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0010540662
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note
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1 Cephalostatin Support Studies 12.
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2
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0001678648
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2 (a) Kubo, S.; Mimaki, Y.; Terao, M.; Sashida, Y.; Nikaida, T.; Ohmoto, T. Phytochemistry 1992, 31, .3969;
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Ohmoto, T.6
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3
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0031552155
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(b) Mimaki, Y.; Kuroda, M.; Kameyama, A.; Sashida, Y.; Hirano, T.; Oka, K.; Maekawa, R.; Wada, T.; Sugita, K.; Beutler, J. A. Bioorg. & Med. Chem. Lett. 1997, 7, 633.
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Mimaki, Y.1
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4
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0023864515
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3 (a) Pettit, G. R.; Inoue, M.; Kamano, Y.; Herald, D. L.; Arm, C.; Dufresne, C.; Christie, N. D.; Schmidt, J. M.; Doubek, D. L.; Krupa, T. S. J. Am. Chem. Soc. 1988, 110, 2006;
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5
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0028871830
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(b) Fukuzawa, S.; Matsunaga, S.; Fusetani, N. J. Org. Chem. 1995, 60, 608; Thus far, 17 cephalostatins and 26 related ritterazines have been isolated.
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6 Akhrem, A. A.; Dubrovskii, V. A.; Kamernitski, A. V.; Skorova, A. V. IZV. Akad. Nauk SSSR, Ser. Khim 1969, 2792.
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12
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9 Kress, M. H.; Ruel, R.; Miller, W. H.; Kishi, Y. Tetrahedron Lett. 1993, 34, 5999.
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33751385720
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11 Houston, T. A.; Tanaka, Y.; Koreeda, M. J. Org. Chem. 1993, 55, 4287.
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12 Williams, D. R.; Kingler, F. D.; Dabral, V. Tetrahedron Lett. 1988, 29, 3415.
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13 Hardinger, S. A.; Wijaya, N. Tetrahedron Lett. 1993, 34, 3821. We intially protected the C3 OH of 10 as its TBDPS or TBS ether, but the resulting homoallylic silyl ether proved to be unstable toward the Lewis acid employed during the subsequent ene reaction to introduce the side chain.
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Hardinger, S.A.1
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20
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0010575602
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note
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21
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0010539165
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note
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15 Details of the crystal structure investigations may be obtained from the Cambridge Crystallographic Data Centre, 12 Union Road, GB-Cambridge CB2 1EZ (UK).
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22
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16 Lipshutz, B. H.; Pollart, D.; Monforte, J.; Kotsuki, H. Tetrahedron Lett. 1985,20,705.
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