Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 887-899

  Pérez, Bianca C ^a   Teixeira, Cátia ^a,b   Figueiras, Marta ^a   Gut, Jiri ^c   Rosenthal, Philip J ^c   Gomes, José R B ^b   Gomes, Paula ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimalarials; Blood schizontocidal; Chloroquine; Cinnamic acid derivatives; Molecular modeling studies

Indexed keywords

2 [3 (4 AMINOPHENYL)ACRYLAMIDO] N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYLPENTANAMIDE; 2 [3 (4 BROMOPHENYL)ACRYLAMIDO] N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYLPENTANAMIDE; 2 [3 (4 CHLOROPHENYL)ACRYLAMIDO] N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYLPENTANAMIDE; 3 (4 BROMOPHENYL) N (7 CHLOROQUINOLIN 4 YL)ACRYLAMIDE; 3 (4 CHLOROPHENYL) N (7 CHLOROQUINOLIN 4 YL)ACRYLAMIDE; 4 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; CINNAMIC ACID DERIVATIVE; N (7 CHLOROQUINOLIN 4 YL) 3 (2 NITROPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (3 FLUOROPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (3 NITROPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (4 FLUOROPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (4 ISOPROPYLPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (4 METHOXYPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (4 NITROPHENYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL) 3 (4 TOLYL)ACRYLAMIDE; N (7 CHLOROQUINOLIN 4 YL)CINNAMAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 2 [3 (3 FLUOROPHENYL)ACRYLAMIDO] 4 METHYLPENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 2 [3 (4 FLUORO PHENYL)ACRYLAMIDO] 4 METHYLPENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 2 [3 (4 ISO PROPYLPHENYL)ACRYLAMIDO] 4 METHYLPENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 2 [3 (4 METHOXYPHENYL)ACRYLAMIDO] 4 METHYLPENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYL 2 (3 ACRYLAMIDO)PENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYL 2 [3 (2 NITROPHENYL)ACRYLAMIDO]PENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYL 2 [3 (3 NITROPHENYL)ACRYLAMIDO]PENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYL 2 [3 (4 NITROPHENYL)ACRYLAMIDO]PENTANAMIDE; N [1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL] 4 METHYL 2 [3 (4 TOLYL)ACRYLAMIDO]PENTANAMIDE; TERT BUTYL[4 [3 [[ 1 [[ 1 [(7 CHLOROQUINOLIN 4 YL)AMINO] 1 OXO 4 PHENYLBUTAN 2 YL]AMINO] 4 METHYL 1 OXOPENTAN 2 YL]AMINO] 3 OXOPROP 1 EN 1 YL]PHENYL]CARBAMATE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINO ACIDS; AMINOQUINOLINES; ANTIMALARIALS; CINNAMATES; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; HEME; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PLASMODIUM FALCIPARUM; POLYMERIZATION; PROTEASE INHIBITORS; PROTEIN CONFORMATION;

EID: 84864402076     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.022     Document Type: Article

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