Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3257-3260

  Zheng, Dan ^a   Guan, Yuyao ^a   Chen, Xiaozhuo ^a   Xu, Yanpeng ^a   Chen, Xiaoguang ^b   Lei, Pingsheng ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytotoxicity; OSW 1; SAR; Steroidal saponin; Synthesis

Indexed keywords

2 O 4 METHOXYBENZOYL BETA XYLOPYRANOSYL (1-3) 2 O ACETYL ALPHA ARABINOPYRANOSYL; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CHOLESTANES; CHOLESTENONES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79956118712     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.030     Document Type: Article

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