. Sci Rep 2012;2:898.
    • (2012) Sci Rep , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3
  • 65
    • 84866558750 scopus 로고    scopus 로고
    • Transmission of synucleinopathies in the enteric nervous system of A53T alpha-synuclein transgenic mice
    • Lee HJ, Suk JE, Lee KW, Park SH, Blumbergs PC, Gai WP, Lee SJ. Transmission of synucleinopathies in the enteric nervous system of A53T alpha-synuclein transgenic mice. Exp Neurobiol 2011;20:181-188.
    • (2011) Exp Neurobiol , vol.20 , pp. 181-188
    • Lee, H.J.1    Suk, J.E.2    Lee, K.W.3    Park, S.H.4    Blumbergs, P.C.5    Gai, W.P.6    Lee, S.J.7
  • 66
    • 85027912037 scopus 로고    scopus 로고
    • Alpha-synuclein and protein degradation systems: a reciprocal relationship [published online ahead of print]
    • Xilouri M, Brekk OR, Stefanis L. Alpha-synuclein and protein degradation systems: a reciprocal relationship [published online ahead of print]. Mol Neurobiol 2012.
    • (2012) Mol Neurobiol
    • Xilouri, M.1    Brekk, O.R.2    Stefanis, L.3
  • 67
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?
    • Chu Y, Kordower JH. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease? Neurobiol Dis 2007;25:134-149.
    • (2007) Neurobiol Dis , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 68
    • 84865249504 scopus 로고    scopus 로고
    • Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein
    • Fauvet B, Fares MB, Samuel F, Dikiy I, Tandon A, Eliezer D, Lashuel HA. Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein. J Biol Chem 2012;287:28243-28262.
    • (2012) J Biol Chem , vol.287 , pp. 28243-28262
    • Fauvet, B.1    Fares, M.B.2    Samuel, F.3    Dikiy, I.4    Tandon, A.5    Eliezer, D.6    Lashuel, H.A.7
  • 69
    • 20444413356 scopus 로고    scopus 로고
    • Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease
    • Masliah E, Rockenstein E, Adame A, et al. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron 2005;46:857-868.
    • (2005) Neuron , vol.46 , pp. 857-868
    • Masliah, E.1    Rockenstein, E.2    Adame, A.3
  • 70
    • 84866679781 scopus 로고    scopus 로고
    • Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission
    • Bae EJ, Lee HJ, Rockenstein E, et al. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci 2012;32:13454-13469.
    • (2012) J Neurosci , vol.32 , pp. 13454-13469
    • Bae, E.J.1    Lee, H.J.2    Rockenstein, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.