Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1

Journal of Medicinal Chemistry

Volumn 54, Issue 9, 2011, Pages 3298-3305

  Maj, Jadwiga ^a   Morzycki, Jacek W ^a   Rárová, Lucie ^b   Oklešt'Ková, Jana ^b   Strnad, Miroslav ^b   Wojtkielewicz, Agnieszka ^a  

^a UNIVERSITY OF BIALYSTOK   (Poland)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

21 BENZYLOXY 20 METHYLPREGN 5 ENE 3BETA,16BETA,17ALPHA TRIOL 6 O [2 O (4 METHOXYBENZOYL) BETA DEXTRO XYLOPYRANOSYL (1 3) 2' O ACETYLARABINOPYRANOSIDE]; 21 O (4 METHOXYBENZOYL) 20 METHYLPREGN 5 ENE 3BETA,16BETA,17ALPHA,21 TETRAOL 16 O [2 O (4 METHOXYBENZOYL) BETA DEXTRO XYLOPYRANOSYL (1-3) 2' ACETYL ALPHA LEVO ARABINOPYRANOSIDE]; 21 O (BUT 2 ENOYL) 20 METHYLPREGN 5 ENE 3BETA,16BETA,17ALPHA,21 TETRAOL 16 O [2 O (4 METHOXYBENZOYL) BETA DEXTRO XYLOPYRANOSYL (1-3) 2' ACETYL ALPHA LEVO ARABINOPYRANOSIDE]; 21 O (UNDEC 10 ENOYL) 20 METHYLPREGN 5 ENE 3BETA,16BETA,17ALPHA,21 TETRAOL 16 O [2 O (4 METHOXYBENZOYL) BETA DEXTRO XYLOPYRANOSYL (1-3) 2' ACETYL ALPHA LEVO ARABINOPYRANOSIDE]; AGLYCONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; OSW 1; SAPONIN; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL CYCLE; CELL LINE, TUMOR; CHOLESTENONES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; SAPONINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955833912     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101648h     Document Type: Article

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