Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3240-3250

  Garcia Prieto, Celia ^a   Ahmed, Kausar Begam Riaz ^a,b   Chen, Zhao ^a,c   Zhou, Yan ^d   Hammoudi, Naima ^a,b   Kang, Ying ^e   Lou, Changgang ^e   Mei, Yan ^e   Jin, Zhendong ^e   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d East Tennessee State University   (United States)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; CALCIUM HOMEOSTASIS; CALCIUM OVERLOAD; CANCER CELLS; CASPASE-3; CYCLOSPORIN A; CYTOCHROME C; CYTOSOLIC; CYTOTOXIC ACTIVITIES; LEUKEMIA CELLS; MECHANISM OF ACTION; MECHANISTIC STUDIES; MITOCHONDRIAL MEMBRANE POTENTIAL; NATURAL PRODUCTS; POTENT ACTIVITY; SURVIVAL FACTOR; TIME-DEPENDENT;

CELL DEATH; CELL MEMBRANES; DISEASES; MITOCHONDRIA; SODIUM;

CALCIUM;

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; CALCIUM ION; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; NATURAL PRODUCT; OSW 1; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

BIOLOGICAL AGENTS; CALCIUM; CALCIUM CHANNELS; CALPAIN; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CHOLESTENONES; CYCLOSPORINE; CYTOCHROMES C; CYTOSOL; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EXTRACELLULAR SPACE; HEAT-SHOCK PROTEINS; HOMEOSTASIS; HUMANS; LEUKEMIA; LYMPHOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; SAPONINS; SODIUM-CALCIUM EXCHANGER; THAPSIGARGIN; TIME FACTORS;

EID: 84873282810     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.384776     Document Type: Article

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